Module 4, Section 2: All About Assays
The Module 4, Section 2 briefing provides a concise overview of modern assay platforms used in early‑stage drug discovery. It references key literature on PRMT5 fragment‑based screening that produced the MRTX1719 candidate, as well as thermal‑shift, surface plasmon resonance (SPR), and polymerase assays. The deck also highlights Merck KGaA‑Vertex’s recent patent on targeting the WFS1 protein and mentions emerging therapeutics such as revumenib and BLU222. Together, these slides illustrate how diverse assay technologies accelerate target validation and lead optimization.
The Court Physician of the Therapeutic State
The essay frames Anthony Fauci’s three‑decade tenure at NIAID through Murray Rothbard’s analysis of state‑driven scientism and regulatory capture. It argues that the NIH functions as a monopsony, steering biomedical research toward patented vaccine platforms and gain‑of‑function bio‑security projects while...
Drug Side Effects Are Often the Main Effects
The article argues that drug side effects are not peripheral accidents but integral parts of a medication’s primary pharmacological action. It explains that the same biochemical pathways that deliver therapeutic benefits also generate adverse outcomes, using aspirin, blood‑pressure agents, and...
The CDC Keeps Stats on Everything, but Here’s One Thing They Have No Number For
The CDC tracks individual childhood vaccines but does not publish a single figure for how many U.S. children have received the full complement of 72 recommended doses by age 18. The 72‑dose ceiling includes recent schedule changes, such as six...
New Senate Report Warns Medicare Premiums Could Double by 2035, Squeezing Social Security Checks
A Senate Joint Economic Committee report warns that Medicare Part B premiums could climb from about $2,200 today to $4,500‑$5,000 per year by 2035, effectively doubling costs for seniors. The surge reflects projected Medicare spending growth, with premiums automatically adjusted to...
Michigan Mother Says She Believes COVID Vaccine Played Role in 17-Year-Old Daughter’s Death, Reacts to Findings From U.S. Sen. Ron...
A Michigan mother, Shanna Carroll, alleges that the COVID‑19 vaccine contributed to her 17‑year‑old daughter Aubrynn Grundy's death in August 2022. The claim resurfaces after U.S. Sen. Ron Johnson released findings questioning whether federal officials adequately warned the public about...
How Minor Injuries Lead to Flesh-Eating Bacteria in Rural Nigeria
In rural Nigeria, minor injuries such as thorns or needle pricks frequently progress to necrotizing fasciitis, a flesh‑eating bacterial infection. Delayed presentation, limited clinic access, poverty, and low wound‑care awareness turn treatable cuts into life‑threatening conditions, often requiring urgent debridement...
ICE Has Not Paid for Detainee Medical Care for 7 Months
On October 3 2025 the Trump administration halted reimbursements to third‑party providers for ICE detainee medical care, creating a seven‑month payment gap. The pause coincided with a sharp rise in detainee deaths, jumping from an average of 9 per year to 33...
The Reality of Social Security and Medicare- My Real Life Experience.
A retiree who paid $132,817 in Social Security taxes (1959‑2010) and an equal amount from his employer now reports receiving roughly $798,750 in combined benefits since 2008, surpassing his contributions after six years. He also paid $98,080 in Medicare taxes,...
Asembia ASX26: The ‘Entirely Pass-Through’ Business Model
At the Asembia ASX26 Summit, Aradigm Health CEO Will Shrank outlined the company’s “entirely pass‑through” business model, which charges only a transparent administrative fee and returns any surplus to purchasers as a dividend. The approach targets the opacity and waste...
The Inflated Reality: Unmasking the Biological Cost of Modern Lip Augmentation
The American Society of Plastic Surgeons reported roughly 1.45 million lip‑augmentation procedures in the United States in 2024, indicating that 5‑10 % of adult women have undergone the treatment at least once. Modern practice relies chiefly on hyaluronic‑acid fillers that are chemically...
€4.8m EU-Funded AI Project to Tackle Child Diarrhoeal Disease in Africa
An EU‑funded CARE‑AFRICA project will develop an AI‑driven tablet tool to identify the pathogen behind diarrhoeal disease in children under five across sub‑Saharan Africa. The €4.8 million (about $5.2 million) grant brings together six partners from Europe and Africa to train models...
Federal Judge Blocks Kennedy’s Vaccine Reforms
On March 16, U.S. District Judge Brian Murphy issued an injunction that blocks Health Secretary Robert F. Kennedy Jr.’s sweeping revisions to the federal childhood immunisation schedule. The ruling followed a lawsuit by the American Academy of Pediatrics and other...
MAHA Vs. The FDA: Dredging up Old Anti-Regulation Revisionist History
A new essay in Science-Based Medicine denounces the “health‑freedom” narrative that seeks to dismantle the FDA. It traces the agency’s authority back to the 1962 Kefauver‑Harris amendment, which linked drug approval to rigorous safety and efficacy trials. The author dismantles...
Viewpoint: How ‘Health Care Guru’ Joe Rogan Circumvented the FDA’s Skepticism on Psychedelics
Joe Rogan directly messaged President Donald Trump about the therapeutic potential of psychedelics, prompting the president to sign an executive order that fast‑tracks FDA review of these drugs. The order creates a priority‑voucher system that accelerates approvals for psychedelic manufacturers,...
Trump’s America First Health Aid Cuts: Retrenchment Has Already Hit Global Malaria, HIV, TB, and Polio Programs
Under President Donald Trump’s 2025 “America First” agenda, the United States froze a portion of its foreign development aid, prompting the termination of several global health programs. The cuts threaten malaria, HIV, tuberculosis and polio initiatives, with USAID projecting up...
Hidden Ingredient in GLP-1 Tablets Raises New Gut Health Questions
Oral semaglutide tablets rely on the absorption enhancer SNAC (salcaprozate sodium) to cross the stomach lining, but only 0.4%‑1% of the drug reaches the bloodstream. A 21‑day rat study published in the Journal of Controlled Release found that the majority...
Cardiovascular Health 2026
A Finnish cohort study of 2,575 men followed for 27.8 years found that the non‑HDL‑C to HDL‑C ratio (NHHR) predicts sudden cardiac death better than individual lipid measures. Men in the highest NHHR quartile had a 2.23‑fold higher risk of...
Vaccines for Longevity
A forum member received the Shingrix shingles vaccine 12 days after a 6 mg dose of Rapamune (sirolimus) and experienced pronounced flu‑like side effects. Participants debated whether the timing was optimal, noting rapamycin’s dual role as an immune modulator that can...
![Special Situation Setup: CVV Sum Of The Parts Mispricing + Biorem Q4 Management Briefing [Geowire Weekly No. 237]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://geoinvesting.com/wp-content/uploads/2026/05/0503_thumbnail.png)
Special Situation Setup: CVV Sum Of The Parts Mispricing + Biorem Q4 Management Briefing [Geowire Weekly No. 237]
GeoInvesting’s weekly wrap‑up highlighted a special‑situations opportunity in CVV after a “blowout” quarter that may be mispriced under a sum‑of‑the‑parts analysis. The newsletter also featured Biorem Inc.’s Q4 2025 management briefing, where the CEO reported record backlog growth and stronger...
Did the Biden Administration Purposefully Ignore COVID Vaccine Side Effects?
The blog argues that the Biden administration deliberately downplayed COVID‑19 vaccine side effects while aggressively promoting uptake. It cites statements from Anthony Fauci, former CDC director Rochelle Walensky, and President Biden that later proved inaccurate. The piece highlights Senator Ron Johnson’s...
A Family Legacy Inspiring Advocacy in Neurodevelopmental Care
Dr. Ronald L. Lindsay, a developmental‑behavioral pediatrician, links a centuries‑old family legacy—from Norman conquerors to American founding figures—to his modern mission of neurodevelopmental advocacy. After years building rural medical‑home programs and publishing rare research on mathematics disability, he shifted focus...
Have LLMs Improved Patient Outcomes?
The post argues that large language models (LLMs) have yet to demonstrate measurable improvements in patient health outcomes. It references Eric Topol’s review and a Nature Medicine editorial, both noting a paucity of clinical evidence despite hype. While LLMs can...
Why Artificial Intelligence Displacement Threatens Medical Specialties
Artificial intelligence is poised to reshape medicine in a tiered fashion, with pattern‑recognition specialties such as radiology and pathology facing functional AI parity within five to ten years. Protocol‑driven fields like cardiology and endocrinology will see AI‑managed routine care in...
Are NHS GPs the Last Line of Defence?
The blog argues that NHS general practitioners are more than gatekeepers—they are the lynchpins of patient safety. Typical GP consultations last about seven minutes, forcing doctors to triage single symptoms quickly. This model functions only when staffing, time, and funding...
The Real Work Starts After a Mental Health Crisis
Emergency physician Dr. Kenneth Scott Burnham recounts his own descent into mental‑health crisis after 23 years of stabilizing patients in the ER. He describes the stark contrast between acute crisis care and the unsupported, confusing period that follows discharge. Burnham...
RESEARCH: NICLOSAMIDE in CANCER and Other Diseases - 2025 Review Paper From Henan, China
A 2025 review paper from Henan, China, evaluates niclosamide—a decades‑old anti‑parasitic—as a repurposed oncology agent. The analysis compiles pre‑clinical data across breast, lung, pancreatic and colorectal cancers, and highlights early‑phase clinical trials showing modest tumor responses. Researchers also discuss formulation...
FDA Closes the 503B Bulks Door on Semaglutide, Tirzepatide, and Liraglutide
On April 30, 2026 the FDA issued a proposal to exclude semaglutide, tirzepatide and liraglutide from the 503B Bulks List, arguing there is no clinical need for outsourcing facilities to compound these GLP‑1 drugs. The move follows the resolution of...
Rethinking Blood Thinners for Atrial Fibrillation Patients
At the American College of Cardiology meeting, a three‑year trial demonstrated that the Watchman left‑atrial‑appendage closure device provides stroke protection comparable to lifelong anticoagulation while causing far fewer bleeding events. The findings challenge the entrenched belief that atrial fibrillation patients...
Flickstop
SSI Mantra announced the Vimana drone‑based surgical system, a portable platform that launches autonomous drones to deliver sterile operating kits and real‑time tele‑medicine support to frontline combat zones. The system pairs a lightweight surgical module with AI‑driven diagnostics, enabling medics...
Low Risk… Until It Isn’t?
Dr. Gator’s latest post examines the paradox in U.S. school health policy: children with active hepatitis B infection are permitted to attend class under the ADA because the transmission risk is deemed negligible, yet unvaccinated children can be excluded despite similarly...
Curing U.S. Health Care, Part II
President Obama signed the Affordable Care Act (ACA) into law in 2010, slashing the uninsured rate from 47 million to 27 million by 2016. The Trump administration’s 2017 repeal effort failed, but subsequent policies are projected to add 16 million uninsured by 2034....
Out of 400 Drugs, Only These Might Help You Live Longer - Dr. Kevin Perez and Siim Land
A UK Biobank study of 500,000 participants tracked medication use for up to 20 years and compared users of 400+ drugs with matched controls. After adjusting for demographics, health status and socioeconomic factors, only fourteen drugs showed a statistically significant...
After Heart Attack, Therapeutic Plasma Exchange (TPE) Rescues the Aging Heart
Researchers at UC Berkeley demonstrated that therapeutic plasma exchange (TPE) performed 24 hours after a heart attack can nearly reverse damage in aged mice, the equivalent of humans in their 60s. By replacing half of the plasma with saline‑albumin solution, the...
NomosLogic Founder Matt Hardy Launches Lyceum and Odyssey on Dendrite Lite
NomosLogic unveiled two consumer‑facing experiences, Lyceum and Odyssey, on its Dendrite Lite platform. Lyceum delivers a personalized genomic‑literacy quiz generated from a user’s own DNA, while Odyssey presents the genome as a seven‑chapter narrative. Both tools leverage NomosLogic’s Hardy Bridge...
Mifepristone Ruling and a Dive Into Trump's Dementia Riddled Brain
The Fifth Circuit Court of Appeals has halted telehealth prescriptions for mifepristone in Texas, Louisiana and Mississippi, leaving the ruling’s geographic reach and the prospect of a nationwide injunction uncertain. At the same time, former President Donald Trump’s Truth Social...
![I Googled My Own Name and a Corporate Clinic I’ve Never Worked at Appeared [PODCAST]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://kevinmd.com/wp-content/uploads/vertical_integration_thumbnail.png)
I Googled My Own Name and a Corporate Clinic I’ve Never Worked at Appeared [PODCAST]
Physician‑owner Stephanie Waggel discovered her name buried under a corporate clinic in Google searches, prompting an investigation into health‑care vertical integration. She explains how billionaire‑backed private‑equity firms and venture‑capital‑funded startups are buying or creating physician practices, crowding out independent doctors....
Why Artificial Intelligence in Medicine Cannot Replace Clinical Intuition
A senior pediatric resident recounts a case where chart data suggested a patient with diabetic ketoacidosis was improving, yet subtle bedside cues indicated a looming cerebral edema. The article argues that artificial‑intelligence tools, trained primarily on electronic health record text,...
BREAKING: 146 NEUROLOGICAL AND PSYCHIATRIC CDC/FDA SAFETY SIGNALS WERE BREACHED WITH COVID SHOTS
A recent Substack post by Nicolas Hulscher alleges that COVID‑19 mRNA vaccines breached 146 CDC/FDA safety signals, citing astronomical relative‑risk figures such as a 3,000‑fold increase in brain clots and a 7.4% national rate of cognitive disability. The author claims...
The Evolving Structural Challenges of Modern Pain Medicine
Interventional pain medicine has expanded dramatically, adding complex device‑based therapies such as spinal cord stimulation, dorsal root ganglion stimulation, and minimally invasive decompression. Simultaneously, training pathways, reimbursement models, and research infrastructure have lagged, creating variability in procedural exposure and declining...
Ten-Year Pivotal Data Demonstrate Long-Term Durability of Edwards Lifesciences’ Resilia Tissue
Edwards Lifesciences released 10‑year results from the COMMENCE aortic trial, confirming that its RESILIA tissue surgical valves retain high durability. At ten years, 97.9% of patients were free from structural valve deterioration and 97.8% avoided reoperation. The data also show...
National Hospital Week Reveals What Care Really Takes
National Hospital Week, observed May 10‑16, highlights the intricate coordination that powers U.S. hospitals. The American Hospital Association reports hospitals employ more than 6.6 million people and purchase over $1.3 trillion in goods and services, driving $4.8 trillion in economic activity. The piece emphasizes...
Is the “Supportive Environment” Driving Gender Medicalization?
The Dutch protocol, the international gold standard for adolescent gender care, requires a supportive social environment before puberty‑suppressing medication can be prescribed. Proponents argue that family and school affirmation reduces distress, yet this prerequisite blurs the line between a safety...
Opinion Dressed Up as Fact (We All Do It)
The post argues that most people, including scientists and doctors, blur the line between opinion and fact, especially when interpreting data. It shows how identical studies can produce opposite conclusions, using the vaccine debate as a vivid example. The author...
The Preclinical Signal in Routine Abdominal CT
A Mayo‑MD Anderson team unveiled REDMOD, a radiomics AI model that flags pancreatic ductal adenocarcinoma (PDAC) signals on routine abdominal CTs previously read as normal. The model delivers 73% sensitivity and 88% specificity, offering a median lead time of about...
How the Law of War Can Reckon with Longer-Term Harms of Attacks on Health
The UN Security Council adopted Resolution 2286 in 2016 to protect healthcare in conflict, yet a decade later more than 18,000 attacks on medical facilities have been recorded, with long‑term harms remaining largely invisible. The article argues that international humanitarian law’s...
The Limits of Large Language Models in Clinical Practice
Large language models (LLMs) such as ChatGPT and Med‑PaLM are entering clinical workflows, primarily for drafting documentation and summarizing records. While they can generate fluent, plausible text, they lack true clinical reasoning, can hallucinate misinformation, and inherit biases from training...
What Are the 8 Tests Your Doctor Overlooks That Predict More About Your Health Than Your Standard Labs?
The article highlights eight health metrics that most physicians skip, despite strong evidence they predict mortality better than routine blood work. Standard panels like metabolic and lipid tests give a single‑point snapshot, missing long‑term trends and hidden risk factors. The...
The Commodification of Sensitive Open Data
The European Union’s European Health Data Space (EHDS) regulation, adopted in March 2025, will make the electronic health records of roughly 450 million residents available for secondary use by March 2029. The framework defaults to inclusion, requiring citizens to opt out and offering...
Monthly Features – April 2026
The LikelyStory blog’s April 2026 roundup spotlights two new releases: TK Thoits’s *SETTUP*, a fast‑paced medical thriller that pulls back the curtain on the multibillion‑dollar clinical‑trial industry, and Bear Pardun’s *The Knight’s Last Stand*, an epic fantasy where a lone...