Fascinating interview with Chief Scientist Sharon Rosenzweig-Lipson about working with the FDA, prepping for clinical trials, and what's next lifespan.io/news/first-human-cellular-reprogramming-trial-cleared-by-the-fda/

Vertical software has fallen 43% this year. DevTools, just 21%. The gap between them, twenty-two percentage points, tells you what markets actually believe about AI. https://t.co/D8KOXY1iu6
This week in enterprise software: Top 10 #SaaS #Cloud multiples as of today's market close
“It is so tragic. Went to work and didn’t come home.” Yet another of 40,000 vehicle deaths a year in USA. Today am at an unplanned funeral. I met Michael McCallister a few times because he was my son’s friend and roommate’s...
Here are a few items you should always say "no way" to when structuring an engagement letter with an investment bank: 1. Ongoing monthly retainers Ongoing monthly retainer fees could incent the banker to stretch out the process unnecessarily. Opt rather for...

$255K in profit from fixing how gyms sell. Live on @acquiredotcom: hardware + SaaS that turns in store visits into guided consults, subs, and recurring revenue for gyms. > $1.16M TTM revenue > $255K TTM profit > 206% YoY growth Full listing: https://t.co/8TlNbA4mqT https://t.co/H2XkQg3xJK
OK it took us a while to get @clay going at SaaStr, but it's clearly the best enrichment tool out there, by far Added to the top AI Agents we use #kudos
Today, the only companies getting headlines are tripling year on year. The landscape is ripe with talk of startup vs. incumbent. AI FOMO is real. And… what the heck is RevTech? Join me Monday on Run The Numbers as I tackle...
Coincidence that $HIMS has suddenly taken down all ads touting “the same active ingredient as Wegovy”? $HIMS may have finally called enough attention to their bullshit antics to get regulators to finally crack down on them. This could...
interesting “While I could bridge the gap by writing skills files to explain how to automate each of my tasks, I think these skills would be personal, context-dependent, and continuously evolving. Skills alone cannot scale to become my virtual coworker.”
🧔♂️ Non-AI startups: - Lots CSMs (vs FDEs) - AI is slow / noncompetitive, not true #1 focus of company - Not gaining market share - Customers don’t want to pay 2x-10x more for AI Agent (honest truth: not great) - Still very large teams...
In jiu-jitsu, when someone taps, you let go. Always. Except when letting go is what hurts them. There's a difference between a real tap and a panic tap. A panic tap is when someone new gets caught in a choke, freaks out, and...

1. Some news about #flu & #measles in the US: 8 more kids have died from flu this winter. That brings the pediatric death toll to 60 & flu season isn't over. Flu B activity seems to be increasing & flu...

What translates from SEO ➡️ AI Search Optimization? The fundamentals don't disappear, they just get applied differently. The skills that made you good at understanding audiences and creating valuable content become your primary competitive advantage. Here's how ⬇️ https://t.co/t2fgxHfLYv

A recent Science #Robotics study uses a #bioinspired robot to demonstrate that “bout-and-glide" swimming, seen in aquatic animals such as zebrafish and humpback whales, is more energy efficient than continuous swimming. https://t.co/8EWURPmuCh https://t.co/bUXSw19YsT
Everyone doing outbound should read Gene 's post. 👇 As a Founder in GTM tech, it's terrifying the best GTM organizations in the world are experiencing “outbound fatigue” and shutting down automation teams as the ROI of automation plateaus. Highly complex workflows...
"We're open to new vendors." That's what CMOs say. Here's what they actually do: We asked 101 mid-market B2B SaaS CMOs how they build their shortlist. 82% start with brands they already know. Only 18% actively seek out new or emerging vendors. But here's where...
You don't realize how much "fake work" you're doing until AI eliminates it. Fake work is all the friction we accepted as necessary just to get the job done. For years, writing strict syntax wasn't the actual engineering. It was just manual...
Agentic AI has not yet crossed the chasm, but it is beginning to test where a crossing might actually hold. In a thoughtful piece for diginomica , Stuart Lauchlan explores where agentic AI sits on the adoption curve, what is slowing...
.@viasat: focus #1: Get final Viasat-3 sats into operation: F2 by May and F3 (if all OK with F2) by September. Priority on cutting debt. Negotiations on #Equatys MSS satellite infrastructure with @space42ai continue, no word on Viasat investment. https://t.co/ERfwbfBgEn
Branded search data has very powerful potential to track even highly localized market movements, and Pizza Hut is a really good example of this. As has been reported in recent days, the Pizza Hut brand has been struggling, announcing a closure...
A Mathematical Introduction to Robotic Manipulation. [📍Save for later] It is a foundational robotics textbook that universities use to teach full graduate-level courses. From body motion to manipulation, grasping, control, and nonholonomic planning. This is the mathematical backbone behind robot arms and hands. 📍...
$IMMX looks like it wants to move higher. Enrollment completion in Feb ’26 is the next key catalyst, setting up the path toward a filing-grade dataset in AL amyloidosis. Market starting to sniff it out. Check out the AL Amyloidosis success story here: https://t.co/1ei6kat25y
AI agents are now prompting humans into boom scrolling instead of deep work. Platforms like Moltbook and Claude Cowork are accelerating the vibe-coding shift, where creation feels effortless and endless. The risk isn’t productivity loss, it’s humans becoming passive users in workflows...

If I were a 22-year-old Stanford grad who wanted to work 9-9-6 for the hopes of making life-changing money, I wouldn't go to Y Combinator and try to create the next OpenAI. I would do the opposite. —- Get a job at a...

I have a dream I was about to leave my friend’s house at 1 a.m. after taking care of him after his knee surgery. Something you have to look forward to as your friends get older. But while there I realized...
“20 ChatGPT prompts to boost productivity” looks useful — but it hides a deeper truth. Prompts don’t create productivity. Operating systems do. Here’s the strategic lens 👇 1️⃣ These prompts are mirrors, not solutions Most prompts here do one thing well: They force clarity. GTD, Ivy...
AI Agents Lead The 8 Tech Trends Transforming Enterprise in 2026 Enterprise technology is transforming fast — and AI agents are at the centre, powering eight key trends that will redefine business operations. Read more 👉 https://lnkd.in/etFdtruh #EnterpriseTech #AI #BusinessTrends #BernardMarr
Your customers will teach you how to go from $1m to $100m ARR, you just have to listen True especially if your initial TAM seems quite small

Today's Operator Links: https://t.co/apSA1AByaF 1️⃣ Shipping Covers All Sins - @sjgoedecke 2️⃣ $285 Billion Wiped Out Because of a Text File @thomas_witt 3️⃣ AI's Private Equity Time Bomb - @Unmack1 4️⃣ OpenClaw Is What Apple Should Have Created - Jake Quist 5️⃣ Company as Code -...
By Geoffrey Moore Author – The Infinite Staircase: What the Universe Tells Us About Life, Ethics, and Mortality Recently, the stock market has reacted to the latest advancements in AI by materially discounting the future returns expected from enterprise SaaS companies like...
The danger of adopting a Danish-style vax schedule: "When we remove a vaccine like the meningococcal shot from the routine schedule, we aren’t just changing a line on a chart. We are inviting previously well-controlled diseases back into our high...

Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer https://t.co/0FLusa7vuB https://t.co/ETU87KRDXd
I'm convinced we are building the best marketing team in software. But I'd rather tell you HOW we work than try to convince you to apply. Here's what you should know about working on this brilliant, global team: We improve every week....
Financial crime compliance is one of the hardest problems in financial services. And it's only getting harder. The institutions fighting it need partners who understand the stakes. Today I'm excited to announce that UiPath has acquired WorkFusion . What drew me to...
20 things agency owners that hit their profit goals say: 1. "We track every change request and bill for scope increases" 2. "I model out financial scenarios before making any hiring decisions" 3. "We have clear payment terms and follow up on overdue...
Claude-using teams on @vercel: ▪️ generated 12.8% of deployments last week ▪️ ship 7.6x more often than non-Claude teams ▪️ growing deployments at 14% WoW

Are bioinformaticians losing their jobs because of AI? After using Claude Code for a couple of months, I'm truly impressed by its ability to write and optimize bioinformatics tools. https://t.co/ojh5bv09fI
Choices are good. Customers love having a choice. Until they don’t… Behavioral scientists know that people crave autonomy. We don’t like to feel forced or pushed. We like to call the shots. So, for example, giving someone 2 choices vs. 1 can increase response. But be careful...
One of my favorite tricks to get marketing teams more comfortable with AI workflows culminates in an AI Talent Show. Start with a hackathon of sorts, but allow people to create something that supports a personal interest. Ask them to think about...

i wrote a lil essay on why execution-level learning changes how robots improve in production on @airstreetpress frontier robotics is moving fast in the lab, but even faster in @sereactai customer facilities today :) https://t.co/SPe81uBAAc

1/ Bioinformatics takes years to master. Not because it’s hard. But because so much of what matters… no one writes down. Let me explain https://t.co/EEboWOxB5C
pricing on openai vs. anthropic is interesting and i think oai is missing out for example, chatgpt biz for $25/month buys you all the value prop of the service - i never hit rate limits meanwhile, claude pro for $20/month i max...
Doing a livestream on how I OpenClaw and Claude Code for business. Will cover this and specific use cases that allow us to do $45k of pSEO work in 20 minutes, $50k of copywriting in 15 minutes, agent squads, deal...
.@skyperfectv: Rev, operating income up for 9M to Dec 31, contract to operate future Japan ISR constellation expected this month. #constellr @SpeQtral_Space @QPS_Inc @synspective @SpaceCompassCo1. https://t.co/yi02Jb63Ce
Most AI failures I see aren’t technical. They happen because someone never articulated: • what they’re actually trying to optimize • what constraints matter • what “good” looks like in this situation AI doesn’t fix fuzzy thinking. It faithfully scales it. This is exactly the muscle we...
Most founders only track revenue. I track *hours I never have to work again*. Every time I automate something, I log it: → 3 hours/month: repetitive booking. → 5 hours/month: repetitive support. → 2 hours/month: managing todos. → 1 hour/month: random small 2-minute things. It adds up. Right...
Everyone wants to make a lot of money. Nobody wants to talk to people about problems. Business doesn't work that way. The more you deeply understand your prospect's problems, the more likely you are to solve them. And THAT is how money gets made. Here's...
One thing most people don't realise about Fin: Fin fully resolves complex queries (refunds, amendments, upgrades etc) end to end, no humans needed. Example: it can discuss a refund with a customer, calculate if it is eligible according to the refund policy,...
Basecamp has long supported OAuth, but our implementation was based on the (now ancient) pre-release spec, and it required hoops for modern clients. We've updated it to be fully compliant with OAuth 2.0 now. https://t.co/ixQWa4GmTH