FDA Draft Guidance Streamlines Low‑Cost Biosimilar Approval
New FDA draft guidance outlines important streamlining of path to getting low-cost biosimilars to the market - could reduce cost of pharmacokinetic studies and allow ex-U.S. comparitor products to be used for proving biosimilarity to U.S.-licensed drugs https://t.co/ErjNOga0qo
Estradiol Levels Don’t Guide Effective Menopause Hormone Therapy
More information about the futility of estradiol levels for managing MHT from @professorsusandavis Professor Davis is a true expert here. I’ve linked to this article in my stories.
Low‑Dose Lithium Orotate May Counteract Alzheimer’s Deficiency
We’ve spent decades treating lithium as a heavy duty psychiatric tool. New evidence suggests it’s actually a foundational brain nutrient and that Alzheimer’s may essentially be a localized lithium deficiency. By using the Orotate salt, we can bypass plaque-induced transport...
Digital Nudges Amplify Lifestyle Gains for GLP‑1 Patients
Medicines plus healthy habits create outcomes that neither could achieve alone. A new @StanfordMed study published in JAMA shows digital lifestyle nudges may catalyze a critical first step toward behavior change for patients on GLP-1 medications. “Achieving your best health involves a...
UniQure Sparks Gene Therapy Rally After Prasad Departs
UniQure leads genetic medicine biotech rally after news of Prasad’s exit https://t.co/zu1CtJfj29 by @realJacobBell $QURE $RGNX $ATRA $LXEO #GeneTherapy
FDA Slashes Advisory Panels, Threatening Drug Safety Oversight
I've covered most of the big controversies the FDA has faced over the past 25 years: Vioxx, drug-coated stents, and Aduhelm all spring to mind. In all of these cases, the FDA's advisory panel system, in which the agency calls together...
Multivitamin Modestly Slows Epigenetic Aging; Cocoa Doesn’t
Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) https://t.co/snOMNsTzW7 https://t.co/a6MhMuRhJb
Oregon's Corporate Health Law Faces First Challenge
After a UnitedHealth Group takeover prompted a physician exodus & turmoil for patients, Oregon lawmakers sought to rein in corporate health care. Now, the new law is facing an early test. https://t.co/ABNLPXk5US via @statnews
Don't Dismiss Chemical Pregnancies—Investigate Underlying Causes
It's more common than you think. A woman gets a faint positive on a pregnancy test, starts telling family, and then bleeds four days later. This is called a chemical pregnancy. And most OBs will say "it was just a...
FDA Leaders Makary and Pazdur Meet Investors in Miami
Re: Prasad, from this morning's @statnews Readout newsletter: FDA Commissioner Marty Makary is in Miami this week speaking to health care investors attending a slew of broker conferences, noted Mizuho health care strategist Jared Holz. That should make for some...
Retinal Implants Let Blind See, BCI Future Looms
Max Hodak (@maxhodak_) is the co-founder of Neuralink and founder of @ScienceCorp_, a company building brain-computer interfaces that can restore sight. Science has developed a tiny retinal implant that stimulates cells in the eye to help blind patients see again. More...
Meet 2026 Innovators at HIMSS Booth 6453
We’re excited to introduce the 2026 Innovators You Need to Know at #HIMSS26! 📍Stop by Booth #6453 Scan QR codes for exclusive insights, guides, and resources… every scan gives you a chance to win prizes.🤩 Start exploring now, or see it in person:...
Utah's AI Prescription Plan Faces Conflict‑of‑interest Critique
Appropriate critique of Utah going with AI for prescriptions based on a @Doctronic preprint written by the company, by @JosephSakran gift link https://t.co/HcFqBy86wb https://t.co/QpVA7HGjRT
Harnessing Immune System: New Frontiers in Cancer Therapy
The new Huberman Lab episode is out: Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson 0:00 Alex Marson 2:21 Diseases & Current Biological Landscape; AI & Computational Tools 5:56 Immune System, Innate vs Adaptive Immune System 10:55 Thymus, T...
FMT Triples the Boost to Cancer Immunotherapy
Not just replication, but triplication of the benefit of revving up cancer immunotherapy with FMT (Yes💩) https://t.co/rXyQdO74FJ
FDA's Turbulent Leadership and Shift Away From Advisory Panels
Two terrific #FDA related pieces by @lizzylawrence.bsky.social & @matthewherper.bsky.social. Matt's is a look at lessons to be drawn from Vinay Prasad's chaotic tenure; Lizzy's delves into the FDA's turning away from adcomms. https://t.co/gC5GNTiPm1 & https://t.co/ygvylHi0uz
Five Key Lessons From Vinay Prasad’s FDA Tenure
. @matthewherper is so damn reasonable. Smart, too. 5 lessons from Vinay Prasad’s turbulent tenure at the FDA https://t.co/R65vPj5ep5
Undermanned VRBPAC Meets to Pick Flu Vaccine Strains
The #VRBPAC committee is scheduled to meet Thursday to advise #FDA on #flu vaccine strain selection. VRBPAC is supposed to have at least 15 members. It currently has 7 voting members & no chair. It has met only twice since...
Healthcare Must Prioritize Safety Over Pure AI Analytics
The cost of failure in #healthcare makes this conversation urgent. Psychological safety, rapid escalation pathways, and empowered frontline teams are just as important as analytics tools. #AI #Risk https://t.co/idxNhb1kRE
RLMD's Strong Bladder Cancer Data Hits IBRX Valuation
The $RLMD bladder cancer data (phase 2) reported this morning look very good. Another competitive blow to $IBRX particularly at its bloated valuation. https://t.co/wYThfwIpG8
Smartphone Ultrasound May Aid Spine Diagnosis, If Cost‑Effective
Smartphone-connected ultrasound devices could bring an interesting new layer to spinal diagnostics. A system like SpineUs combines a handheld ultrasound scanner with tracking software and AI-based reconstruction to create 3D visualizations of the spine’s surface in near real time. According to Verdure...
Mitochondrial Quality Control Drives Senolytic Resistance
Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance "findings suggest that mitochondrial quality control is a key determinant of resistance to ABT263-induced and ARV825-induced senolysis, providing a possible framework for rational combination senotherapies." https://t.co/xB0wFkzIW9
Vinay Prasad: Anti‑Science Extremist Influencing FDA Decisions
A key read regarding some (just some) examples of inappropriate, offensive, and/or inaccurate comments by Vinay Prasad (from May of last year) An Anti-Science MAHA Extremist Is Playing a Major Role at the FDA https://t.co/oFNaYm0qlD via @newrepublic https://t.co/P1V9lMdDjn
Add AI Breast Artery Calcification Scan to Mammograms
Mammography should include AI assessment of breast artery calcification, since it provides very useful information about cardiovascular risk https://t.co/yfTbTRrOuY https://t.co/h1C8ZnHepJ
AI Won’t Replace Radiologists: Lessons for All Doctors
My latest Substack: Why predictions that radiologists will be replaced by AI (including, famously, by genAI founding father and Nobel laureate Geoffrey Hinton) have been wildly off base, and what that teaches us about job replacement for doctors. https://t.co/hz2gKz6Ewh https://t.co/waJUY22Qk1
Seattle Book Launch Tackles Racial Trauma and Healing Costs
Are you looking to be part of a meaningful conversation, Seattle? On April 1, I’ll be at Elliott Bay Book Company for the launch of my book, The Cost of Healing in Silence. We’ll be in conversation about racial trauma, culturally...
Vinay Prasad Mocked for Hosting Controversial HHS/FDA Call
Too funny. @emilyakopp (below) outs Vinay Prasad as the host of Thursday’s HHS/FDA media call to discuss $QURE.
U.S. Healthcare Wastes $450 Billion Annually
Reminder that it’s costing us about $450 BILLION more every year to have this shitty healthcare system https://pubmed.ncbi.nlm.nih.gov/32061298/
COVID Infection Can Cause Lasting Immune Damage, Masks Essential
A single Covid infection can permanently destroy your immune system, (yes even if you’re fully vaxxed). That’s why it’s so crucial to actually prevent infection by wearing a respirator mask and ventilating the air
Understanding CGM Accuracy and Usage – Join Our Webinar
Learn what CGM sensors measure, how accurate they are and get clear guidance on how to use them. Register to the webinar: https://t.co/ZfMJ6h3ak0 https://t.co/0YCTKzK85x
Key Modifiable Dementia Risks Identified in Norway Seniors
Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study https://t.co/8DUSdzlf4e
Zero Calcium Score Redefines Heart Disease Risk
The Power of Zero - Why CAC Scoring Changes Everything for Heart Disease Risk https://youtu.be/XVNLubDAE-M https://www.innerscopic.com/
Health IT Licensing Must Shift From Seats to Token Usage
Direct implications for Health IT licensing -- as HTI-5 proposes AI/RPA as a first-class means of "access"/"use" of health information.
Magnesium Balances Vitamin D: Boosts Deficiency, Lowers Excess
As a medical school professor, I've watched patients take vitamin D for years with zero improvement in their blood levels. Now a Vanderbilt clinical trial explains why: they're missing magnesium. Key findings: > Magnesium RAISED vitamin D in people who were deficient > But...
Stronger Grip Cuts Senior Mortality by 12%
As a medical school professor, I tell my students: muscle isn't vanity. It's a longevity organ. A new JAMA Network Open study of 5,000+ women ages 63-99 just proved it: > Every 7kg increase in grip strength = 12% lower mortality > Faster...
Consumer Biotech Set to Outgrow Disease‑Focused Pharma
GLP-1s already have market cap close to 1/3 of the top 10 biopharma companies combined. Consumer health biotech products will dwarf disease-focused biotech products.
Creatine Boosts Body, Brain, Strength, Sleep in Menopause
Impact of creatine supplementation on menopausal women’s body composition, cognition, estrogen, strength, and sleep https://t.co/8ZqpAr94uG
AI Bots Deliver CFO Insights, Save Hours for Doctors
Dr. Selene Castrejon runs a medical practice. She doesn’t have time for AI experiments that don’t work. Every hour matters. Inside the AI Business Lab® Mastermind, she built trained AI bots that now provide CFO-level insights and marketing strategy—saving hundreds of...
Thoughtful Dialogue on Healthcare AI with DM Gorenstein
I've known @dmgorenstein for 2 decades and have always found him to be extraordinarily thoughtful – not afraid to ask tough questions and to grapple with nuance and, yes, tradeoffs. It was great to chat with him on his @tradeoffspod...
Patent Battles and GLP‑1 Turf Wars Prompt FDA Crackdown
Patent Fights, GLP-1 Turf Wars, and the FDA Tightens the Screws | Ep. 952 https://t.co/v0fulR3NfB https://t.co/9gGdkAVvlv
Agentic AI Slashes Denials 60% in One Month
A revenue-cycle nurse cut denials by 60% in 1 month using agentic AI. See how in the new article from Anshar AI 👉 https://t.co/mKAaugRe28 Meet them at #HIMSS26 or book a private workflow session. #AnsharAI #HITSM
83% Unaware of DORAs: Sleep Knowledge Gap
There's a lot you can learn about sleep. Like 83% hadn't heard of DORAs. https://t.co/2lV3Fw6cwg https://t.co/IWRTdPTMOL
Cures for some Autoimmune Diseases Now a Reality
One of the most impressive advances we've ever seen for some autoimmune diseases: cures https://t.co/OZDuq4Iooy
Fragmentomic Liquid Biopsy Detects Early Breast Cancer, Subtypes, Nodes
Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment https://t.co/RC5rTrFO4l https://t.co/s0Z6lc7Jeb
Cryotherapy Boosts Metabolism and Hormones, Best for Higher BMI
"A series of WBC sessions improved carbohydrate metabolism and modulated adipokine and sirtuin profiles, with the most pronounced effects observed in individuals with elevated BMI. However, this effect generally may require a longer treatment series." The effect of whole-body cryostimulation treatments...
Warmer Temperatures Linked to Higher Adult Obesity
Ambient Temperature and Adult Obesity: Evidence from U.S. County-Level Panel Data "The results indicate that higher ambient temperatures are associated with higher adult obesity rates, even after accounting for correlated environmental conditions..." https://t.co/ewEuMdqr3O
Bright Light Therapy Boosts Glymphatic Flow and Prefrontal Activity
Bright light therapy influences glymphatic system function in individuals with subthreshold depression: a randomized clinical trial Highlights 👇👨🏻⚕️” 🔘 Bright light therapy (BLT) influences glymphatic function in subthreshold depression. 🔘 BLT enhanced brain functional activity of the prefrontal cortex. 🔘 BLT links glymphatic system...
Bitter Compounds Protect Brain in Diabetic Cognitive Decline
Bitter Compounds as Multifunctional Agents against Diabetes-associated Cognitive Dysfunction: Bridging Metabolic Regulation and Neuroprotection https://t.co/Xv3xItlP20
Accelerating Years of Startup Work in Weeks with AI Agents
joked with my old cofounder about using the next 90 days to vibe replicate all the products and data tools that took us 3 years to build at our startup... I think i'll be done in 7. next up: AI agents...
Grant-Funded Pilots Die without Upfront Purchase Commitment
A health system once celebrated our Health Tech partnership’s amazing results, and then walked away - all because of the most dangerous word in innovation: “grant-funded.” I've watched more grant-funded pilots quietly die than I care to count. The problem? A...