
Opening the Crib Broke Her Sense of Safety
What seemed like an INNOCENT change of opening our daughter’s crib turned out to be our WORST decision of the last 6 months… When we got back from our summer trip, we thought it would be fun to open up our daughter’s crib. Letting her crawl in and out on her own was super cute and made her bed more accessible. At the time, it felt like one of those small parenting upgrades you don’t overthink. Then nights slowly started to change. Queue dracula music. 👻 She’d wake up crying. We’d go in to comfort her. Sometimes one of us would lie down on the floor of her room. Other nights she’d end up on a mattress with us. We started trading off sleeping in her room, waking up exhausted, and just assuming this was a phase. But it never really stopped. Only recently did we realize what we’d missed. We had opened the crib. What we thought was a harmless change had accidentally removed something important: a clear signal that her bed was safe. That’s a second-order consequence. The first-order effect of opening the crib was obvious: more freedom, easier movement, a cute milestone. The second-order effect was invisible at first: disrupted sleep, anxiety at night, and parents sleeping on the floor. It made me think about how often this shows up in business. - You change a refund policy to be more customer-friendly and suddenly customers treat purchases as risk-free trials. - You adjust pricing and accidentally attract a completely different type of buyer. - You add features and don’t realize you’ve doubled your support load. - You move fast, A/B test everything, and miss how incentives are shifting underneath you. The lesson isn’t “don’t change things.” It’s to slow down long enough to ask: What happens after this works? Second-order consequences are rarely obvious. They show up later quietly and then compound. That little crib change was a good reminder for me, both as a parent and a creator: before making a change, don’t just ask if it’s a good idea. Ask what new behaviors it unlocks. Sleep well. 💤
New Engineered Living Materials Advance Synthetic Biology
It’s not AI, JPM or anything to do with the Bay Area so probably no-one left on this site cares, but here is some new #synbio Engineered Living Materials work from our lab @ImperialBioeng and the Hub for Biotech in...
All 320 Podcast Transcripts Open for AI Exploration
Here are the full transcripts from all 320 of my podcast episodes. It's been super fun for me to play with AI to extract insights from this data. Now you can to. My only ask is that if you do something cool...

AI Generates Full GTM Plans, Redefining Marketing Jobs
If Claude Code can draft an ENTIRE GTM plan for you that's basically 95% there, what happens to most marketing roles? In here, we have podcast/YT ad scripts. We have event definitions for analytics. We have full funnel e-mail sequences. We have outbound e-mail...

AI Can Now Draft Complete GTM Plans Instantly
Claude Code literally drafted us an entire GTM plan for ClickFlow. I mean, just look at this one-shotted onboarding e-mail copy. Legit. How does this not just happen across the board for every role? The world is going to look very different...
Measuring AI Investment ROI Becomes Essential for All Companies
Fired up* to work w/ @rfradin @jlarrison @aktwits @arampell @a16z on the Board of @Larridin. We used Larridin at Gainsight to measure the ROI of our AI investments & this is a problem every company will need to tackle. *Russ promised to...

Combined Exercise, Sleep, and Diet Boost Healthspan and Lifespan
Concurrent improvements in physical activity (MVPA), sleep, and diet are associated with meaningful improvements in healthspan (DFLE) and lifespan LD-low quality diet, MD-moderate, HD-high New @eClinicalMed, @uk_biobank 59,000 participants w/ 8 year follow-up https://t.co/gl36VSQVFh
Robotic Dog Inspects Critical Communication Cables in Tunnel
#Robotic Dog Patrols Tunnel, Inspecting Critical Communication Cables by @tweetciiiim #Robotics #MachineLearning #ArtificialIntelligence #Innovation #Technology https://t.co/4x5YC99f9g
Ensure Your Brand Appears in AI Search Results
Try this: Type “What’s the best [your industry]” into ChatGPT. Does your brand show up? If not, you’re risking being invisible in AI search. Here’s some thoughts on how to fix that: https://t.co/yHNIjWFdZM

Soft‑skill Platforms Can Generate Six‑figure Profits
People underestimate how profitable “soft skills” businesses can be. Live on @acquiredotcom: A 15-year social skills training platform built on live, coach-led practice. > $561K TTM revenue > $275K TTM profit > 4,400 active members Full listing: https://t.co/woKnEzxZXN https://t.co/Ejax6k1Lqx
AI Fluency Code Red: Master Claude Code in Six Months
Claude Code is a seminal moment. So much so that we're requiring the @singlegrain team to be proficient with it within the next 6 months. E-mail I sent today: Hi all, I didn’t get to fully land my message during the all-hands...
Original Content Drives AI Prompt Influence, Not Vendor Replication
HOW do vendors influence AI prompt results? #sponsored Gary Nugent , CEO of Informa TechTarget says THIS is the top question customers are asking. Full convo here: https://bit.ly/44hmmEc As buyers turn to AI, visibility and influence comes down to original...
Trump’s 10% Credit Card Cap: Relief or Risk?
Trump wants a one-year 10% cap on credit-card interest. @Klarna's CEO is in. @BillAckman says it’s a mistake. Is this real consumer relief or a risky distortion? https://t.co/A6XQ4D9n8S @ScrawlGirl @kelseyvlamis @businessinsider
Timing Beats Tactics: Offer Success Depends on When
Most marketers copy tactics, few study timing. • A good offer at the wrong time: crickets. • A weak offer at the perfect time: record sales. It’s not just what you say, it’s when you say it. Timing is leverage.
Prioritize Share of Voice Over Short‑Term ROI
Companies are very quick to ask if marketing is getting enough return from its budget, but rarely ask if that budget is doing enough to maintain a presence in the market. When marketing is judged on the short-term efficiency of...

Milestone‑Heavy PD‑L1×VEGF Deals Signal Low Conviction
PD(L1)xVEGF the Keytruda replacement? The deal making market is clearly not pricing it that way. 🗣️“We want exposure to a hot mechanism, but we want most of the price contingent on Phase 2/3 and commercial proof.” Great analysis below...

Glucose Metabolism Fluctuations Drive Cognitive Aging Changes
The brain's glucose metabolism, cognition, and aging: "Variability in the moment-to-moment metabolism of glucose is biologically and functionally important to cognition and in explaining metabolic and brain network changes in aging." https://t.co/0cFbXJFQD5 https://t.co/sCO98PHBL0

Boeing Adds Strakes to SLS to Curb Unexpected Vibrations
Don't remember hearing about this before, but Boeing says on Artemis I, SLS "faced higher-than-expected vibrations" near the SRB attach points. They've fixed it by adding "four strakes--thin fin-like metal structures" as shown in photo. https://t.co/0lj4l5SpIH https://t.co/SYAXk6i2Q9

Teaching AI Assistants API Basics Empowers Everyone
With Claude code, everyone is a builder. Just taught my EA about API keys so she can build out even better automations. Welcome to API 101. https://t.co/3ZfW4pxZWB
CEOs Doubt C‑suite AI Competence More than Past Tech Savvy
Who's surprised by this finding from Gartner that CEOs have less faith in their C-Level colleagues being AI-savvy in 2025/26 than they had in those same colleagues being tech savvy in 2019/20?

Treat AI as Levers, Focus on High‑impact Use Cases
AI use cases aren’t an alphabet. They’re levers. Predict Optimize Personalize Automate Pick the 2–3 that unblock real decisions first. That’s how AI earns, not decorates. https://t.co/JI90tVylhH
Close the Intent‑Action Gap with Decision‑Focused Pages
After a while, you realize pipeline is not created by volume alone. You also think about it as something you can either catch or miss. Most buying journeys do not announce themselves. They show up in small, uneven bursts. A...

ArianeGroup Appoints Anne Quillon as New CPO
.@ArianeGroup names Anne Quillon Chief Procurement Officer. She's former CPO for GE Renewable Energy Hydro and for @Alstom Power Europe, Middle East and Africa. https://t.co/QkfA5z0caa

Fine‑tuning Improves Feel, Alignment Ensures Safe Behavior
Do you know why a model feels “better” after fine-tuning? And why a very smart model can still give unsafe or confusing answers? In this post, we break down Fine-tuning and Alignment. This is part of Introduction to AI in 42 terms (we’ve covered...

Ship 39 Secured to Megabay Crane, Ready for Lift
Ship 39 has been attached to the Megabay gantry crane. Lifting soon? 📸: @jordanguidry6 https://t.co/pmI4FsY6qF

Early AI Adoption Secures Lasting Competitive Edge
Being first matters more than ever. Institutions that harness generative AI today can redefine customer experiences and gain lasting advantage. Get the free report: https://t.co/k3GpJ9wvLy https://t.co/qxfNMFDFfa

Why Most AI Deployments Failed and How to Fix Them
The ROI Of #AI: Three Reasons Why Most AI Deployments Failed In 2025 (And How To Fix Them In 2026) by Jeff Torello @Forbes Learn more: https://t.co/sriKpHy0AN #MachineLearning #ArtificialIntelligence #ML https://t.co/9B9Oj8vTDi

Thales Belgium to Supply
.@Thales_Alenia_S Belgium to provide 179 electronic units to be fitted into #SABCA thrust vector control systems on 27 #Ariane6 rockets - flights 16 to 42. Follows SABCA Oct contract w/ @ArianeGroup, valued at EUR 85M ($99M), for the TVCs. https://t.co/tcG9lo00bA
AI Success Demands Discipline, Execution, and Measurable Results
AI adoption now hinges on disciplined execution and measurable outcomes. This SVEN (Silicon Valley Executive Network) session brings together leaders across building, implementing, and investing to focus on what drives real results. #AI #strategy Brian Reynard
Ethics Guardrails on Crypto Profits Threaten Market Legislation
Worth taking a step back and remembering how absolutely insane it is that ethics guardrails prohibiting public officials from profiting off of crypto business ties is a controversial point that could sink market structure legislation.
Testing Daily Signals to Boost Operator Decision Speed
For 11 years, I’ve sent a weekly newsletter. Five hundred seventy-two issues built around links people consistently tell me they actually read. That cadence works. I’m keeping it. But frequency isn’t the same thing as usefulness. A lot of operator...
ARR Numbers Mislead when Definitions Are Vague
Most ARR disclosures are technically correct — and still wildly misleading. After reviewing hundreds of public tech company ARR definitions and calculations, one thing became clear: 👉 The problem isn’t the ARR number 👉 It’s how companies define, calculate, and...

Factor Development Risk with Probability of Success
Incorporating Probability of Success (PoS) is a unique aspect of #biotech valuation investors must be aware of. It tries to factor development risk into revenue and cost assumptions. Here is a table of PoS values: #learnbiotechinvesting #investing #BiotechPrometheus https://t.co/Sv8XodkWXg

David Zamora Appointed Chairman of Space Data Association
The @spacedata Assn names David Zamora, head of flight dynamics at @EutelsatGroup, as new chairman. He's been an executive director of SDA for 8 yrs. https://t.co/cxn2PcqXZd
Robotic Hand Surpasses Human Reflexes in Speed
Faster Than Human Reflexes: A #Robotic Hand Redefining Speed and Precision by @sciencegirl #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/BmEVMLqLKS
White House Leverages Crypto Threat to Pressure Banks
This strikes me as a little too advanced for this White House to have come up with it on its own, but it would be smart strategy by the crypto lobby. However, I would imagine banks are smart enough to not...
Profit Focus and Strong Team Fuel Founder Happiness
I’ve talked to over 20 founders the past 4 weeks and every one of them is miserable. They want me to be miserable too … but I’m NOT. 11 years in, I’m more excited than ever. Here’s the top 5...
AI Destroys Per-Seat CRM Pricing, Shifts to Outcomes
The "per seat" business model is officially dead for CRMs. For the last 20 years, the logic of SaaS pricing was simple. You build a database, and you charge companies for every human who logs in to update it. The...

Fasting‑mimicking Diet Eases Symptoms, Reduces Inflammation in Crohn’s
A fasting-mimicking diet improved the clinical course and suppressed inflammation in people with mild or moderate Crohn's disease in a randomized trial https://t.co/pVVJ4HD4gD https://t.co/2PyJObeAqQ
Three Hours Coaching Boosts Sales Attainment Above 100%
The data is clear: teams receiving 3+ hours of coaching per rep per month consistently outperform (thanks Gartner for the analysis). But most teams never get out of reactive mode. “I wish I had more time to coach my reps....
Real-Time World Model Paves Way for Instant TV
A new real-time world model. This is a step towards instant TV or, sometime in the next 24 months, holodecks. As I told you last year, world models are going to be the theme of 2026.
Prioritize the Right Platform, Don’t Spread Yourself Thin
Important Reminder for All Marketers: 👇 Yesterday I was chatting with a client (boat retailer) that told me they wanted to focus more on their LinkedIn efforts. My response: Why would you put your energy on a B2B platform when...

Tech Roles Now Dominate UK Finance Hiring, up 12%
Software and tech roles now claim 16% of finance vacancies—edging out investment management and banking at 15% each. The hiring signal is clear. AI and tech skills drive 12% rise in finance job vacancies in 2025 in the UK. https://t.co/SZximqlQwW https://t.co/p4haTYDTHh
AI Wins by Replacing, Not Automating, Deterministic Workflows
Most companies claim they are becoming AI first. Almost none understand what that actually requires. The surprising truth: AI does not transform your business by automating existing workflows. It transforms it by replacing deterministic workflows entirely. I explore this with @hala_zeine, Chief Strategy...

Epiploic Fat Fuels Inflammation in Severe Obesity
Fat surrounding the large intestine (epiploic) is rich in immune cells and can drive inflammation. Study in people with severe obesity. @Cell_Metabolism https://t.co/kN1B77XrCm https://t.co/YlNrpCGZjI

New Cell Studies Link EBV to Multiple Sclerosis Mechanisms
3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement https://t.co/JXThwhZugq https://t.co/fO1aDsZmmB https://t.co/fO1aDsZmmB https://t.co/eUNrrRGw0s
Deep Product Knowledge Outweighs CEO Polish
For a long while, you probably aren't a great CEO But you know the customers The software The feature gaps The roadmap The competition How to sell it How to market it How to build it So maybe as flawed as you are You are still the best CEO
FDA's Regulatory Firewall Cracked, Staff Faces Trauma
Conducting interviews on stage can be emotional. Last night I got to speak with Richard Pazdur, the long-time FDA cancer czar who recently retired, along @ScottGottlieb and former FDA official Julie Tierney. Pazdur changed the way medicines are regulated, getting them...
Boston Dynamics Robot Becomes Versatile On‑Set Cameraman
Boston Dynamics' #Robot Evolves into Multi-Talented Cameraman by @aitrendz_xyz #MachineLearning #AI #Robotics #ArtificialIntelligence #ML #Innovation https://t.co/wM7GhT5uxS

Total‑body MRIs Yield High False‑positive and False‑negative Rates
Total body MRI scans generate lots of false positive results. Then there's the false negatives, too. https://t.co/7NITyu2sqM @PeterWhoriskey https://t.co/PW1Q2XjOn4