Comprehensive Genomic Landscape of Small Bowel Adenocarcinoma Revealed
Genomic profiling of small bowel adenocarcinoma: a pooled analysis from 3 databases [May 14, 2024] Aparicio et al. @BrJCancer https://t.co/xfznlhD4fh #sbcsm #cagenome HT @OncoThor
Disney's HoloTile Stalls, Leaving Therapeutic Potential Untapped
From time to time, I revisit some technologies that seemed to be exciting to see whether there is any news or updates about them. And sometimes it's heartbreaking to see nothing. Just like in the case of Disney's HoloTile floor...
Denial Delays Fuel Physician Burnout and Payor Tension
Having seen so many MD requests for either prescriptions or procedures reflexively denied initially, and requiring considerable additional effort from MDs office to get coverage, it's easy to appreciate both MD burnout and hostility towards payors.
Current LLMs Lack Safe Clinical Reasoning Capability
Assessment of 21 LLMs for generating a differential diagnosis "Off-the-shelf LLMs have not yet achieved the intelligence required for safe deployment and remain limited in demonstrating advanced clinical reasoning." https://t.co/9Nvo0kPrZA https://t.co/Odja5lkq8F
Multiplexed In‑Vivo Screening Drives Next‑Gen Drug Development
Multiplexed in vivo screening is the future of drug development. @ManifoldBio is multiplexing protein therapies in vivo. @GordianBio is multiplexing gene therapies in vivo. @waypointbio is multiplexing cell therapies in vivo. GT Bio is multiplexing LNPs in vivo. 50Y portcos all https://t.co/DT2AwXbKtB
ALLO May
Has $ALLO found a niche for allo Car-T at last? It's early days, so the answer is maybe. Via @APEXONCO -> https://t.co/bO3A1hpAY8
Rigorous Trials, Not Hype, Prove Cancer Drug Value
Today's $RVMD study outcome in pancreatic cancer is a good lesson for all the $IBRX @DrPatrick fans. Stop with all the hand-waving "cancer cure" podcasting social media nonsense. Shut up and run well-designed clinical trials with definitive endpoints. If you have...
Time‑restricted Eating Cuts Glucose, Insulin Resistance, HbA1c
Efficacy of different types of intermittent fasting in improving glycemic control in adults with overweight or obesity: a systematic review and network meta-analysis "Compared with a CON, TRE resulted in a larger reduction in fasting glucose... insulin resistance... HbA1c..." https://t.co/Jq9EpoAy3u
Peptides Are Potent Therapeutics, yet only a Few Qualify.
“The big picture is that peptides are a legitimate, powerful class of therapeutics, but the legitimacy is confined to a relatively narrow subset of them.” —Peter Attia 👨🏻⚕️
Talking Enhances Attention, Memory, Mood and Brain Health
Brand new TPH episode with Dr. Maryellen Macdonald about how talking sharpens attention, boosts memory, regulates emotions, and even protects against cognitive decline. https://t.co/f39rfYufQO
Rising Health Costs Force Trade‑offs in Hiring
Rising #healthcare costs will increasingly force employers to trade off between compensation, benefits richness, and hiring volume, potentially slowing workforce growth or shifting roles toward lower-cost geographies and employment models. https://t.co/rOx2TUN5yM
Same DEXA Score, Different Fracture Risks Explained
Your DEXA scan gives you a number, your doctor gives you a category, but the conversation often ends there... there's so much more nuance. Two people with the exact same T-score can have completely different fracture risk, and DEXA...
Pancreatic Cancer Trials Yield Only 1‑2 Month Gains
I remember years ago in pancreatic cancer trials you were realistically looking for 1 to 2 months improvement in survival (at best) in pancreatic cancer trials. Bravo $RVMD.👏
Second‑line RVMD Improves Pancreatic Cancer Survival over First
As noted by others, the $RVMD dara mOS in 2nd line PDAC is better than mOS for current first-line regimens.
Low‑Cost Vaccine Creator Outshines Rogan’s Diet Critique
I make low cost vaccines for global health, including a Covid vaccine technology for $2-3 per dose reached 100 million people, bypassed big pharma, didn’t make money, and all these Rogan types can talk about is a joke I made...
One Gene Therapy Platform Could Cure Obesity and More
Eric Kelsic makes the compelling case on using gene therapy technology to eventually treat common diseases, like obesity: “Fundamentally, we all share the same genetics." Because our bodies run on the same genetic blueprint, a disease - whether common or rare -...
Keep Moving: Rest Worsens Knee Osteoarthritis
Knee Osteoarthritis... Thread #2 ! Your knee hurts. Your instinct is to rest it. Please don't. That instinct is very often wrong — and following it makes osteoarthritis worse, not better. Movement is one of the best evidence-based primary treatments for...
Avalyn Pharma Outlines IPO Fund Allocation, IVVD, REPL Updates
13April: How does Avalyn Pharma plan to spend the proceeds of the IPO for which it has filed paperwork? Read what's been made public about the company's planned initial public offering, plus updates on $IVVD and $REPL in my latest...
Daraxonrasib Halves Pancreatic Cancer Mortality, Doubles Survival
Finally, best news of the morning (and something you didn't expect so soon)... Revolution Medicines $RVMD daraxonrasib Ph3 results in second-line pancreatic cancer. Median overall survival in ITT patients (KRAS mutants + wild type combined) Dara 13.2 months vs chemo 6.7...
Parents Underestimate Deadly Risk of Vaccine‑preventable Diseases
https://youtu.be/sLyGdEtRPyQ?si=HhO95z45Mz20D6kp We never imagine that our children could suffer or die from a vaccine-preventable disease.
Allogeneic CAR‑T Achieves 42% MRD Boost, Safe Profile
Allogene $ALLO cema-cel interim ALPHA3 results just reported: B-cell lymphoma MRD negativity: cema-cel 58% vs observation 16% A 42% absolute difference in MRD clearance is better than expected. Clean safety profile, too. Allogeneic CAR-T may have found its role. Nice...
Eliminating Cancer Could Add $197 Trillion to Economy
New @nberpubs: "The Economic Value of Eliminating Cancer" https://t.co/BJtM1578oY "Eliminating cancer mortality generates $197 trillion in economic benefits over 35 years, corresponding to approximately $16,282 per American per year, or $41,684 per American household per year" https://t.co/QQ3KYmQezj
Flavored E‑cig Ban Cuts Vaping Interest, Boosts Smoking Demand
New @nberpubs: "Consumer Tobacco Product Choices in China: The Impact of a Ban on Flavored E-Cigarettes" https://t.co/GeojsfqozA "a ban of flavored e-cigarettes decreases stated preferences for e-cigarettes but also has the unintended consequence to increase stated preferences for cigarettes" 😲
Spyre's SPY001 Achieves 40% Remission in UC Trial
Spyre $SYRE just reported SPY001 (long-acting alpha4beta7 antibody) ulcerative colitis induction data. Here's the efficacy chart, notable for a 40% clinical remission rate at week 12, albeit with small number of patients. https://t.co/aEoLWPRjEL
LUT014 Shows Promise for RASi‑Induced Skin Rash
*Disclaimer : the company developing LUT014 is a Pontifax portfolio company.* Mechanistically LUT014 should be effective in RASi induced-rash as it was designed to activate RAS signaling in the skin so using it topically could de-couple RAS inhibition in the tumor...
High‑dose GLP‑1s Raise Optic Nerve Risk; Titrate Carefully
Patients are not asking if GLP-1s are right for them. They are asking how much you charge for tirzepatide. Shiv K. Goel breaks down what physicians need to know about oral Wegovy. Pharmacovigilance data: Wegovy carries nearly five times higher...
Regular Sleep Reduces Risk of Major Cardiac Events
Consistent sleep patterns may be essential for cardiovascular health 🫀💤 This new study investigated sleep habits and cardiovascular events in over 3,000 individuals 🔍 Participants were followed for ~10 years or until experienced a MACE (acute myocardial infarction, unstable angina, stroke, heart...
ALLO's Alpha-3 DLBCL Data Set to Spark Pre‑Market Move
Key $ALLO catalyst coming pre market today, with first data from cema-cel's Alpha-3 study in DLBCL consolidation. What to look for: https://t.co/a19BVEppqP
Darovasertib Shows Promise in Optimum-02 Uveal Melanoma Trial
$IDYA darovasertib data from registrational Optimum-02 trial in uveal melanoma are out. What to look for: https://t.co/1LQa0X6xJa
Whiteboard Tactics Unlock Major NHS Negotiation Wins
The Whiteboard Windfall: A Lesson in NHS Negotiations by @Timothy_Hughes https://t.co/2JqnBxsbKP @DLAIgnite #SocialSelling #DigitalSelling #Sales #SalesTips #SalesLeader #Salesforce #SalesEnablement #RevOps #Leadership #Marketing #SalesNegotiation https://t.co/XpSE4j8Xm8
Pets May Shield Against Cognitive Decline, Review Finds
The protective role of companion animal ownership in cognitive aging: current status of the literature https://t.co/TKXjlA0FTR https://t.co/kmWE6BHeQm
AI Powers Cancer Cures While Robots Learn Chores
AI is designing molecules that boost chemotherapy effectiveness by 70%, and humanoid robots are learning tasks by watching gig workers record themselves doing chores... we're literally teaching machines to cure cancer AND do our laundry.
Targeted mRNA Nanoparticles Halt Lung Tumors and Cachexia
Follistatin mRNA delivered via targeted lipid nanoparticles enables a dual therapeutic effect by simultaneously suppressing lung tumor growth and preventing cancer-associated muscle wasting (cachexia). https://t.co/56fCFZU0vk
Court Blocks Cleanup as Rats Spread Leptospirosis in Berkeley
Rats spread leptospirosis — a tropical disease — through Berkeley's Harrison encampment . Courts blocked cleanup. This is what "protecting" unhoused people looks like. https://t.co/YObL8rvtIt
Post‑hospital Food Delivery Boosts Heart Failure Patients' Quality of Life
Delivering healthy food to heart failure patients after hospitalization is highly feasible and well accepted, with early evidence suggesting improvements in quality of life and strong patient engagement. foodasmedicine
IPSC Therapies Succeed; In‑vivo Reprogramming Remains Hype
your regular reminder that Yamanaka factor-driven production of iPSCs is already producing real medicine (eg dopaminergic neural progenitor for Parkinson's, cardiomyocyte sheets for heart failure & more) iPSC tech is not done in vivo... ppl isolate the well behaved cells away...
Daily Evoked Gamma Therapy Shows Safety and Cognitive Benefit
Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease 👉 “Our results demonstrate that 1-h daily treatment with [CogTx-001] was safe and well-tolerated and demonstrated potential clinical benefits in mild to moderate AD.” 🔘 Participants underwent...
Top Doctors Shun Rural Ohio, Urban Care Thrives
Nobody wants to be honest, but good doctors generally don’t choose to work in rural areas. Hate to say it, but it’s true. I can read the bios of the doctors around rural Ohio, where I live and then compare...
China Deploys Robots to Revolutionize Hospital Operations
How China Is Transforming Hospital Operations with #Robots by @Arcfunmi #Healthcare #MedTech #HealthTech #TechForGood https://t.co/Tx2XMAoO8i
Cancer Patients Need Proper Nutrition, Not Just Calories
Dietitian here, who worked over a decade in clinical care with high acuity patients. You might be wondering what could POSSIBLY be worse than a cancer patient ordering pizza + chocolate chip cookies for lunch on their hospital tray... Let me tell...
Musk Pivots From Covid Errors to Vaccine Advocacy
It wasn't sufficient for Musk to have gotten everything wrong on Covid at the time so he's now a *vaccine truther*. https://t.co/uOnL637BEi
Dementia Poised as 3rd Leading Death Cause by 204
ADI leads new research forecasting dementia to become the 3rd leading cause of death by 2040 Additionally, the number of people living with dementia "is set to almost triple in number by 2050, to 139 million." https://t.co/WSm2Rhp3ju
Drugs May Slow, but Not Fully Reverse Aging
Just like we can't turn a human into a naked mole rat with drugs (requires too many specific molecular changes), I don't think we will fully reverse ageing pharmacologically. We may be able to slow human ageing with drugs, but reversing...
AI and CRISPR Will Turn Sickcare Spending Into Cures
.@demishassabis understands that most of the healthcare budget today is really “sickcare”, that AI and CRISPR will cure the sick, and that trillions of chronic sickcare dollars will shift toward cures and prevention.
Rare Diseases Need Molecular Surgery, Not Drug Barriers
The turning point for rare diseases, which affect >300 million people around the world. A call to get rid of its many structural obstacles, to consider it as molecular surgery unlike drug treatments gift link: https://t.co/DQ0OZ9tXXc https://t.co/RELCwTr88i
Rebalancing Autonomic Nervous System May Slow Aging
“We propose that, at the core of aging, there is an imbalance between the SNS and PNS, which provides opportunities for therapeutic intervention.” How? Read more below👇 👨🏻⚕️ 🔎 “Hand-held, non-invasive wellness devices are being deployed in the U.S. military to enhance...
Reimbursement Gap Forces Doctors Out of Private Practice
Hospitals get paid two to three times more than a private practice office for the exact same visit. Then we wonder why 75 percent of doctors left independent practice. Neurologist Scott Tzorfas has run a solo practice for 30 years....
Former Pfizer Employee Not Involved in COVID Vaccine
He referring to Helmut Sterz’s testimony. He had nothing even remotely to do with the Pfizer vaccine. He left Pfizer in 2007. Pfizer signed a licensing agreement to acquire Covid vaccine in March 2020. Boosting his claims by calling him...
One in Nine Over‑45 Americans Report Cognitive Decline
1 in 9 US adults above age 45 report cognitive decline https://t.co/LGVGmeYRUN & https://t.co/JIh6SYKrJK https://t.co/i2cQjfwUdv
Safe Cell Reprogramming Restores Identity, Nature Reports
You're confused. Let me explain: My student @Y_Ryan_Lu worked for years to find a SAFE way to reprogram cells so they'd only RE-GAIN identity, not LOSE it, as Prof Yamanaka showed We tried innumerable combos to find the solution Story is @Nature...