OCE's Objections Caused Rejection, Not Vinay Prasad
$REPL my read of the RP1 CRL suggests OCE (CDER) took the lead in the review. Their objections led to the first rejection, as I previously reported, and nothing Replimune submitted for the second review was enough to support an approval. In other words, don’t blame Vinay Prasad for this one.
Health AI's Real Gold Lies Beyond Prestige Hospitals
Health AI startups are chasing "prestige logos": the 400 big academic medical centers. That's only 7% of the market. Mark Sendak (VegaHealth) on why the other 93% is the real opportunity 👇 * $45B IT market * Faster buying cycles * 18% claim denial rates...
Replimune's FDA‑targeted Skin Cancer Drug Faces Another Rejection
Replimune $REPL skin cancer drug that became FDA flashpoint is rejected again https://t.co/7aOfKy8vC7 via @Jasonmmast
Psychedelic Therapies May Outpace GLP‑1s Commercially
I believe the commercial potential of #psychedelic therapies is likely to exceed that of GLP-1s. $ATAI $CMPS $DFTX
Vegetative Patients May Possess Greater Awareness Than Assumed
.@katieengelhart stories are always quietly devastating and illuminating. This is another must read. Take your time with it this weekend. Vegetative Patients May Be More Aware Than We Knew https://t.co/tWdzIs0AKm
International Mega-Analysis Shows Psychedelics Alter Brain Circuit Function
An international mega-analysis of psychedelic drug effects on brain circuit function lots of great researchers involved in this paper. (whole article) https://t.co/vKhH0duJqv
Sex Drives Distinct Immune Aging Patterns and Disease Risks
The way our immune cells age differs substantially by sex, from single-cell analysis of ~1,000 people. Implications for propensity for autoimmune diseases (women), vulnerability to cancer (men), immunosenescence and inflammaging @NatureAging https://t.co/GjcuZ8luNM
Personalized CRISPR Fixes Baby KJ’s Genetic Defect
In just 6 months a team at @ChildrensPhila & @PennMedicine designed a personalized CRISPR based Rx to correct the single misspelled letter in Baby KJ’s DNA that results in CPS1 deficiency. Recent advances in mRNA science & CRISPR gene...
AI Predicts Heart Failure Five Years Early via CT
AI to detect risk of heart failure 5 years ahead of symptoms via CT scan epicardial fat tissue https://t.co/RuZu8pSIAy @JACCJournals https://t.co/Gz052Ajj4X
Ultrasound Enables Non‑Invasive Control of Body Cells
"Sonogenics" is an emerging scientific field that uses ultrasound to non-invasively control and manipulate specific cells in the body, such as neurons or heart cells
New Neuroscience Reveals Hidden Consciousness in Brain‑Injured Patients
In-depth piece in @nytimes - out yesterday - all about the neuroscience detecting covert consciousness after brain injury, and the ethics of communicating with these patients. Featuring (of course) the pioneering work of @Comadork @CIFAR_News https://t.co/lZw8eMaWOw
NMN Daily Restores NAD, Supports Healthy Aging
David Sinclair takes 1 gram of NMN every single day. Here's why. As you age, your body loses up to 50% of a molecule called NAD. NAD is a molecule that acts like fuel powering your sirtuin genes - the genes responsible...
Young Mitochondria Transplants Could Reverse Aging and Disease
What if aging, ALS, Parkinson's, stroke, and diabetes all share a single upstream cause — and the fix is a transplant the size of a bacterium? Dr. Catherine Baucom and Van Hipp of MitoSense explain how injecting healthy young mitochondria...
Blocking 15-PGDH Reverses Age‑Related Cartilage Loss
As a medical school professor, I was taught that lost cartilage is gone forever. Stanford just proved that wrong. Researchers discovered that blocking a single protein (15-PGDH) -- which rises as we age -- can actually REGROW joint cartilage in aging mice. The...
New GLP‑3 Drug Reta May Target Fat, Spark Hunger
Like it or not, GLP-1-based weight loss drugs are here to stay. 1/2) What's more, people are experimenting with newer evolutions, like "reta" (retatrutide/GLP-3). As an MD PhD & metabolism scientist, I decided to start my own experiment to help answer...
Meth Patients Face Dental Crisis Amid Medicaid Gaps
You check the heart, the lungs, the skin, the reflexes. Then you skip the mouth entirely. A dentist at a safety-net clinic in Massachusetts treated a patient who had been on methamphetamine for seven years. Every tooth decayed. Gums bleeding...
X‑rays Mislead Knee Osteoarthritis Treatment Decisions
Osteoarthritis Of The Knee... Thread #1... of 4 "Bone on bone." "Your cartilage is worn away." "You have the knee of a 90 year old." I've heard these phrases bantered about thousands of times in 25 years. They are very common...
Decoding ORR: What RECIST v1.1 Means for Investors
Investors will often see ORR quoted or displayed for oncology clinical trial results for solid tumors Here's what the CRs/PRs/SDs mean at a high level These are assessed on scans I'm using RECIST v1.1 definitions #learnbiotechinvesting #biotech #investing #BiotechPrometheus https://t.co/eZb86TcoLL
Reassembling ACIP Is Wasteful Under Anti‑vaccine HHS
Look, reconvening ACIP in any form when you have incurious antivaccine activists/ideologues in charge at HHS = waste of U.S. taxpayer dollars. Until there are changes at HHS, there’s no point. For RFK Jr ACIP is meant to legitimize dangerous...
New Cancer Radiotherapy Machines Arrive at Mpilo Hospital
AT MPILO HOSPITAL, Old Radiotherapy Machines are being decommissioned & the newly procured machines are being installed. These are the “Cancer Machines” Zimbabweans have been talking about. President @edmnangagwa DELIVERED. ED2030🔥🔥🔥🔥 https://t.co/uoDZihr6L6
Patient Scholars Must Coauthor Future Health Research
Publishing with patient scholars should be a requirement in a scientist's career. In this paper, The Evolution of Patient Empowerment and Its Impact on Health Care’s Future, we did exactly that. "𝐴𝑠 𝑤𝑒 𝑙𝑜𝑜𝑘 𝑡𝑜 𝑡ℎ𝑒 𝑓𝑢𝑡𝑢𝑟𝑒, 𝑤𝑒 𝑝𝑜𝑠𝑖𝑡 𝑡ℎ𝑎𝑡 𝑡ℎ𝑒 𝑐𝑜𝑛𝑡𝑖𝑛𝑢𝑒𝑑...
China's AI Hospital Makes Patients the Care Hub
China just defined what an AI Hospital is! It is a new type of smart healthcare model in which AI is embedded into the system itself, linking offline medical expertise with the broader reach of online services to deliver more...
Future Healthcare: Unseen Jobs Emerging by 2040
From Organ Designers To Telesurgery VR Planners: Healthcare Jobs In 2040 https://t.co/rsVU8Ce7d1 Healthcare’s rapid transformation guarantees the emergence of entirely new, currently unimaginable roles within the next few decades. Looking ahead and envisioning these potential roles, particularly where distinct fields intersect, offers...
Advanced Biotech Delivers Precise Disease Detection
Accurate Disease Detection with Advanced Biotech Diagnostics by @antgrasso #MedTech #Healthcare #HealthTech #Tech #TechForGood https://t.co/71nTNGOdDQ
Shingles Vaccine May Curb Inflammation, Aging, Dementia
From rash to resilience: how herpes zoster vaccination may influence inflammation, aging biology, and dementia risk https://t.co/hA0U1BlLp9
Menopause Market Booms; Doctors Warn Against Hype
Menopause products are having a hot minute. But doctors urge women to be wary of the marketing surge https://t.co/hUy7IghPF6 https://t.co/0cnzrlcdl5
Reclaiming Humanity and Peace in a Broken Healthcare System
Finding peace and reclaiming humanity within a broken health care system [PODCAST] http://dlvr.it/TRyT2Q Podcast #Psychiatry
Three AI Tools Should Power Every Mammogram—Free, Proven, Ignored
Every mammogram should be supported by 3 different AIs for improved detection of cancer, prevention, and risk of heart disease. At no cost to patients. My new @TheLancet essay reviews the evidence and the lack of implementation https://t.co/AslAZroL73 https://t.co/znfjtV04HB
Safety and Efficacy Assessments Created to Prevent Thalidomide Disaster
The current system of assessing safety and efficacy was literally invented to avoid the best thalidomide 😃
New TB Vaccines Safe, Effective for Children, Not All Forms
Two new tuberculosis vaccines demonstrated safety and immune response in a large Indian trial, but did not provide broad protection against all TB forms; notable efficacy was observed against extrapulmonary TB and in children. tuberculosis
40 AI‑Biology Leaders Converge at SynBioBeta 2026
40 of the biggest names in AI x Biology will be on stage at @SynBioBeta May 4–7 in San Jose, California. Get your tickets here: https://t.co/8abYWJ1GbK Marc Tessier-Lavigne (@Xaira_Thera), Kim Branson (@GSK ). @GabriCorso (Boltz). Peter Clark (@novonordisk ). Dave Hallett (@RecursionPharma). Ashoka...
Pediatricians: Your Baby’s Best Defense for Lifelong Health
Pediatricians are specially trained to help you give your baby the best chance to arrive at adulthood healthy and intact. We want to prevent all of the things t
Illinois Draws a Quarter of U.S. Reproductive‑care Travelers
Close to 1 in 4 people who travel in the U.S. for reproductive healthcare come to Illinois. A new philanthropic partnership with the state could be a model for other places. Connie Matthiessen Reports: https://tinyurl.com/43smhtkn Related IP Resources: Grants for Reproductive Justice &...
CDC Vaccine Panel Rules Target Lawsuit, Boost Kennedy Allies
New rules for CDC vaccine panel aim to address lawsuit, empower Kennedy’s allies https://t.co/miSg4oOYSu via @statnews
Therapists Need Balanced Training Beyond Rigid Echo Chambers
There are therapists trained to follow strict therapy protocols and they're told that it's the only way to be evidence based in their work - and they still believe it. There are therapists who are trained in almost no direct...
Vaccines Work, Are Safer; Learn to Read Science
Vaccines (a) work and (b) are safer than not getting the vaccines. Learn how to read scientific papers, deniers.
Trump vs Anti‑abortion Forces Amid Medicare Cuts
on this week's #WTHealth podcast: Trump admin v anti-abortion forces, it's budget season, and cutbacks in Medicare AND Medicaid. With @AliceOllstein, @mayagoldman_ , and @LaurenWeberHP https://t.co/fwsdaC20ZJ
FDA Reopens Mifepristone Safety Review Amid Court Pressure
FDA is working on another safety review of abortion drug mifepristone, after a Louisiana court order/pressure from @HawleyMO - FDA in 2021 said it did not find increases in adverse events after allowing remote prescribing https://t.co/FcznZ41p45
Scientists Advance mRNA Immunotherapies for Cancer, Funding Lags
Now in addition to our @TexasChildrens @BCM_TropMed protein vaccines for global health, our scientists are refining the mRNA technology for new immunotherapies for pancreatic cancer and triple negative breast cancer, if only the grant support would hold… https://t.co/NEgq6DX4qz
Interpretability Becomes New Scalability in Synthetic Biology
One of the most clarifying conversations we've had about where biotech should go next. Krish Ramadurai of @aixventureshq argues interpretability is the new scalability, and that the founders who build mechanistic, measurable platforms will define the next era of synthetic biology. He...
AI‑Native Platforms Treat Genome Like Code, Transform Biotech
Investor Liliana Nordbakk believes the genome behaves like code and AI-native biology platforms will transform biotech. Excited to have her speaking at #SynBioBeta2026. Visit the SynBioBeta website to read the full article. https://t.co/3WOSXsz1zy
Exercise Cuts Dementia Risk; Sitting and Irregular Sleep Raise It
The Relationships between physical activity, sedentary behaviour, sleep, and dementia: A systematic review and meta-analysis of cohort studies "Regular physical activity significantly reduced the risk of incident dementia (pooled RR = 0.75... Prolonged sedentary behaviour (8 + hours/day sitting) increased dementia risk (RR = 1.27)... both short (8 hours;...
Family's Funding Fuels Hope for New Dementia Therapies
Investing in hope A wealthy family fighting its own disease boosted research.. Can it spur new dementia treatments? 🗣️"Here was this beautiful family that really wanted to find a cure. And none of us scientists wanted to let them down." https://t.co/DBmpjpkxkl
AI Poised to Transform Healthcare Into Supercharged General Practice
.@peteratmsr on why AI could shift healthcare away from subspecialties, and toward a supercharged version of general practice. Catch my episode with Peter (President of Microsoft Science) on Lifers: Apple: https://t.co/e5WslnfSee Spotify: https://t.co/TaqlqEsE3f YouTube: https://t.co/eAaMF0XEiB
Little‑Known Kymera Fact Worth Sharing Today
With Kymera in the news today, reposting this cool little known fact about them that I learned on a prior visit. https://t.co/ctlvveAlJZ
3D-Printed Scaffold + Vesicles Boost Bone Regeneration
Reprogramming of cells via a 3D printed scaffold and extracellular vesicles substantially enhances bone regeneration https://t.co/w6AyvguUjS https://t.co/R32ULM1Rzt
Avalyn Targets Hard-to-Treat Lung Disease, Prepares IPO
Chasing a tough-to-treat lung disease, Avalyn plans an IPO https://t.co/743svTKTS4 by @gwendolynawu #IPO $AVLN $BMY $ABBV
Eli Lilly's GLP-1 Pill Ignites Rivalry with Novo
Lilly launches GLP-1 pill, kicking off showdown with Novo Nordisk https://t.co/zM6udFvuNE by Kristin Jensen $LLY $NVO #obesity
Right‑to‑Repair Settlement Shows Interoperability Beats Antitrust Breakups
Interoperability wins come in all shapes and sizes. This week's shape is... tractor? John Deere just agreed to a $99 million right-to-repair settlement that includes a 10-year court-supervised mandate to open its diagnostic tooling to farmers and independent repair shops. The...
B‑cell Reboot Shows Promise Across Multiple Autoimmune Diseases
More success for rebooting B cells towards cure of different autoimmune diseases beyond lupus, MS and others https://t.co/sFGMiFeiEF https://t.co/Dbvca9eox8