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Dual Regulatory Roles of CPT1C in Chronic Stress-Induced Depression-Related Outcomes

A recent study reveals that carnitine palmitoyltransferase 1C (CPT1C) exerts dual regulatory functions in chronic stress‑induced depression‑related phenotypes. CPT1C enhances surface expression of GluA1‑containing AMPA receptors via SAC1‑mediated lipid signaling while simultaneously dampening mTORC1 activity through AMPK pathways. Genetic deletion or pharmacological inhibition of CPT1C mitigates stress‑evoked synaptic deficits in the nucleus accumbens and hippocampus, producing antidepressant‑like behavior in mouse models. These findings position CPT1C as a bidirectional hub linking metabolic cues to excitatory synapse plasticity in mood disorders.