
Grant-Funded Pilots Die without Upfront Purchase Commitment
A health system once celebrated our Health Tech partnership’s amazing results, and then walked away - all because of the most dangerous word in innovation: “grant-funded.” I've watched more grant-funded pilots quietly die than I care to count. The problem? A grant is a lottery ticket. It can help a health system try your product, but it’s not proof of having truly sold anything yet. Lemme explain with a story… We once won a grant to pilot @SeamlessMD at a health system. We had an amazing clinical champion and together we reduced readmissions by 50%+. Turning this grant into long-term funding felt inevitable. That is, until we presented the results to the C-suite...only to find out that readmissions reduction wasn't a strategic priority for them. So despite our “success”, there was no path to procurement. Upon reflection, if we had instead asked them to buy upfront, we would have gotten one of two answers: either a “No”, which would've saved us months of hard work, or a “Yes” tied to a different KPI that actually mattered to them. Either way, we'd have been better off. Here's what first-time innovators miss about the value of a true purchase: when a health system pays out of a real operating budget, a human being stuck their neck out. They made a case to finance, defended the ROI and must own the outcome now. That accountability ensures that the Health Tech brought in not only must matter enough to get funded in the first place, but it creates an incentive to ensure the initiative goes well. Because if you don’t take the initiative seriously, no one will trust you with money again in the future. Whereas with a grant, nobody’s neck is truly on the line. All you need to do is complete the project and submit a report - success doesn’t truly matter. Which means when the grant runs out, the uncomfortable question of “should we actually pay for this?” must finally be asked. But this is actually a question that should have been answered BEFORE the grant started, not after. Now, I'm NOT saying to never take grant funding. In the early days, when you have zero customers and zero proof points, and grants help you get your first users, they are awesome. Grants help you cover costs while you prove value and figure out your implementation playbook. But once you’re actively selling your product in market, if you’re consistently relying on grants to get in the door - something’s wrong. Because if there's real product-market fit, you should be able to get purchased without needing a grant. So if you're going to take a grant, ask yourself these questions first: 1/ Is there a clinical or operational leader who would fight for the budget if the grant disappeared tomorrow? 2/ Is there an internal executive sponsor whose performance is tied to this initiative succeeding? If the answers are no, your grant-funded pilot is permanently at-risk until proven otherwise. Grants can open doors, but they definitely can't keep them open.
Ten Emerging U.S. Healthcare Trends Shaping 2026
The future of U.S. medicine: 10 health care trends in 2026 https://t.co/Cp6QufTISs #Physician #Malpractice via @kevinmd
AI Transforming Clinical Care Guides New HHS Policies
Artificial intelligence in clinical care: Shaping the HHS policy landscape https://t.co/XF7GFSav1j #Policy #PublicHealthPolicy via @kevinmd
HGH May Harm Tendon‑Bone Healing Recovery
Human Growth Hormone May Be Detrimental When Used to Accelerate Recovery from Acute Tendon-Bone Interface Injuries https://t.co/L4EOFMKjys

PEP Slows Aging by Blocking Inflammation Pathway
PEP protects against age-related inflammation, puts the brake on the aging process in mice, high levels in humans correlate with low inflammation So what is PEP, you ask? phosphoenolpyruvate, from glucose metabolism, a, master regulator, blocks cGAS-STING https://t.co/glMvaHSjOq https://t.co/MSVMBJbHm4
Partnering Beats In‑House Development for Medication Management
More EHR vendors are realizing: Medication management isn’t a side feature—it’s a specialty. Why partnering can unlock more innovation than building it all in-house: https://t.co/SfXzUvDcRb @DrFirst #medicationmanagement #HITSM
Roche, Zealand Stocks Tumble After Bland Obesity Drug Data
Roche, Zealand shares fall on ‘undifferentiated’ obesity drug results https://t.co/5pSR2vcHBD by @Lilah_Alvarado $RHHBY $ZEAL $LLY $NVO #obesity
Servier Spends $2.5B to Expand Cancer Pipeline
Servier to build cancer drug pipeline with $2.5B purchase of Day One https://t.co/aH0z8jt9tr by @realJacobBell $DAWN #biotech
AWS Introduces AI‑Powered Amazon Connect Health for Admin Automation
AWS launches Amazon Connect Health: to automate administrative tasks like scheduling and documentation with AI... https://t.co/DDCqpspUyd
Senior FDA Official’s Attack Sparks Debate Over Leadership
Gee, who could this "senior FDA official" be? It's a head scratcher. But he might tell Vinay Prasad that thinly veiled attacks against, oh, UniQure, and going off on advisory councils is a great way of keeping the political pot...

Mitochondrial Oxidative Stress Drives Insulin Resistance
I taught medical students that insulin resistance is a mystery. It's not. A new study in Science Advances just identified the molecular trigger - mitochondrial oxidative stress. Here's what they found: > Lipid overload floods mitochondria with reactive oxygen species > This blocks GLUT4...

Fasting Insulin: The Overlooked Test Doctors Miss
The Hidden Blood Test Your Doctor Isn"t Ordering Why Fasting Insulin Matters More Than Glucose https://youtu.be/ylkO3ETjEIE
FDA's New Attack on UniQure Sparks Controversy
New from me on $QURE and FDA. Free, no paywall. The FDA, urged to avoid controversy, creates a new headache with attack against UniQure Anonymous diatribe from a senior official plunges agency back into headlines https://t.co/ceDE0TXjdI

Your Zip Code Rewrites Gut Microbiome, Raises Diabetes Risk
As a medical school professor, I tell my students: disease doesn't start in your organs. It starts in your environment. A new Nature study just proved it - your zip code literally rewires your gut microbiome. Researchers studied 1,390 people and found: >...

Buyers Judge Healthcare AI by Friction, Not Novelty
Most healthcare AI founders think they’re selling innovation. They’re not. They’re being screened for friction. Implementation drag. IT burden. Workflow disruption. Hidden costs. Governance risk. That’s how buyers actually evaluate healthcare AI. We’re building around that reality inside WomenInGenAI’s AI in Healthcare space. Reply “healthcare” and I’ll send the link.

Sleep Masterclass: Expert Tips From Topol and Ju
A Master Class on Sleep, with plenty of practical tips Eric Topol with Guest Professor Yo-El Ju https://t.co/sKY9e7Tinq https://t.co/Gofntnw02o
Higher Dietary Fiber Linked to Stronger Bones
Association between dietary fiber intake and bone mineral density: a systematic review and meta-analysis of observational studies https://t.co/Q3yGX1Xd8j

B7‑H3 ADC HS‑20093 Shows Early Lung Cancer Activity
HS-20093, a B7-H3-targeted antibody-drug conjugate in lung cancer: Results from the ARTEMIS-001 phase 1a/b trial https://t.co/Jr90iovVeo https://t.co/Nl2WkprjU3
Job Market Slips as Medicaid Work Rules Tighten
The job market is weakening as work requirements are poised to go into effect for Medicaid and ACA premium assistance is decreasing.

Servier's $2.5B DAWN Deal Closes Ojemda Saga
$DAWN acquisition by Servier for $2.5bn is quite the ending for Ojemda. Who remembers this RAF inhibitor's bizarre & convoluted history? $BIIB $TAK https://t.co/uD5drO9ymr

Proanthocyanidins Show Promising Neuroprotective Mechanisms
Advance in neuroprotective effects of proanthocyanidins (PCs): Structure, absorption, bioactivities, mechanism, and perspectives https://t.co/AMfxcjo4m6 https://t.co/oTMCLW0CKL

Epic Partnerships Shrink, Garden Plot Expansion Leads 2026
@HeyEpic's Workshop category is down to 3 vendors, as @PressGaney just got moved to Toolbox, and the rest are likely to follow. So what does it actually look like to partner with Epic in 2026? I mapped it out (from...

Stem Cells Show Promise for Neurodegenerative Disease Treatment
A narrative review on the therapeutic potential of stem cells in neurodegenerative diseases: advances, insights, and challenges 👉"Stem cell therapy offers regenerative potential for neurodegenerative diseases. 👉Mesenchymal stem cells (MSCs), induced pluripotent stem cells, and neural stem cells show promise through neuroprotection...

BBC Infographic Explains UniQure Gene Therapy for Huntington
Especially after the recent disappointing regulatory update regarding $QURE AMT-130 clinical candidate for treating Huntington disease and the FDA refusal to move forward 🧵👇- here is an excellent Infograph by the BBC which explains how exactly the mechanism of @uniQure_NV’s...

Lancet Study Validates Digital Stethoscopes for Primary Care
In early 2026, The Lancet published the TRICORDER study, a pragmatic, real-world evaluation involving 205 primary care practices and about 1.5 million patients, proving that digital stethoscopes have a place in care. For clinicians seeking practice-ready digital transformation, this device could...

Don't Bet on One AI Vendor: Claude Beats ChatGPT, Gemini
The AI tool I called “best in class” just got dethroned - in three months. So when health systems go all-in on one AI vendor, is that a BIG mistake? I was loyal to ChatGPT. Then I became Gemini-pilled. Recently my...
PBM Critics Overlook Their Owners' Low, Stagnant Margins
So I've read a few long essays on how abusive pharmaceutical benefit managers and group purchasing organizations are, and they all make a strong case. And then I look at the companies that own PBMs, and their margins are a)...
Glass 4.0 AI Tops NOHARM, Beats Human Physicians
Today, @DrJessePines, writing in @Forbes, covered the NOHARM benchmark — one of the most rigorous evaluations of clinical AI to date. 100 real medical cases across 10 specialties, 12,747 specialist annotations on beneficial and harmful medical actions, and 31 AI systems rigorously...
Sleep Quality Tied to Eating Timing and Duration
Indices of Sleep Health Are Associated With Timing and Duration of Eating in Young Adults - Journal of the Academy of Nutrition and Dietetics https://t.co/RztLzXUScr
Ribosome-Targeted Drugs Redefine Psychiatry and Beyond
Ribosomes as Drug Targets. The Quiet Rewrite of Psychiatry and Beyond. | Ep. 950 https://t.co/gKlWpzO1Ci https://t.co/ImGOmUVrSO
AI Accelerates Rare Disease Diagnosis, Saving Lives
What good things is AI doing? Here's 10 things my AI agents found here on X that are examples of good things AI has done for humans. +++++ 1. "ChatGPT saved my life" — grocery store conversation about an ultra-rare diagnosis "Doctors...

Longevity Conference Calendar Revealed, Forum Starts Next Week
2026 aging/longevity conferences mostly have announced dates now. A few date just announced. Here's what the schedule looks like at the moment. Next up is Longevity Global's Longevity Innovation Forum in San Diego next week. https://t.co/mIDmfQD38H I'll be there & speaking. https://t.co/4mRLXJmGgg
Omada Launches Flexible GLP‑1 Care for Employers
When it comes to GLP‑1s, many employers feel stuck between “do nothing” and “all‑in coverage.” That’s not a great set of choices, especially when they want to find a way to say yes. I’m excited that @OmadaHealth is adding a...

Resveratrol Eases Neuropathic Pain via Mitochondrial Restoration
Neuropathic pain affects 7-10% of all people globally. New 🐁 study finds resveratrol alleviates neuropathic pain associated with restoration of mitochondrial dynamics 👏 https://t.co/zJ8LvwZ9UP https://t.co/hdCK7UgqBj
Healthcare's Hidden Fees: Records, Forms, and ER Parking
Things that I think are diabolical: 1) Being charged per page for your *electronic* medical records 2) Being charged for your doctor to complete a necessary form 3) no validation for emergency room parking Yes, there are far more diabolical things...
Fragmented Workflows Turn Liability as AI Defies Hierarchy
Ambient scribe → codes → claims → payments. AI doesn’t respect org charts. NextGen explains why fragmented workflows are becoming a liability. 👀 🔗 https://t.co/557h8ofHZ0 @NextGen #AmbulatoryEHR #HITSM

Self‑amplifying RNA Could Protect Future Heart‑attack Patients
Will we give a shot of protective, self-amplifying RNA in patients with a heart attack in the future? @ScienceMagazine an intriguing innovation https://t.co/FcJme1ElyU https://t.co/lABFRkR3qg

Medicare Chief Outlines Flat MA Rates, AI Integration
For Second Opinion, we had a long sit-down with Medicare chief Chris Klomp. We covered: -- MA rates staying flat -- Steps to thwart info blocking -- Bringing AI into healthcare outside of the fee schedule -- The ACCESS model & more https://t.co/dZEzyUtWbz https://t.co/PGO80SlZ9T

Bladder Cancer Landscape Shifts, Opening New Strategic Opportunities
When cancer niches are rapidly changing they create both a vacuum of indecision and fresh opportunities for smart players. Here we explore bladder cancer and look at where the field is headed... https://t.co/cf93Qb8dhe https://t.co/fx5V1MVwYN
MEDITECH Showcases AI-Driven Interoperability for Universal Care
Tech equity means every clinician, every patient, every setting. See how MEDITECH is bringing AI + interoperability to rural & urban care at #HIMSS26 👉 https://t.co/fz78ijGID8 📍 Booth #5031 @MEDITECH #HIMSS26 #HITSM
Eli Lilly Courts Employers to Expand Obesity Drug Access
Lilly targets employers in new bid to broaden access to obesity drugs https://t.co/Y6fmcmTcf1 @ByJonGardner $LLY $NVO #obesity
China's Rise Threatens US Gene Therapy Market
China competition is coming for the US's multimillion-dollar gene therapies -- a must-read from @Jared_Whitlock about what's happening there and how it will affect access around the world: https://t.co/F7KaMv3Kkp
Agentic AI Will Transform Care Models, Hospitals Must Act
Agentic AI will automate tasks today — and redesign care models tomorrow. Hospitals & plans can’t afford to ignore this shift. Read the article 🔗 https://t.co/iAzZysMNQp And continue the conversation with NTT DATA at #HIMSS26 🙌 @NTT_DATA_NA #AgenticAI #HITSM

AI Generalist Excels Across Diverse Medical Imaging Modalities
Can an AI model be a generalist to work and perform well for all types of medical images? Just published, our MedVersa paper @NEJM_AI Led by @pranavrajpurkar Free access https://t.co/5llNf94hAF https://t.co/Bf01zUZ1sk

Yamanaka Stem Cells Earn Conditional Approval for Heart and Parkinson's
20 years of Yamanaka stem cell factor research culminates in 2 conditional approvals for heart disease and Parkinson's disease in Japan https://t.co/8oxKxXYafu by Shinya Yamanaka @CellStemCell https://t.co/U878IxSfSi @ScienceMagazine https://t.co/HCCPaTEP7e

Red Blood Cell–PD1 Conjugates Show Promise in Resistant Tumors
Erythrocyte–anti-PD1 conjugates in persons with advanced solid tumors resistant to anti-PD1/PDL1: preclinical characterization and results of a phase 1 trial https://t.co/1GQMlUHn4Y https://t.co/0it5nTvUm0
FDA Veteran Decries Huntington Therapy Refusal as “Evil”
Amazing quote in this NYT story on the FDA from @By_CJewett. Janet Woodcock, a top drug regulator for decades, said reversals for a promising therapy send shock waves through the industry. “The Huntington’s refusal I thought was truly evil,” she told NYT....
Call for a Balanced, Transparent FDA Approach
My friend @adamfeuerstein delivers some great reporting and smart commentary on the FDA's direction that $QURE conduct a new randomized trial for its Huntington's drug. A senior FDA official and the company disagree on the basic question of whether the...
FDA's Extremist Shifts Harm Rare Disease Stakeholders
In this week's Biotech Scorecard newsletter: The extremism of the FDA’s Peter Marks and Vinay Prasad has come with costs Two regulators, two extreme regulatory philosophies, one replacing the other. The rare disease community is suffering whiplash. Drugmakers ( $QURE...
Knee Pain Signals Years of Inactivity, Not Surgery Need
The hardest conversation I have in my office isn't about surgery. It's about time. A 58-year-old sat across from me with knee pain. She’s otherwise healthy, but menopause has been rough on her. Her MRI shows some cartilage changes — age-appropriate,...