E192: Building Biotech: What It Takes to Lead a Public Life Sciences Company
Dr. William Ho, CEO of IN8 Bio, discusses how his Wall Street background informs his strategy for building a public biotech focused on Gamma Delta T‑cell therapies, and how AI—from NLP‑driven drug‑target discovery to LLM‑guided manufacturing—accelerates development, cuts costs, and streamlines regulatory compliance. He shares concrete examples of using AI, RNA‑seq, and single‑cell analysis to identify therapeutic gaps and optimize cell‑therapy production, while also addressing the new dynamics of capital markets where investors discover biotech on platforms like TikTok. Ho’s vision of "Cancer Zero" hinges on data‑driven innovation to make cancer treatments universally effective and affordable.
AI-Powered Clone Restores Site Faster than Major Sites
Really proud of the DeepLearningAI team. When Cloudflare went down, our engineers used AI coding to quickly implement a clone of basic Cloudflare capabilities to run our site on. So we came back up long before even major websites!
AI Enhances Authentic Brand Connection, Not Replaces Humanity
Navigating the future of marketing isn't just about adopting new tech, it's about fundamentally rethinking how your brand connects, tells its story, and builds trust in an AI-powered world. I've seen countless leaders grapple with this shift – the tension...
I Tested Gemini 3, ChatGPT 5.1, and Claude Sonnet 4.5 – and Gemini Crushed It in a Real Coding Task
Google unveiled Gemini 3 Pro, and the author put it to the test by prompting it to build a web‑based Thumb Wars game. Gemini generated functional HTML/CSS/JS code in seconds, iteratively adding features such as customizable masks, 3‑D ring perspective,...
Republicans Are Looking for a Way to Bring Back the AI Moratorium
House Republicans are reviving an effort to preempt state AI regulations by inserting language into the National Defense Authorization Act (NDAA). Majority Leader Steve Scalise said the amendment would effectively ban state AI laws, echoing former President Donald Trump’s call...
Cloudflare Outages Aren’t a Matter of if — but When
Cloudflare suffered a multi‑hour outage that knocked out major sites such as X, ChatGPT, Spotify and Canva, marking the third significant internet‑infrastructure failure in a month after incidents at Microsoft Azure and Amazon Web Services. The disruption was traced to...
The Rise of the Super Worker in the Age of AI with Josh Bersin
In this episode, Jason Stoughton and AI analyst Josh Bersin discuss how AI is reshaping work, introducing the "super worker"—employees amplified by AI tools to tackle complex problems rather than routine tasks. They highlight the pivotal role of HR in...
Avoid Content Sameness: Build a Strong Marketing Operating System
Let's talk about content marketing in 2026 for a sec... So - here's your Tuesday existential question: if every brand pumps out the same AI-glossed content at the same time… does any of it actually exist? Or does it all...
Three Humans, Twenty AI Agents: Same Revenue, Less Drama
In 2020, we had so many folks on Team SaaStr, we needed a second office. 20+. 3 designers, 5 in sales, 3 in content, etc. Today, we have 3 full-time folks and ... 20 full time AI agents Same scale,...
Cursor Hit $1B ARR in 24 Months: The Fastest Scaling SaaS Ever?
Jason Lemkin highlights Cursor’s unprecedented growth, reaching over $1 B ARR in just 24 months and a $29.3 B valuation after a $2.3 B Series D—making it the fastest‑scaling B2B SaaS ever. The post attributes this speed to a product‑led strategy with zero marketing...
AI Struggles with Visual Tasks; Human Expert Wins
ChatGPT-5.1-Thinking finds a hidden object, describes its location accurately, but fails to provide correctly annotated image. Claude-4.5 Sonnet Thinking finds it, but describes and annotates the wrong location when asked. Gemini-3 fails the find and location. Average human (asked three friends) failed. Scientist friend...
Proactive Agents for the Web with Devi Parikh - #756
In this episode, Devi Parikh, co‑founder and co‑CEO of Yutori, explains how proactive web agents can transform browser interactions by using visually‑grounded models that operate on screenshots instead of the fragile DOM, resulting in more robust handling of complex interfaces....
AI Agent Handles 77 Conversations, Amplifying Small Team Power
Our general AI Agent (“Digital Jason”) handled 77 conversations and 203 messages yesterday. Most were pretty good, I am sure. But the real point is I couldn’t have done it. Nor could our tiny team. This is some of the...
Hugging Face CEO Says We’re in an ‘LLM Bubble,’ Not an AI Bubble
Hugging Face CEO Clem Delangue told an Axios event that the current hype surrounds large language models (LLMs) rather than AI as a whole, warning that the "LLM bubble" could burst as early as next year. He argued that LLMs...
AI Deal Web Too Complex, Need Clear Visualization
I keep track of and talk about all these AI deals for a living, and even I have whiplash. Anyone have a great visualization of all the investments and deals between the labs, cloud, and AI infrastructure companies? eg Google owns...
GrowthRise Mastermind Recap Nov 18, 2025
The GrowthRise Mastermind call covered practical adjustments for B2B marketers, including shifting the meeting time to accommodate time zones, treating cold email as a brand‑awareness channel with long‑term attribution, and leveraging paid LinkedIn Thought Leader Ads for faster lead generation....
Jiga Secures $12M Series A to Accelerate AI-Driven Parts Manufacturing
Congrats to @Jiga3d on their $12M Series A! They're building the custom parts manufacturing platform for AI-era speed. Engineers upload drawings and get routed to vetted suppliers with direct communication, while Jiga automates the administrative grunt work and keeps humans in...
ChatGPT Users Crave Spotify‑Wrapped Style Memory Recap
I need ChatGPT and Claude to start releasing an opt-in Spotify Wrapped ASAP. Memory is probably my favorite feature, but it needs a jolt of fun and delight. --- EXAMPLE: "You asked how to fix things 15 times. 10 of those were...
Creating Human-Centered Workplaces in the Age of AI with Oz Rashid at MSH
In this episode, Oz Rashid, founder and CEO of MSH, discusses people‑first leadership and the need for authentic, connection‑driven hiring in an era where AI is reshaping talent acquisition. He explains how MSH’s data‑driven platform Aeon is expanding beyond recruitment...
Gartner‑backed Vectara: Must‑see Demo for GenAI Enterprises
The most important thing to take away from Gartner's recognition of @Vectara in two of their Magic Quadrants: If you an enterprise building anything that leverages GenAI or Agentic AI, get a briefing and demo from Vectara on what they...
Gemini 3 Turns Any Image Into Interactive Experience
With Gemini 3, you can take an image of anything, like a board game, a floor plan, or a doodle, and make it an interactive experience. This is because of Gemini 3’s deep multimodal understanding. The model is able to analyze...
SaasRise Enterprise Mastermind Call Recap Nov 18, 2025
The post recaps a SaaS‑focused mastermind call that tackled seven strategic areas, from VP bonus design and lead‑generation tooling to a business pivot, sales compensation, talent hiring, operational monitoring, and phantom equity. Key takeaways include using new MRR rather than...
Scaling AI Agents Drives Transformative Business Results
Fewer than 10% of orgs are scaling AI agents in any one business function. But they're the ones seeing transformative results. McKinsey & Company 's new State of AI report shows that while 62% of companies are experimenting with agents,...
A Simple Framework for Delivering Bad News Effectively
Every leader eventually faces the moment they fear.....delivering bad news. Handled poorly, it drains trust and momentum. Handled well, it preserves dignity and helps people move forward. In my latest MIT Sloan Management Review article, I share a simple framework...
Lovable’s 8M-User Surge: The Future of AI App Building
In this episode, hosts Jaeden and Jamie dissect Lovable’s rapid growth to nearly 8 million users, highlighting how its AI‑driven app‑building platform is reshaping software creation. They discuss the platform’s core strengths, such as rapid prototyping and user‑friendly design, alongside security...
Infracost Raises $15M to Embed Cloud Cost Checkout
Congrats to @infracost on their $15M Series A! They’ve built the checkout screen for cloud—right inside GitHub/GitLab so engineers can see the cost of infra changes before deploy and how to optimize them. Already used by 3,500+ companies, including 10% of the...
Build a Best Answer Brand with Full‑Funnel Thought Leadership
I had a great (and full) session this morning at #mpb2b in Boston presenting on Full Funnel Thought Leadership, our new research report and how to build a Best Answer Brand using the TopRank Marketing BAM Framework. Thanks Pam Didner...
Sen. Warren Presses Trump Admin on Potential AI Bailout Plans
Sen. Elizabeth Warren wrote to White House AI adviser David Sacks and OSTP director Michael Kratsios demanding answers on whether the Trump administration intends to "backstop" major AI firms such as OpenAI with taxpayer money, citing OpenAI’s request to expand...
Gemini 3 Shows Tier‑1 Performance, Yet Benchmark Gaming Persists
I played with Gemini 3 yesterday via early access. Few thoughts - First I usually urge caution with public benchmarks because imo they can be quite possible to game. It comes down to discipline and self-restraint of the team (who is...
Sustainable SaaS Growth Requires Sales Focus, Not Exit Chase
I’ve had the privilege of following many SaaS journeys over the years, but the story of Design Master Software is a pretty surprising. When founder David Robison came to the SaaS Institute after 25 years in the business and essentially...
Poolside AI Acquires Fern Labs, Forming Full‑stack Frontier AI Powerhouse
news! @poolsideai has acquired @fern_labs, in which @airstreet was the first and sole investor - and a first investor into poolside as well. i met @ashedwardst in late 2024 before fern had a name or team. his technical depth, product taste...
AI Finally Enables True Drag‑and‑drop Development
AI that can finally make drag and drop software.
Dreamforce Keynote Unveils Agentic Enterprise Collaboration
The Dreamforce Keynote is now on YouTube! ❤️ Welcome to the Agentic Enterprise: Humans and Agents working together! ❤️🤖 https://t.co/oKdoLA5zd5
Google's Antigravity IDE Adds Screen Recording, Gemini 3 Dominates
Wait, what? Google's new Antigravity IDE can do screen recordings to verify how your app work 🤯 Gemini 3 just crushed the game. https://t.co/vHwDzKa8Qv
ChatGPT‑5.1 and Gemini‑3 Ace Colorblind Test
ChatGPT-5.1-Thinking and Gemini-3 both pass the colorblind test. Claude and I both failed. https://t.co/VSdB5E3vz9
Original Research Drives Higher B2B ROI
Report Links Original Research to Higher #B2B ROI https://t.co/oMcf4xnBnB
Replit Design Now Auto‑creates Videos for You
Replit Design will generate videos for you!
Gemini 3 Launch Highlights Massive Coordination Effort
Gemini 3, besides crushing evals, the most impressive thing is the massive scale of people and products coordinated for today’s launch.
Goldbridge's Ramp Boosts Property Values 20% in Three Months
Goldbridge (@trygoldbridge) is building Ramp for Real Estate. It's an all-in-one financial platform for real estate owners that can increase their property values by 20 percent in less than three months. Congrats on the launch, @alvinsalehi_ & Greg! https://t.co/esEgdymet5 https://t.co/rv1JcBxDkv
Consistent Naming Crucial Even With Autocomplete Assistance
It doesn’t matter as much in the age of autocomplete as it used to, but the tiny mental friction of naming inconsistencies like “start_dim” vs “keepdim” still sticks out for me. Carefully pick names as if millions of developers may...
Transformer Sets New Translation SOTA with Comman A
The Transformer was built for translation back in 2017. Very proud of the team for setting a new SOTA with Comman A Translate!
Craft Problem‑Solving B2B Content That Drives Conversions
How to Create Problem-Solving Content that Converts - B2B Marketing Blog | Webbiquity - https://t.co/1ihX0PUy6t via @seosmarty
Data Access Drives AI Adoption in B2B Marketing
Data Accessibility Affecting AI Adoption for #B2B Marketers: Hightouch https://t.co/PKnmZ9S6SV
Explore Top B2B AI VCs with SaaStr Research
Want to learn more about top VCs in B2B + AI? Browse our new SaaStr AI Research VCs -> https://t.co/3JyImX3jMX We'll even help pick the best ones for you (and much more to come) https://t.co/rG7K5x5YYU
Replit Launches Design: AI-Powered Beautiful UI Experience
Announcing Design, a new Replit experience focused on beautiful UIs. The first non-slop AI design experience, powered by Gemini 3.0 https://t.co/wssUgV9Zuk
First‑Week Buyer Outreach Numbers Reveal Rapid Interest
"How many buyers reached out within the first week on @acquiredotcom?" https://t.co/8zCjkJeLGw
AI Success Depends on the Right External Partners
AI project success often hinges on enlisting the right outside expertise. The best partners know your business, value outcomes, and deliver seamless collaboration. https://t.co/3eYBy5MKN6
Own Hardware Pipelines Enable Aggressive, Low‑cost Inference Scaling
Wanted to say this is because the competition focused on cheaper models. But that eve doesn't seem true. What seems more plausible is that teams with strong training pipelines and their own hardware can push much more aggressive inference-time scaling at...
Cellbyte Secures $2.75M Seed to Accelerate Global Drug Launches
Congrats to Cellbyte on their $2.75M seed! Cellbyte helps pharmaceutical companies launch new drugs worldwide. Their platform streamlines pricing, market access, and regulatory workflows for drug launches by automating data extraction and insight generation, enabling faster, more efficient decision-making across global...
Collective Learning Models Aren’t Simple Superintelligence
Assuming every frontier model learns from every other, how is it different from straight-shot superintelligence?