Melatonin Shields Mitochondria, Offering Neurodegenerative Therapy
Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases https://t.co/kp4LZEbZzN https://t.co/boWzW7fcjM
Screen at 45: My Colonoscopy Experience Eases Anxiety
It’s Colorectal Cancer Awareness Month, so I wanted to pop on here with a gentle reminder: if you’re 45 or older, it’s time to schedule your colon cancer screening. I had mine done last year, and because I had plenty of...
Wireless EMG Bionic Hand Achieves Independent Finger Control
Wireless EMG-Controlled Bionic Hand with Independent Finger Movement by @CyberRobooo #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/7zrAgN3ahU
Heal Postpartum Mood by Fixing Your Gut
So many women feel emotionally flat after birth. Not full postpartum depression, but just off. Low energy, foggy, no motivation, etc. Too often the conversation jumps straight to medication. But nobody asks about their gut. Pregnancy wrecks your gut....
Consider Evidence-Backed Supplements for PMDD Symptom Relief
Women with PMDD: Have you wondered about the genuine clinical evidence behind supplements that may help with symptom relief? These are worth a conversation with your medical provider 👇
New Trial Trains Future Doctors in Evidence Generation
One new trial is underway to teach future doctors how evidence is generated and evaluated. https://t.co/UaDJW1e28g #sustainability #infrastructure #IoT #AI #5G #cloud #edge #futureofwork https://t.co/lETrJfupXu
Toilet Camera Could Detect Colon Cancer Early
Put a camera on your toilet? I have two of these. The freakiest product of my life. But once you get over that you have a camera aimed at your poop it might save your life. My best friend died at...
AI Augments, Not Replaces, Human Insight in Complex Biology
"AI will not replace biological reasoning, but it may become indispensable for navigating biological systems whose complexity exceeds human intuition." A perspective on future applications for cancer neuroscience https://t.co/TnDFZ7NRFN @scisignal https://t.co/ijbhfbjXcs
AI Adoption Soars, Strategic Roadmaps Lag Behind
AI adoption is everywhere. AI strategy is not. 98% using it 7.5% with a roadmap Adam Turinas on the healthcare AI maturity gap... https://t.co/YWIbRTtFT9 #HealthLaunchpad #AIforMarketing #hcmktg https://t.co/pGsi557iIJ
TALK Commands ~3× Revenue Multiple, Outpacing Digital Health
This is actually good news for health-tech. TALK’s takeout multiple of ~3.0x revenues actually represents a fairly healthy premium to the recent digital health average (recall ACCD was taken out at ~1x). https://t.co/4FyXzAiny4
Weight‑loss Meds Cut Alcohol Use in Half of Users
Study shows nearly half of weight loss participants reduced alcohol use after starting anti-obesity medication (GLP-1 agonists, metformin, naltrexone). https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827069 https://www.gatlan.com/ @GatlanHealth
Burnout Is Blocked Energy, Not Just Exhaustion
Physician burnout isn't an empty battery. It’s an engine revving while stuck in park. 🏎️💨 It’s not just exhaustion; it’s blocked energy. When your moral agency is stripped away, your "aliveness" turns into cynicism. It’s time to reframe the problem. 🧵 👇 Link...
Leucovorin Approved for Limited Autism Subgroup, Not Mass Treatment
Last fall the administration was talking about leucovorin as a potential treatment for large numbers of people with #autism. Today's approval suggests the evidence supports its use in a much smaller group of people, @rosebroderick_ reports. https://t.co/NlJR8KlaqP
Debunking Vaccine, Tylenol, Leucovorin Myths in Autism
In my recent @BakerInstitute article, “reframing autism,“ I debunk the nonsense around vaccines, Tylenol, and leucovorin https://t.co/pxLaDLInlf
BioNTech Founders Leave to Launch New mRNA Venture
BioNTech founders to step down and helm new mRNA startup https://t.co/yjvsVRQH2D by @Lilah_Alvarado $BNTX - 20%
Xenon Scores Epilepsy Win; FDA Revives Duchenne Cell Therapy Review
Xenon hits a ‘home run’ in epilepsy; FDA restarts review of Duchenne cell therapy https://t.co/l40xYeW2Xh $XENE $CAPR + 15% $REGN $PFE $ABBV $GSK #biotech
Taiwan's AI Pavilion Showcases Hospital-Ready Integration
Can it run inside your hospital? Taiwan’s debut pavilion at #HIMSS26 showcases AI built for integration, uptime & scale. Booth #6035. Mixer TODAY | 1:30 PM. Get the info: https://t.co/YmpW6r2H5Y #TaiwanExcellence #HITSM
BBIO, ALNY Surge on Pfizer Tafamidis Patent Win
$BBIO $ALNY moving higher on apparently good news re: Pfizer's tafamidis patent defense. If you have access to Umer Raffat's research, he has all the details.
Psilocybin Plus Therapy Boosts Quit Rates Sixfold
🚨 @NPR spotlights our new JAMA Network Open study: One psilocybin dose + therapy gives 6X better odds of quitting smoking vs. nicotine patch + therapy. Game-changer for tobacco smoking addiction?
Doctors Still Beat AI on Practicality and Cost
Comparison of AI and primary care physicians for 100 patients in a prospective real-world assessment —The physicians outperformed AI [AIME] for practicality and cost-effectiveness —AI was comparable for diagnosis, management plan, appropriateness and safety @AdamRodmanMD @alan_karthi @PeterBrodeurMD @googledeepmind https://t.co/FNWYoHVkkw
Blood Test Predicts Alzheimer's up to 25 Years Early
Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70 https://t.co/aOActAUN27 https://t.co/Bxl2YZxnlf
Long
But hey, it’s all in our heads, amirite? (And for those who think this is all vax-induced: Bear in mind that the majority of long-haulers came from wave one, pre-vaccine.) https://t.co/wykHr4y0tX
AI Proven to Boost Breast Cancer Screening Accuracy
3 new reports and an editorial @NatureCancer reinforce the benefit of AI for breast cancer screening https://t.co/MlFns7M0yB https://t.co/MF3fj0CuIE https://t.co/a436srKDaD https://t.co/1XTMIsAPfg
DNA Repair Mutations Predict Response to Chemo‑Immunotherapy in Pancreatic Cancer
DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma https://t.co/v39bOreJwu
AI's Evolution Will Revolutionize Healthcare Delivery
On the latest episode of Lifers, I’m joined by @MSFTResearch President @peteratmsr. We dive into the evolution of AI and his bold predictions for the future of healthcare. Timestamps: (00:00) Preview (01:23) Intro (02:54) Evolution from deep neural nets to modern AI (04:30) Demystifying model...
FDA Adds Six Former Members, Total Nine Voters
Correction: I took down a post about Thursday's #VRBPAC meeting because it contained an error. #FDA has named 6 temporary voting members (not 2), which will bring the number for the meeting to 9. The temps are all former members....
FDA Accepts CAPR's Deramiocel Resubmission, Decision Aug 22
$CAPR resubmission of the deramiocel application accepted by the FDA. New decision date: Aug. 22. https://t.co/mWSyyXg8di
BioNTech Founders' Exit Needed as Sales Plunge
This morning's BioNTech news strikes me as very odd. Certainly, founder Ugur Sahin and Ozlem Tureci shouldn't feel compelled to run the company forever, and they may not be the right people to manage both the continued decline of Covid-19...
CRISPR's Natural Blueprint Powers Gene‑Therapy Breakthroughs
How CRISPR works (in nature) and how it’s being leveraged as a tool for gene editing to cure and prevent diseases. Dr Alex Marson MD PhD of UCSF on the Huberman Lab podcast out now. https://t.co/fiL48JHxSL
Medicare Advantage Overpayments Add $13.4B to Seniors' Premiums
“Overpayments to Medicare Advantage insurers increased Part B premiums by $13.4 billion in 2025, the committee said, a cost mostly borne by seniors.”
GSK Secures Approval Yet Refuses to Produce Drug
$GSK is ostensibly the "sponsor" that won the approval but is once again saying it won't produce the drug.
BioNTech Founders Launch New Biotech, Eye FDA Acceptance
Sticking with the science. I find that really impressive. BioNTech founders Uğur Şahin and Özlem Türeci are leaving the biotech they founded to start a new one. Maybe by the time they have something for the clinic, the FDA will...
Weekly AI and Health Tech Trends for Clinicians
Every week, I track the signals that show where medicine is really going from the latest AI breakthroughs and digital health tools to the cultural shifts redefining patient care. The Medical Futurist Newsletter brings you: ✅ Curated insights on the most impactful...
From Human Review to Full Automation: AI’s Oncology Journey
Today, I gave a virtual talk to a leading pharma company's team about the future of oncology. As they asked me to focus on AI's role in that, I'll describe real-life and some hypothetical examples of how the 5 levels...
Officials Avoided Saying “Vaccine” For over a Year During Measles Outbreak
https://open.substack.com/pub/pauloffit/p/the-v-word?utm_campaign=post-expanded-share&utm_medium=web More than one year passed before a public health official said the "V" word during a recent measles epidemic. Why?
AI-Driven Solutions Target Autism at Frontera Panel
Great evening with Frontera’s mgmt team and Denver area founders. Frontera is using AI to impact behavioral disorders, esp Autism. No holds barred panel w/ friends Ben Hemani (Bison Ventures, ex Gates Ventures), Galym Imanbayev (Lightspeed) and Amol (Frontera, ex...
RFK Jr. Contradicts Himself on GRAS Chemical Policies
Another example of how RFK Jrs version of MAHA is totally incoherent. --> he wants to end 'GRAS' chemicals in food (generally regarded as safe) --> his FDA opens door to flavored e-cigs (which use GRAS chemicals - NEVER TESTED FOR INHALATION...
NCI Grants Halted Under Trump, Cancer Research Stalls
Trump has collapsed cancer research. —> The National Cancer Institute hasn’t made a single grant this fiscal year https://t.co/3mKjoMua8Q
Chronic Pain Requires Years, Not Two‑Month Fixes
PAIN takes PATIENCE It takes years to develop chronic pain. We can’t fix that in two months. 
IPV Doesn’t Block Infection, but Stops Paralytic Polio
Actually he has it a bit backwards, those vaccinated with IPV can still acquire poliovirus and shed virus, but it prevents the virus from entering the bloodstream + protects almost 100% paralytic polio, just like the Covid vaccine protects 80-90%...
Vertex Drug Cuts Kidney Disease Marker in Late-Stage Trial
Vertex $VRTX says its drug successfully reduced marker of kidney disease in late-stage trial https://t.co/TbEkcHVYBB via @Jasonmmast
Oracle Sets New Standard for Intelligent, Secure Healthcare Solutions
Oracle isn’t just working to keep pace with industry change. We’re setting the standard by delivering intelligent and secure solutions that can directly impact patient care and boost efficiency across the healthcare ecosystem. Here’s what you can expect this week at...
Uterine Immune Cells Differ; Blood Tests Miss Pregnancy Tolerance
Pregnancy is an immunological paradox. Half the baby's DNA comes from someone else. Your immune system should reject it the way it rejects a transplant. But it doesn't. Your body pulls off this precise immune shift where the immune cells...
Bristol Myers Reports Positive Results for Next‑Gen Blood Cancer Drug
Bristol Myers claims success in study of another next-gen blood cancer drug https://t.co/fqPbZ2Szv8 by @gwendolynawu $BMY
Plastic Chemical DEHP Linked to Higher Breast Cancer Risk
The link between exposure to DEHP and its metabolite MEHP, found in plastics, and risk of breast cancer in a 20-year prospective study https://t.co/wKEVlMxWHT https://t.co/j5NL5QfTBu
Psoriasis' Immune Activation Reduces Skin Cancer Risk
Chronic inflammation generally poses a higher risk of cancer, so why does psoriasis-like disease have a lower risk of skin cancer. Why? Sustained immune cell activation https://t.co/kcxUHC8Ahk https://t.co/igqNDv5mdj
New Study Examines Psychedelic Use–Schizophrenia Connection
Exciting & important new study from my lab. Have you ever wondered how strong that alleged connection is between psychedelic use and #Schizophrenia? This project aims to point the telescope there & give it a focused look. Please share widely. @AlexaM_Molinaro...
Societal Issues Stall US Life Expectancy Growth
Why hasn't life expectancy been increasing in the United States? It's complicated. "The fact that the United States is far from a leader in longevity and that it continues to fall further behind nearly all other high-income countries indicates that there are...
Obesity Raises Risk for Multiple Cancer Types
Obesity and overweight are risk factors for several types of cancer. Why? A @JAMA_current review https://t.co/fn5tfxNnsM https://t.co/caCsAt2vuB
Leave Newborn Vernix On: Natural Protection, No Rush
My midwives never washed the white coating off my babies after birth. They told me to leave it on as long as I could. With all three kids, I delayed the first bath for about a week. That coating is called...