Building A New Antibody Discovery Platform With Infinimmune's Wyatt McDonnell, Ph.D.
In the latest episode of Business of Biotech, Life Science Leader’s Ben Comr sits down with Wyatt McDonnell, Ph.D., co‑founder and CEO of Infinimmune, to discuss the company’s novel antibody discovery platform that combines a vast repository of human blood and tissue samples with advanced artificial‑intelligence algorithms. McDonnell traces his journey from a hands‑on microbiology graduate at Vanderbilt, through a pivotal stint at 10X Genomics, to launching Infinimmune four years ago, highlighting how single‑cell sequencing and computational biology shaped his vision. Infinimmune’s approach hinges on integrating barcode‑enabled antigen‑mapping workflows with AI‑driven design, enabling rapid pairing of antibody sequences to their target antigens. This multi‑omics strategy, built on a curated human sample database, has already attracted a marquee partnership: a discovery deal with Merck valued at up to $838 million. The platform promises to cut traditional discovery timelines and costs by leveraging high‑throughput data and predictive modeling. McDonnell recounts key moments that informed the technology, from witnessing the rise of next‑generation sequencing at Vanderbilt to the COVID‑19 pandemic’s spotlight on antibody therapeutics. He notes, “When the pandemic hit, the need for rapid antibody mapping became obvious, and our barcode‑enabled workflow was a natural fit.” The conversation also underscores the cultural influence of 10X’s collaborative environment, which taught him to bridge wet‑lab expertise with software development. The implications are significant: AI‑augmented antibody discovery could accelerate pipeline development for biotech firms, reduce reliance on costly animal models, and deliver more precise therapeutics to patients faster. For investors, Infinimmune’s Merck deal validates the commercial potential of AI‑centric biologics platforms, signaling a shift toward data‑driven drug discovery across the industry.
The Entry Level Job Crisis, Consulting Collapse, and Shadow AI | Newsday
The Newsday segment tackled three intertwined trends reshaping health‑IT: the rise of shadow AI, the collapse of traditional consulting models, and the looming entry‑level job crisis. Host Bill Russell and guests Drex Ford and Sarah Richardson explored how clinicians and...
Clearance Isn’t Enough: Proving Cybersecurity in 2026 with Christian Espinosa
2026 marks the moment regulatory frameworks finally caught up with cyber‑security realities for medical‑device manufacturers. The FDA’s updated FDI guidance and Quality System Regulation now require security to be designed into products and supported by an operational plan for post‑market...
Lecture 3.2.11: Reimbursement Regulatory Sandbox Pathways
The lecture examines how digital therapeutics move from concept to market through three pillars: reimbursement pathways, agile development, and regulatory sandboxes. It outlines the flow from physician prescription to insurer payment and highlights regional models such as Germany’s DiGA, U.S....
AI, Cancer & Programmable Biology
The video explores how artificial intelligence and programmable biology are converging to create bespoke molecular tools that can deliver mRNA, CRISPR components, vaccines or immunotherapies directly to diseased cells. By leveraging single‑cell RNA sequencing, researchers can map the expression levels of...
My IVF Journey With Kindbody From Infertility to Pregnant | Macro Beauty | Refinery29
The video follows Sophia Jenison, a 29‑year‑old nurse, documenting her IVF journey with Kindbody, from initial infertility struggles to eventual pregnancy. It details diagnostic workup, costs, male factor prevalence, and treatment steps—stimulation, egg retrieval, embryo creation, multiple cycles, a failed transfer,...
Naomi T. Nkinsi, MD, MPH, on Racial Bias in Diagnosing Kidney Disease
In a recent interview, Dr. Naomi T. Nkinsi, MD, MPH, highlighted how racial bias is embedded in clinical algorithms used to diagnose kidney disease in the United States. She explained that the historic use of a race‑based coefficient in estimated glomerular...
Hantavirus: Screening Ramped up at Entry Points, over 20,000 Vessels Inspected
Health Minister Datuk Seri Dr. Dulkafi Ahmed announced that Malaysia has intensified health screenings at all international maritime entry points to block the spread of hantavirus. To date, 22,367 ships and boats have been inspected, resulting in the issuance of...
The New Asbestos Scandal? The Luxury Kitchen Crisis Killing Young Workers
The video warns that engineered quartz kitchen worktops, now ubiquitous in UK homes, are creating a silent health crisis. When cut or polished, the material releases respirable crystalline silica, a dust that can trigger accelerated silicosis – a fatal lung...
India Activates Surveillance After Hantavirus Outbreak on Cruise Ship Leaves 3 Dead
India’s health ministry has activated precautionary surveillance after a Hantavirus outbreak aboard the cruise vessel MV Hondius, working closely with the World Health Organization, the National Centre for Disease Control and the Integrated Disease Surveillance Programme. The WHO disclosed eight probable...
Lecture 1.3.4 | Probability, Statistics & Bayesian Inference | Masters in Medical Robotics
The lecture introduces the foundational trio—probability, statistics, and Bayesian inference—tailored for students in medical robotics. It explains how probability measures uncertainty before any data is observed, statistics extracts meaning from collected data, and Bayesian inference revises beliefs as new evidence...
47,000 Couples to Benefit From LPPKN Fertility Assistance Programme
The Ministry of Women, Family and Community Development (LPPKN) unveiled an expanded fertility assistance programme, targeting 47,000 eligible couples with subsidised in‑vitro fertilisation (IVF) covering up to two treatment cycles. Since its launch, the scheme has handled more than 373,000 sub‑fertility...
Medical Staff Board Hantavirus Cruise Ship in Spain's Canary Islands
The video reports a sudden hantavirus outbreak aboard a cruise liner that arrived in the Canary Islands, prompting immediate action from Spanish health officials. The vessel, carrying hundreds of tourists, was placed under quarantine as medical staff boarded to assess...
Leading Through Effective Health Strategies (9 Minutes)
The nine‑minute video frames health leadership as a strategic imperative, arguing that modern leaders must go beyond decision‑making to actively shape wellness cultures across workplaces and communities. It defines effective health strategies as adaptable plans built on clear objectives, resource...
LIVE From Tenerife: Media Briefing on Hantavirus with Dr Tedros and Spanish Government Officials
A joint press briefing in Tenerife detailed an unprecedented multinational operation to evacuate a cruise ship after a suspected hantavirus case. Spanish authorities, in coordination with the World Health Organization, the European Centre for Disease Prevention and Control, and the...
Prioritizing Health in Economic Development Strategies (9 Minutes)
The video argues that health should be treated as a core pillar of economic development rather than a peripheral social goal. By reframing wellness as a driver of productivity, innovation, and stability, policymakers can embed health outcomes into growth strategies. Evidence...
How to Know If You Need HRT: Symptoms, Labs & What to Track in Perimenopause
The video explains how women can determine whether they are good candidates for menopause hormone therapy (HRT) by combining proactive symptom tracking, regular laboratory testing, and personalized dosing. It introduces the Parsley Symptom Index, a two‑minute, bi‑weekly online questionnaire that scores...
Investigation: Cancer Nurses and Risk of Miscarriage
The video investigates a possible link between oncology nurses’ exposure to chemotherapy and a rise in miscarriages and other reproductive health issues. It follows personal accounts from NHS cancer nurses Alison Simons and Sam Tolland, who both suffered miscarriages while...
Going to the Doctor Is Not Weakness (Why Proactive Health Is Leadership) Ft. Dr. Lenny Kaufman
The podcast centers on Dr. Leonard “Lenny” Kaufman’s advocacy for proactive men’s health, framing regular check‑ups as a leadership trait rather than a sign of weakness. He contrasts reactive approaches—waiting until symptoms appear—with preventive strategies that catch conditions like prostate...
Progesterone vs Progestins: Why the Difference Matters for Women’s Health | Felice Gersh, MD
In this video, integrative OB/GYN Dr. Felice Gersh clarifies the often‑confused distinction between progesterone—the body’s native hormone—and progestins, the synthetic compounds marketed in contraceptives and hormone‑therapy products. She explains that progesterone is a single, neurosteroid produced by the ovaries, adrenal glands...
Perfuze CEO Lays Out the Challenge – and the Promise – of Buildin...
The latest Device Talks weekly podcast recapped the successful Minnesota gathering and turned its focus to the upcoming Device Talks Boston conference, slated for May 27‑28. Organizers highlighted a 25% early‑bird discount (code DTW25) and a packed agenda featuring keynotes, panels...
Intention to Treat: The Race Equation (Teaser)
The teaser introduces “The Race Equation,” a New England Journal of Medicine series that investigates how race is embedded in clinical algorithms used daily in U.S. hospitals. These tools determine everything from organ‑transplant eligibility to ventilator allocation, yet many incorporate race‑based...
Lecture 3.2.8: FDA Digital Health & CE Mark Pathways
The lecture walks developers through the regulatory maze for software‑based medical devices, comparing the U.S. FDA framework with the European CE‑mark pathway. It defines "software as a medical device" (SaMD), outlines the FDA’s three‑tier risk classification, and explains how each...
The ACCESS Model: Health Tech’s Next Gold Rush?
The video outlines a forthcoming Medicare Access Program that will allow beneficiaries and their physicians to obtain FDA‑cleared health apps and wearable devices with federal reimbursement. Unlike today’s corporate‑benefits model, providers will face a senior population with lower digital health literacy,...
AI Isn’t Just Changing Software. It’s Changing Medicine.
The video illustrates how artificial intelligence is reshaping medicine through a real‑world case study. GitLab’s founder, diagnosed with bone cancer and denied trial access, leveraged AI to dissect his own tumor’s molecular profile and then released the data publicly for...
Urinary Incontinence in Women | Johns Hopkins Medicine Webinar
The Johns Hopkins webinar focused on urinary incontinence in women, outlining the two most common forms—stress and urge—incontinence and clarifying what constitutes normal urinary patterns. The presenter highlighted that a typical adult female voids 300‑400 ml six times daily, and that...
Statin Intolerant? What to Do Instead (2026 Update)
The video tackles statin intolerance, outlining the 2026 clinical update on how to manage patients who cannot tolerate traditional statin‑fibrate therapy. It follows a case study of a man whose statin‑induced myositis prompted a shift to a health‑promoting diet, fish‑oil...
How North Korea's Fake Company Compromised Millions | 2 Minute Drill with Drex DeFord
The video details a supply‑chain attack in early 2026 where North Korea’s threat group UNCC 1069 created a fake company to trick Axios maintainer Jason Samon into installing a malicious file. The actors spent two weeks building a realistic Slack workspace, LinkedIn...
They Removed Half His Brain to Save His Life — Gabriel’s Story
Gabriel, a healthy infant from Puerto Rico, began experiencing seizures at age six. After local doctors only identified epilepsy, his family sought a second opinion in the United States, where specialists diagnosed him with Rasmussen encephalitis—a rare, progressive brain disorder...
Are ObGyns Prescribing Birth Control "Like Candy"? 🍭
The video argues that obstetric‑gynecologists are treating oral contraceptives as a catch‑all medication, prescribing them not only for birth control but also for acne, polycystic ovary syndrome and even infertility. The speaker likens this practice to handing out candy, suggesting...
A RSV Vaccine in Pregnancy Cuts Your Baby's Chance of Hospital Admission by up to 85% #pregnancy
The video reports findings from the largest real‑world evaluation of the maternal respiratory syncytial virus (RSV) vaccine in England, tracking nearly 300,000 births between September 2024 and March 2025. Researchers found infants whose mothers received the RSV shot during pregnancy were...
Did You Know: Caring Well for Older People Is About Understanding the Whole Person
The video spotlights integrated, person‑centered care for seniors, arguing that treating older adults solely by disease overlooks the broader context of their lives. It underscores that a 75‑year‑old often manages three chronic conditions, seven daily pills, and five specialists who...
Why These Former FDA Officials Left the Agency
The STATus Report video examines why a wave of seasoned FDA officials departed during the second Trump administration, highlighting a confluence of mass layoffs, political meddling, and cultural shifts that pushed long‑time scientists out of the agency. Interviewees describe abrupt...
MedTech Innovator APAC MedTech Spotlight SG 2026 14 15 Apr Highlight Reel
MedTech Innovator APAC’s latest highlight reel showcases the annual accelerator that convenes emerging medical‑technology startups with a panel of investor judges, creating a rare one‑stop platform for networking and funding. The sixth edition underscores the program’s role in building a...
When Screening Guidelines Shift: Impacts on Healthcare Access & Use
The podcast examines how recent revisions to screening and treatment guidelines—particularly the ACC/AHA lipid recommendations, newer hypertension targets, and lowered colon‑cancer screening age—reshape health‑care utilization and spending. The lipid update introduces the Prevent risk equations, lowers the treatment threshold to a...
How Digital Workflow Tools Deliver Significant Benefits in Healthcare Settings
The video explains how digital workflow tools—specifically electronic journey boards and integrated handover solutions—are reshaping clinical operations by providing real‑time visibility into patient discharge timelines and task assignments across all hospital departments. By surfacing expected discharge dates, flagging unavailable allied‑health staff,...
Rare Disease Families Find Roadmap to Drug Development at Bootcamps
The video spotlights a growing movement of rare‑disease bootcamps that equip non‑scientist parents with the tools to launch drug‑development projects for their children. Hosted by biotech firm Ultragenics, the multi‑day, sponsor‑funded curriculum walks participants from early research concepts through...
Why Ukraine May Restrict Its Booming Surrogacy Business | Global News Podcast
The BBC Global News Podcast examines Ukraine’s rapidly growing surrogacy market, which has rebounded to near‑pre‑war levels despite the country’s ongoing conflict. A draft bill now seeks to restrict the practice by prohibiting foreign couples from commissioning surrogacy unless at...
Lecture 3.2.5: Signal Preprocessing ECG, PPG + Feature Extraction, Windowing & HRV Spectral Features
The lecture walks through converting raw ECG and PPG voltages into actionable physiological metrics, focusing on preprocessing, feature extraction, and heart‑rate‑variability (HRV) spectral analysis. Aksha outlines three dominant noise sources—power‑line interference, baseline wander, and EMG artifacts—and recommends a “Goldilocks” filter chain:...
Can You Prevent Macular Degeneration? Diet, Gut Health & New Research | NYU Langone Health
The video, presented by NYU Langone ophthalmology professor Dimmitra Scondra, outlines the burden of macular degeneration and related retinal disorders, emphasizing that they are the most common cause of irreversible blindness in adults over 50 and comparable in prevalence to...
Safer Stem Cell Transplants — without Chemotherapy or Radiation | Stanford Medicine
Stanford Medicine researchers have introduced a novel conditioning regimen that replaces traditional chemotherapy and radiation with an antibody, Briquilimab, for bone‑marrow transplants in patients with Fanconi anemia—a disorder marked by defective DNA repair. The approach targets the CD117 receptor on...
2026 Community Challenge Aims to Expand Access to Life-Saving Medical Supplies
The 2026 Community Challenge, launched by Partners for World Health, calls on innovators to create scalable solutions that increase the flow of in‑date medical supplies from U.S. hospitals to underserved populations worldwide. Founded in 2009 by nurse Elizabeth McClellan, the nonprofit...
605 - The Cost of Care: Improving Transparency and Access in Australian Healthcare
The Talking Health Tech podcast featured Jacomi Matthews, founder and CEO of GotoHealth, discussing how her startup aims to bring price transparency and easier access to allied‑health services across Australia. Matthews cites research that 48% of Australians have postponed or cancelled...
Raise the Line Podcast: Dr. Mel Herbert & The Pitt - Mental Health
The Raise the Line podcast featuring Dr. Mel Herbert of the University of Pittsburgh tackles the mounting mental‑health crisis among clinicians, linking it to recent security lapses on hospital campuses. Herbert argues that inadequate safety protocols not only endanger patients...
How to Actually Get Tested for Low Testosterone
The video explains how clinicians should correctly order and interpret testosterone testing to avoid misdiagnosis. It stresses that blood draws must occur between 7:00 and 10:00 a.m., after an overnight fast, and when the patient is not acutely ill or sleep‑deprived. A...
Congenital Syphilis
The video spotlights a surge in congenital syphilis, warning that cases in Baltimore have jumped almost four‑fold since 2020. It frames prenatal testing as the primary defense against a disease many assume is extinct. Syphilis, a bacterial infection transmitted through any...
New Smart Data Archiving Features at MediQuant
MediQuant unveiled a suite of archiving upgrades aimed at compressing clinician workflow and cutting storage costs. The announcements, made at HIMS, were delivered by senior VP of product strategy Mike Magcguire, who outlined new AI‑driven clinical summaries, lossless DICOM handling,...
Overcoming Challenges in Healthcare AI
The speaker framed the talk around the stark reality of today’s U.S. healthcare system – spiraling costs, massive waste, chronic‑disease dominance, and a looming clinician shortage that fuels burnout. He opened with a personal story of a community matriarch whose...
Meet the Equation
The video investigates how a race‑adjusted eGFR (estimated glomerular filtration rate) formula, introduced in the late 1990s, has systematically over‑estimated kidney function for Black patients, affecting diagnosis and treatment decisions. It traces the origin of the correction factor to...
Healthcare’s Future Unveiled: Insights From Private Equity Leaders on Innovation & Trends
The panel, featuring leaders from NVIDIA, 7Wire and Vistria, dissected the evolving healthcare investment landscape, focusing on private‑equity trends, artificial‑intelligence adoption, and the balance between hype‑driven sectors and core fundamentals. Panelists agreed that private‑equity capital is poised to fuel the next...