Gushwork Bets on AI Search for Customer Leads — and Early Results Are Emerging
Gushwork, an India‑founded startup, closed a $9 million seed round that values it at $33 million post‑money. The company’s AI‑driven platform creates search‑optimized content, builds backlinks, and tracks leads to help businesses appear in AI‑powered search results such as ChatGPT and Gemini. Early traction includes over 300 paying customers, $1.5 million in annualized recurring revenue and month‑over‑month growth of 50‑80 percent. The firm aims to double ARR to $3‑3.5 million within the next quarter using the new capital.
BioLife Solutions Inc (BLFS) Q4 2025 Earnings Call Transcript
BioLife Solutions reported 2025 revenue of $96.2 million, a 29% year‑over‑year increase, driven largely by its biopreservation media (BPM) franchise which now represents 85% of total sales. Adjusted EBITDA rose to $25 million (26% margin) and the company posted adjusted net income...
This Compound Enhances Long-Term Memory of Mice — but only in Females
Researchers injected acetate, a common metabolic by‑product, into mice and tested long‑term memory using spatial and object‑recognition tasks. Female mice that received acetate showed significantly better performance 24 hours later, while male mice displayed little to no improvement. The memory...
Terawulf Inc (WULF) Q4 2025 Earnings Call Transcript
Terawulf Inc. reported a transformative 2025, shifting from Bitcoin mining to a power‑backed high‑performance computing (HPC) platform. Revenue rose 20% to $168.5 million, driven by $12.8 billion of credit‑enhanced HPC lease contracts and $6.5 billion of new financing. Adjusted HPC margin reached 77%...
AvePoint Inc (AVPT) Q4 2025 Earnings Call Transcript
AvePoint reported Q4 2025 revenue of $114.7 million, up 29% year‑over‑year, driven by SaaS revenue of $88.9 million representing 78% of total sales. Annual recurring revenue climbed to $416.8 million, with net new ARR of $26.8 million—a 48% increase and a record quarter. The...
D-Wave Quantum Inc (QBTS) Q4 2025 Earnings Call Transcript
D‑Wave Quantum reported fiscal 2025 revenue of $24.6 million, up 179% year‑over‑year, driven by $16.2 million in system sales and $5.5 million in QCaaS subscriptions. Bookings jumped 471% in Q4 to $13.4 million after a €10 million multiyear contract, while the sales pipeline expanded nearly...
Ecommerce: Your Ads Are Boring And Facebook Is Punishing You
In this episode of the Hammersley Brothers e‑commerce podcast, Mark and Ian dissect why many e‑commerce ads fail to scale, focusing on the concept that "your ads are boring." They explain that both Meta (Facebook) and Google act as "gorilla"...
Pacira Biosciences Inc (PCRX) Q4 2025 Earnings Call Transcript
Pacira BioSciences reported a record $726 million in total 2025 revenue and an all‑time high non‑GAAP gross margin of 80%, driven by growth in its flagship product EXPAREL. EXPAREL sales rose 7% year‑over‑year to $155.8 million, though the increase was partially offset...
PubMatic Inc (PUBM) Q4 2025 Earnings Call Transcript
PubMatic reported a 9% year‑over‑year revenue increase for 2024, with underlying Q4 growth of 16% after excluding a DSP‑related headwind and political ad boost. CTV surged to 20% of quarterly revenue, more than doubling its share, while adjusted EBITDA margin...
Akebia Therapeutics Inc (AKBA) Q4 2025 Earnings Call Transcript
Akebia Therapeutics reported 2025 total revenue of $236.2 million, a 47% increase driven by the commercial launch of Vafseo and higher Auryxia sales. Net product revenue reached $227 million, with Vafseo contributing $45.8 million and gaining prescribing access for 290,000 dialysis patients. The...
OPKO Health Inc (OPK) Q4 2025 Earnings Call Transcript
OPKO Health reported a $369 million cash position for Q4 2025, driven by asset sales, BARDA funding and partnership payments. The company repurchased 34.6 million shares for $47 million and allocated $109 million to stock and convertible note buybacks. Diagnostics revenue dropped to $71.1 million, but...
OrthoPediatrics Corp (KIDS) Q4 2025 Earnings Call Transcript
PolyPid announced successful completion of the Phase III SHIELD II trial, with D‑PLEX100 achieving its primary and key secondary endpoints and demonstrating a meaningful reduction in surgical site infections. The FDA provided written support for a rolling NDA review, and the company...
Synaptic Correlates of Benzodiazepine Tolerance
Recent pre‑clinical work has mapped the synaptic changes that underlie benzodiazepine tolerance. Chronic exposure uncouples GABA(A) receptors from their benzodiazepine binding site, down‑regulates α1‑subunit mRNA, and reshapes receptor trafficking through auxiliary proteins such as Shisa7. These alterations weaken inhibitory signalling,...
Delcath Systems Inc (DCTH) Q4 2025 Earnings Call Transcript
Delcath Systems reported record 2025 revenue of $85.2 million, driven by over 40% volume growth and 28 REMS‑certified treatment centers. Gross margins held at 85% for Q4 and 86% for the full year, while adjusted EBITDA turned positive to $25.1 million and...
How We Built a Distributed Work Scheduling System for Pulumi Cloud
Pulumi Cloud needed a unified scheduler to orchestrate deployments, Insights scans, and policy evaluations across both its own infrastructure and customer‑managed runners. The team built a database‑backed background activity system that treats each workflow as a typed, persistent activity with...
Anika Therapeutics Inc (ANIK) Q4 2025 Earnings Call Transcript
Anika Therapeutics reported total revenue of $27.8 million for the quarter, a 6% year‑over‑year decline driven primarily by lower pricing in its OEM osteoarthritis pain‑management channel. Commercial channel revenue rose 22% to $12 million, powered by a 25% surge in...
Personalis Inc (PSNL) Q4 2025 Earnings Call Transcript
Personalis reported a record $18.2 million Q4 2019 revenue, a 38% year‑over‑year increase, and full‑year revenue of $65.2 million, up 73% from 2018. The VA Million Veteran Program (MVP) remained the core revenue driver, contributing $43.5 million for the year and $13.8 million in...
MannKind Corp (MNKD) Q4 2025 Earnings Call Transcript
MannKind reported a record Q4 2024 with $77 million in revenue and a full‑year total of $286 million, a 43% increase year‑over‑year. Afrezza sales grew 17% to $64 million, and the company announced a pediatric filing for the inhaled insulin in the first...
Secure and Fast Deployments to Google Agent Engine with GitLab
The tutorial shows how to deploy a Google Agent Development Kit (ADK) AI agent to Google Cloud's Agent Engine using GitLab’s native Google Cloud integration and CI/CD pipelines. It walks through configuring IAM with Workload Identity Federation, creating a .gitlab-ci.yml...
Vipshop Holdings Ltd (VIPS) Q4 2025 Earnings Call Transcript
Vipshop Holdings reported Q4 2025 net revenue of RMB 21.4 billion, a 3.4% year‑over‑year increase, driven by an 11% rise in active Super VIP members who now account for 51% of online spend. Gross margin slipped to 23% as higher incentives pressured profitability,...
Cars.com Inc (CARS) Q4 2025 Earnings Call Transcript
Carvana reported a record 596,006 retail units sold in 2025, a 43% increase year‑over‑year, and Q4 revenue of $5.6 billion, up 58%. Adjusted EBITDA hit a new quarterly high of $511 million, while net income surged to $951 million, largely due to a...
Biodesix Inc (BDSX) Q4 2025 Earnings Call Transcript
Biodesix reported fourth‑quarter 2021 revenue of $7.2 million and total 2021 revenue of $54.5 million, a 20% year‑over‑year increase driven by strong growth in its core lung‑diagnostic portfolio. Core lung‑test sales jumped 49% to $18.7 million, while COVID‑19 testing revenue collapsed, lifting the...
A Nuclei-Specific Fronto-Amygdala Pathway and Its Neurotransmitter Receptor Distribution: Implications for Antidepressant Selection
Recent neuroimaging and tract‑tracing studies have identified a nuclei‑specific fronto‑amygdala pathway that links distinct amygdala subregions with ventromedial prefrontal cortex. The work maps serotonin, norepinephrine and dopamine receptor densities across these nuclei, revealing divergent pharmacological profiles for SSRIs and SNRIs....
DoubleVerify Holdings Inc (DV) Q4 2025 Earnings Call Transcript
DoubleVerify reported a 15% year‑over‑year revenue increase to $657 million in 2024, driven by double‑digit growth across measurement, activation and a 25% surge in supply‑side revenue. The company recorded a record $8.3 trillion in billable media transactions and delivered a 33% adjusted...
MDxHealth SA (MDXH) Q4 2025 Earnings Call Transcript
MDxHealth reported Q4 2025 revenue of $29.5 million, a 19% year‑over‑year increase, driven primarily by a 128% surge in liquid‑based test volume. Gross profit rose 20% to $18.7 million, while operating loss widened to $5.3 million and net loss expanded...
The Novel Role of GADD45A in the Etiology of Autism: Modulating Neuronal Excitability via TET1/R-Loop Dependent Regulation of KCNQ5
Researchers identified GADD45A as a hub gene dysregulated in both valproic acid‑induced and MECP2‑related autism models. Deleting Gadd45a in mice produced core autistic traits, heightened neuronal excitability, and seizures, while rescuing GADD45A in excitatory mPFC neurons restored normal social behavior....
Clear Channel Outdoor Holdings Inc (CCO) Q4 2025 Earnings Call Transcript
Clear Channel Outdoor reported fourth‑quarter 2020 revenue of $541 million, a 27% year‑over‑year decline, but showed sequential improvement in the Americas. The company added 74 digital billboards in Q4, bringing its U.S. digital inventory to over 1,400 screens, and expanded programmatic...
Mixture of Experts (MoEs) in Transformers
Mixture‑of‑Experts (MoE) Transformers replace dense feed‑forward layers with multiple lightweight experts, activating only a few per token to keep inference cost low while preserving the capacity of much larger models. The Hugging Face transformers library introduced a WeightConverter that merges and splits...
Organogenesis Holdings Inc (ORGO) Q4 2025 Earnings Call Transcript
Organogenesis Holdings posted a record fourth‑quarter 2025, delivering $225.1 million in net product revenue, a 78% year‑over‑year increase driven largely by an 83% surge in advanced wound‑care sales. Gross profit rose to 78% of revenue and GAAP operating income jumped 519%...
Endometrium-Targeted mRNA-Lipid Nanoparticles for Treating Reproductive Conditions
Researchers have engineered ligand‑conjugated mRNA‑lipid nanoparticles that home specifically to the endometrium, delivering therapeutic mRNA directly to uterine tissue. In a murine model of endometrial injury, the targeted formulation restored embryo implantation rates to near‑normal levels. Safety profiling showed reduced...
Definium Therapeutics Inc (DFTX) Q4 2025 Earnings Call Transcript
Definium Therapeutics reported that its lead psychedelic candidate DT120 ODT has fully enrolled the EMERGE Phase III trial for major depressive disorder, with top‑line results expected in late Q2 2026. The VOYAGE Phase III study for generalized anxiety disorder is...
Arbe Robotics Ltd (ARBE) Q4 2025 Earnings Call Transcript
Arbe Robotics reported Q4 2025 revenue of $300,000, a three‑fold increase year‑over‑year, while narrowing its operating loss to $11.5 million and maintaining a strong cash position of $52.6 million. The company highlighted progress toward four OEM design wins slated for the next...
Autodesk Inc (ADSK) Q4 2026 Earnings Call Transcript
Autodesk reported fiscal 2025 fourth‑quarter revenue up 12% year‑over‑year and billings rising 24%, surpassing the top end of its guidance despite foreign‑exchange headwinds. Margins improved, with GAAP operating margin reaching 22% and non‑GAAP margin 37%, while free cash flow hit...
BioCryst Pharmaceuticals Inc (BCRX) Q4 2025 Earnings Call Transcript
BioCryst Pharmaceuticals reported a 37% year‑over‑year rise in Orladeyo revenue to $159.1 million in Q3 and lifted its 2025 sales guidance to $590‑$600 million. The company completed the divestiture of its European business, repaid a $200 million term loan and entered Q3 with...
Streamline Your Network Operations with Red Hat Ansible Automation Platform and Cisco Meraki
Red Hat Ansible Automation Platform now integrates with Cisco Meraki through the Cisco Marketplace, delivering a unified, cloud‑based solution for network automation. The partnership enables rapid provisioning, configuration, and scaling of branch and edge devices while embedding audit, compliance, and security...
Deep Dive: How Linkerd-Destination Works in the Linkerd Service Mesh
The article dissects linkerd-destination, the core component of Linkerd’s control plane that drives service discovery, policy distribution, and service‑profile enforcement. It explains how the service uses Kubernetes watches and EndpointSlices to translate cluster events into real‑time gRPC streams for proxies....
Cytek Biosciences Inc (CTKB) Q4 2025 Earnings Call Transcript
Cytek Biosciences reported Q3 2025 revenue of $52.3 million, a modest 2% year‑over‑year increase driven by strong APAC growth and expanding recurring service and reagent streams. The company posted a net loss of $5.5 million and adjusted EBITDA of $2.5...
Coupang Inc (CPNG) Q4 2025 Earnings Call Transcript
Coupang reported record Q4 2023 results, with active customers reaching 21 million and a 16% year‑over‑year increase. Net revenue rose 23% to $6.6 billion, while free cash flow hit $1.8 billion and cash balances grew to $5.6 billion. Adjusted EBITDA for the quarter was...
Puma Biotechnology Inc (PBYI) Q4 2025 Earnings Call Transcript
Puma Biotechnology reported total 2025 revenue of $75.5 million, driven by $59.9 million net product revenue from its HER2‑positive breast cancer drug NERLYNX and a surge in royalty income to $15.6 million after a large shipment to a Chinese partner. Ex‑U.S. inventory rose...
Relay Therapeutics Inc (RLAY) Q4 2025 Earnings Call Transcript
Heron Therapeutics reported full‑year 2025 net product sales of $155 million and adjusted EBITDA of $14.7 million, surpassing its guidance. Acute Care drove growth, with ZYNRELEF revenue up 48% YoY and the franchise expanding 57% overall, helped by the CrossLink IGNITE incentive program,...
IQIYI Inc (IQ) Q4 2025 Earnings Call Transcript
iQIYI reported total revenue of RMB 6.7 billion for Q4 2025, a modest 1% sequential increase driven primarily by premium long‑form dramas and a 48% jump in distribution revenue from theatrical investments. Membership services rose 3% sequentially, while online advertising slipped 2% as...
D Market Elektronik Hizmetler Ve Ticaret AS (HEPS) Q4 2025 Earnings Call Transcript
Hepsiburada reported a 57% year‑on‑year increase in gross merchandise volume (GMV) and 63% revenue growth for Q2 2022 on an unadjusted basis, but inflation‑adjusted figures showed a 10% GMV decline and a 6% revenue dip. The company posted positive free cash...
Rackspace Technology Inc (RXT) Q4 2025 Earnings Call Transcript
Rackspace reported Q3 GAAP revenue of $671 million, a 1% sequential increase but a 1% year‑over‑year decline, beating the midpoint of its guidance. Non‑GAAP operating profit rose 17% sequentially to $32 million, while private‑cloud bookings grew 5% YoY, driven by major enterprise...
Castle Biosciences Inc (CSTL) Q4 2025 Earnings Call Transcript
Castle Biosciences reported $344.2 million revenue for 2025, beating its own guidance, and projected $340‑$350 million for 2026. Core test volumes surged, with TissueCypher reports up 86% to 39,014 and total reports reaching 105,053, while DecisionDx‑Melanoma grew modestly 9%. The company posted...
Baidu Inc (BIDU) Q4 2025 Earnings Call Transcript
Baidu posted a modest 2% year‑over‑year decline in Q4 total revenue to RMB 34.1 billion, while its AI‑focused businesses accelerated. AI Cloud revenue jumped 26% YoY to RMB 7.1 billion, driven by strong ERNIE API adoption that rose 178% quarter‑over‑quarter. Consumer products also performed...
Nautilus Biotechnology Inc (NAUT) Q4 2025 Earnings Call Transcript
Nautilus Biotechnology reported a 23% drop in operating expenses to $15.4 million for Q4 2025, driven by lower R&D and administrative costs, while ending the quarter with $156.1 million in cash and a reduced cash burn of $50.2 million. The...
Alerts Just Got Easier to Find – Here Are 6 to Set Up First
Fastly announced a unified notification drawer that consolidates observability alerts, service advisories and spend warnings into a single bell‑icon panel across the control‑panel UI. The new drawer shows only active alerts with key details and a one‑click link to the...
Vericel Corp (VCEL) Q4 2025 Earnings Call Transcript
Vericel Corp. reported record third‑quarter revenue of $67.5 million, driven by a 25% jump in MACI sales to $55.7 million and a 21% rise in burn‑care revenue. Margin expansion outpaced top‑line growth, with adjusted EBITDA climbing 70% to $17 million and gross profit...
Kymera Therapeutics Inc (KYMR) Q4 2025 Earnings Call Transcript
Kymera Therapeutics reported Q4 2025 revenue of $2.8 million, entirely from its Gilead collaboration, while maintaining a cash balance of $978.7 million that extends runway into the second half of 2028. Adjusted R&D and G&A expenses fell 7% and 3% quarter‑over‑quarter, respectively....
Asure Software Inc (ASUR) Q4 2025 Earnings Call Transcript
Asure Software reported Q3 2025 revenue of $36.3 million, a 24% year‑over‑year increase, driven by strong growth across payroll, benefits, recruiting and time‑and‑attendance solutions. Recurring revenue rose 11% to $31.8 million, while professional services and hardware revenue jumped to $4.4...