Technology Social Media and Updates

New Engineered Living Materials Advance Synthetic Biology
SocialJan 14, 2026

New Engineered Living Materials Advance Synthetic Biology

It’s not AI, JPM or anything to do with the Bay Area so probably no-one left on this site cares, but here is some new #synbio Engineered Living Materials work from our lab @ImperialBioeng and the Hub for Biotech in...

By Tom Ellis
All 320 Podcast Transcripts Open for AI Exploration
SocialJan 14, 2026

All 320 Podcast Transcripts Open for AI Exploration

Here are the full transcripts from all 320 of my podcast episodes. It's been super fun for me to play with AI to extract insights from this data. Now you can to. My only ask is that if you do something cool...

By Lenny Rachitsky
AI Generates Full GTM Plans, Redefining Marketing Jobs
SocialJan 14, 2026

AI Generates Full GTM Plans, Redefining Marketing Jobs

If Claude Code can draft an ENTIRE GTM plan for you that's basically 95% there, what happens to most marketing roles? In here, we have podcast/YT ad scripts. We have event definitions for analytics. We have full funnel e-mail sequences. We have outbound e-mail...

By Eric Siu
AI Can Now Draft Complete GTM Plans Instantly
SocialJan 14, 2026

AI Can Now Draft Complete GTM Plans Instantly

Claude Code literally drafted us an entire GTM plan for ClickFlow. I mean, just look at this one-shotted onboarding e-mail copy. Legit. How does this not just happen across the board for every role? The world is going to look very different...

By Eric Siu
Measuring AI Investment ROI Becomes Essential for All Companies
SocialJan 13, 2026

Measuring AI Investment ROI Becomes Essential for All Companies

Fired up* to work w/ @rfradin @jlarrison @aktwits @arampell @a16z on the Board of @Larridin. We used Larridin at Gainsight to measure the ROI of our AI investments & this is a problem every company will need to tackle. *Russ promised to...

By Nick Mehta
Combined Exercise, Sleep, and Diet Boost Healthspan and Lifespan
SocialJan 13, 2026

Combined Exercise, Sleep, and Diet Boost Healthspan and Lifespan

Concurrent improvements in physical activity (MVPA), sleep, and diet are associated with meaningful improvements in healthspan (DFLE) and lifespan LD-low quality diet, MD-moderate, HD-high New @eClinicalMed, @uk_biobank 59,000 participants w/ 8 year follow-up https://t.co/gl36VSQVFh

By Eric Topol
Robotic Dog Inspects Critical Communication Cables in Tunnel
SocialJan 13, 2026

Robotic Dog Inspects Critical Communication Cables in Tunnel

#Robotic Dog Patrols Tunnel, Inspecting Critical Communication Cables by @tweetciiiim #Robotics #MachineLearning #ArtificialIntelligence #Innovation #Technology https://t.co/4x5YC99f9g

By Ronald van Loon
Ensure Your Brand Appears in AI Search Results
SocialJan 13, 2026

Ensure Your Brand Appears in AI Search Results

Try this: Type “What’s the best [your industry]” into ChatGPT. Does your brand show up? If not, you’re risking being invisible in AI search. Here’s some thoughts on how to fix that: https://t.co/yHNIjWFdZM

By Ross Simmonds
Soft‑skill Platforms Can Generate Six‑figure Profits
SocialJan 13, 2026

Soft‑skill Platforms Can Generate Six‑figure Profits

People underestimate how profitable “soft skills” businesses can be. Live on @acquiredotcom: A 15-year social skills training platform built on live, coach-led practice. > $561K TTM revenue > $275K TTM profit > 4,400 active members Full listing: https://t.co/woKnEzxZXN https://t.co/Ejax6k1Lqx

By Andrew Gazdecki
AI Fluency Code Red: Master Claude Code in Six Months
SocialJan 13, 2026

AI Fluency Code Red: Master Claude Code in Six Months

Claude Code is a seminal moment. So much so that we're requiring the @singlegrain team to be proficient with it within the next 6 months. E-mail I sent today: Hi all, I didn’t get to fully land my message during the all-hands...

By Eric Siu
Original Content Drives AI Prompt Influence, Not Vendor Replication
SocialJan 13, 2026

Original Content Drives AI Prompt Influence, Not Vendor Replication

HOW do vendors influence AI prompt results? #sponsored Gary Nugent , CEO of Informa TechTarget says THIS is the top question customers are asking. Full convo here: https://bit.ly/44hmmEc As buyers turn to AI, visibility and influence comes down to original...

By Katie Martell
Trump’s 10% Credit Card Cap: Relief or Risk?
SocialJan 13, 2026

Trump’s 10% Credit Card Cap: Relief or Risk?

Trump wants a one-year 10% cap on credit-card interest. @Klarna's CEO is in. @BillAckman says it’s a mistake. Is this real consumer relief or a risky distortion? https://t.co/A6XQ4D9n8S @ScrawlGirl @kelseyvlamis @businessinsider

By Spiros Margaris
Timing Beats Tactics: Offer Success Depends on When
SocialJan 13, 2026

Timing Beats Tactics: Offer Success Depends on When

Most marketers copy tactics, few study timing. • A good offer at the wrong time: crickets. • A weak offer at the perfect time: record sales. It’s not just what you say, it’s when you say it. Timing is leverage.

By Kody Nordquist
Prioritize Share of Voice Over Short‑Term ROI
SocialJan 13, 2026

Prioritize Share of Voice Over Short‑Term ROI

Companies are very quick to ask if marketing is getting enough return from its budget, but rarely ask if that budget is doing enough to maintain a presence in the market. When marketing is judged on the short-term efficiency of...

By Liam Moroney
Milestone‑Heavy PD‑L1×VEGF Deals Signal Low Conviction
SocialJan 13, 2026

Milestone‑Heavy PD‑L1×VEGF Deals Signal Low Conviction

PD(L1)xVEGF the Keytruda replacement? The deal making market is clearly not pricing it that way. 🗣️“We want exposure to a hot mechanism, but we want most of the price contingent on Phase 2/3 and commercial proof.” Great analysis below...

By BowTiedBiotech
Glucose Metabolism Fluctuations Drive Cognitive Aging Changes
SocialJan 13, 2026

Glucose Metabolism Fluctuations Drive Cognitive Aging Changes

The brain's glucose metabolism, cognition, and aging: "Variability in the moment-to-moment metabolism of glucose is biologically and functionally important to cognition and in explaining metabolic and brain network changes in aging." https://t.co/0cFbXJFQD5 https://t.co/sCO98PHBL0

By Eric Topol
Boeing Adds Strakes to SLS to Curb Unexpected Vibrations
SocialJan 13, 2026

Boeing Adds Strakes to SLS to Curb Unexpected Vibrations

Don't remember hearing about this before, but Boeing says on Artemis I, SLS "faced higher-than-expected vibrations" near the SRB attach points. They've fixed it by adding "four strakes--thin fin-like metal structures" as shown in photo. https://t.co/0lj4l5SpIH https://t.co/SYAXk6i2Q9

By Marcia Smith
Teaching AI Assistants API Basics Empowers Everyone
SocialJan 13, 2026

Teaching AI Assistants API Basics Empowers Everyone

With Claude code, everyone is a builder. Just taught my EA about API keys so she can build out even better automations. Welcome to API 101. https://t.co/3ZfW4pxZWB

By Allie Miller
CEOs Doubt C‑suite AI Competence More than Past Tech Savvy
SocialJan 13, 2026

CEOs Doubt C‑suite AI Competence More than Past Tech Savvy

Who's surprised by this finding from Gartner that CEOs have less faith in their C-Level colleagues being AI-savvy in 2025/26 than they had in those same colleagues being tech savvy in 2019/20?

By Cassie Kozyrkov
Treat AI as Levers, Focus on High‑impact Use Cases
SocialJan 13, 2026

Treat AI as Levers, Focus on High‑impact Use Cases

AI use cases aren’t an alphabet. They’re levers. Predict Optimize Personalize Automate Pick the 2–3 that unblock real decisions first. That’s how AI earns, not decorates. https://t.co/JI90tVylhH

By Giuliano Liguori
Close the Intent‑Action Gap with Decision‑Focused Pages
SocialJan 13, 2026

Close the Intent‑Action Gap with Decision‑Focused Pages

After a while, you realize pipeline is not created by volume alone. You also think about it as something you can either catch or miss. Most buying journeys do not announce themselves. They show up in small, uneven bursts. A...

By devbasu
ArianeGroup Appoints Anne Quillon as New CPO
SocialJan 13, 2026

ArianeGroup Appoints Anne Quillon as New CPO

.@ArianeGroup names Anne Quillon Chief Procurement Officer. She's former CPO for GE Renewable Energy Hydro and for @Alstom Power Europe, Middle East and Africa. https://t.co/QkfA5z0caa

By Peter B. de Selding
Fine‑tuning Improves Feel, Alignment Ensures Safe Behavior
SocialJan 13, 2026

Fine‑tuning Improves Feel, Alignment Ensures Safe Behavior

Do you know why a model feels “better” after fine-tuning? And why a very smart model can still give unsafe or confusing answers? In this post, we break down Fine-tuning and Alignment. This is part of Introduction to AI in 42 terms (we’ve covered...

By Louis Bouchard
Ship 39 Secured to Megabay Crane, Ready for Lift
SocialJan 13, 2026

Ship 39 Secured to Megabay Crane, Ready for Lift

Ship 39 has been attached to the Megabay gantry crane. Lifting soon? 📸: @jordanguidry6 https://t.co/pmI4FsY6qF

By Felix Schlang
Early AI Adoption Secures Lasting Competitive Edge
SocialJan 13, 2026

Early AI Adoption Secures Lasting Competitive Edge

Being first matters more than ever. Institutions that harness generative AI today can redefine customer experiences and gain lasting advantage. Get the free report: https://t.co/k3GpJ9wvLy https://t.co/qxfNMFDFfa

By Jim Marous
Why Most AI Deployments Failed and How to Fix Them
SocialJan 13, 2026

Why Most AI Deployments Failed and How to Fix Them

The ROI Of #AI: Three Reasons Why Most AI Deployments Failed In 2025 (And How To Fix Them In 2026) by Jeff Torello @Forbes Learn more: https://t.co/sriKpHy0AN #MachineLearning #ArtificialIntelligence #ML https://t.co/9B9Oj8vTDi

By Ronald van Loon
Thales Belgium to Supply
SocialJan 13, 2026

Thales Belgium to Supply

.@Thales_Alenia_S Belgium to provide 179 electronic units to be fitted into #SABCA thrust vector control systems on 27 #Ariane6 rockets - flights 16 to 42. Follows SABCA Oct contract w/ @ArianeGroup, valued at EUR 85M ($99M), for the TVCs. https://t.co/tcG9lo00bA

By Peter B. de Selding
AI Success Demands Discipline, Execution, and Measurable Results
SocialJan 13, 2026

AI Success Demands Discipline, Execution, and Measurable Results

AI adoption now hinges on disciplined execution and measurable outcomes. This SVEN (Silicon Valley Executive Network) session brings together leaders across building, implementing, and investing to focus on what drives real results. #AI #strategy Brian Reynard

By Geoffrey Moore
Ethics Guardrails on Crypto Profits Threaten Market Legislation
SocialJan 13, 2026

Ethics Guardrails on Crypto Profits Threaten Market Legislation

Worth taking a step back and remembering how absolutely insane it is that ethics guardrails prohibiting public officials from profiting off of crypto business ties is a controversial point that could sink market structure legislation.

By Alex Johnson
Testing Daily Signals to Boost Operator Decision Speed
SocialJan 13, 2026

Testing Daily Signals to Boost Operator Decision Speed

For 11 years, I’ve sent a weekly newsletter. Five hundred seventy-two issues built around links people consistently tell me they actually read. That cadence works. I’m keeping it. But frequency isn’t the same thing as usefulness. A lot of operator...

By Hiten Shah
ARR Numbers Mislead when Definitions Are Vague
SocialJan 13, 2026

ARR Numbers Mislead when Definitions Are Vague

Most ARR disclosures are technically correct — and still wildly misleading. After reviewing hundreds of public tech company ARR definitions and calculations, one thing became clear: 👉 The problem isn’t the ARR number 👉 It’s how companies define, calculate, and...

By Ben Murray
Factor Development Risk with Probability of Success
SocialJan 13, 2026

Factor Development Risk with Probability of Success

Incorporating Probability of Success (PoS) is a unique aspect of #biotech valuation investors must be aware of. It tries to factor development risk into revenue and cost assumptions. Here is a table of PoS values: #learnbiotechinvesting #investing #BiotechPrometheus https://t.co/Sv8XodkWXg

By Biotech Investor
David Zamora Appointed Chairman of Space Data Association
SocialJan 13, 2026

David Zamora Appointed Chairman of Space Data Association

The @spacedata Assn names David Zamora, head of flight dynamics at @EutelsatGroup, as new chairman. He's been an executive director of SDA for 8 yrs. https://t.co/cxn2PcqXZd

By Peter B. de Selding
Robotic Hand Surpasses Human Reflexes in Speed
SocialJan 13, 2026

Robotic Hand Surpasses Human Reflexes in Speed

Faster Than Human Reflexes: A #Robotic Hand Redefining Speed and Precision by @sciencegirl #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/BmEVMLqLKS

By Ronald van Loon
White House Leverages Crypto Threat to Pressure Banks
SocialJan 13, 2026

White House Leverages Crypto Threat to Pressure Banks

This strikes me as a little too advanced for this White House to have come up with it on its own, but it would be smart strategy by the crypto lobby. However, I would imagine banks are smart enough to not...

By Alex Johnson
Profit Focus and Strong Team Fuel Founder Happiness
SocialJan 13, 2026

Profit Focus and Strong Team Fuel Founder Happiness

I’ve talked to over 20 founders the past 4 weeks and every one of them is miserable. They want me to be miserable too … but I’m NOT. 11 years in, I’m more excited than ever. Here’s the top 5...

By Adam Robinson
AI Destroys Per-Seat CRM Pricing, Shifts to Outcomes
SocialJan 13, 2026

AI Destroys Per-Seat CRM Pricing, Shifts to Outcomes

The "per seat" business model is officially dead for CRMs. For the last 20 years, the logic of SaaS pricing was simple. You build a database, and you charge companies for every human who logs in to update it. The...

By Wes Bush
Fasting‑mimicking Diet Eases Symptoms, Reduces Inflammation in Crohn’s
SocialJan 13, 2026

Fasting‑mimicking Diet Eases Symptoms, Reduces Inflammation in Crohn’s

A fasting-mimicking diet improved the clinical course and suppressed inflammation in people with mild or moderate Crohn's disease in a randomized trial https://t.co/pVVJ4HD4gD https://t.co/2PyJObeAqQ

By Eric Topol
Three Hours Coaching Boosts Sales Attainment Above 100%
SocialJan 13, 2026

Three Hours Coaching Boosts Sales Attainment Above 100%

The data is clear: teams receiving 3+ hours of coaching per rep per month consistently outperform (thanks Gartner for the analysis). But most teams never get out of reactive mode. “I wish I had more time to coach my reps....

By Mark Roberge
Real-Time World Model Paves Way for Instant TV
SocialJan 13, 2026

Real-Time World Model Paves Way for Instant TV

A new real-time world model. This is a step towards instant TV or, sometime in the next 24 months, holodecks. As I told you last year, world models are going to be the theme of 2026.

By Robert Scoble
Prioritize the Right Platform, Don’t Spread Yourself Thin
SocialJan 13, 2026

Prioritize the Right Platform, Don’t Spread Yourself Thin

Important Reminder for All Marketers: 👇 Yesterday I was chatting with a client (boat retailer) that told me they wanted to focus more on their LinkedIn efforts. My response: Why would you put your energy on a B2B platform when...

By Marcus Sheridan
Tech Roles Now Dominate UK Finance Hiring, up 12%
SocialJan 13, 2026

Tech Roles Now Dominate UK Finance Hiring, up 12%

Software and tech roles now claim 16% of finance vacancies—edging out investment management and banking at 15% each. The hiring signal is clear. AI and tech skills drive 12% rise in finance job vacancies in 2025 in the UK. https://t.co/SZximqlQwW https://t.co/p4haTYDTHh

By Efi Pylarinou
AI Wins by Replacing, Not Automating, Deterministic Workflows
SocialJan 13, 2026

AI Wins by Replacing, Not Automating, Deterministic Workflows

Most companies claim they are becoming AI first. Almost none understand what that actually requires. The surprising truth: AI does not transform your business by automating existing workflows. It transforms it by replacing deterministic workflows entirely. I explore this with @hala_zeine, Chief Strategy...

By Ronald van Loon
Epiploic Fat Fuels Inflammation in Severe Obesity
SocialJan 13, 2026

Epiploic Fat Fuels Inflammation in Severe Obesity

Fat surrounding the large intestine (epiploic) is rich in immune cells and can drive inflammation. Study in people with severe obesity. @Cell_Metabolism https://t.co/kN1B77XrCm https://t.co/YlNrpCGZjI

By Eric Topol
New Cell Studies Link EBV to Multiple Sclerosis Mechanisms
SocialJan 13, 2026

New Cell Studies Link EBV to Multiple Sclerosis Mechanisms

3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement https://t.co/JXThwhZugq https://t.co/fO1aDsZmmB https://t.co/fO1aDsZmmB https://t.co/eUNrrRGw0s

By Eric Topol
Deep Product Knowledge Outweighs CEO Polish
SocialJan 13, 2026

Deep Product Knowledge Outweighs CEO Polish

For a long while, you probably aren't a great CEO But you know the customers The software The feature gaps The roadmap The competition How to sell it How to market it How to build it So maybe as flawed as you are You are still the best CEO

By Jason Lemkin
FDA's Regulatory Firewall Cracked, Staff Faces Trauma
SocialJan 13, 2026

FDA's Regulatory Firewall Cracked, Staff Faces Trauma

Conducting interviews on stage can be emotional. Last night I got to speak with Richard Pazdur, the long-time FDA cancer czar who recently retired, along @ScottGottlieb and former FDA official Julie Tierney. Pazdur changed the way medicines are regulated, getting them...

By Matthew Herper
Boston Dynamics Robot Becomes Versatile On‑Set Cameraman
SocialJan 13, 2026

Boston Dynamics Robot Becomes Versatile On‑Set Cameraman

Boston Dynamics' #Robot Evolves into Multi-Talented Cameraman by @aitrendz_xyz #MachineLearning #AI #Robotics #ArtificialIntelligence #ML #Innovation https://t.co/wM7GhT5uxS

By Ronald van Loon
Total‑body MRIs Yield High False‑positive and False‑negative Rates
SocialJan 13, 2026

Total‑body MRIs Yield High False‑positive and False‑negative Rates

Total body MRI scans generate lots of false positive results. Then there's the false negatives, too. https://t.co/7NITyu2sqM @PeterWhoriskey https://t.co/PW1Q2XjOn4

By Eric Topol