Accelerating Next Generation Medicine with New Drug Delivery Platform
Scientists at the University of Nottingham have unveiled a modular materials platform that self‑assembles with RNA to form nanoscale delivery particles. The system uses reversible host‑guest linkages, allowing rapid tuning of stability and behavior for diverse therapeutic needs. In pre‑clinical studies the RNA‑loaded nanoparticles matched or outperformed commercial transfection reagents, silencing cancer genes and protecting mice against H1N1 influenza. Automated manufacturing met critical quality attributes, indicating strong industrial scalability.
Founder-Product Fit: Solve Your Own Problem
I was building products nobody wanted, burning money on APIs, and watching SaaS after SaaS stall out. So yeah, not my finest chapter. And when you're stuck in that loop, you start asking different questions. The one that changed everything: "Am I solving MY...
Box Spreads: Low‑cost Synthetic Loans Explained
In recent years, a new form of 'synthetic' lending has emerged as a potential alternative to margin loans or SBLOCs for short- and medium-term borrowing: The "box spread". https://t.co/xmNXcFkoUQ Kitces Nerd Ben Henry-Moreland shares the mechanics of box spreads, why the...
Spain Arrests Suspected Hacktivists for DDoSing Govt Sites
Spanish Civil Guard arrested four alleged members of the hacktivist group Anonymous Fénix, accused of orchestrating DDoS attacks on government ministries, political parties, and public institutions in Spain and South America. The campaign intensified after the October 2024 Valencia floods, with...
Three AI Glasses Tiers: Ultra-Light, Middle, Heavyweight Picks
I did a live stream over on LinkedIn this morning on another show and saw @auradeluxe asked me what my latest thinking on AI-driven glasses are. For me, it splits up into three different categories: 1. Ultra-lightweights Where...
Petition: SAVE NASA’s GENELAB
NASA’s Biological and Physical Sciences Directorate plans to reduce funding for the Open Science Data Repository (OSDR) and GeneLab, including the Sample Processing Laboratory (SPL), starting in 2025. OSDR currently houses nearly 600 studies, 1,000 datasets across 45 species, and...
Optus Launches ‘Pride Blooms From Yes’ For Mardi Gras 2026 Via Apparent
Optus has unveiled its ‘Pride blooms from Yes’ campaign, marking the telecom’s fifth year supporting the Sydney Gay and Lesbian Mardi Gras 2026. Developed by creative agency Apparent, the platform features a video series that spotlights personal moments from Optus’s...
State Bill Could End Tax Break for Large Digital Lenders
Washington State’s House Bill 2089 seeks to restore dwindling wildfire‑prevention funding by revoking a tax deduction that currently benefits large digital mortgage lenders. The deduction, originally crafted for community banks, generated $91.6 million in savings in 2024, with 65 % captured by...
AWS Quantum Technologies Releases Qiskit-Braket Provider v0.11, Now Compatible with Qiskit 2.0
AWS Quantum Technologies launched Qiskit‑Braket provider version 0.11, adding BraketEstimator and BraketSampler primitives and full support for Qiskit 2.0 while retaining backward compatibility to v0.34.2. The update introduces a versatile `to_braket` function that compiles circuits from Qiskit, OpenQASM 3, and native Braket inputs...
Woolworths Senior Media Manager Joins Comcast’s FreeWheel
Comcast’s FreeWheel has hired Woolworths senior media manager Alan Jenner as Director of Platform Partnerships for Australia and New Zealand. Jenner spent nearly five years leading programmatic at Woolworths and previously held senior roles at LiveRamp, Comscore, Optus and Telstra. FreeWheel,...
Prime-Edited Therapy Restores Immune Function in Teen
Below is the story of the first patient treated with a prime-edited therapeutic, developed by @PrimeMedicine in a trial led by Dr. Élie Haddad and his team at CHU Sainte-Justine. This teenager suffered from chronic granulomatous disease (CGD), an immunodeficiency,...
Laser Shockwaves Transform Carbon Nanotube Films Into Graphene-Rich Networks without External Heating
Researchers have demonstrated that nanosecond laser‑induced shockwaves can transform single‑walled carbon nanotube (SWCNT) thin films into multilayer graphene‑rich networks in a single, chemical‑free step. The process applies ~2.27 GPa pressure pulses without external heating, causing the nanotubes to unzip and coalesce...
Chinese Ship Completes First Autonomous Docking and Cargo Handling
Four years after launching the world’s first autonomous electric feeder, China’s 300‑TEU vessel Zhi Fei completed its first fully autonomous docking at Qingdao Port, completing the maneuver in just 30 seconds. The ship, capable of crew‑managed, remote‑controlled or unmanned navigation, operates...
Ultrafast X-Rays Reveal Physical Principles Behind Lipoprotein Motion Within Egg Yolk Plasma
An international team employed megahertz X‑ray photon correlation spectroscopy at the European XFEL to record low‑density lipoprotein (LDL) motion inside egg yolk plasma on microsecond timescales. They found LDLs become temporarily caged by neighboring particles and proteins, slowing diffusion up...
KPGZ Captures Kearney Championship Run With Comrex
102.7 KPGZ in Kearney, Missouri leveraged Comrex’s FieldLink sideline reporter codec to enhance its live coverage of the Bulldogs’ high‑school football playoff run. The FieldLink system, which uses the free FieldTap app on iOS and Android smartphones, provided crisp, wireless...
Before We Predict The End Of Lawyers, Let’s Take A Deep Breath
Generative AI is being touted as a productivity breakthrough for law firms, but the author argues it may actually increase workload. Drawing on the Solow paradox, the piece suggests that more information leads to more analysis, verification, and billable hours...
Before We Predict The End Of Lawyers, Let’s Take A Deep Breath
Stephen Embry argues that generative AI, while touted as a productivity miracle for law firms, may actually generate more work rather than reduce it. He frames this counter‑intuitive outcome with the Solow paradox, which observes that new technologies often raise...
How Interior Designers Build a Shopify Store That Captures Product Revenue From Day One
Interior designers with sizable followings can turn their influence into direct e‑commerce revenue by launching a Shopify store that combines service bookings, curated dropship products, and content publishing. The model promises 20‑35% of annual income from product sales and bookings,...
Newcastle Leading the Way with DA
The City of Newcastle council introduced an Accelerated Development Applications (ADA) framework that has halved development‑application processing times, bringing the average turnaround to under ten days. Since its 2022 launch, more than 1,300 applications across ten development categories have been...
Keller Williams Opens Command as Investor Ties Deepen
Keller Williams unveiled an open, integration‑driven version of its Command platform, aligning with Stone Point Capital’s portfolio firms and introducing the Command Launchpad API framework. The move brings third‑party AI tools such as Cotality, Lone Wolf, and Rejig.ai into a...
How GPs and LPs View AI Disruption: Thoma Bravo’s Holden Spaht and New York’s Anastasia Titarchuk
At the PEI Group’s NEXUS 2026 summit, Thoma Bravo partner Holden Spaht and New York‑based LP specialist Anastasia Titarchuk discussed how artificial‑intelligence disruption is reshaping private‑equity dynamics. Both highlighted accelerating deal flow in AI‑enabled software and the need for deeper technical diligence....
Ottonomy Unveils Platform Connecting Robots, Drones and Smart Infrastructure on NVIDIA
Ottonomy unveiled Ottumn.AI, a cloud‑based platform that orchestrates autonomous robots, drones, and smart infrastructure across healthcare, manufacturing, and commerce. The solution runs on NVIDIA AI hardware, leveraging Jetson edge devices, Isaac Sim digital twins, and cloud GPUs for sub‑30 ms decision...
Hair-Width LEDs Could Replace Lasers
Researchers at UC Santa Barbara have demonstrated hair‑thin microLEDs that outperform conventional designs in efficiency, output power, and beam control. By enclosing the InGaN/GaN emitting region with distributed Bragg reflectors, the devices deliver 20% more air‑side light, over 130% more...
Google Discover Update: Early Data Shows Fewer Domains In US via @Sejournal, @MattGSouthern
NewzDash’s early analysis of Google’s February 2026 Discover core update shows a shift toward locally relevant, in‑depth content and a drop in click‑bait style items. In California, local articles in the top 100 rose from 10 to 16, while Yahoo’s presence fell...
Why Amazon Sellers Need a Specialized Agency After $500K in Revenue
Amazon sellers reaching $300K‑$500K in monthly revenue encounter a structural shift in operational complexity that outpaces a lean, generalist model. Managing dozens of ASINs, multi‑marketplace listings, and five‑figure ad budgets requires specialized expertise across PPC, SEO, content, and inventory. The...
New AI Agent Logs Directly Into College Platform Canvas to Do Your Homework for You
Companion.AI unveiled "Einstein," an autonomous AI agent that logs into Canvas, watches lectures, writes essays, participates in discussions and submits assignments on a student’s behalf. The startup markets the tool as a full virtual computer that can perform any browser‑based...
This One Feature Helped Me Turn My Meta AI Glasses Into a Garmin for Video Workouts
Meta’s AI glasses can now overlay fitness data from Strava onto recorded workout videos, thanks to a new app integration. Users must launch the workout from the Strava app, preferably on a Wear OS watch, to capture heart‑rate and other metrics....
Why Connecting AI Everywhere Fails, Embrace Autonomous Agents
Built an MCP server recently? Did developers actually use it, or is it collecting dust? 😵 I'll be speaking at @theleaddev London (June 1-2) about why "connecting AI to everything" doesn't work and what actually does when building tools that...
Sony Has Big PS5 Deals on PlayStation Direct and PlayStation Store
Sony Interactive Entertainment is offering deep discounts across its PlayStation ecosystem, targeting both physical and digital PS5 games, accessories, and the PSVR2 headset. Prices on flagship titles such as God of War Ragnarök and Marvel’s Spider‑Man 2 have dropped to $19.99‑$29.99, while...
Electrochemical Signals Can Reshape Bacterial Protein Patterns, Boosting Electron Transfer
Cornell researchers discovered that the inner‑membrane protein CymA in Shewanella oneidensis can self‑assemble into a biomolecular condensate, a behavior previously unseen in electroactive bacteria. By applying an external electrochemical signal, they induced the condensate, reorganizing CymA and its electron‑transfer partners...
SEO Agency's AI Hype Hides Paid Self‑promotion Tactics
Another SEO agency that claims to be a great partner to lead clients into the AI search era This one not only uses self-promoting listicles, but clearly pays to be listed on everyone else's "best of" listicles too I'd be a bit...
New Brand Boosts Profitability, Prepares March Scale
First month on with a new brand - already improving profitability overall and looking to scale moving into March. New Offer + New account Strategy. Next week we launch first round of UGC we curated and first large batch of ad creative....
Commercial Real Estate Lease Analysis Tool (Updated Feb 2026)
A new Commercial Real Estate Lease Analysis Tool has been released, offering landlords, tenant‑rep brokers, and prospective buyers a structured Excel model to abstract lease terms and forecast cash flows. The tool features three core worksheets—Lease Abstract, Lease CF, and...
Anthropic Fined Billions for Massive Training Data Theft
Anthropic is guilty of stealing training data at massive scale and has had to pay multi-billion dollar settlements for their theft. This is just a fact.
Big $400M Firm Forgets Favicon, Obvious SEO Slip
$400M software company. No favicon in the SERPs. Took me 3 seconds to find the problem. 🤣🤦♂️ https://t.co/KAHXJpjGXY
Animal Crossing Watches Capsule Toys Appear in Japan
Takara Tomy announced a new Animal Crossing: New Horizons watch capsule toy set, rolling out in Japanese gashapon machines this week. Each pull costs 400 yen (≈$2.60) and yields one of five digital watches themed after iconic NPCs. The watches feature...
AI Surge Makes Software Competition Easier, Threatening Companies
“I’m more bullish on AI than I’ve ever been. And that’s exactly why I’m bearish on most software companies. Not because their customers will leave, but because their next thirty competitors just got a lot easier to build.”
Old AI Giant Falls as Young Startup Takes Over
IBM, a 115-year-old company, pioneered AI with Watson a decade ago. Today, a 3-year-old startup (Anthropic) just wiped $28 billion off IBM’s market cap. Mercy is for the weak.
India’s Carbon Capture Moment Has Arrived
India’s 2026‑27 Union Budget earmarked roughly $2.4 billion (₹20,000 crore) for a national carbon capture, utilisation and storage (CCUS) programme targeting steel, cement and other heavy‑industry emitters. The funding marks a shift from research‑only projects to a full‑scale industrial strategy, driven by...
AI's Task-Specific Skills Don't Equal General Intelligence
The field of AI is still struggling with the fact that task-specific skill is not the same as general intelligence
BESS Bankability Shifts to Operational Performance in 2026
Redefining BESS bankability in 2026: from installed capacity to operational performance #energysky -- via Energy Storage News: https://t.co/oeWGFHHUsy
Embedding AI: The Next Step
Generative AI is transitioning from experimental projects to core business workflows. Companies are now emphasizing data readiness, robust governance, and quantifiable productivity improvements rather than lofty automation promises. This shift reflects a pragmatic approach to AI adoption, focusing on measurable...
OpenAI Teams Up With Consulting Firms for Enterprise AI
🚨 ANALYST TAKE: OpenAI just partnered with the very management consulting firms AI is supposed to replace. Here’s why this is NOT really a contradiction. It’s actually one of the key endgames of enterprise AI. Thread 🧵👇 https://t.co/wTKfR4kW6t
Google Commits Major AI Investment for Teachers
Exclusive: New Google Partnership a ‘Sizable Investment’ in AI for Teachers - my latest for @The74 (link in first comment) https://t.co/lQsA79rTiH
How CBA Unlocked 90 Percent of Its Customer and Transaction Data
Commonwealth Bank completed a migration from an on‑premises SAP R/3 mainframe to an SAP S/4 HANA core hosted on AWS in October 2023. The new in‑memory architecture cut infrastructure costs by 30% and boosted processing performance by the same margin,...
AI Is Redefining How We Build Software
The first recording from The Pragmatic Summit is available to watch for anyone: How AI is Reshaping the Craft of Building Software. With @thsottiaux (Head of Codex, OpenAI) and @vijayeraji (CTO of Applications, OpenAI) A very good one. Watch it here: https://t.co/apNHGykKbg...
Google’s AI Detection Triggers Ongoing Traffic Drops
Wow, the Jan 21 unconfirmed update was a bloodbath, and impacted sites are still dropping to this day This is another one in the marketing space; lots of AI-assisted content, self-promotional listicles, who/what/when content, etc. I think Google is getting better at...
AI and Real Estate Data: Who’s Making the Rules?
The real‑estate industry is racing to set data rules before AI triggers another wave of litigation. California has enacted a law requiring agents to disclose AI‑altered listing photos, prompting brokerages to add similar language to agreements. MLS providers are revising...
Most Heated Steering Wheels Have A Strange Quirk That Annoys Some Drivers
Heated steering wheels are a popular comfort feature in modern vehicles. Recent observations reveal a temperature imbalance in the 2023‑2026 Toyota Tundra, where one side of the wheel stays cold while the opposite side heats above 114 °F. Thermal‑imaging evidence shared...
The Specific Results From the B2B SaaS Growth Program That Just Finished
The B2B SaaS Growth Program transformed a cohort of founders from ad‑hoc experiments into a coordinated growth engine within sixteen weeks. Participants built ABM lead lists, AI‑personalized outbound sequences, matched‑audience and retargeting ads, and began weekly tracking of CPL and...
