AI Drug Discovery: Hype Overwhelms Real Clinical Success
AI Drug Discovery – Revolution or Expensive Illusion? | Ep. 978 https://t.co/YLQ8QNlnWv [ 00:34 ] Billions into AI drug discovery [ 01:04 ] AI doesn’t cure diseases [ 01:38 ] Expensive illusion vs reality [ 02:23 ] Original pitch inefficiency problem [ 03:48 ] Only 10 percent solved [ 05:09 ] Clinical trials sobering results [ 06:45 ] Speed vs success in clinic [ 08:07 ] Big Pharma deal shift [ 13:10 ] Valuation bubble and CRO risk
Local AI Models Essential as Cloud Backup
At 4 p.m. today @NousResearch's CTO will be on an audio space here today to talk about Hermes. Why is that important? We all need to move to local models, at least as a backup for when the big models in...
Apple’s Future iPhone: Simpler, No Dedicated AI Executives
The iPhone 50 years from now – and why Apple won’t have AI execs https://asymco.com/2026/03/31/the-iphone-50-years-from-now-and-why-apple-wont-have-ai-execs/
Claude Managed Agents Simplify Scalable Autonomous AI Development
Claude Managed Agents -> Anthropic announces Claude Managed Agents, offering developers an agent harness and other tools to build and deploy AI agents at scale, available in public beta "Managed Agents handles the complexity. You define your agent's tasks, ...
Give Value, Skip Intro, Automate Freebies for Reel Success
I've been testing Trial Reels... and I finally had one "pop off" 👀 What I've seen working so far: ✓ give a TON of information away in the video ✓ these aren't posts for people to get to know you ✓ use a ManyChat...
1865 Theory Predicts AI-Driven Age of Abundance
This economic theory from 1865 argues that we’re headed for an AI age of abundance by @Timothy_Hughes https://t.co/Zjf7k9y123 @DLAIgnite #SocialSelling #DigitalSelling #Sales #SalesTips #SalesLeader #ArtificialIntelligence #Technology #Innovation #Tech #TechNews #Marketing #Strategy
Quest Users Abandon Headsets Over Frustrating UI Decision
And with that, the last remaining Quest users will put their headsets on the shelf because of the frustration this UI will cause. Worst decision they've yet made.
AI Makes Thousands of Manga Series Affordable to Animate
A full K-pop action series just got made in 3 days on Higgs with Seedance 2.0. One person. No studio. No budget. There are over 100,000 manga and webtoon titles that have never been animated because it costs $150K to $300K per...
Maximizing Battery Storage Value in Australia’s NEM
VIDEO: Extracting more value from battery storage assets in Australia’s NEM #energysky -- via Energy Storage News: https://t.co/qiEiRcisAk
Apple’s Proprietary Chargers: Forced Lock‑in and Frequent Breakage
I HATE how Apple locks you into their own chargers, and then they break every three months.
Ensuring Cyber Control Over Autonomous AI Systems
Maintaining cyber control when #AI can act #Autonomously by Matthew Lloyd Davies @techradar Learn more: https://t.co/0BeRyZaQ5S #CyberSecurity #Infosec #IT #Technology https://t.co/hGtv2pnZa8
Take Control: Ditch Your Meta Agency Today
You should fire your meta agency. Go to your Facebook ad account, select all your campaigns, and click View History or view edits. Every single change your media buying agency has made will show up there. What you'll probably find is that...
Google's Core Update Pushes YouTube to AI Overviews Dominance
Just checked a client that ranked in AI Overviews last week and now the top 4 links in AI Overviews are all YouTube. Let me guess: the core update was another way for Google to boost YouTube, like it did with...
How to Remove Unnecessary AI Watermarks From Images
While it's good to be able to differentiate AI-created photographs from real photos, there are many images that don't need the AI mark. Here's how to remove it, as needed, and how it all works behind the scenes: https://t.co/m8yBJd6MVt #ai...
AI Amplifies or Diminishes Learning Based on Use
🎥 Just shared on YouTube 👉 AI is a diminisher or an amplifier depending on how a learner uses it! Vibe Coding, Agentic AI, and What Schools Must Teach Now https://t.co/mmHO6FgTzZ https://t.co/Kuvh29Wrj8
Synthetic Biology Platform Outpaces De‑extinction Hype
Most people hear “bring back the woolly mammoth” and say, “impossible.” Colossal might be considered a de-extinction company, but Ben Lamm is actually building a synthetic biology platform with consequences that could be much bigger than bringing back mammoths. -- $10B...
Links Earn No Boost, Others Gain Algorithmic Advantage
Let me give a precise model of "link deboosting," which I believe is, for all intents and purposes, real. Forgive me, modest longpost for the full model. Jeff Bezos has argued that when anecdotes and data disagree, the anecdotes often hold the...
Nebraska Tops Starlink Speeds, 58% Meet 100/20 Mbps
Update: @Speedtest said Nebraska led the nation for @Starlink performance, with 58.31% of Starlink users meeting 100/20 Mbps in the second half of 2025, up from 32.16% in the first half. https://t.co/VXH7nlVrW4
Apply Organizational Structures to Tame LLM Hallucinations
Hallucinations remain in LLMs, but note that over centuries we have developed complicated, successful machines that take uncertain output from unreliable sources & reduce the risk of errors. We call those machines organizational structures & we can apply similar approaches to...
AI Gateway Guarantees Peace of Mind, Zero Hassles
AI Gateway is quite literally a “peace of mind” product: ✅ No downtime ✅ No lock-in ✅ No keys 🆕 No training
Asynchronous Courses: A Service Tool, Not Just Scaling
You can want an asynchronous course in your business cause you're tired of repeating yourself to every client. Courses (asynchronous or otherwise) don't need to be about scale. They can be another tool in the service toolbox.
Protect Core Skills From AI-Driven Erosion
Don’t Let AI Destroy the Skills That Make Your Company Competitive https://t.co/0li40LMDQF While a business may appear technologically sophisticated, it can be quietly losing the expertise it needs to innovate, respond to crises, and compete. #AI #skills #employeeexperience https://t.co/embQAz7vxM
FCC to Boost Satellite Internet Speeds by Raising Power Limits
The FCC will vote this month to supercharge your Internet. Lifting outdated power limits on satellite Internet means faster speeds and more capacity. 🚀 🛰️ 🛜 https://t.co/Qy7yuHv8Mx
Lenovo Yoga Slim 7x 2026: 14‑inch, Longest Battery Life
14" Laptop with THE longest battery life right now. Lenovo Yoga Slim 7x 2026. Video up
LLM Hallucinations Real—Verify Chatbot Answers Like Searches
The critics who talk about LLM's hallucination problem are, IME, completely correct. Other than for coding, I just use the chatbots as glorified search engines, and I don't think you should trust a word they say if you can't find a...
Tiny Open-Weight Models Replicate Anthropic's Vulnerability Detection
"But here is what we found when we tested: We took the specific vulnerabilities Anthropic showcases in their announcement, isolated the relevant code, and ran them through small, cheap, open-weights models. Those models recovered much of the same analysis. Eight...
AR Camera Maps Real World for Holodeck Experiences
I got a demo of this. You aim your phone’s camera at almost anything in the real world and it knows exactly where that thing, say a building is, and exactly where your camera is too. Makes a great platform for...
Explore Muse Spark on Meta AI With
try muse spark via the Meta AI app or https://t.co/DipeeIuXm2! check out this simulation i made: https://t.co/nAnYiwruoo
Meta's AI Model Puts Zuckerberg Among Tech Titans
Meta's New AI Model Gives Mark Zuckerberg a Seat at the Big Kid's Table https://t.co/CfXI4k47cS https://t.co/yurW8ELgJy
Seeking User Priorities for New AI‑Native GRC Platform
What is the most important thing you want in a GRC platform? We are building something new, AI-native from the ground up. Would value input from people actually using these systems day to day.
Defenders Must Build Infrastructure Now; Models Ready, Ecosystem Lagging
"The priority for defenders is to start building now: the scaffolds, the pipelines, the maintainer relationships, the integration into development workflows. The models are ready. The question is whether the rest of the ecosystem is." https://t.co/z2GZ3SdDwW
AI in Education: Real Classroom Use Cases Explored
🎧 A new bonus episode of the Easy EdTech Podcast is out with practical examples of AI in education. 📚 I welcome back Caroline Haebig to talk through real classroom use cases for teachers and students. 🤝 I’m excited to partner with...
Hacker Claims Breach of China's Supercomputer, Offers Data
A hacker has allegedly breached one of China’s supercomputers and is attempting to sell a trove of stolen data https://t.co/IR3JGutX9t
80% Reject AI as Direct Supervisor, Poll Shows
Using AI at work is one thing, but would you work for AI? A new Quinnipiac University poll found that 80% percent of Americans would be unwilling to have a job where their direct supervisor was AI, while 15 percent would...
Nvidia's Rubin GPU Delayed by Memory Shortage, Technical Hurdles
Nvidia's Rubin GPU is likely to be late thanks to memory shortage and technical challenges https://t.co/VMHNcFjnzc https://t.co/jjDxxHh9FN
Standardize Pipelines to Achieve SaaS‑speed Enterprise Platforms
Want SaaS-level speed in the enterprise? Standardize pipelines, reduce configurations, and productize your internal platforms. #DevOps #PlatformEngineering https://t.co/e4TERhpY2r
Early Kindles Remain Among Last Reliable Tech
this is terrible. the early kindles are some of the last pieces of Good Tech that still work without issue
Mythos Mirrors Trend, No ECI Acceleration Detected
Anthropic's Mythos does not appear to show any acceleration of ECI. After normalizing Anthropic's internal ECI with @EpochAIResearch 's public ECI, it's clear that the two metrics are extremely close, and that Mythos is pretty much on trend, just slightly...
Brand Prompts Guarantee Mentions, Non‑brand Halves Output
🚨 Brand Bias in Prompts: An Experiment by Dr. Pete Meyers: How often did each type of prompt result in the presence of a brand in the output? * Every prompt (100%) that included a brand returned one or more brand mentions...
Detect Code Pain Points with Five Git Commands
"Five git commands that tell you where a codebase hurts before you open a single file. Churn hotspots, bus factor, bug clusters, and crisis patterns." https://t.co/szukDCA4TB < educational post. By running these commands, you can learn a lot about what...
Tech Firms Skip Middle East, Boost Latin America Data Hubs
Outstanding day for LatAm today. War ending or not… one thing seems highly likely: None of the major tech companies will go out of their way to allocate capital toward building new data centers or large-scale facilities in the Middle East anytime...
Context, Not Just Tools, Powers AI Engineering Agents
The Missing #ContextLayer: Why Tool Access Alone Won’t Make AI Agents Useful in Engineering https://t.co/YUMKTXLOex https://t.co/smhAxllyVs
Tesla FSD V14.3 First Drives Reveal Superhuman Speed
We've put together a compilation of some of the best Tesla FSD V14.3 first drive clipa that we've seen. Including "inhuman" reaction times and a "more mature" Mad Max mode: https://t.co/B10P58tHfQ
Trust, Not Software, Drives GLP‑1 Startup Success
If anyone can build a GLP-1 company for $50K, what actually separates the winners? I asked Josh Tauber and @keatonbedell on Lifers, their answer: not software. Trust. WATCH/LISTEN: Spotify: https://t.co/hrs0ZbILVz Apple: https://t.co/e8IxsoZ2bB Youtube: https://t.co/ORjNyzcOli
AI Memory Becomes Critical Security Attack Surface
AI memory is becoming a management liability. We treat AI agents like Claude Code as intelligent partners, asking them to learn our habits and project context. But new research from Cisco highlights a fundamental business constraint: AI agents are currently too...
LLMs Dictate Tech Stacks; Every Business Needs a CLI
LLMs decide what languages and libraries we use. They’ll also decide what products a business runs on. They'll prefer ones that work with them. Every business now needs a CLI. fin(.)ai/cli https://t.co/ycezh9XYWd
Mythos Gains Not Driven by Recursive Self‑Improvement
Anthropic's Mythos achievements were not a result of AI Recursive Self Improvement. (Per the Mythos system card.) https://t.co/zYN8UMQpri
2026 Market Forecast Jumps $200B, Extending ROIC Horizons
It is wild that about two months ago, consensus memory in dollars for 2026 was ~$600B and now people are saying north of $800B... Very challenging to square this with ROIC timelines now, as they will have to lengthen, and...
IBM System/360's Tiny Compilers Birthed PL/I
History of the IBM System/360. Compilers in 10’s of k. (“New Programming Language” is what became PL/1) https://t.co/05GlEITHrf
Google AI Overviews Frequently Wrong, Listicles Skew Answers
It's live: @trippmickle & a few other authors from @nytimes published new research about how frequently Google's AI Overviews are wrong. It includes a quote from both @thomasgermain and me about listicles influencing AI responses. Check it out - https://t.co/cIouYjP8kt https://t.co/jMhk3MH27F
