Aim for Peak Longevity, Not Just Healthspan
Check out my new https://t.co/lzzxyoQMxZ post titled "Peakspan: The True North of Longevity and Why We Must Aim Beyond Healthspan?". Link in the comments. Geroscience got a bit too woke for my taste. Can we set staying at or near the peak as the objective function? https://t.co/H9n7CVKZTO
Next-Gen Yellow Fever Vaccine Shows Promise in Mid
My comments and interview with @Medscape Next-Gen Yellow Fever Vaccine Hits the Mark in Mid-Stage Trial https://t.co/kFfGH4c5gt
Artemis 2 Crew Set to Become Fastest Humans Ever
Imagine having this view as you’re commuting home. The Artemis 2 crew is now falling to Earth, picking up speed every second as gravity relentlessly pulls them. When they plow into the upper atmosphere they’ll be the fastest humans in history...
View mRNA‑CRISPR as Molecular Surgery, Not Drugs
What if we started thinking of mRNA-CRISPR gene editing as molecular surgery, not as a pharmaceutical product? Excellent @nytimes guest essay ⤵️ https://t.co/S61XwNRVZF
Rapamycin Fails to Slow Epigenetic Aging, Sinclair Concedes
David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals •...
Weight‑loss Drug Semaglutide Cuts Depression Risk by 42%
A 10-year study finds weight-loss drugs lower the risk of #depression and anxiety. Published in The Lancet Psychiatry, the #research revealed a 42% lower risk of #mentalhealth hospitalisation during periods of semaglutide use. https://t.co/CphnQl0Khx
Emperor Penguins Now Endangered as Sea Ice Melts
Antarctica’s iconic emperor penguins have been declared an endangered species as climate change threatens the sea ice they rely on https://t.co/kQa06fvEbf
Orbiting Compute Becomes Real Infrastructure
𝗦𝗽𝗮𝗰𝗲 𝗱𝗮𝘁𝗮 𝗰𝗲𝗻𝘁𝗿𝗲𝘀 𝘀𝗼𝘂𝗻𝗱 𝗮𝗯𝘀𝘂𝗿𝗱. Until you notice who is already moving. And the economics are changing fast. Launch costs have fallen from roughly $10,000/kg to around $1,000/kg, with some projecting near $200/kg by 2027. The moment orbit starts competing with prime terrestrial infrastructure,...
Loss of Smell Predicts Five‑year Mortality Risk
A failing sense of smell may be an early warning sign of biological decline. In a study of ~3,000 older adults, those who couldn’t identify common odors had 3–5x higher risk of dying within 5 years, independent of disease, smoking, or...
Local Temperate Forest Sounds Boost Well‑being More than Tropical Recordings
Audio recordings of local temperate forests enhance short-term well-being and evoke stronger feelings of awe and restoration than sounds from distant tropical forests, regardless of actual animal diversity. soundscapes
Western Overturning Circulation Drops, AMOC Nears Critical Tipping Point
New study finds "canary in the coal mine" for the #AMOC: a consistent decline of the western overturning circulation, down from 20 to 15 Sv during 2004-2023 at 26° N. AMOC "could be at or near a critical tipping point, potentially...
Schizophrenia Linked to Barrier Dysfunction and AhR Modulators
Schizophrenia as a Disorder of Biological Barriers: A Narrative Review and Potential Interventions https://t.co/IEkOVzShh6 @IJMS_MDPI "AhR ligands relevant to neuropathology. Microbial and synthetic phenazines, pollutants, lipid peroxidation derivatives, and nutrients are AhR modulators..."👇
AI Redefines Scientific Discovery Beyond Speed
A new phase of scientific discovery is beginning. AI is enabling researchers to learn, reason and tackle complex biological challenges in ways that were previously not possible. This is more than acceleration. It is changing how discovery itself happens. https://t.co/yEh5pmDu5X @ConversationUS
Federal Scientists Celebrate Artemis II Success Amid Challenges
"Artemis II: Beleaguered federal scientists take a victory lap" by @chelseaeharvey for @EENewsUpdates /@politico: https://t.co/79kGMuySrj
Analyzing Causal Datasets to Uncover Disease and Aging Mechanisms
Now lets do this for the datasets that contain causal information on how diseases and aging work
China’s Solar Drone Redefines Strategic Infrastructure Power Shift
China just made one thing very clear: the future of strategic infrastructure will not be built only in space. It may also fly for months in the stratosphere, powered only by sunlight. That is why this matters. China has fielded a fully independent solar-powered...
Artemis II May Only Teach Us How to Explore Again
So what, exactly, is Artemis II's contribution to our knowledge of the Moon? Maybe it's just relearning how humans can explore. https://t.co/yslyyDUYUA
Aging Biology Targets Key to Better Stroke Outcomes
Targeting the Biology of Aging in Cerebrovascular Disease: Inflammation, Metabolism, Senescence, and Regeneration 🔎Addressing age-specific pathophysiology will be critical for improving outcomes in cerebrovascular diseases in the aging population... https://t.co/DuScTnSIh5 https://t.co/Irok29jqMx
Asia's Energy Path: Coal Return or Renewables Surge?
Will Asia return to coal, or will a new renewables future emerge from the Iran crisis? David Fickling and Akshat Rathi discuss https://t.co/PdxxKr6KZD
Regenerative Medicine Needs Data Over Hype
I recently had the opportunity to sit down with Scott Carney for a wide-ranging conversation on regenerative medicine, stem cells, peptides, and the growing gap between scientific promise and clinical reality. In the conversation, we dig into: – Why stem cell therapies...
Scientists Build Living Tree Powered by Algae and Sunlight
Scientists Create Living “Tree” Powered by Algae and Sunlight by @MrLaalpotato #EmergingTech #Technology #Innovation #Engineering #Automation https://t.co/fxeZBLRL7z
Engineered Bacteria Consume Tumor Core, Overcoming Drug Barriers
JUST IN: Scientists built bacteria that EATS cancer from the inside out. The future of cancer treatment isn't a drug. It's a living organism that devours tumors from the inside. Here's how it works: Solid tumors have a dead center. No oxygen. No...
SIRT6 Gene Therapy Remains Safe, Effective in Aged Beagles
Genflow sees sustained safety and efficacy in SIRT6 beagle trial 🐶 “Genflow Biosciences reported that three-month follow-up data from its SLAB trial in aged beagles show sustained safety and efficacy of its SIRT6 centenarian gene therapy, with no adverse events and...
Antarctica Mirrors Humanity’s Next Frontier in Space
This is an absolutely delightful article about Antarctica, with very deliberate insights into human exploration of space.
Statins for Seniors: Benefits vs Diabetes, Alzheimer Risks
Should older adults use statins for heart health? Do statins increase the risk of diabetes and Alzheimer's Disease? Dr. Gregory Charlop shares the results of an important new health study. www.buckheadlongevity.com/blog/should-older-adults-use-statins-a-top-atlanta-longevity-doctor-answers
Sodium‑ion Battery Creates Internal Heat Barrier, Preventing Fires
Chinese researchers develop sodium-ion battery design that forms internal heat barrier to stop thermal runaway reactions linked to battery fires. https://t.co/FkcIBp6aFj
New Trial Compares Dara‑Bor‑Dex vs Cy‑Bor
EAA241 - Ph 2 RCT Dara-Bor-Dex vs Cy-Bor-Dex in the treatment of Newly Diagnosed Multiple Myeloma with Light Chain Cast Nephropathy (LCCN) [Study activated 8/11/25] @keruakous https://t.co/1NgvVZ3fTA #NCT07085728 #mmsm @eaonc https://t.co/18HJ5kRuNj
Phase
#EAOnc EQUATE EAA181 Effective Quadruplet Utilization After Tx Evaluation: Ph3 RCT NDMM Not Intended for Early ASCT [Activated: 10/27/20] PI= @myelomaMD https://t.co/qD26HMx3J8 #NCT04566328 #mmMRD #mmsm @eaonc @mweissmdphd @VincentRK @LynneWagnerPhD Wei Snyder Kostakoglu @mtmdphd
Single Gene Therapy Dose Eradicates Brain Tumors in Mice
GENE THERAPY SAFELY ERADICATES BRAIN TUMOURS IN MICE A single dose of an innovative gene therapy could eliminate hard-to-treat brain tumours and prevent them from coming back, according to a pre-clinical trial in mice, reported in Nature. “More than 80 per cent...
Neuroscience Must Redefine Methods to Embrace Consciousness
How should neuroscience evolve if it is to take consciousness seriously? An engaging discussion between Professor Kevin Mitchell and Dr. Tevin Naidu. https://t.co/zkgtRYn0Wv
Dietary Amino Acid Restriction Shows Promise Against Pediatric Brain Cancer
Can rebooting the diet, eliminating 2 essential amino acids, help treat an aggressive brain cancer in children? mechanism and potential established from experimental model https://t.co/wmAFM2ErRB https://t.co/PAOr5SL30y
Urolithin A Enhances Mitochondrial Health and Endurance
I'm fascinated by Urolithin A. It's a compound that stimulates mitophagy (mitochondrial autophagy), helping clear out and replace damaged or dysfunctional mitochondria. Recent studies show that urolithin A improves endurance performance and even keeps immune cells "younger" with age. The data are early...
Nancy Prepares for Space Mission Exploring Dark Matter
I’ve been in a clean room all day with my friend Nancy here. She’s pretty cool and is about to go to space to explore dark matter and exoplanets this year. She’s Hubble’s cousin 🛰️ ✨ What have I missed...
Grifters Weaponize NASA Name While Vilifying Mainstream Science
I was tagged in a video that said 'NASA Scientist discovers new physics'. It should come as no surprise that there was no new physics and the guy was only loosely connected to scientific research at NASA. But what boggles...
Artemis 2 Updates: NASA, Canada Host Evening Conferences
Today, Apr 8: NASA's Artemis 2 Daily News Conf is at 5:00 pm ET. Canadian Space Agency will have one at 7:00 pm ET incl Prime Minister Carney. Then a crew media conf at 9:45 pm ET. The NASA...
Statins Cut Mortality for Over‑80s Without Added Risks
Should people over age 80 use statins? The answer is increasingly: YES. A recent study found that patients over 80 on statins had a one-third reduction in mortality. Perhaps more telling, people who stopped their statins appeared to have a 1/3...
Flu Shot Cuts Alzheimer’s Risk Up to 55%
💉 Want to reduce the risk of Alzheimer' by 55%? A simple flu shot at the dosage recommended by the CDC for those 65 and older should do the trick. With 165,000 people in the study, they also...
Synthetic Biology Platform Outpaces De‑extinction Hype
Most people hear “bring back the woolly mammoth” and say, “impossible.” Colossal might be considered a de-extinction company, but Ben Lamm is actually building a synthetic biology platform with consequences that could be much bigger than bringing back mammoths. -- $10B...
New Catalyst Quickly Builds Complex Molecules for Drug Discovery
A new catalytic method enables rapid, selective synthesis of branched molecules from simple, inexpensive reagents, streamlining early drug discovery and expanding access to complex molecular architectures. drugdiscovery
Microbiome Loss Triggers Intestinal Cells to Absorb Nutrients
Loss of gut microbiota increases a dual-function cell in the large intestine, shifting its role from mucus secretion to nutrient absorption and revealing adaptive changes in the intestinal barrier, especially with age. microbiome
Male Octopuses Safeguard Mating Arm, Avoid Risky Tasks
Male octopuses exhibit risk-averse behavior by protecting their third right arm, the hectocotylus, which is essential for mating, minimizing its use in risky situations to preserve reproductive capability. animalbehavior
Early Cancer Detection Saves Lives—Don’t Wait for Symptoms
When cancer is found early, the chances for a cure are dramatically higher. The controversial part: most people never look. Don't wait for symptoms.
Runners Carry Genes That Guard Against Soft‑Tissue Injuries
Born to run? Competitive runners have better genes for resistance to injury: "Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes." https://t.co/LRVb5hkLFx https://t.co/GroBFhSk2T
Eggs Pack Hundreds of Thousands of Mitochondria, Powering Life
Your heart cells have about 5,000 to 8,000 mitochondria each. Your muscle cells have about 1,000 to 2,000. Your eggs have over 100,000. Some estimates go as high as 600,000. Nothing else in your body comes close. That should tell you something about...
Disabling Light Sensing Extends Worm Lifespan by 40%
Great study in the bristleworm showing that light perception can regulate lifespan. Disrupting light sensing slows development, prolongs growth and extends lifespan by ~40%. More evidence that aging is not just damage accumulation, but is modulated by developmental processes.
Greater Optimism Linked to Reduced Dementia Risk
No cause and effect established, but the more optimism the less dementia in >9,000 individuals with up to 14 year follow-up https://t.co/8pTnuJ9XSF https://t.co/Lcg4uExYrO
Adaptive Coherence Framework Guides Smarter Microbiome Health
We can be smarter about our microbiome health by cueing into host interactions, an "adaptive coherence framework" @cellhostmicrobe https://t.co/mprFgV7Gjq https://t.co/rQiPeK2aJP
2024 NIA‑AA Definition Connects Biomarkers Directly to Care
The 2024 NIA-AA biological definition of Alzheimer’s disease: linking biomarkers to clinical practice https://t.co/00cP1mXXHR https://t.co/VQ59YeIUR1
Questioning the 98% Human‑Chimp DNA Claim
Did you see this?👇 Evolution vs. Evidence: Are We Really 98% Chimp? #science #chemistry #abiogenesis #evolution https://t.co/1KxmyjpHBz https://t.co/JHUbue8dRm
Genomics Predicts Individual Weight Loss From GLP‑1 Drugs
Genomics of GLP-1 drug response and side effects With genomic and demographic data it's possible to predict magnitude of weight loss response @23andMe https://t.co/iAS2Fjjxig https://t.co/AXsWnZw2Ub