Researchers introduced BQTML‑CB, an NQO1‑responsive prodrug that releases cytochalasin B inside tumor cells, disrupting actin filaments and halting migration and proliferation. The design exploits the enzyme NQO1, overexpressed in many aggressive cancers, to achieve tumor‑selective activation while sparing NQO1‑deficient cells and neutrophils, thereby reducing systemic toxicity. In vitro studies showed potent anti‑migratory effects across multiple NQO1‑high carcinoma lines with minimal impact on normal cells. The work positions the prodrug as a precision migrastatic with potential for combinatorial cancer therapy.
Researchers have engineered biomimetic nanocarriers that combine liposomal structures with Myxobacteria outer‑membrane vesicles (OMVs) to deliver antibiotics. The hybrid carriers achieve higher drug loading and can penetrate intracellular Gram‑negative pathogens, while native OMVs avoid immune clearance and sustain extracellular exposure....
Researchers introduced an N‑methyl‑2‑pyrrolidone (NMP)‑mediated self‑assembly method that leverages π–π stacking to fabricate highly uniform polyaniline/reduced graphene oxide (PANI@RGO) composite gels with up to 85 % polyaniline loading. The resulting M‑PANI@RGO‑85 % cathode exhibits a specific surface area of 189.55 m² g⁻¹ and mesopores...
If you have more endurance than everybody else, it’s going to be tough to lose. Follow @chasecalhoun.realestate for more on build-to-rent and real estate investing. #realestate #investmentproperty #buildtorent #alexhormozi
U.S. grocers are under increasing scrutiny as state and federal lawmakers target dynamic, or “surveillance,” pricing enabled by electronic shelf labels (ESLs). More than 100 price‑transparency bills have been filed in 33 states, while the UFCW’s national campaign backs the...

On 17 March 2026 the Prudential Regulation Authority released consultation paper CP5/26 to modernise the UK liquidity policy framework. The PRA proposes that firms must assess liquidity composition and monetisation risk, conduct weekly stress tests, and remove the exemption for...
I don’t do polymarket, but that is not going to happen during this U.S. administration or Israeli government watch. Iran’s entire nuclear program has been attacked (from top scientists, centrifuges, centrifuge manufacturing, weaponization, research centers, and every component of the...

North Korean APT group Konni weaponized South Korea's KakaoTalk in a sophisticated spear‑phishing campaign. The group sent emails posing as a lecturer on North Korean human‑rights issues, tricking recipients into running a malicious shortcut that installed remote‑access malware. After compromising...

On 17 March 2026 the European Commission opened a public consultation on proposed revisions to the EU taxonomy, aiming to simplify the framework and reduce reporting burdens. The draft changes streamline criteria and clarify compliance across most sectors covered by...

Private equity firms are facing a growing bottleneck in their exit pipeline as IPO markets stay muted, M&A activity slows, and secondary‑sale demand wanes. Elevated interest rates and tighter credit conditions are compressing valuations, forcing managers to hold assets longer...
BMO Financial Group announced plans to open 145 new U.S. branches—130 in California and 15 in Arizona—over the next five years, with seven California locations slated for this year. The expansion follows the Bank of the West acquisition and aims...
The AI in Healthcare Forum convened clinicians, executives, and technologists in Boston to showcase real‑world AI applications across care delivery, operations, and governance. Sessions covered policy frameworks, data challenges, scaling strategies, and emerging clinical AI tools, featuring leaders from Sutter...
Fat Brands, burdened by over $1 billion in debt, has filed a Chapter 11 motion to market and sell all or part of its assets, setting an April 3 deadline for non‑binding indications of interest. The company is pursuing debtor‑in‑possession financing and remains...
Thirteen state attorneys general have filed a lawsuit against OneMain Financial, alleging the lender misled subprime borrowers into purchasing costly add‑on products such as credit insurance. The complaint says employees pressured borrowers, financed premiums into loans, and sometimes charged add‑ons...
Teledyne SP Devices announced a high‑speed disk‑streaming solution built around its ADQ35 digitizer and the open‑source libads library. The platform promises sustained multi‑gigabyte‑per‑second data rates, enabling continuous capture of extreme‑volume signals without loss. Integration with standard PCIe storage and configurable...

America’s Cutting Edge (ACE), IACMI’s workforce development program, has surpassed 20,000 online students and 5,000 in‑person boot‑camp participants since its 2020 launch. The initiative now delivers 11 CNC machining courses at 43 sites nationwide, drawing participants from colleges, high schools...

The Court of Appeal ordered the remittance of Sex Matters’ judicial review against the City of London’s trans‑inclusion policy for the women’s pond, overturning a High Court dismissal. The High Court had rejected the claim on procedural grounds, citing missed...
Publicis has instructed its clients to stop recommending The Trade Desk after a third‑party audit uncovered improper fee applications and a lack of transparent cost invoicing. The audit, performed by FirmDecisions, concluded that The Trade Desk charged fees without clear...
Investor‑owned utilities have generated more than $200 billion in net income from 2021 through 2025, according to the Energy and Policy Institute. Their average profit margin rose to 14.6 cents per dollar collected in 2025, up from 12.8 cents in the earlier period....
The FDA issued a third complete response letter rejecting Aldeyra Therapeutics' lead dry‑eye candidate, reproxalap, citing a lack of substantial evidence and inconsistent efficacy data. The agency noted the drug failed to demonstrate clear benefit in well‑controlled studies, though no...
Ukraine has accepted the European Union’s offer of technical and financial assistance to repair the Brody pumping station on the Druzhba oil pipeline, which was damaged in a suspected Russian aerial strike. The repair is expected to take about one...

Ports of Indiana announced the launch of its first overseas trade office in Ireland, appointing maritime veteran Brian Dooley to lead the European Trade Office based in Cork and Kildare. The office aims to develop a direct Europe‑Indiana container service...

The traditional procurement playbook of aggregating spend to secure rebates is eroding as tariffs become a permanent, volatile cost factor. Companies now must treat tariffs as explicit line‑item expenses and redesign sourcing models to reflect ongoing trade policy shifts. Geographic...

Big oil has its prophets of doom. When it's unhappy, it trots them out to prophesy doom. One such forecast in 2022 was oil would hit $380 because of the G7 price cap. This is lobbying on behalf of big...

NASA released X‑ray computed tomography scans of asteroid Bennu samples on March 17, 2026, revealing intricate crack networks inside the material. The scans show that Bennu’s boulders are highly porous, a property that accounts for the low thermal inertia measured...
Dole is shifting its supply chain from a pure execution function to a strategic growth engine, according to VP of Supply Chain Todd Stillwell. The company has created a dedicated supply‑chain general‑manager role embedded within business teams to influence product...
Iran’s recent drone strikes and naval posturing have effectively shut down most commercial traffic through the Strait of Hormuz, the world’s most critical oil conduit. While the United States and Gulf allies scramble to keep energy supplies flowing, the Omani...
1 rental = proof 5 rentals = options 10 rentals = freedom 20 rentals = legacy
A new analyst report shows the West Coast’s share of U.S. and Western Canadian import TEUs has slipped from 59% in 2010 to below 49% in 2025, marking a ten‑point decline. The drop mirrors a broader erosion of intermodal rail’s...
TotalEnergies will take the final investment decision on the second phase of Azerbaijan’s Absheron gas and condensate field in the second half of 2026, with first gas expected to flow to shore by September 2029. The expansion will add about...
Much of the conversation around healthcare and AI right now pits doctors and AI against each other. This is the wrong framing. Yes, it is important to have studies that look at how good AI is at various tasks that physicians...
“I don’t want to be the person they call and say, can we hit the enter button on this command. But I also don’t have a God complex.” @davidu of @a16z on the Anthropic-DoD rift, why VC has a right to...

The UK government has tabled an amendment to the Pension Schemes Bill that will empower it to publish the long‑awaited guidance on trustees’ fiduciary duties, particularly regarding ESG considerations. The change formalises the government’s commitment to clarify how sustainability factors...
This week on Lifers, Graham Walker is “sounding the alarm” for physicians. * 50% of medical students already plan to quit before they finish school. * Doctors are becoming "factory employees," losing their authority to care for patients. * Tech focuses on the...

Unilode Aviation Solutions and cargo‑equipment maker SATCO have launched a joint MRO facility at Los Angeles International Airport, providing on‑site ULD maintenance and repair. The partnership also includes a long‑term agreement for Unilode to source SATCO’s fire‑resistant cargo nets, bolstering...

SecurityInfoWatch and SecureXperts have unveiled Cybersecure, a training initiative that launches with an NSA‑backed Commercial Solutions for Classified (CSfC) Trusted Integrator Workshop at ISC West. The program targets the chronic shortage of qualified integrators capable of designing CSfC‑compliant architectures for federal...

Spain is evaluating a new rail terminal 11 km west of the Algeciras port to alleviate current capacity constraints, with an estimated €62 million price tag. The proposal includes five new sidings and a 3.65‑km link directly into the port, addressing the...

Engineers at the University of Hong Kong have unveiled SonoMeta, an AI‑assisted ultrasound lens built from metamaterials that can image heart and lung structures up to 10 cm behind the rib cage with CT‑like resolution. Validation shows spatial resolution under 500 µm...
Dr Niamh Lynch is urging the NHS to launch a catch‑up MenB vaccination programme for all UK teenagers born before September 2015, after a deadly meningitis B outbreak in Kent claimed two lives and left eleven seriously ill. The strain now...

Pro Bono Net announced it is rebranding as Scale Justice, reflecting a shift from coordinating pro bono services to a broader, technology‑driven access‑to‑justice mission. The nonprofit, founded in 1998, now reaches more than 8 million people annually and claims to have...

EE and Samsung are launching free AI masterclasses at EE’s Westfield White City studio, running daily through 5 April. The 20‑minute sessions, limited to eight participants, demonstrate Galaxy AI features on the new Samsung S26 Ultra, covering photography, translation, note‑taking and...
Spotify’s top 80 artists generated $10M+ each in royalty payouts in 2025. I estimate that these artists generated $2B total, nearly 20% of Spotify’s payout pool. Here’s how I see it:
Part of how they want to enact this is by rolling out mass censorship and surveillance online through things like “reforming” section 230 and laws like KIDS Act/KOSA which would remove LGBTQ, abortion content etc from the internet (and “leftists”/liberals...

The 2025 State of Agtech Investment in Africa report reveals total sector funding fell to $170 million, a near‑20 % year‑on‑year decline, while equity’s share dropped below half for the first time. Debt, grants and blended‑finance structures now dominate capital deployment, reflecting...

Neurodegenerative diseases at the single-cell level, a powerful tool to differentiate and better understand https://t.co/Pkz4qW0ELM @jclinicalinvest https://t.co/LiJ4FojRYZ

For Saint Patrick’s Day, one of my favorite rocket launch photos… Black Rock Desert, NV The green glow comes from barium chloride mixed into the AP propellant. I planned the camera location in advance to bisect the moonrise, and then...

Insight Works announced a strategic partnership with 2Ship to embed the 2Ship carrier platform into its Dynamic Ship app for Microsoft Dynamics 365 Business Central. The integration adds parcel, LTL and FTL shipping support, delivering carrier rates, label generation and...
This is the PC Launch Trailer for “DEATH STRANDING 2 ON THE BEACH.” Once again, I did the structure, editing, sound design, and mix myself. It features a track by WOODKID. Hope you enjoy it. Releasing on March 19. 🙏🙇🏻🫶😍👍...
#TechTuesday. June 19, 2009. Zynga releases the game Farmville, an agriculture simulation social network game. Guess why it is so addictive. (The Deal Dragon) #Vintage #Gaming #JVGpost https://t.co/DytruPKuwH
As Disney CEO Bob Iger Steps Aside, a Look at His Tenure as a Dynamic, Transformative Leader — With an Asterisk or Two https://t.co/zmQnYUUxDV via @variety