Pinnacle Medicines Adds $89M for Oral Peptides With Properties of Injectable Biologics
Pinnacle Medicines announced an $89 million Series B financing, bringing its total capital to $134 million, to advance an AI‑driven platform that designs orally bioavailable peptide drugs. The startup aims to launch its lead asthma and chronic obstructive pulmonary disease program in human trials by the end of 2024, with additional candidates for obesity, cardiovascular disease, inflammatory bowel disease and atopic dermatitis slated for 2027. By focusing on peptide engineering rather than excipient formulation, Pinnacle hopes to create first‑in‑class oral peptides that match injectable biologics in efficacy. The funding also supports research into bispecific oral peptides that hit two targets simultaneously.
Gemma 4 Fast On-Device, but Small Models Lack Agency
I am impressed by Gemma 4, there’s a lot of power for an on-device model at fast speeds. But I am not convinced you can get real agentic workflows out of a small model on device. So much depends on...
Will OpenClaw Usage Rise After Anthropic Subsidy Cut?
I'm curious if OpenClaw's usage on OpenRouter will go up after Anthropic closed the subsidies.
New: Elektor’s Robotics and Automation Special
Elektor International Media has released a new special edition focused on robotics and automation, targeting engineers and hobbyists. The issue features practical projects built with affordable platforms like Arduino and Raspberry Pi, ranging from a drawing robot to a Mars rover...
Don’t Skip Research: Live Shopping Demands Deep Dive
Please don’t get to slide 4 because if you do .. you might have to put in a lot of work to research what’s going on with live shopping 🛒 📱 .. what’s going on on TikTok and whatnot and...
Satellite Lifetime Drops Sharply With Altitude, Study Shows
Today's calculation: how long does a satellite in a circular orbit stay up when it stops all reboost burns? Depends on a lot of things, especially solar activity, but let's average over all of that and do a Kaplan-Meier analysis...
Los Angeles Traffic Is So Bad The Fire Department Got New Electric Motorcycles To Quicken Response Time
The Los Angeles Fire Department has added 30 ERidePro electric motorcycles to its fleet, thanks to a donation from Google and YouTube. The two‑person bikes are equipped with basic medical gear and are fully integrated into LAFD dispatch. California’s lane‑splitting...
AI Reveals Optimal Sub‑System Pairings and Allocation
I've been playing around with AI to look closer into some old strategies of mine by feeding it a 10-year trade list. I initially asked it to assess the 10 sub-systems within this short-term strategy and look for issues that...
Scale SEO with AI‑Generated 150‑Page Templates
I built a skill for Claude Code that creates SEO pages at scale using templates and data — programmatic SEO done right. You tell it the keyword pattern you want to target (like "[tool] alternative" or "best [category] software") and it...
I Had No Idea 5G Was Actually Slowing My Phone Down
The article explains why many users experience slower speeds and higher battery drain on 5G compared to LTE. It highlights that 5G comprises low‑band, mid‑band, and high‑band (mmWave) spectra, each with distinct performance characteristics. Dynamic Spectrum Sharing (DSS) lets 5G...
Teach Kids How to Learn, Not Specific Skills
I finally wrote out an answer to the question I get so often: "What should I be teaching my kids right now to prepare them for an AI-scrambled job market?" Hint: The best educational choice you can make for your ...
Need Automated Sync From AI Chats to Knowledge Base
This may be a dumb question but I’ll ask it here anyways: I can’t find a good way for my various AI chats to automatically sync its conversation history into a structured knowledge base. So that as I update various chats...
Chief Data and Artificial Intelligence Officer for the United States Space Force, Chandra Donelson, Steps Away
Chandra Donelson, the first permanent Chief Data and Artificial Intelligence Officer for the United States Space Force, announced her resignation on April 3, 2026, ending a tenure that reshaped the service’s data strategy. She led the shift toward a data‑centric architecture that...
Benioff Redirects $330M to Anthropic After Microsoft Block
Microsoft blocked Salesforce from investing in OpenAI. So Marc Benioff put $330M into Anthropic instead. That's one of many stories from our conversation with Marc Benioff (@Benioff), CEO of @salesforce. We also covered: > Slack was always about agents. > Marc thinks using AI...
14 Releases in One Day, Delivery Fully Automated
14 releases one day. Delivery on autopilot 🛩️ Just checked reports, Claude and Pilot are building.
Pixel Desktop Mode, the Problem with Aluminium OS, Nothing (4a) Pro Review, Vivo V300 Ultra and V300s, and More with...
In this episode, Miriam Joir and Android Authority’s Rita El Khoury dive deep into Android’s evolving desktop experiences, from Pixel’s Desktop Mode to the upcoming Aluminum OS. They discuss the practical challenges of using tablets and foldables as true productivity...
Optimizing Transcriptome Workflow with C Timing Tests
Now time to vibe some more. Working on some tests to see where I can speed up some steps to streamline the transcriptome workflow I'm envisioning. Asking the bot to do some wall-clock timings in C to peep a few...
Fact of the Week – 4/06/2026
Gartner predicts that by 2029 AI agents operating in physical environments will generate ten times more data than all current digital AI applications combined. This surge stems from agents capturing logical, spatial and multi‑agent information as they interact with the...
Maine Leads Nationwide Push to Ban New Data Centers
JUST IN: Maine is about to become the first US state to ban new data centers. And 10 other states are right behind it. Maine wants to freeze massive construction projects until late 2027. The bill passed the Democratic-controlled House (with Republican support)....
Meet MaxToki: The AI That Predicts How Your Cells Age — and What to Do About It
MaxToki is a transformer‑decoder foundation model trained on nearly one trillion single‑cell RNA‑seq tokens to predict how individual cells age over time. By encoding transcriptomes as ranked gene lists and extending context length to 16,384 tokens, it can infer the...
Leverage Each Big‑3 AI for Its Strengths
Each of the “big 3” AI models are better at different things. I use all 3, but have Claude Opus do the research and plan, and then have the other model implement.
Agrivoltaics Can Save US Farmers In More Ways Than One
A new Cornell study shows that agrivoltaic solar arrays can slash wind speeds by up to 50%, outperforming traditional windbreaks and cutting soil erosion. The research used computational fluid dynamics to identify a lowered‑front‑row configuration that protects 90% of the...
Elon Musk Pressures Potential SpaceX Investors to Advertise on X
Elon Musk is pressuring banks, law firms and other advisers involved in the upcoming SpaceX IPO to become paying customers of his AI chatbot xAI’s Grok and to purchase advertising on X. The tactic is part of Musk’s broader effort...
What Is Prospecting and How Can It Grow Sales? (2026)
Sales prospecting is the disciplined process of identifying, researching, and contacting potential buyers before they enter the sales funnel. By defining an ideal customer profile and prioritizing leads based on fit, intent, budget, and timing, teams can personalize outreach across...
How One Local Council Helped 1,200 Low-Income Residents Finance Solar and Home Energy Upgrades
Darebin City Council’s Solar Saver program (2014‑2025) enabled roughly 1,200 low‑income Melbourne homeowners to install rooftop solar, reverse‑cycle air conditioners and heat‑pump water heaters, covering A$4.8 million (about US$3.2 million) of upfront costs. The council financed the installations and attached an interest‑free,...
Understanding the Different Types of Semiconductor Products
#Technology #Newsletter #Semiconductor #Manufacturing #Product NLOG-298 | Semiconductor And Beyond Newsletter | The Semiconductor Product Types: https://newsletter.chetanpatil.in/p/semiconductor-and-beyond-newsletter-298/
How to Build a Netflix VOID Video Object Removal and Inpainting Pipeline with CogVideoX, Custom Prompting, and End-to-End Sample Inference
The MarkTechPost tutorial walks readers through building a full‑stack video object removal pipeline using Netflix’s open‑source VOID model combined with the CogVideoX inpainting backbone. It covers environment setup on Google Colab, secure token handling, downloading the 5‑billion‑parameter CogVideoX model and the...
Increasing Volume Drives Lower Biosimilar Medication Prices
We are just getting started. As our volumes go up, our prices go down. And we are adding more branded meds and soon more specialty meds. If you use humira, stelara or other meds that have biosimilars, we...
AI in 2030: Visionary Insights From Matt Mishak
#TimTalk – What does AI in 2030 look like? with Matt Mishak https://t.co/bkbG8uIvh6 via @DLAIgnite #SocialSelling #DigitalSelling #Sales #SalesTips #SalesLeader #SalesEnablement #Marketing #Leadership #Tech #TechNews #ArtificialIntelligence #FutureofWork https://t.co/k2MXT5LSHD
UCSB Unveils Liquid Solar‑Thermal Battery with Double Lithium‑Ion Energy Density
Scientists at UC Santa Barbara have built a liquid‑based solar‑thermal battery that stores and releases heat on demand, achieving double the energy density of conventional lithium‑ion cells and demonstrating the ability to boil water under ambient conditions. The breakthrough could reshape...
Claude Gives My Mobile UI a 4/10 Rating
Codex rating Claude on a UI design and polishing of a mobile app I'm building. 4/10. https://t.co/rvzVMD29y9
Master iPad Pencil Gestures: Simple Step‑by‑Step Guide
An Apple iPad pairs beautifully with an Apple Pencil, but the gestures to paste, scribble, and annotate images are surprisingly unintuitive. No worries, I gotcha covered. Here's how to do it all, step-by-step: https://t.co/A7HWnNAQSt #ipad #applepencil https://t.co/t2pPEO7q9L
Astronaut Reid Wiseman Juggles Artemis II Command and Single Fatherhood
NASA astronaut Reid Wiseman, commander of the upcoming Artemis II mission, is finalizing preparations for the first crewed lunar flight in over 50 years while raising his teenage daughters Ellie and Katherine as a single parent. His candid discussion of estate...
AI‑Optimized Content Crucial: 20% Traffic Loss Ahead
By Q3 2026, businesses without AI-optimized content will lose 20% of their organic (Google) discovery traffic. Not because Google dies, but because people will ask AI first, then click the sources it trusts. And guess where AI will find those sources?
Text Tasks to Claude, Runs on PC Instantly
Claude Dispatch lets you text a task from your phone. Claude does it on your computer. No Docker. No API keys. No command line. Two-minute setup. $20/month. https://t.co/MFj5pVF0o6
Anthropic Commands $2 Billion in Late‑Stage Private‑Market Funding, Outpacing OpenAI
Anthropic's shares have become the most sought‑after private‑market asset, with investors ready to deploy $2 billion, according to Rainmaker Securities. The surge eclipses demand for OpenAI and underscores a broader private‑equity pivot toward AI startups.
Why Claude, CoWorker, and Code Have Separate UIs
why are claude, cowork, and code three different uis? why is this not all just claude?
SIRT1 Activation Shows Promise for Age‑related Brain Disorders
SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential "...SIRT1 could be a promising pharmacological target for age-associated brain disorders, warranting more robust translational studies to validate these findings in humans..." https://t.co/hGVxZ4RErM
Broadcom Shares Climb 0.3% as Analysts Set $472.50 Price Target, Deem Chipmaker Undervalued
Broadcom shares edged up 0.29% after analysts lifted the median price target to $472.50, roughly 50% above the current $314 price. The upgrade reflects confidence in Broadcom’s dominant data‑center networking chips and its 60% share of custom AI accelerators, positioning...
Live NASA Artemis II Visualization Powered by X API
New @X API + @Replit is lots of fun. @tannerlbraden built a @NASAArtemis II mission visualization w/ live @X feed & stats. https://t.co/ptLIf58yCr
More Tokens Keep Scaling AI Reasoning Performance
Unappreciated fact is the second scaling law does not seem to completely plateau in many tasks: throw more tokens at a reasoning AI model and get better answers, especially with a simple harness. Benchmark performance is actually limited by token usage....
Wattage Pick for Longevity
A forum thread on AnandTech discusses how to choose a gaming PC power supply. The original poster suggests selecting a PSU sized so the system runs at roughly 50% load, citing peak efficiency at that point. Respondents agree the method...
Check and Update Your Kobo eReader's Firmware Easily
Have a @Rakuten @Kobo eReader? Smart choice, it's quite as capable as an Amazon Kindle, with strengths all its own. But is it up-to-date with system software? Here's how to check (and update it, as needed): https://t.co/L67emcu2fa #rakuten #kobo #software...
Agentic Commerce Fails; Invisible, Agent‑native Payments Win
Agentic commerce is dead. Despite ALL the hype from payments companies, agentic commerce isn't happening. Walmart saw a 66% drop in conversion when adding agentic commerce. We shouldn't embed checkouts in chatbots. We should make payments invisible and agent-native.
SKILL0: In-Context Agentic Reinforcement Learning for Skill Internalization
The paper introduces SKILL0, a framework that trains large language model agents to internalize specialized skills directly into their parameters, removing the need for runtime skill retrieval. Using an in‑context reinforcement learning curriculum, explicit skill descriptions are gradually withdrawn as...
Meta Halts AI Training After Data Breach Exposes Secrets
Meta freezes AI data work after breach puts training secrets at risk https://t.co/WtjqyiuUAu via @thenextweb
Electrostates Win by Outpacing Fossil Demand with Electrification
Every country in the World is trying to figure out how to electrify more of their economy. Electrostates win when they reduce exposure to volatile imported molecules faster than demand in transport, heat, and industry can reconstitute it elsewhere. https://t.co/KGtlYPCZwK
AI Agents Skim X so You Stay Informed
My AI agents read the AI community on X so you don't have to: https://t.co/kiuZ7QXLzb What are your AI agents doing so you don't have to?
Automated LinkedIn Invite Filtering with Perplexity and Comet
Used Perplexity Computer and Comet to go into LinkedIn, sort through 350 invitations, and accept or ignore based on specific criteria. Winning. https://t.co/al8VDW3TQ8
User Seeks Help Recovering Hijacked X Account
Hey @nikitabier my friend JT’s X account got taken over. It was @tcmllc I can send over any details via DM Can you help us out?