AI Will Redefine Doctor-Patient Dynamics, Says Henry Blodget
I loved my interview with legendary business analyst & founder of "Business Insider", Henry Blodget (@hblodget), on his podcast, "Solutions." Lots of smart questions about AI and healthcare, and how it'll change what it means to be a doctor and a patient. https://t.co/agYEC83qqH
GLP‑1 Drugs Cut Substance‑abuse Risk in Veterans
Best evidence yet that GLP-1 drugs reduce the risk of substance abuse, from >600,00 US Veterans across alcohol, nicotine, opioid, cocaine, cannabis @bmj_latest @zalaly @Miao_Cai_SLU https://t.co/rcqUt0kY77
Low Insulin Can Be Healthy—Check HbA1c and Liver
Insulin has an inverse U-shape during aging, so by itself low values may be optimal, but also indicative of B-cell failure Adding HbA1c provides more context. If it's low with low insulin this is potentially good news Also check liver enzymes, to...
Cell‑free DNA Test Predicts Liver Disease and Mortality
We've used a blood test—cell free DNA—for detecting cancer or prenatal fetal abnormalities. It turns out it can be used to detect liver diseases and all-cause mortality from other conditions @ScienceTM https://t.co/IJxPMq7hGU
Uniform Consent Language Needed for Scalable Health Data Interoperability
When every state regulates consent differently, scale breaks. Mariann Yeager shares why model language and technical standards are critical for nationwide interoperability. 👇 https://t.co/Aa3zjJYTw4 @sequoiaproject #patientadvocates #HITSM https://t.co/I3cN0lmdLk
Canadian Pediatric Journal Admits 100+ Fabricated Case Reports
This is probably just the surface and it goes much deeper. The official journal of the Canadian Paediatric Society has just acknowledged that more than 100 of its case reports are fabricated. Incredible reporting from @RetractionWatch: https://retractionwatch.com/2026/03/03/canadian-pediatric-society-journal-correction-case-reports-fictional-paediatrics-child-health/
FDA COO Butler Retires After One Year; Deputy Assumes Role
after just one year in the position, FDA COO Butler will retire, and his deputy will take over in April - https://t.co/9qmmIiuWX2
Blackstone Invests $400M in Teva, Sanofi Gut Drug
Blackstone puts $400M into Teva, Sanofi gut disease drug https://t.co/CkxPaI6CPr @ByJonGardner $TEVA $SNY $MRK $RHHBY
AI Predicts 5‑year Health Risks From Routine CT Scans
When your "normal" abdominal CT tells you about the 5-year future risks that can't be seen by radiologists, but can by AI (Merlin) https://t.co/DemC983uKz https://t.co/9jqZyVTD3p
CTMX Soars 660% Ahead of Masked ADC Catalyst
$CTMX, +660% in 12 months, approaches its masked ADC catalyst. Via @ApexOnco -> https://t.co/oQI1iQiV4N ( $JANX -58% in the same timeframe)
Evo 2 Open‑Source Tool Predicts Non‑Coding Pathogenicity
It got me at "across all domains of life" Predicting pathogenicity of non-coding regions, produces sequences at genome scale, and much more Evo 2, open-source, @Nature today @arcinstitute @pdhsu @BrianHie https://t.co/9CZWmPFhjd
UnitedHealth Slashes Disclosed Subsidiaries, Undermining Transparency Claims
Last year, UnitedHealth Group disclosed 3,100 subsidiaries. This year? Just 10. The health care giant is paring back transparency right as its executives say they are embracing it. https://t.co/Wp1TYSUKTa
Batch Effects Misclassified 162 Patients, Causing Unnecessary Chemo
Batch effects once caused 162 patients to be misclassified. 28 of them received incorrect or unnecessary chemotherapy. The culprit? Contaminated RNA extraction that introduced technical artifacts into the data. https://t.co/WBBFKgvzVC
CognomIQ Launches Semantic Data OS for Healthcare AI
Healthcare AI ≠ just LLMs. CognomIQ unveils a semantic data operating system at ViVE 2026. One platform. End-to-end. From #ViVE2026 👇 https://t.co/HatKWPoOWo
Future Cancer Blood Tests May Accurately Screen High‑Risk Groups
Cancer blood tests for screening? Not the way they've been studied to date (age 50+) A new feature @Nature “I’m confident we’re going to see more accurate tests going forward. In high-risk groups, such as those with a genetic predisposition,...
10 Hours of Brain Training Cuts Dementia Risk 25%
I spent years teaching neurology residents that once cognitive decline begins, nothing can reverse it. A 20-year NIH trial just proved me wrong. The ACTIVE study — the largest cognitive training RCT ever conducted — found that just 10 hours of "speed...
AI Flags Alzheimer’s Risk Two Years Before Diagnosis
Earlier diagnosis can change the trajectory of Alzheimer’s. Yet thousands of people in the UK still live with dementia for years before receiving a formal diagnosis. The signals are often already present in clinical records, they are simply fragmented across...
Digital Tourniquets Could Soon Become First‑aid Essentials
Maybe it's not new, but that's the first time I saw a digital tourniquet. It is designed to help anyone quickly stop the bleeding. No training required. Just tighten, press, and save a life. This is the line companies like XMetix...
Device Captures Brain Waves in Human‑Like Mini Brains
New Device Detects Brain Waves in Mini Brains Mimicking Early Human Development by @ShellyFan https://t.co/oMMhx9ux8Q https://t.co/6321RBopxf
Gut Health and Toxins Drive Parkinson’s Disease Surge
The gut and environmental toxins are key underpinnings of the Parkinson's disease pandemic @jclinicalinvest https://t.co/e8o4UuIafG https://t.co/7634Yg2Qo5
Tirzepatide Delivers up to 21% Weight Loss, Dose‑dependent
Tirzepatide: In the SURMOUNT-1 trial, weight reduction percentages were dose-dependent: 5 mg: ~15.0% weight reduction. 10 mg: ~19.5% weight reduction. 15 mg: ~20.9% weight reduction (Jastreboff et al., 2022). https://www.nejm.org/doi/10.1056/NEJMoa2206038 https://www.gatlan.com/ @GatlanHealth 
Prime Medicine Pursues Approval After Two-Patient Gene Editing Trial
Prime Medicine $PRME to seek approval for gene editing treatment after two-patient trial https://t.co/nBnrUzqSCN via @Jasonmmast
Pierre Fabre Pushes to Revive US Cell Therapy Approval
Pierre Fabre seeks to revive US approval chances for spurned cell therapy https://t.co/gJeklT8asd @ByJonGardner $ATRA $QURE $RGNX
FDA Guidance Boosts Biotech, HHS Calls It Fake
Did the FDA’s individualized therapy guidance put a spike in the heart of a startup biotech? Fake news, says the HHS. Yeah, it did, says an insider. Exclusive from @RLCscienceboss and @Jared_Whitlock https://t.co/IN9o4VIp03
Small Language Models Offer Efficient, Transparent Healthcare AI
Small language models (SLMs) are gaining attention in the generative AI field. SLMs are trained on relatively small amounts of data and have a relatively small number of parameters. SLM can be more practical than large language models as they are...
Align Boards, Embrace Simplicity: Surviving Three Health Pivots
This week on Lifers, I interviewed @othman about how he navigated @color through three massive pivots—from cancer genetics to national COVID infrastructure and now a virtual cancer clinic. Timestamps: (00:00) Preview (00:58) Intro (01:03) Lessons from Figma and betting on the tortoise over the...
LLM Medical Research Overwhelmingly Lacks Real Clinical Data
A new systematic review of LLMs in medicine @NatureMedicine @ekoermann https://t.co/npvDeqUvel “Despite thousands [4,609] of publications since late 2022, only a small fraction use real clinical data and just 19 randomized trials exist.”
T‑cell Engagers Offer New Autoimmunity Treatment Opportunity
T-cell engagers for autoimmunity. Listen to Ken Song describe the opportunity as CEO of San Diego-based Candid Therapeutics. Sponsored by @AlphaSenseInc & Dash Bio. https://t.co/Ct2viH00c4
MRI Offers Low Yield for Isolated Dizziness without Neuro Signs
What is the diagnostic yield of MRI in adult emergency patients with dizziness or vertigo? While MRI is efficient for detecting central causes of dizziness, its yield is low in cases of isolated dizziness without neurological signs. 👇 https://t.co/170qBbHrq7
FDA Doubts QURE Gene Therapy Benefit, Leaks to Media
New reporting from me taking you inside the $QURE - FDA Huntington's gene therapy imbroglio. I spoke to a senior FDA official late yesterday, who told me agency reviewers "are not convinced there’s any therapeutic benefit of the product. If...
AI‑Discovered Gal‑3 Blocker Cuts Inflammation, Boosts Memory in Mice
Alzheimer’s research is increasingly looking beyond plaques and tangles to the brain’s immune response. A study published in Elsevier's Pharmacological Research journal used AI to screen 1.6M compounds for a Galectin-3 (Gal-3) blocker that could cross the brain barrier. In Alzheimer’s-like...
Mixed Reality Revolutionizes Anatomy Learning, Yet Remains Costly
I remember what it was like to study the heart from textbooks and medical atlases. This video demonstrates how different the experience could be with mixed reality. It could lead to a new level of understanding of anatomy and pathology. The...
ChatGPT: Doctor’s Smart Assistant, Not a Diagnosis Tool
How to use ChatGPT as a doctor (properly) Not for diagnosis. Not to replace your brain. Use it to: • Simplify complex topics for patients • Draft patient education handouts • Create clinic SOPs • Generate content ideas • Structure research summaries • Prepare presentations • Improve communication clarity Think of...
Cross‑check AI Answers and Heed Red‑flag Symptoms
@PBS: Five things to consider before asking a chatbot for health advice (by @AP_FDAwriter). Among them: ask two different AIs and see if they agree; don't stay home if you have red flag symptoms like chest pain, shortness of breath....
Clinicians Discuss Real-World AI Applications on Zoom
I’ll be joining a Zoom discussion hosted by Roon on March 5, 1:30-2:30 ET. We'll discuss how clinicians are using AI in actual practice and the implications. I'll be joined by 3 eminent colleagues: Mandy Cohen, Sara Murray, & Spencer...
Colorado Leads, Washington Should Follow on Insulin Caps
In Colorado, we’ve been laser focused on saving Coloradans money on prescription drugs since day one, and it’s past time that Washington catches up. Colorado was the first state to cap insulin costs long before the federal government and expand...
P‑tau 217 Blood Test Outperforms Total P‑tau 217 For
The breakthrough blood test p-tau 217 for risk and diagnosis of Alzheimer's disease is more accurate than total p-tau 217, in a head-to-head comparison using PET imaging https://t.co/faILpVr9Ua https://t.co/lzUgFnFUP5
No Evidence Bans Improve Minors' Mental Health
"There is no scientific evidence to support the assumption that banning minors from accessing services would have a positive effect on their mental health and development." https://t.co/eOCmTZvNiE
Set Up Your Clinic on Glass in Minutes
Onboarding your team or clinic to a new AI tool is so important, but often difficult. At Glass, we've made it incredibly easy — you can now get your whole clinic set up in a few minutes.
AI Computes Freely, Humans Bear the Cost of Errors
🚨Computation Without Consequence 👉A clinical study reveals the divide between AI computation and human judgment. 📌AI handles patterns with ease. 📌Humans feel the weight of being wrong. 📌That’s where the divide becomes clear and important. https://t.co/tjfOTsWnCC #AI #medicine #digitalhealth
GLP‑1 Weight‑Loss Drugs Work Better for Women
A systematic RCT analysis of GLP-1 drugs show they are more effective in women than men for weight loss https://t.co/cycwi4nnN5 https://t.co/KOl0FgKaZD
Roche's MS Drug Shows Promise, Approval Still Uncertain
Roche pill succeeds in another MS study, but approval questions linger https://t.co/JY8uZCI5iA @ByJonGardner $RHHBY $SNY
FDA Demands Extra Study for UniQure's Huntington Gene Therapy
UniQure says FDA wants another study of Huntington’s gene therapy https://t.co/1pgFDoE2V9 by @realJacobBell $QURE - 35% #GeneTherapy #Huntingtonsdisease
Optimism Boosts Longevity More Than Traditional Risk Factors
I taught my medical students about every risk factor for early death — smoking, obesity, diabetes, hypertension. I never once mentioned optimism. A PNAS study of two large epidemiologic cohorts found that the most optimistic people lived 11–15% longer on average —...
Professor Launches Free Newsletter on Longevity Secrets
I'm excited to announce something new. After 30 years of teaching at UCLA and USC, I've started a newsletter called Health Longevity Secrets. Every week: what medical school gets wrong, how to read your labs, evidence-based longevity strategies. Free: http://robertlufkinmd.substack.com
AI Pathology for Cancer Markers Hindered by Shortcut Learning
AI of whole slide images for cancer molecular markers is not ready for clinical use due to confounding and biases ("shortcut learning"), supported by multiple examples @natBME https://t.co/zG8uVIxrJf https://t.co/hQ0tjiapIJ
Exercise‑derived Muscle Vesicles Boost Brain Microglia, Improve Cognition
A new mechanism for improved cognitive function from exercise in the Alzheimer's disease model Skeletal muscle EC vesicles interact with the brain and rev up microglia function https://t.co/eZu14YVasY
Human Trust Beats AI in Patient Engagement
I keep seeing AI-pilled people arguing that AI agents will magically solve patient engagement - but it won’t. If it were that easy, non-Tech solutions would’ve solved it already. At @SeamlessMD, I’ve spent the last 13+ years working with health systems...
Consolidation Saves Space, But Disrupts Clinical Documentation Trust
System consolidation looks efficient—until you count the cost of disruption. Strong view from @Provationmed on why migrating away from purpose-built clinical documentation puts adoption, revenue, and trust at risk. ➡️ https://t.co/WahjLaV8Wl #ClinDoc #CIOInsights #HITSM
Aardvark Pauses Pivotal Prader‑Willi Trial over Safety
Safety concerns spur Aardvark to halt key Prader-Willi drug trial https://t.co/PWkOuDMIvo $AARD - 52% $SLNO