Vaccine Pioneer Warns: We’re Heading Downhill.
Stanley Plotkin, known as the “godfather of vaccines,” in an interview with @HelenBranswell: “All I can say is that I’m beginning to regret having lived so long — because we’re going downhill.” https://t.co/A2zcoP2Ghd
Antibody Plus Ozempic Drives Significant Weight Loss
New @NatureMedicine A randomized trial of antibody vs activin type II receptors with or without semaglutide (Ozempic). The antibody, bimagrumab, promotes muscle growth. Marked weight loss with the combination https://t.co/XUK93GTAmA
Veteran Vaccine Pioneer Warns of Eroding Confidence
Stanley Plotkin had a major hand in the development of a number of vaccines in use today; he designed the rubella vaccine. He remembers the world before widespread use of vaccines & knows what's coming as vaccine policy is rewritten...
Future: Real-Time Immune Monitoring Like Glucose Tracking
Someday we'll be able to track our immune system like we do glucose Today @NatBME https://t.co/HFcFiUeyFg Previously @ScienceMagazine https://t.co/EcgBdwGxcd https://t.co/SpoZ5bLtjx
Ozempic Reverses Osteoarthritis Cartilage Damage, Study Shows
I used to teach that osteoarthritis was "wear and tear" — lose weight, take painkillers, wait for a knee replacement. A study just published in Cell Metabolism proved that wrong. Semaglutide (Ozempic) didn't just reduce joint pain in osteoarthritis patients — it...
Flare's GU26 Targets Undruggable PPAR‑γ, Yet Caveats Remain
Who's heard of Flare Therapeutics? #GU26 late-breaker shows promise in hitting "undruggable" PPAR-γ target, with a few major caveats. Via @ApexOnco -> https://t.co/1GepvywtL0
Europe Braces for Fallout of Trump's Drug Pricing Plan
“Nobody wants to feel cornered:" Europe braces for the fallout of Trump's drug pricing plan https://t.co/HZjZH0mdCU
Advocacy Bias Keeps Unproven DMD Therapy, Blocks HD Progress
The Duchenne muscular dystrophy patient & advocacy community keeps a gene therapy and multiple drugs on the US market, stopping the FDA from taking action, despite failed confirmatory clinical trials showing no efficacy and questionable safety. The Huntington's disease patient and...
FDA Limits NTLA Gene Therapy to Mild Cases, Undermining Demand
$NTLA drug is off hold but now being restricted by the FDA to the least severe/sick patients, which would logically be those least likely to want/need an experimental gene editing therapy. Existing options will dominate. Target/disease selection is a...
MRK's Ovarian Cancer Claim Rejected by FDA, EMA
$MRK claims a survival benefit in ovarian cancer irrespective of PD-L1 status, but FDA & EMA say BS. Via @ApexOnco -> https://t.co/Cld1O7Uuvp #ESGO26
FDA Demands Sham‑controlled Trial for uniQure’s AMT‑130
$QURE AMT-130 update: Still blocked The FDA stated that it cannot agree that data from the Phase I/II studies, compared to an external control, are sufficient to provide the primary evidence of effectiveness required to support a marketing application for...
Vaccine Policy Shifts Spark Resurgence of Deadly Diseases
But also it’s not only measles, pertussis (whooping cough) is also returning, and based on latest ACIP (or what used to be ACIP) stunts, we’ll see rotavirus, meningococcal meningitis, HBV liver cancer, return after that. A public health disaster built...
NMN Restores NAD, Shields Heart via SIRT3
According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁 New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet https://www.sciencedirect.com/science/article/pii/S0022316626000842
The Hunger Code: Rethinking Weight Loss Without Counting Calories
Checking out the humanoid robots with Jason Fung at the Tesla Diner as we celebrate the release of his remarkable new book, The Hunger Code—a bold rethinking of obesity and weight loss. The Hunger Code is poised to help thousands lose...
Microplastics Detected in Human Brains, Linked to Dementia
I never once mentioned microplastics in 20 years of teaching at medical school. Now they've been found inside human brains — and at significantly higher concentrations in people with dementia. A Frontiers in Neurology review lays out the damage: Microplastics cross the...
Primary Care Gets Just Five Cents per Dollar
Primary care receives only five cents of every health care dollar [PODCAST] http://dlvr.it/TRD584 Podcast #PrimaryCare
Welireg Poised to Broaden Reach per GU26 Data
$MRK Welireg could be about to expand its reach at last. #GU26 data via @ApexOnco with relevance to $RCUS -> https://t.co/k59284INdK
Comprehensive CT Metabolic Scan: Heart, Liver, Bones Nationwide
Complete Metabolic Heart Scan * CT Coronary Artery Calcium Score� * CT Calculated Arterial Age� * CT Liver Fat Quantification� * CT Bone Mineral Density� (available anywhere in the US) https://www.innerscopic.com/
Paper on Target Trial Emulation Overlooks Confounding by Indication
How is it that a paper that claims to show how to do target trial emulation does not address confounding by indication and its ramifications for data collection? https://t.co/dzGZZdpBoc #Statistics
Accelerating CAR Engineering Shows Promising Cancer Immunotherapy
Some very good news about engineering our cells vs cancer (accelerating the CAR). A short thread 1. For background, a new 5★ review on cancer immunotherapy @Cancer_Cell https://t.co/1Qz2rCs8I5 https://t.co/sJ6BwaXyjk
Single-Cell Atlas Links Marrow Immune Dysregulation to Myeloma Outcomes
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma https://t.co/5t0M2eX0fB https://t.co/p3kv8LEzrC
Tylenol Not Linked to Autism Genes, Study Shows
There are a few known chemical exposures in early pregnancy that interact with autism genes. But not Tylenol. I’ve spoken to RFK Jr about them but he had no interest, and he can’t process scientific information. Here’s my article https://t.co/pxLaDLInlf
Aspirin Risks Kids: Choose Acetaminophen, Vaccinate
Reye’s syndrome is a well known condition that causes life-threatening cerebral swelling in children infected w/ certain viruses like chickenpox or Flu; it’s associated w/ treating the fever w/ aspirin. Prenatal cases are extremely rare. Baby aspirin is used in...
AI‑Biotech IPO Slumps 23% on Opening Day
A leader of this next wave of AI-focused biotechs has completed its IPO, a milestone tarnished by a brutal first few hours of trading. Day 1 for $GENB: -23% https://t.co/u3WQcDD3jL
Smart Hospitals Reduce Admin, Bring Clinicians Closer
"Smart” doesn’t mean distant. The smartest hospital ecosystems actually bring clinicians closer to patients by reducing administrative burden. Insights from Jeff Fallon at eVideon: https://t.co/x7o1COnGIe @eVideon @TigerConnect #SmartHospitals #HITsm https://t.co/PVVG70mbKN
Comparing Lorigerlimab, Volrustomig, Cadonilimab: Design Lessons
An intriguing tale of three cities. How do the PD1xCTLA4 bispecific agents lorigerlimab, volrustomig, and cadonilimab stack up when it comes to design and performance? Some useful and pointed lessons here for biotech execs: https://t.co/xaSW15Fvdl https://t.co/dhXbiI3N6v
Atrium Launches to Tackle Rare Heart Diseases with RNA
Atrium spins out of Avidity, aiming to target rare heart diseases with RNA https://t.co/xLp2oQDHGy $RNA $NVS #startups
De Novo Proteins Expected in Clinics Within Two Years
“The era of de novo proteins is coming a lot faster than probably people recognize,” Generate's CEO Mike Nally tells me. “I think within the next year or two you’ll start seeing de novo designs enter the clinic.” https://t.co/u3WQcDD3jL
Hospitals Now Demand Deep Integration of Virtual Care
Hospitals aren’t asking IF they need virtual care anymore — they’re asking how deeply it integrates. Insightful take from @_artisight's Jay Lyonett at #ViVE2026. 👉 https://t.co/ckEzNYH8oS
Study Finds Inconsistent Patient Safety in ChatGPT Health
An important study just came out that is the first to evaluate patient safety when it comes to ChatGPT Health. Millions of people are using LLMs every week to triage health conditions, but this new study has found concerning inconsistencies. https://t.co/etjthA2olM
Smartphone AI Beats Endocrinologists in Acromegaly Diagnosis
AI is helping to make the diagnosis of rare diseases. A new multicenter study in Japan showed smartphone AI diagnosis of acromegaly via hands was better than experienced endocrinologists https://t.co/qBiazetToV https://t.co/dSZpJ2us84
Wearable Rhythm & Activity Predict Inflammation‑Driven Aging
I used to teach that "aging is just wear-and-tear." A new Nature paper used 7 days of wrist-wearable data from ~62,000 adults and found your circadian rhythm patterns (amplitude + stability) and MVPA predict inflammation-linked biological aging. Low rhythm amplitude and poor...
Former Surgeon General Urges Senate Reject Unqualified SG
Former surgeon general: The Senate must not approve an SG who can’t practice medicine https://t.co/TfgRw59xFd
Watch Webinar Linking Top 100 Biotech VCs Insights
Here's the link to watch yesterday's webinar on venture capital, a companion to this year's top 100 biotech VCs list with @ChrisDoko Lots of positive feedback here. Post your thoughts. https://t.co/c16y04mFsD
Novo's Missteps Echo Bristol Myers' Strategic Failure
Elizabeth Cairns' piece on $Novo is reminiscent of Bristol Myers' strategic fail against Merck and Keytruda. They were focused on the wrong things, made bad trial design decisions and got stuck in the mud of their own making. Everyone should...
Obesity Accelerates Neurodegeneration, New NatMetabolism Study Shows
How does obesity catalyze neurodegeneration? Our paper just out @NatMetabolism https://t.co/kx25urgpJx free access https://t.co/aL1FBN9MyI Phenomenal work by @chen_bandy pulling this together
Trial Failures Stem From Flawed Design Choices
“You can’t stand there after the fact and blame the open-label design,” he said. “You designed it. You designed a noninferiority margin. You picked the patients. And then the trial doesn’t work.” https://t.co/acS5i5s5NU
Alumni Dr. Leroy Versteeg Highlights Brown Talk at UTHealth
Great to see our former National School of Tropical Medicine @BCM_TropMed trainee Dr. Leroy Versteeg at my Brown Molecular Medicine talk at @UTHealthHouston in our @TXMedCenter https://t.co/F9IGkVNkfM
Minnesota's Autism Service Use Soars—Cause Unclear
Dramatic increase in autism program utilization in Minnesota. Is this a true increase in autism rates or some other reporting/diagnosis factor or just fraud? Are other states seeing this? (This is not a political question).
Top Medical Specialties Poised to Thrive with AI
While every medical specialty will benefit from digital health and AI, some will especially thrive thanks to these innovations. Here, I listed the top medical specialties with the biggest potential for development in the future. Read on: https://t.co/KhId1Okqf2 https://t.co/rgvsDAjS1q
Clicker Training Boosts Surgeons' Knot‑Tying Success to 100%
Clicker training works on orthopaedic surgeons. A study taught surgical skills using a clicker for real-time feedback. 100% of that group nailed every step of a knot tie, vs 33% who learned by demonstration alone.
Biotech IPOs Surge with $400M Offering
New: Generate caps a strong month for #biotech IPOs with $400M offering https://t.co/HzslZOPcwM by @gwendolynawu $GENB $AZN $AMGN #IPO
Blood Test for Small RNAs Predicts Longevity
Simple Blood Test For Small RNA Molecules Could Predict Who Is Likely To Live Longer https://t.co/lr59o4Yegp https://t.co/MccF3k72pT
Digital Tools Turn Clinician Advice Into Reduced Heart Failure Readmissions
Clinicians know what actions help patients stay healthy. Digital interventions help patients actually take them. Shahid Shah shares more on how CareCognitics is tackling heart failure readmissions: https://t.co/yNe0013amg @CareCognitics #HospitalReadmissions #HITSM https://t.co/SDVIK5m79S
Gut Bacteria Interactions Dictate Health and Disease Risk
🆕 @ScienceMagazine How gut bacteria interactions [cooperation vs competition, positive vs negative] shape risk for health and disease https://t.co/q8TvbaHDQI https://t.co/kS0S3uUIli
Improved Sepsis Prediction Cuts Unnecessary Antibiotic Use
Some hospitals start the SEP-1 bundle early… but ~25% of those patients don’t actually have sepsis. Better prediction could mean fewer unnecessary antibiotics. Learn from Robin Carver: https://t.co/tPRGLQGdIV @PrenosisInc #patientsafety #HITSM https://t.co/CFk7cA5Wib
Blueprint for Interoperable Vaccine Records
An Interoperable Vaccine Record: A Roadmap to Realization https://t.co/H1yL7kXH8z #mdpivaccines via @Vaccines_MDPI @HardeepSinghMD @McWilliamsSBMI @HarvardDBMI https://t.co/UCP8IXdHve
AI Could Unlock $5T Healthcare Market and Drive Prevention
What is Infinite Healthcare Worth? As AI becomes a new site of care and automates administrative orchestration, it rapidly eats into $5T+ worth of traditional health care services spend, and potentially represents the biggest market opportunity in all of healthtech....
EHealth Exchange Expands Beyond Treatment Exchange by 2026
As national networks mature, the strategy is shifting. Jay Nakashima shares how eHealth Exchange is expanding beyond treatment exchange in 2026. 👀 🔗 https://t.co/uK1RKnn15e @eHealthExchange #QHIN #HITSM https://t.co/7qKBmbZ6FY
Immune Cells Drive Transition From Healthy Aging to Alzheimer’s
What accounts for the progression from healthy aging to Alzheimer's disease over an extended period of time? The critical role of the immune system, particularly T cells and microglia. A new, excellent review @ImmunityCP https://t.co/XqEBcptTuG https://t.co/Xt24BvkDWe