Healthcare Blogs and Articles
Healthcare Blogs and Articles
Healthcare Pulse
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EMAIL DIGESTS
Daily
Every morning
Weekly
Tuesday recap
The lipid serine hydrolase PNPLA3, especially its I148M mutant, has emerged as a genetically validated driver of MASLD/MASH, prompting a wave of genotype‑focused drug programs. RNA‑based modalities—Arrowhead’s GalNAc‑siRNA ARO‑PNPLA3 and AstraZeneca/Ionis’ GalNAc‑ASO AZD2693—are in clinical trials aiming to lower mutant protein levels. Small‑molecule efforts have also intensified, with Pfizer’s covalent monovalent degrader PF‑07853578 and Novartis’ reversible PPI inhibitor targeting the mutant’s interaction with CGI58. These parallel approaches illustrate a broader shift toward precision therapies for complex metabolic liver disease.
The article contends that an over‑emphasis on formal assessment in residency programs suppresses residents' natural curiosity and deep reasoning. When attendings prioritize grading over dialogue, trainees like June learn to memorize correct answers rather than explore underlying mechanisms. This performance‑driven...
Researchers at Politecnico di Milano have demonstrated a console‑free mixed‑reality teleoperation system for the da Vinci Research Kit, leveraging Microsoft HoloLens 2 to control the robot via hand gestures, head tracking, and speech. The prototype was tested on camera navigation and...
The MHRA has opened a public consultation proposing that CE‑marked medical devices be recognised indefinitely in Great Britain. Around 90% of devices used in the GB market currently carry a CE mark, and the agency aims to align transition timelines...
The article highlights a persistent gender gap in medical care for menstrual health, noting that up to 75% of menstruating individuals experience PMS and 3‑8% suffer from PMDD, yet these conditions remain underdiagnosed and underfunded. A survey of 3,000 Japanese...
Age‑related decline in O‑GlcNAc Transferase (OGT) activity contributes to neurodegenerative disorders such as Alzheimer’s, Parkinson’s and ALS. Traditional approaches aim to raise O‑GlcNAc levels by inhibiting O‑GlcNAcase, but recent research highlights transcriptional control of OGT as a more direct therapeutic...
Researchers have identified inflammatory glycogen produced by gut microbes as a driver of age‑related neurodegeneration, especially in ALS and frontotemporal dementia linked to C9ORF72 mutations. In germ‑free mice lacking C9ORF72, colonization with glycogen‑producing Parabacteroides merdae triggered monocytosis, blood‑brain barrier breakdown,...
The episode examines Epic Systems' recent courtroom setback in the CureIS litigation, focusing on the court's denial of a motion to stay discovery and the nuanced protective order regarding "Highly Confidential – Attorneys' Eyes Only" information. It highlights how Epic's...
In 2013 Dr. Eric Dickson took the helm of UMass Memorial Health as the system teetered on the brink of default and faced declining patient and caregiver satisfaction. He introduced a CEO‑driven lean management system that standardized nine core processes and...
Sword Intelligence has launched its AI‑driven care‑operations platform in the UK, aiming to automate triage, coordination and scheduling to ease NHS waiting‑list pressures. The company is also building one of Europe’s first AI‑powered healthcare “front doors” in Greece for a...
The FDA has opened submissions for its PreCheck Pilot Program, targeting new U.S. drug‑manufacturing facilities that will begin construction by the March 1 2026 deadline. Eligible sites must be stand‑alone plants, located in the United States or its territories, and commit to...
The Centers for Medicare & Medicaid Services released its proposed 2027 Notice of Benefit & Payment Parameters, a 577‑page rule outlining changes to ACA implementation. Key proposals include stricter marketing restrictions, removal of the gender‑identity definition of sex, lowering the...
Researchers at RMIT and international partners engineered flexible acrylic films stamped with dense nanopillar arrays using ultraviolet nano‑imprint lithography. The 60 nm pitch configuration reduced human parainfluenza virus type 3 infectivity by up to 94 % within one hour, achieving mechanical rupture of...
Mobile wound‑care providers face tighter Local Coverage Determinations, heightened CMS surveillance, and expanded documentation mandates in 2026. These regulatory shifts narrow reimbursement, limit visit frequency, and force clinicians into defensive practices. The burden disproportionately impacts high‑acuity, home‑bound patients who rely...
The Bureau of Labor Statistics reported a 3.6% rise in hospital compensation costs and a 3.2% increase for nursing homes in 2025, while January 2026 saw healthcare add 82,000 jobs, the bulk of total payroll growth. The January CPI showed...
A rural Taiwanese patient faced a 20‑day wait for a diagnostic mammogram at a large tertiary hospital, while a community hospital in Taipei provided immediate evaluation and treatment. The article attributes the delay to fragmented administrative structures, global‑budget constraints, and...
Louis‑Hunter Kean, a 34‑year‑old, died in November 2023 after a year of high fevers, organomegaly, and multiple hospitalizations. Although clinicians repeatedly noted “visceral leish” and ordered a PCR, the test was never completed and his travel to Tuscany was buried in...
Medtronic is revamping its indirect procurement model to become a strategic, business‑focused function. By segmenting its supplier base, the company concentrates resources on high‑risk, high‑spend vendors while using digital pathways for low‑complexity suppliers. Leadership emphasizes speaking the language of EBITDA...
In this episode, the host revisits his deep‑dive analysis of Carl Zeiss Meditec, using the company’s Q1 FY2025/26 earnings call as a live case study to demonstrate how investment theses should evolve with new data. He critiques the common practice...
Mifepristone is banned in 14 states and restricted in another 10, forcing patients to rely on misoprostol‑only regimens. The dual‑drug protocol achieves 95‑98% success with less than 0.5% serious complications, while misoprostol monotherapy raises emergency department visits to 7.9% and...
In Ghana, child mortality has fallen but remains high, with 37 per 1,000 children not reaching age five and neonatal deaths at 21 per 1,000. Malnutrition still affects roughly 17‑18% of under‑five children, while 15,000‑20,000 newborns are born with sickle...
On February 15, 2026, a blog post announced the first deployment of the Toumai robotic surgery system at Orsi Academy. The post features an image of a surgeon in blue scrubs operating the robot from a console, underscoring the hands‑on...
![Sabbaticals Provide a Critical Lifeline for Sustainable Medical Careers [PODCAST]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://kevinmd.com/wp-content/uploads/The-Podcast-by-KevinMD-WideScreen-3000-px-3-scaled.jpg)
Physicians rarely receive formal sabbaticals, yet burnout data shows they need extended breaks. A 2021 American Journal of Medicine survey found only 51% of medical schools reported any faculty sabbaticals, typically senior white‑male researchers rather than clinicians. Christie Mulholland’s experience...
The article argues that modern medicine’s obsession with cures has sidelined genuine caring, eroding patient trust. It highlights how women experience chronic pain yet often have their symptoms dismissed, and how minority groups remain invisible in clinical research. Evidence shows...
Researchers at Wenzhou and Fuzhou Universities unveiled a three‑wheel DNA nanomachine (TW‑harvester) that rides a gold‑nanoparticle track inside living tumor cells. The device uses a DNA tetrahedron with an aptamer targeting nucleolin and miR‑21‑triggered wheel activation to cleave fluorescent substrates,...
Scientists at King’s College London discovered that loose‑fit clothing can track human movement more accurately than tight wearables, delivering 40% higher precision while using 80% less data. The research, published in Nature Communications, suggests that simple fabric elements—such as a...
The episode breaks down the release of the largest publicly available Medicaid claims dataset, detailing its composition, gaps, and immediate utility for health‑tech builders and investors. It quantifies the scale of Medicaid spending (~$849 B) and improper payments (over $30 B annually),...
The episode explains InterSystems' new Payer Connector, clarifying that it is not a rival to Epic's Payer Platform but a complementary integration layer that helps payers connect Epic's standardized edge to their fragmented internal systems. It highlights the challenges payers...
Longevity Global is launching the inaugural Longevity Innovation Forum in San Diego on March 11‑12, 2026, gathering leading scientists, clinicians, biotech founders and investors to accelerate healthy‑aging research. The two‑day summit features high‑profile speakers such as Mike Snyder, Eric Verdin,...
Scientists at EPFL applied a three‑factor (OSK) partial reprogramming cocktail to memory‑encoding engram neurons in 9‑10‑month‑old mice and Alzheimer’s‑model strains. Using a dual‑AAV system gated by doxycycline, OSK expression was limited to neurons active during a learning event, preserving cell...
The episode examines the University of Minnesota Medical School’s decision to discontinue a UnitedHealth Group‑sponsored course after investigative reporting by Dr. Allison Leopold exposed the curriculum as corporate propaganda rather than unbiased medical education. Leopold, a participant in the pilot,...
The episode breaks down CMS’s new ACCESS Model, which replaces fee‑for‑service chronic care payments with a per‑beneficiary Outcome‑Aligned Payment (OAP) that is partly withheld until specific clinical and patient‑reported outcomes are met. It explains the four clinical tracks—early and advanced...
Jason Wilt, an emergency and sports‑medicine physician, recounts his stint at Williams‑Sonoma and how the harsh retail environment taught him to handle difficult patients. He draws parallels between customer aggression and patient hostility, noting that many patients’ frustration stems from...
The episode dissects OpenClaw, an open‑source, agentic AI platform that can autonomously interact with files, commands, and dozens of applications, and evaluates its viability for payer and provider health organizations. It explains why the default, unsecured version violates HIPAA, outlines...
The U.S. FDA declined to review Moderna's mRNA influenza vaccine, even though two phase‑3 trials involving 43,800 participants demonstrated a 27% efficacy advantage over the standard Fluarix vaccine and a 49% reduction in hospitalizations. FDA officials cited the comparator arm...
The episode explores the rapid convergence of organoid technology and artificial intelligence, highlighting how AI-driven image analysis, multidimensional data integration, and high‑throughput screening are transforming organoid research. It introduces the emerging field of Organoid Intelligence, where brain organoids act as...
The medical referral process is plagued by delays, miscommunication, and inappropriate specialist assignments, causing many patients to fall through the cracks. Studies show up to half of specialty referrals are never completed and over a third do not match the...
Physician wellness initiatives—pizza parties, mindfulness apps, and burnout surveys—are increasingly seen as superficial "wellness theater" that fail to address the structural drivers of physician distress. The article argues that burnout is better understood as moral injury arising from time pressure,...
Researchers engineered CD4+ T cells with chimeric antigen receptors (CARs) derived from FDA‑approved Alzheimer’s antibodies aducanumab and lecanemab. The lecanemab‑based CAR (Lec28z) selectively bound fibrillar amyloid‑beta and reduced plaque burden in mouse brains, especially when delivered via transient mRNA transfection....
Antimicrobial resistance (AMR) is now a global health emergency, with the WHO noting up to one‑in‑five infections in parts of Africa are drug‑resistant. While antibiotic misuse is visible, the deeper drivers are social: poverty, overcrowding, and limited clean water fuel...
The episode examines how private insurance is infiltrating the Veterans Health Administration via the Veterans Community Care Program (VCCP) and the proposed Community Care Network (CCN) Next Generation, a move that could channel up to $1 trillion of taxpayer money into...
The episode recaps the ASTP Annual Meeting, highlighting its role as the premier gathering for health‑tech and interoperability stakeholders and noting the scarcity of concrete announcements. The most significant insight came from a surprise panel on Information Blocking featuring the...
Immigrant families like the Sureshes are caring for elderly relatives while awaiting Medicaid eligibility, which requires a five‑year waiting period for lawful non‑citizen permanent residents. The father, a remote‑work tech professional, provides full‑time care for his 95‑year‑old mother, incurring high...
![Business Literacy Empowers Physicians to Lead Sustainable Health Systems [PODCAST]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/articles/4f44f3669b3c12e1a928e85742e2cb1b.webp)
In a recent KevinMD podcast, family physician Kelly Bain discusses how business literacy is essential for physicians navigating today’s increasingly employed and value‑based health‑care environment. Drawing from her three‑phase career—from rural solo practice to a large multi‑specialty group and finally...
The U.S. Food and Drug Administration has cleared an investigational new drug application for Life Biosciences' ER‑100, a viral gene‑therapy that delivers inducible Oct‑4, Sox‑2 and Klf‑4 (OSK) to the eye. The first‑in‑human trial will enroll a small cohort of...
