Tumor Whole-Genome Sequencing Influences Care in 40%+ Patients
Why should tumor whole genome sequencing (WGS) be done for cancer? In real practice of medicine study of 888 patients with solid cancers, WGS directly led to clinical consequences in over 40% @NatureMedicine https://t.co/kFho0yuLS7
Biotech Giant Earendil Labs Secures $787M Funding
Giant biotech round that hit right after I sent Pro Rata: Earendil Labs raises $787M https://t.co/NWt2bBA9Lr
Prasad’s CBER Saw Frequent Overrules, Unlike Rest of FDA
caveat here is that it was routine when Prasad ran CBER (at least 4 overrules in Prasad's 10 mo. tenure) but it didn't/doesn't still seem to be happening elsewhere in FDA
Former FDA Chief Warns Political Pressure Plagued Trump Era
Political influence ‘a serious problem’ for FDA under Trump, former commissioner says https://t.co/52IR3LfECD via @statnews
Promising Therapeutics' Future at Risk Under Trump FDA
The future of promising therapeutics is on the line in the Trump administration's FDA, says the agency's former commissioner https://t.co/vyt49FkDsb
Rebuilding Vaccine Trust After Ideologically Flawed ACIP Recommendations
Good news for America’s children. ACIP was devoid of vaccine expertise and made harmful and ideologically driven recommendations that went against pediatric medical science. Hopefully we can rebuild pubic confidence in vaccines despite their efforts to undermine it, but it...
OpenClaw Enables Continuous Self‑Prompting AI for Healthcare
Some experts do not think OpenClaw is relevant to AI in healthcare. They are wrong. OpenClaw represents us phase shifting in the way we relate to AI systems again. We are moving past promting a chatbot to ask a question so...
Hydration Doesn't Reduce Kidney Stone Recurrence, Study Finds
If you've had a kidney stone, you've been advised that the most important thing to prevent another bout is to increase hydration. Now a randomized trial of hydration in over 1600 participants showed no benefit, despite evidence of increase...
ER Doctor Recounts Bizarre Case of 9‑year‑old Bullet
Emergency physician Graham Walker, MD shares the most bizarre story from his 20 years in the ER. The mystery? A 9-year-old bullet. This week on Lifers with @chrissyfarr
FDA’s Post‑Prasad Path: Six Drugmakers, Six Months
This week's Biotech Scorecard newsletter: Six drugmakers, six months: Charting the FDA’s course in the post-Prasad era $REPL Pierre Fabre $ATRA $QURE $CAPR $RGNX https://t.co/sGa7G6YTDn
Verily Secures $300M, Ends Alphabet’s Majority Control
Major scoop from @ShelbyJLiv: Verily has raised $300M, ending Alphabet's majority control over the company https://t.co/6kjuC2FND7
Stress Triggers Skin Inflammation via Newly Identified Neural Circuit
New @ScienceMagazine Discovery of a circuit that connects stress and skin inflammation https://t.co/Dkmmcs96JT https://t.co/chrXyKrG2N https://t.co/7nOPn9fCoU
Gene Therapy Delivers Real Results Amid Hype
Katrine Bosley: There's no question “hopes and aspirations” got ahead of the pace of any new science on gene editing #STATBreakthrough Seng Cheng: “The promise of gene therapy is correct. I think it has made that promise. and that's demonstrated by...
Early Experiments May Mislead; Models Need Validation
Jane Grogan from $BIIB again, on the fundamental challenge of drug discovery: do you believe what early experiments tell you? "We need to understand when [models] can be predictive and when they help at answering our hypothesis... “If you...
China Produces Triple U.S. PhDs, Boosting Biotech Innovation
$BIIB’s Jane Grogan on the impact of China on biotech innovation. “There's three times more PhDs that have been given last year in China than in the US. ... That's a lot of bright young things out there who are going...
Higher GLP‑1 Doses Show Cardiac Safety Signal
This definitely looks like a cardiac safety signal at the higher doses. The GLP-1's all slightly increase pulse rate as a starting point.
Breakthroughs Take Years, Then Appear Overnight
$BMY chief scientist Robert Plenge: says there is “a joke” drug developers often repeat. “It's an overnight sensation a decade in the making. These things can actually be going on for a very long time, and then suddenly the field catches...
Four Biomarkers Can Meaningfully Assess Coronary Artery Disease Risk
The 4 biomarkers to meaningfully assess a person's risk of coronary artery disease @rayshafarah @aklfahed @pnatarajanmd @JACCJournals @uk_biobank https://t.co/CPfBPVRENq https://t.co/xTlj2ykr45
NIH Scientists Describe Research Climate as Chaotic, Bankruptcy‑Like
“This is the equivalent of working in a company that feels like it’s on the verge of bankruptcy." A @statnews survey of #NIH funded scientists finds the research community is in chaos a year into the Trump administration. @JonathanWosen...
Oral Ozempic Trials Fail to Show Alzheimer's Benefit
The negative oral Ozempic randomized trials (EVOKE, EVOKE+) for Alzheimer's disease have now been published @TheLancet https://t.co/Xx0YknTSC2
GLP‑1 Drugs May Protect Heart, Vessels, Kidneys in Type 1 Diabetes
GLP-1 drugs have established benefit for Type 2 diabetes. New data suggests that extends to Type 1 diabetes, with heart, vascular, and kidney protection https://t.co/nZDKHoFIRm https://t.co/lTHIgoj4ir
Judge Blocks Kennedy's Attack on CDC Vaccine Schedule
Maybe you heard that a federal judge ruled against @SecKennedy's attack on the CDC vaccine schedule. Always great to win a battle, but we are still at war. The damage already done can’t be repaired. @JessicaMalaty & I break it all...
Measles 97% Preventable; Vaccine Safer Than Supplements
I read from an influencer nurse that measles is “going around”. She is selling vitamin A supplements. Having measles is not inevitable. Especially if a population is vaccinated. And that has been proven in the US for the past 30...
One in Ten ACA Holders Lose Coverage as Premiums Surge
This won't show up in any market data, but it's a profound hollowing-out and weakening of America. "Nearly one in 10 people who had Affordable Care Act plans last year dropped health insurance altogether, after premium costs rose sharply" https://t.co/LfNP8wRTD1
CMS and FDA at Critical Junctures Discussed at STATBreakthrough
Many interesting conversations ahead today at #STATBreakthrough — including on CMS and FDA, both at critical junctures: https://t.co/aThGw2QEfw
Connected Data Powers Adaptive, Evidence‑based Oncology Care
Unlocking the full potential of cancer care starts with connected data. Proud of how Oracle is helping to bring adaptive, evidence-based oncology insights directly to the point of care.
Vaccines Shield Vulnerable Populations; Declining Rates Endanger Protection
Multiple vaccines offer benefits beyond protecting the vaccinated individual from the disease the vaccine targets. Some protect fetuses in the womb, some protect people who are immunocompromised, some protect seniors. As vax rates fall, these benefits are threatened. https://t.co/zmiws8gAnw
FDA Lets Sarepta Push Failed Drugs, Blocks UniQure
Let's look at how the FDA is treating $SRPT and $QURE differently. The FDA grants accelerated approval to Amondys and Vyondys to treat Duchenne muscular dystrophy. Sarepta conducts a post-marketing confirmatory study that fails to show a benefit for either...
Congruence Launches First Drug, Secures $40M Funding
Exclusive: Clarissa Desjardins' newest biotech has put its first drug in the clinic + raised $40M more. Congruence also expects to put 2 more molecules into clinic in early 2027, seeing its platform driving its R&D efficiency: https://t.co/pzxcnmKFBj
Side Effects Signal Unaffordable Medication Costs
When side effects are actually a cry for help with medication costs http://dlvr.it/TRZqBj Physician #Cardiology
Higher Body Fat and Inflammation Raise Mortality Risk
Linking adiposity and inflammation with all-cause and cardiovascular mortality https://t.co/JXj1WDWHHx via @medical_xpress #health #lifestylemedicine #CardioTwitter #MedTwitter #hearthealth
Mindset Boosts Aging: 45% Seniors Improve Over Time
45% of Seniors Got Better With Age (Yale / Geriatrics) Nearly half of adults over 65 got BETTER with age -- not worse. And mindset was the biggest predictor. As a medical school professor, I was trained to see aging as inevitable...
Value-Based Care Incentivizes Dropping Sicker Patients, Not Healing
Value-based care was supposed to save healthcare. In some cases, it created a new incentive: getting rid of the sickest patients. In a recent episode of The Podcast by KevinMD, Dr. Jonathan Bushman reveals the dark side of healthcare analytics. He...
Face-to-Face Requirement Would Hinder Early Legal Abortions
Yet another account that does not know the law. Pills for terminations cannot be obtained from the NHS after 10 weeks gestation. The vanishingly small number of cases of drug-induced late termination involved pills illegally obtained from a foreign online...
Heavy Strength Training Reduces Osteoporosis Mortality Risk
Please stop telling people with osteoporosis not to lift anything heavy... I've heard it from docs, PTs, Trainers, etc... This might seem protective... but it's not. This risk calculation... A hip fracture in an older adult carries a one-year...
Doctors Must Prioritize Clinical Care Over Profit
I personally think that if you’re a doctor building a business in healthcare, it doesn’t mean you “let go” of clinical practice. If anything, my co-founder and I feel an even greater responsibility to stay at the forefront of weight loss...
WHO Validation Gives Patients Long‑Awaited Treatment Legitimacy
People say this was “obvious”… “macam dah lama je” but if it really was, it wouldn’t take the WHO to make it official. For years, patients have been asking for help — and being met with inconsistent care, shortcuts, or being...
Alaska Clinic Under‑dosed Patients, Billed Full, Doctor Sentenced
This story is nuts. Prosecutors say that patients at an Alaska-based clinic were underdosed, injected with free or expired drugs, and billed for full doses. Now, the doctor who was calling the shots is going to jail. https://t.co/E2U3LKBi9o
GLP‑1 Drugs Cut Mental‑health Hospitalizations and Sick Leave
GLP-1 medications, commonly prescribed for diabetes and obesity, are linked to reduced hospital care and sickness absence due to depression, anxiety, substance use disorders, and suicidal behavior. mentalhealth
Implant vs Meds: Randomized Trial Questions LAA Closure Benefit
Questioning the benefit of an implant to close the left atrial appendage vs medical therapy in a randomized trial @NEJM https://t.co/N0hpdIfmLe https://t.co/8bkk8FzLuY
HaloMD, a Texas Duo, Dominates No‑Surprises Arbitration
A new company you've probably never heard of is dominating the No Surprises Act's arbitration process. Behind HaloMD is a larger-than-life Texas couple who built their wealth on questionable arrangements with out-of-network providers. https://t.co/p1jCEZFBaA via @statnews
Stopping GLP‑1 Therapy Quickly Erodes Cardiovascular Protection
A new finding after stopping GLP-1 drugs in a large cohort with Type 2 diabetes: rapid erosion of CV benefit/protection New @bmj_latest by @zalaly @Biostayan https://t.co/JG6yB8wTJJ See thread: https://t.co/6JvfIIjVBw https://t.co/wUgWhvs9Yy
CBER Updates SOPs, Enables RMAT for Held Therapies
CBER changes its standard operating procedures to open the door to RMAT designations for therapies on clinical hold - https://t.co/bZmhga8xxC
EHRs Will Become Records; AI-Driven Action Layers Rise
Sharp take here from healthcare VC Sam Toole on the future of EHRs in an AI world. Do they become systems of record, and entrepreneurs can build systems of action that sit on top? Link to read the full piece...
In‑body Genome Editing Promises Cheaper, Practical CAR‑T Therapies
What if we could engineer T cells in the body, making CAR T vs cancer, autoimmune diseases, and other applications far more practical, much less expensive? A step forward today via genome editing T cells https://t.co/FjgQA8NUlu https://t.co/XXk43WL1ac https://t.co/rpC7eCAlJH
Repeated Psilocybin Doses Yield 73% OCD Response
A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive–compulsive disorder 73.3% were responders (⩾35% reduction in YBOCS scores), with 40% in remission. These effects diminished but remained substantial at 6 months. https://t.co/tp2SPIKDrB
Uruguay's Healthcare Guide for Immigrants: Public & Private Options
For anyone considering immigrating to Uruguay here's a great overview of how the medical system works and how immigrants can sign up for either public or private healthcare. https://t.co/TZTE9AwEkv
RBC Flags Revolution, Xenon, Arrowhead as Top Biotech Takeover Targets
RBC: Revolution, Xenon, Arrowhead among top #biotech takeover targets https://t.co/h1toH9szrU by @realJacobBell $ARWR $XENE $RVMD $DYNE
Killing Costly Patients, Not Rationing, Solves Healthcare Costs
I now realize that the "solution" to the rising cost of healthcare will not be to ration healthcare. It will be to kill the most expensive patients.
ChatGPT Health Excels on Textbook Cases, Fails Real Emergencies
Is "textbook performance" enough for medical AI? The first independent stress test of ChatGPT Health is out in @NatureMedicine. The Good: Near-perfect triage for textbook stroke and anaphylaxis. The Bad: A 51.6% under-triage rate for true emergencies. But there’s a massive elephant in the...