GLP-1 medications, commonly prescribed for diabetes and obesity, are linked to reduced hospital care and sickness absence due to depression, anxiety, substance use disorders, and suicidal behavior. mentalhealth

Questioning the benefit of an implant to close the left atrial appendage vs medical therapy in a randomized trial @NEJM https://t.co/N0hpdIfmLe https://t.co/8bkk8FzLuY
A new company you've probably never heard of is dominating the No Surprises Act's arbitration process. Behind HaloMD is a larger-than-life Texas couple who built their wealth on questionable arrangements with out-of-network providers. https://t.co/p1jCEZFBaA via @statnews

A new finding after stopping GLP-1 drugs in a large cohort with Type 2 diabetes: rapid erosion of CV benefit/protection New @bmj_latest by @zalaly @Biostayan https://t.co/JG6yB8wTJJ See thread: https://t.co/6JvfIIjVBw https://t.co/wUgWhvs9Yy
CBER changes its standard operating procedures to open the door to RMAT designations for therapies on clinical hold - https://t.co/bZmhga8xxC

Sharp take here from healthcare VC Sam Toole on the future of EHRs in an AI world. Do they become systems of record, and entrepreneurs can build systems of action that sit on top? Link to read the full piece...

What if we could engineer T cells in the body, making CAR T vs cancer, autoimmune diseases, and other applications far more practical, much less expensive? A step forward today via genome editing T cells https://t.co/FjgQA8NUlu https://t.co/XXk43WL1ac https://t.co/rpC7eCAlJH
A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive–compulsive disorder 73.3% were responders (⩾35% reduction in YBOCS scores), with 40% in remission. These effects diminished but remained substantial at 6 months. https://t.co/tp2SPIKDrB
For anyone considering immigrating to Uruguay here's a great overview of how the medical system works and how immigrants can sign up for either public or private healthcare. https://t.co/TZTE9AwEkv
RBC: Revolution, Xenon, Arrowhead among top #biotech takeover targets https://t.co/h1toH9szrU by @realJacobBell $ARWR $XENE $RVMD $DYNE
I now realize that the "solution" to the rising cost of healthcare will not be to ration healthcare. It will be to kill the most expensive patients.
Is "textbook performance" enough for medical AI? The first independent stress test of ChatGPT Health is out in @NatureMedicine. The Good: Near-perfect triage for textbook stroke and anaphylaxis. The Bad: A 51.6% under-triage rate for true emergencies. But there’s a massive elephant in the...

Potential of mitochondrial transfer to prevent or treat Parkinson' s disease, in mouse and monkey models @CellCellPress https://t.co/c0oqfagddX https://t.co/KyBc1zQttc
Does it stack the deck in favor of the standard antidepressants to pull data from placebo-controlled trials for one condition (the psychedelic) and compare it with single condition data for the standard antidepressants? Also...

80% of healthcare practices that invest in AI automation fail to see ROI. Not because the tools don't work, but because there was no digital strategy. Don't be the 80% See more & JoinUs https://t.co/05FgGDavR7 #healthcare #ai #businessautomation #smallbusiness #medical #doctor...
If you are vibe-coding apps for the healthcare sector I beg you - pay a deeply experienced technologist to audit it before anyone uses it. hipaa laws are no joke. I’ve personally been through the compliance audits, defending our encryption...

From a clinical perspective, patients are not asking for abstract years. They are asking for time with family, time in full cognition, time in independence, and time living on their own terms. That is why geroscience should be judged not...
How to get rich on out-of-network medical bills -- and how to get angry reading about it. By @TaraBannow https://t.co/fbmFyZhcic
Chinese biotech startup Excalipoint banks $69M for next-gen T cell engagers https://t.co/809RqRWJNL by @gwendolynawu #biotech #startups

AI and Digital Health are booming. In this book, we explain why now it's a good time to invest in Digital Health and give recommendations on where to invest by looking at the top 24 technological trends we find the...

Medical residents are the backbone of the hospital system. They are also its favorite punching bag. We expect them to work 80 hour weeks. We expect them to accept low pay. But we also force them to endure systemic disrespect, microaggressions,...

Sunway Healthcare Holdings Bhd (SUNMED, 5555) debuted strongly on Bursa Malaysia Main Market today. Opening price hit RM1.70 → 17% above IPO price of RM1.45. Price climbed fast to RM1.80–RM2.00 range in morning trade → market cap exceeded RM20 billion. Retail offering...
When I was at the Brigham/Harvard I saw how we billed different insurance levels as well as the uninsured. The uninsured got screwed the worst. Always. Different payers pay remarkably different prices for the identical things. It all comes down...

How about we ask @govofco how much more reinsurance is costing Colorado? And don’t give me the bs talking points about the average premium reduction, babes.
Yesterday one of my co-conspirators messaged to let me know that over 7k pregnant people and 20k children have health coverage because of the policy we passed years ago…Cover All Coloradans I have so many feelings that I can’t fully figure...

No evidence that medicinal cannabis effectively treats anxiety, depression, or PTSD - according to the largest review of cannabinoids ever conducted.
BEING WITH DYING: Professional Training Program for Clinicians in Compassionate Care of the Seriously Ill and Dying (In Person 2026) May 8-15 50 CME's for clinicians https://t.co/nt2OWCudf6
Cigarette smoking in the US falls below 10% of the population for the first time. https://t.co/JReSJgZA85
So it's time for an update on me playing around with Retatrutide. This is typed from mobile, so forgive any typos or missing words. First, I stopped using it about 2 weeks after post below. I didn't run out. I'm just...

Our bottleneck for some of the biggest change ahead may be humans. I shared the story of Paul Conyngham and his dog Rosie on my Instagram when it broke. When I read the coverage, my shock was less that ChatGPT...

Hospital of the Future — Advancing smart, connected care through data-driven innovation. Join me for a deep @DigitalDHealth dive with @StephenKonya @jconleymd, Manish Ladha, and Casey Granak This Thursday at 10am PST / 1pm EST for our https://t.co/YGpenFx8zW Studio Series Register here-->...
In France, women who give birth are routinely prescribed pelvic floor rehab. They get about 10 sessions with a physiotherapist covered by the government. This has been standard since the 1980s. In the US, you get a 6 week...

This week's Editor's Choice highlights a study by Valette and colleagues that evaluates a feedback system to improve gait and perception when using a knee prosthesis. @rlvalette Learn more in Science #Robotics: https://t.co/pWQ3r6aGLs https://t.co/xqUZp2YyCH
Adding complement proteins to the blood testing schedule is in the arena Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years https://t.co/qDwmnbxHHY

GIP preferentially enhances glucose storage and triglyceride deposition in healthier subcutaneous fat, particularly under conditions of hyperinsulinemia and hyperglycemia. Tirzepatide contains a GIP agonist. https://doi.org/10.2337/db10-0098 https://www.gatlan.com/ @GatlanHealth
It’s not one big delay that hurts care. It’s 60 seconds… repeated 100 times a day. Marianne Soucey explains how tiny workflow friction turns into real patient risk ↓ https://t.co/UjbpWUtOH1 @ConsensusCS @medq_inc #RSNA25 #HITSM https://t.co/6X9UwqHjHx

A pro se plaintiff just sued @HeyEpic in federal court, arguing its EHR architecture is a defective product. But sneakily, I don’t think it’s about Epic at all: it's a discovery pathway around the Texas malpractice rules that froze her...
Ketamine, an operating-room anesthetic also prized as the street drug “K” is now at the heart of a largely unregulated online industry offering depression relief. https://t.co/pGd0TO5uFy via @WSJ
Bicycle to lay off 30% of staff, pivot away from Padcev challenger https://t.co/m3JFu2mwoB @ByJonGardner $BCYC $PFE $MRK

Corporate life is damaging the health of Indian youth. According to reports 1 in 4 men aged between 31–35 shows pre-diabetes or high BP risk. The reasons behind this are: Long sitting hours Stress Poor sleep Junk food Pushing all corporate professionals into lifestyle diseases much earlier. Men...
Pfizer’s Ibrance successor moves forward with new study data https://t.co/ozXAZYmc3M by Kristin Jensen $PFE $LLY $NVS $RHHBY $ONC

A study asserts lack of disproportionate loss of muscle mass or strength cf weight loss from GLP-1 drug treatment, in mice and a small short term (12 weeks) trial in men The issue remains unsettled and counters the efforts by companies...

Neurodegenerative diseases at the single-cell level, a powerful tool to differentiate and better understand https://t.co/Pkz4qW0ELM @jclinicalinvest https://t.co/LiJ4FojRYZ
Much of the conversation around healthcare and AI right now pits doctors and AI against each other. This is the wrong framing. Yes, it is important to have studies that look at how good AI is at various tasks that physicians...
This week on Lifers, Graham Walker is “sounding the alarm” for physicians. * 50% of medical students already plan to quit before they finish school. * Doctors are becoming "factory employees," losing their authority to care for patients. * Tech focuses on the...

Some clinical updates tell you exactly what they are. Others ask to be read twice. CytomX’s latest CRC data belong firmly in the second category. Is the die cast? https://t.co/dfdPxx4zXs https://t.co/y9QAoahMut

Analyzing the future of medicine and healthcare, especially during the rise of digital health and artificial intelligence, should rely on established futures methods that the discipline of futures studies has been using for decades. By employing such methods, healthcare professionals,...
The Trump administration is "gearing up for war" to push Congress to codify its drug pricing policy — despite little appetite for it on the Hill. Still, the pharma industry sees risk in the back-and-forth. https://t.co/DR2LotvXFq
A brain-computer interface allowed people with paralysis to type with their minds https://t.co/W5icU6ye8c via @statnews

Mechanical forces play essential roles in biology. Measuring and controlling these forces represent emerging strategies for disease diagnosis and therapeutic intervention, to complement more traditional approaches. This review article, published today in Nature Reviews Bioengineering (https://t.co/byKGFuVFLH), summarizes the status of...