Lipocine’s Oral Brexanolone Phase 3 Fails, Shares Crash 78%
Lipocine Inc.’s Phase 3 trial of LPCN‑1154, an oral brexanolone for postpartum depression, failed to meet its primary endpoint, triggering a 78% plunge in the company’s share price. The setback raises questions about the viability of oral neurosteroid therapies and puts pressure on the firm’s capital‑preservation plan.
![[Editorial] Childhood Cancer: Progress, but Not Enough](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/28aa7b79a0e44fd8c1effd8b006a4c38.webp)
[Editorial] Childhood Cancer: Progress, but Not Enough
The CONCORD‑4 study shows that 68 countries have met or exceeded the WHO 60 % five‑year survival target for childhood cancer, with high‑income nations reaching 85‑90 % survival. However, 85 % of the 377,000 new cases in 2023 and 94 % of deaths occur...
SETDB1 Modulates Neuroinflammation in the Mouse Cortex by Regulating Neuronal P2rx7 Expression
A recent mouse study demonstrates that the histone methyltransferase SETDB1 suppresses neuroinflammation by repressing neuronal P2rx7 expression. Conditional loss of SETDB1 in cortical neurons doubled P2X7 mRNA levels, amplified microglial IL‑1β release, and produced anxiety‑ and depressive‑like behaviors. Pharmacologic blockade...
![[Comment] Childhood Cancer: An Equity Test for Global Health](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/5a4bd36d35a3297cb37f33621515df0d.webp)
[Comment] Childhood Cancer: An Equity Test for Global Health
A new Global Burden of Disease (GBD) analysis provides the first comprehensive estimates of childhood cancer incidence, mortality and DALYs from 1990 to 2023. The study highlights that only 21% of the world’s population lives in regions with population‑based cancer...
![[Comment] 10 Years After NOBLE: More Nuance in Left Main Revascularisation](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/51d0100d0ee81bbb3726be7a062c50fb.webp)
[Comment] 10 Years After NOBLE: More Nuance in Left Main Revascularisation
The recent 10‑year follow‑up of the NOBLE trial re‑examines revascularisation of unprotected left‑main coronary disease, finding no significant mortality difference between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). However, PCI continues to be associated with higher rates...
Local Chemoarchitecture Explains Widespread Lower Cortical Thickness Associated with Clinical High Risk for Psychosis
A new multimodal study links the widespread cortical thinning observed in individuals at clinical high risk (CHR) for psychosis to the brain's local chemoarchitecture. By integrating structural MRI with neurotransmitter receptor density maps, the researchers showed that regions with specific...
Assessing Molecular Gene by Treatment Interactions Using a Population of Neural Progenitors Exposed to Valproic Acid and Lithium
Researchers exposed a genetically diverse panel of 83 human neural progenitor cell lines to valproic acid (VPA) and lithium, measuring chromatin accessibility and gene expression. They identified over 1,000 gene‑by‑treatment interaction loci, many of which overlap with psychiatric disorder risk...
Neuronal HDAC9: A Key Regulator of Cognitive and Synaptic Aging, Rescuing Alzheimer’s Disease-Related Phenotypes
Recent research identifies neuronal HDAC9 as a pivotal regulator of synaptic health and cognition during aging. The study shows that HDAC9 expression declines in the cortex of Alzheimer’s disease (AD) patients and aged mice, correlating with synaptic loss and memory...
A Prefrontal Cortex-Nucleus Accumbens Circuit Attenuates Cocaine-Conditioned Place Preference Memories
Researchers identified that infralimbic prefrontal cortex neurons projecting to the nucleus accumbens shell (IL‑NAcSh) become hypoexcitable after repeated cocaine exposure, a change that lasts at least 15 days into withdrawal. This intrinsic hypoexcitability reduces the circuit’s ability to suppress cocaine‑associated...
2026 Grand Prix De L’Imaginaire Shortlist
The 2026 Grand Prix de l’Imaginaire shortlist, honoring the best science‑fiction and fantasy published in France in 2025, was released today. It features five French novels, six translated foreign novels, short fiction, YA titles, and a dedicated translation prize. Winners...
Jurassic Ichthyosaur Fossil Found in Cuba
Paleontologists have uncovered the most complete ichthyosaur skeleton ever found in Cuba, recovered from a limestone cave in the Viñales Geopark. The specimen dates to the Tithonian stage of the Late Jurassic, roughly 145 million years ago, extending the island's ichthyosaur...
Ruth Berman Named SFPA Grand Master
The Science Fiction and Fantasy Poetry Association announced Ruth Berman as its 13th Grand Master, honoring her decades‑long impact on speculative poetry. Berman’s work spans premier genre magazines such as Asimov’s, Analog, and Weird Tales, and she has earned top...
BLACKPINK’s Jennie’s Backless Crochet Cover-Up Comes With a Sheer Twist for Frankies Bikinis
Jennie, the South Korean star of BLACKPINK, fronted Frankies Bikinis' latest Instagram campaign wearing a black, backless crochet mini dress with sheer detailing. The brand highlighted the piece, named Gabriella, emphasizing its U‑shaped neckline, thin straps, and lace‑up back. Fans...
‘Time’s Ticking,’ Indeed: Every Song That’s Taken More Than a Year to Reach No. 1 on Billboard’s Country Airplay Chart
Justin Moore’s single “Time’s Ticking” finally topped Billboard’s Country Airplay chart after a 67‑week climb, setting a new record for the longest ascent in the chart’s 36‑year history. The song’s slow rise follows a recent trend: 15 other tracks have...
Schlock Jock: Joshua Citarella at the Whitney Biennial
Joshua Citarella’s podcast *Doomscroll* was presented as a live artwork at the 2026 Whitney Biennial, sparking debate over whether a market‑oriented video interview series belongs in a museum. Originally a net‑art project exploring fringe online politics, Citarella rebranded the show...
Wellness Retreat Aims to Help First Responders Break Out of ‘Survival Mode’
Law Enforcement Coaching launched its 2026 Recalibration Retreats, a three‑day wellness program for first responders held in June on Whidbey Island. The retreats, limited to 25 participants per session, combine OODA‑loop‑informed coaching, peer discussions, outdoor activities and NuCalm’s technology‑supported relaxation....
Hong Kong: Advancing Smart Therapeutics, Translational MedTech
Hong Kong is positioning itself as a regional hub for biopharmaceutical innovation, focusing on advanced therapeutic products (ATPs) such as cell therapy. Invest Hong Kong is attracting mainland and international firms to set up R&D in the city, backed by...
Ken Burns’ Visions of America
Ken Burns, the celebrated documentary filmmaker, is premiering a six‑part series, *The American Revolution*, after a decade of research and production. The series, set to air on the BBC later this year, delves into both well‑known events and overlooked civil‑war‑like...
Local Grants and National Initiative Cushion Washington Post Cuts
Donations to dynamic local outlets – and support from one big national initiative – have offset major downsizing at The Washington Post. Celia Wexler Reports: https://tinyurl.com/2xfrabf4 Related IP Resources: Journalism Grants -https://tinyurl.com/4nwuxehu Washington D.C. Grants -https://tinyurl.com/2e3wspm8 Civic & Democracy Funders -https://tinyurl.com/4zbzy78h Journalism
Australia: ANU Fosters AI in Science and Healthcare
The Australian National University has joined three other institutions in a national agreement to embed artificial intelligence across scientific research, healthcare, and education. The partnership emphasizes generative AI for genomic analysis, aiming to accelerate rare‑disease diagnosis and precision‑medicine breakthroughs. Simultaneously,...
This Maison Margiela Collection Is Honestly a Must See
Maison Martin Margiela’s Fall 2026 ready‑to‑wear show earned a glowing review from Vogue, praising its daring reinterpretation of 19th‑century garments. The collection featured dresses from the 1870s drenched in beeswax, creating amber‑like forms that cracked under runway stress. Vintage velvets, metal...
Zach Bryan Cancels Tulsa Performance Due to ‘Dangerous Weather’: ‘I’ve Never Canceled a Show in My Life’
Zach Bryan announced the cancellation of his Friday Tulsa concert after local authorities issued tornado and severe thunderstorm warnings, marking the first time he has ever called off a show in his five‑year touring career. He assured fans that refunds...
We Are Stardust - Edin Custo - 20289
We Are Stardust, a Norwegian documentary by Elisabeth Rasmussen, follows musician‑turned‑stardust hunter Jon Larsen as he spends a decade sifting urban gutters, roofs and roadsides for micrometeorites. The film documents his quest to prove that extraterrestrial dust can be collected in...
One Day, I May Need to Figure Out How to Get Pregnant
Chanel Contos, founder of Teach Us Consent, shares how she spent her twenties learning to decode her menstrual cycle, eventually identifying ovulation through subtle physical cues. She describes the gradual, self‑directed process of mapping moods, cravings, discharge, and minor aches to hormonal...
IWC Mark XX Earth Brown Nylon Strap on Sale
Single piece nylon straps at BarkAndJack.com IWC Mark XX on our Earth Brown Ribbed Nylon (on sale)
Vera C. Rubin Observatory Discovers Over 11,000 New Asteroids
Using the Vera C. Rubin Observatory, astronomers have cataloged over 11,000 previously unknown asteroids, including 33 near‑Earth objects and roughly 380 trans‑Neptunian bodies. The observations, gathered over a month and a half, amount to about one million individual measurements and...
Decode Your Baby’s Thoughts with an Evidence‑Based Guide
Ever wanted a translation guide to your baby/toddler? That’s why we created What’s my Baby 👶 Thinking? - evidence- based - easy to use - beautifully illustrated Parenting for a new generation of switched-on parents. From @dkbooks Find the reviews https://geni.us/WhatsMyBabyThinking
Watch A$AP Rocky Perform ‘Don’t Be Dumb’ Tracks for Amazon Music’s ‘Songline’ Series: ‘Live From New York’
A$AP Rocky teamed with Amazon Music for the Songline series, delivering a 40‑minute live performance of eight tracks from his 2026 album “Don’t Be Dumb.” The show, originally streamed on Jan. 18 for Yams Day, highlighted Rocky’s cinematic vision and featured...
Cantino’s Dolce Era & Everlane’s Eviction Notice
Stefano Cantino, the former Gucci executive, has launched a new luxury label called Dolce Era, positioning it as a high‑end alternative that draws on his deep industry connections. The brand aims to capture affluent shoppers seeking contemporary Italian craftsmanship. Meanwhile,...
Canada Returns 11 Artefacts to Turkey in the First Repatriation Between the Countries
Canada returned eleven Ottoman‑era artefacts to Turkey, marking the first official repatriation between the two countries. The collection includes seven manuscript pages, two printed work pages and two modern calligraphy pieces dating from the 17th to 19th centuries, seized by...
Accept Mismatches, Skip Sending Disappointment Notes
If you ever find yourself sending a message to a creator that says “hey I’ve agreed with everything you’ve said but your last piece of content really let me down and I’m disappointed in you,” maybe don’t send it and...
Floyd Channels Tom Hanks' Everyman Warmth
Floyd’s innate goodness radiates through Harbour’s performance. It’s as if he’s tapped into the “everyman” warmth long associated with performers like Tom Hanks — “America’s Dad” — channeling it to reach new emotional depths in his acting arsenal. https://t.co/9ia6jVQUWb
Quantum Circuits Reveal Hidden Entanglement Changes with New Entropy Measures
Researchers at Seoul National University have introduced a new framework for analyzing the full distribution of entanglement entropy in hybrid quantum circuits that combine random Clifford gates with measurements. By calculating higher‑order moments such as variance, skewness, and the index...
Kids' Bedrooms Harbor Harmful Chemicals, Study Finds
Young Children’s Exposure to Chemicals of Concern in Their Sleeping Environment: An In-Home Study https://t.co/PIv6V5yVVo https://t.co/81UD6d8M1m
Best Garden Carts Tested for Heavy‑Duty Use
Garden carts can carry everything from soil and plant trays to bricks and power tools. Our top picks highlight the ones that performed best in our tests. https://t.co/32gGuaPGjH https://t.co/rNsartp0fx
Episode 934: John Stezaker
In this episode of Bad at Sports, host Brian Andrews and co‑hosts sit down with contemporary artist John Stezaker to discuss his new exhibition "Raft" at Grey Gallery. Stezaker explains that the works are collages made from Victorian topographical photographs,...
Twitter's Owl City–Vampire Obsession Mirrors Boomer Nostalgia
people on twitter just taking about owl city and vampire all day, feels like boomers who just kept reliving the '60s into the '80s and '90s
Success Begins with Believing a Better Future & Personal Power
Successful people start with two core beliefs: the future can be better than the present, and I have the power to make it so.
6D Reimagines Off-Road Goggles With Launch Of The New ‘MAX’
6D Helmets has entered the off‑road eyewear market with the MAX goggle, featuring the oversized MAXVIEW polycarbonate lens that is 87% larger than standard goggles and maintains Class 1 optical clarity. The new FLOAT Fit system transfers structural load to the helmet,...
Happiness Requires Letting Go of Past and Future
“To be happy you must eliminate two things, the fear of a bad future and the memory of a bad past.”
Consistency Wins: Show Up Even When It’s Hard
“The future belongs to the consistent. Not the talented. Not the lucky. But the ones who show up, even when it is hard. Show up. Effort does not betray you.”
Doc ‘Green Superheroes 2030’ Due on Blu-Ray Disc April 14 From BayView
BayView Entertainment will release the documentary "Green Superheroes 2030" on Blu‑ray Disc on April 14, 2026. The film follows a diverse group of environmentalists aged five to seventeen as they develop innovative, science‑driven projects to protect the planet. By combining...
Resale Becomes Fashion’s Central Value Flywheel
Fashion resale has moved from the margins to the center of the fashion ecosystem. Resale Becomes The Fashion Industry’s New Value Flywheel via @forbes https://t.co/q11K1GVRFs
Lifestyle Factors Modulate Autophagy in Alzheimer’s
Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease https://t.co/aFGuo2R84Y https://t.co/vu2Jt7OvuZ
![[Correspondence] Cancer, Climate Change, Fossil Fuels, and War: A Call for Action](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/5c188eba14ae6153b256f9c474d09bfe.webp)
[Correspondence] Cancer, Climate Change, Fossil Fuels, and War: A Call for Action
Nancy Krieger’s correspondence highlights a growing body of research linking climate change to cancer, while exposing a glaring gap in accountability for fossil‑fuel‑driven wars. The article cites recent studies on pollution, occupational exposures, and climate refugees, and draws attention to...
Your Daughter Values Your Presence Even When Unspoken
Even if she doesn’t say it—your daughter still values your support, your interest, and your presence. Show up. 🎧 https://t.co/IU6PAsW9Lv
5‑MeO
I mis-spoke here. This study showed 5-meo-DMT much more effective than psilocybin. This was specifically on treatment resistant depression. A 15 point MADRS reduction there is ~2x psilocybin and ~3x ketamine. 5-meo-DMT really is the most potent antidepressant known to...
![[Correspondence] Sound Mind, Sound Place: Ibasho and Post-Disaster Mental Health](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/8605818caa7c5d4c136c9bacd704ce51.webp)
[Correspondence] Sound Mind, Sound Place: Ibasho and Post-Disaster Mental Health
The correspondence argues that post‑disaster mental health must move beyond acute symptom checklists toward community‑based recovery, highlighting Japan’s *ibasho*—a locally‑led place that embeds individuals in social networks and meaningful roles. Data from the 2011 Great East Japan Earthquake show that...
Director Watch Podcast Ep. 147 – ‘The Tales of Hoffman’ (Powell and Pressburger, 1951) with Special Guest Christina Jeurling Birro
Episode 147 of the Director Watch podcast dives into Michael Powell and Emeric Pressburger’s 1951 opera film The Tales of Hoffmann. Co‑hosts Ryan McQuade and Jay Ledbetter are joined by Pop Culture Confidential host Christina Jeurling Birro for an in‑depth analysis...
The 7 Best Bathroom Fans for Stopping Mold and Mildew
Popular Mechanics reviews seven bathroom fans designed to stop mold and mildew. The selections span a low‑cost 70 CFM unit without a light to premium models with humidity sensors, smart color‑changing LEDs, and integrated heaters. Each fan is evaluated on airflow,...