Sex Differences Crucial for Glucagon Obesity Drug Efficacy
Male and female bodies respond differently to glucagon-based obesity drugs, and FGF21 plays an important role—especially in females. This means future treatments need to account for sex differences to be effective and safe. https://t.co/Z9gllk02Dj
Cloud‑run OpenClaw Offers Secure, Affordable Alternative
Alex Finn, @AlexFinn, says OpenClaw running on the cloud is a scam: https://t.co/mGrteVR3oq While he is right in a perfect world that everyone would have it running on a local computer, there are many who don’t want to do that,...
Claude Opus 4.7 Available, Direct Upgrade Costs More Tokens
.@Anthropic launches Claude Opus 4.7, migration advice https://t.co/5V88wwwCvp Anthropic said Claude Opus 4.7 is generally available, but the direct upgrade from Opus 4.6 may burn more tokens.

Exynos 2600 Beats Snapdragon 8 Elite Gen 5 by 20fps
Exynos 2600 once again outperforms the Snapdragon 8 Elite Gen 5 in gaming Achieving 102fps, over 20fps more than the 8 Elite Gen 5, is an incredible result From @ luancastro_lc on X
BESS Attractiveness for M&A Explored at Energy Summit
VIDEO – Energy Storage Summit 2026: How attractive is BESS for M&A? #energysky -- via Energy Storage News: https://t.co/AAtsgcK6vP
Chinese Astronauts Conduct 5‑hour Spacewalk on April 16
Astronauts Zhang L. and Wu F. made a spacewalk from the Chinese Space Station on Apr 16 from about 1206 UTC to 1736 UTC
Hybrid Cloud Essential for Deploying AI Agents at Scale
Why hybrid cloud? More CIOs look to bring AI Agents to production; they'll need to consider where to run AI inference. #CIO #AI #Cloud https://t.co/v3MPhHTyuw
AI Succeeds when It’s for You, Not Happening to You
The difference between feeling AI is happening to you instead of FOR YOU is success and failure. https://t.co/IgznkMNkMF

Snapdragon X2 Could Thin Surface Laptop Studio Design
Surface Laptop Studio with Snapdragon X2 Elite Extreme would be a dream come true At the same time, it would allow this design to be more feasible thanks to not needing as much cooling, maybe even eliminating the stacked base in...
Rebuild Your Campaigns for Immediate Performance Boost
So spend yesterday rebuilding a lot of our campaigns and oddly today is popping. Some of the best numbers since last week. If you're still seeing bad performance today as you have all week I suggest trying this in your campaigns.

State Threatens to Intervene over EV Charging Tariffs
State to “step in” if regulator and network fail to remove EV charging “handbrakes and sort out tariffs #energysky -- via Renew Economy: https://t.co/TnXmAWWV3C https://t.co/qdFWboEvmI

Allbirds' $50M AI Data Centre Can Power Seven Chatbots
SCOOP: Leaked photo of the first AI compute data centre that Allbirds built with its recent $50m investment. Insiders say that the rack has enough capacity to provide tokens for 7 AI chatbot users. https://t.co/eWfoeVYWCq

STAT's Live AACR Coverage: Newsletter, Event, Recap
A heads up: starting Sunday, and through the beginning of next week, STAT is going to be taking the annual meeting of the American Association of Cancer Research by storm. This is one of the best venues for spotting new ideas...

Six New Production-Ready AI Marketing Tools Open‑Source
We just open-sourced 6 more production AI marketing skills to our big AI business skills repo (1.9k stars) Total count: 17 skill categories, 32K lines of code, all MIT licensed. New additions: → Video Clip Pipeline: 60-min episode to 5 clips in 15...
Hold DM Icon to Instantly Copy Link on Threads
Threads has a small new feature: hold the paper plane icon dm and the link copies instantly.

Claude Self‑diagnoses Its Own Tool Error, Hinting at Autonomous AI
This is quite fascinating. Claude gave me 3 options A, B, and C for a possible approach and left A completely blank. It states below the blank "The tool rendered one. Here are the two other strategic angles to choose...

Lennybot Now Lives Inside Substack, Ready for Queries
New: Lennybot now lives natively within my Substack. Trained on all of my ~350 newsletter posts and ~300 podcast interviews. Check it out, ask it a question: https://t.co/3DzeiuQpl6 You can also text or call him anytime: +1 (877) 537-9455 https://t.co/DT4mtt7gtH
AI‑Powered ERP Guarantees Audit Trails for Regulated Finance
ERP systems with AI agents offer a clear audit trail, making them ideal for regulated industries like financial services. This predictability can be more reassuring than standalone AI. #AI #ERP #RegTech https://t.co/5CDZxYsjfj

AI Tweets Miss My Voice, but Embrace Absurdity
I asked Opus 4.7 to come up with 10 tweets in my voice. And they sound nothing like me. But some of them have a kind of bizarre or absurd quality that I kind of like https://t.co/PcZyz7DCVK
AI Coding Alone Can Lead to Costly Mistakes
I messed up... maybe letting AI do all our coding isn't a great idea https://t.co/becnMOkZkV
A Tiny Elite Sees AGI; Rest See Hallucinations
Incredible…. The 2% of people using these tools are experiencing AGI, and the other 98% belief AI is a ChatGPT 3.5 result filled with hallucinations One month is seven months of progress right now There is no precedent for what we...
Canva Forces AI; Optional Use Should Remain
Canva won't make you use its new AI https://t.co/nvHtdWaBrF < it's probably blasphemy for me to say (and I'll check to see if my badge works tomorrow), but using AI should be *an* option, not the *only* one, in your...
NASA Denies Non‑Polar Artemis IV Landing Rumors
FYI I've been hearing murmurings that NASA is seriously considering a non-polar landing for Artemis IV. @SpcPlcyOnline also had an intriguing story about a month ago (linked below). Anyway, I asked NASA about it this week and got a firm...
AI Accelerates Attention‑Span Collapse Beyond Social Media
I think AI is gonna kill attention spans wayyy more than social media supposedly has. It’s instant gratification within search. The idea of slow learning & patience are over.
New Tech Cuts Silver Use in TOPCon Cells Tenfold
New tech reduces silver use in TOPCon solar cells by a factor of 10 #energysky -- via pv magazine global: https://t.co/bWZdpaj0ge

AI Agents Prioritize Data-Driven Vendor Criteria over Brand Legacy
If an AI Agent doesn't care about legacy brands or emotional storytelling, what specific parameters does it evaluate when shortlisting vendors https://t.co/YV3RT3pqcl @DLAIgnite #SocialSelling #DigitalSelling #Leadership #ArtificialIntelligence #Marketing #MarketingSuccess #MarketingStrategy #Branding
AI Fails without Data Quality and Business Context
Most companies think they have one AI data problem. They actually have two: Data quality (clean, accessible, governed) Business context (what the data means) Fixing #1 without #2 leads to AI that is fast—but wrong. That’s the gap most teams are missing. More: https://t.co/GmvEnNXPrb

Rivian R2 Brings Clean, Fun Electric Driving to Colorado
Sneak peek 👀 at Rivian’s (@rivianofficial) new R2. We are proud that Coloradans have a variety of options for going electric - a fun, quiet, clean way to get around while cutting pollution. This addition is great news for Colorado families...

257K Views Per Clip
TBPN's 257K views per clip turned their ad business from $5M to $30M in a single year. I dive into what I call "The Clip Economy" in my latest newsletter: bit.ly/ClipEconomy

AGI Won’t Replace Most Jobs, Says Yale Economist
A Yale economist says AGI won’t automate most jobs—because they’re not worth the trouble https://t.co/no1ySx10mU #ArtificialIntelligence #Innovation #Technology #Tech #TechNews https://t.co/3zYHUNgVwh
France Leads Approval of IV Ketamine for Suicidal Crises
Scientists test if ketamine has antidepressant effects under anesthesia; France is the first to approve IV ketamine for severe suicidal crisis https://t.co/s7W7YlAOMr

Opus 4.7 Excels at Visual Design Transformations
Opus 4.7 has a STRONG affinity for certain design aesthetics. Left - Claude Design creating a slide preso for me. Right - Claude Code redesigning my homepage. https://t.co/qrvVX118Iq

How to Remove Unnecessary AI Watermarks From Images
While it's good to be able to differentiate AI-created photographs from real photos, there are many images that don't need the AI mark. Here's how to remove it, as needed, and how it all works behind the scenes: https://t.co/m8yBJd6MVt #ai...
Casual Contributors Rely on AI, Skip Safety; Maintainers Double‑check
Does this research surprise you? Casual codebase contributors use AI agents to do the heavy lifting (and skip safety checks more often) while core maintainers use agents to take on toil, while still double-checking work themselves. https://t.co/VQUivyGjju
UCB to Acquire Neurona for $1.2B, Targeting Seizure Cell Therapy
UCB, betting on seizure cell therapy, to buy Neurona for up to $1.2B https://t.co/LxI1Omodan by @realJacobBell $UCB
CZ-4C Launches Daqi-2 Atmospheric Satellite From Jiuquan
LAUNCH at 0410 UTC Apr 17 of a CZ-4C from Jiuquan with the Daqi-2 atmospheric research satellite
US Visibility Shifts Reveal March 2026 Core Update Trends
Google March 2026 Core Update Visibility Shifts & Patterns In the US - International SEO Consultant, Author & Speaker | Aleyda Solis https://buff.ly/zC9McSD
Tools Are Easy; Business‑focused Risk Understanding Is Hard
The more time I spend in security, the more I believe tools are the easy part. Understanding risk in a way the business cares about and then acting on it is where most teams struggle.
Let AI Do the Research, Unleash X API Superpower
Best advice: do your own homework. Even better advice? Have your AI read all of X and do the homework for you. I did and the X API with AI is a super power.

One Week Later: Artemis II’s Purpose and Legacy
A week since splashdown and I’m thinking a lot about the motivations and legacy of Artemis II…
Build a Neighborhood Storm‑Overlay App in Minutes
If you want to watch the weather, I have a list for you: https://t.co/VJ80K1PTy0 Put it into @Pokee_AI (or your favorite AI agent that has access to the X API) and build an app to lay the storms over your neighborhood....
Team Pauses Swift BAT Observations to Save Power
Noteworthy: “On April 7, the team also halted observations by Swift’s Burst Alert Telescope to reduce power consumption.”
OpenAI and InSilicoMeds Partnership Promises Significant Growth
A collaboration between @OpenAI and @InSilicoMeds has great upward potential. Would you be open to exploring this @sama ?

AI Design Tools Force Agencies to Sell Expertise, Not Output
Every agency founder’s quiet fear is that AI will make their business obsolete in six months. That’s not true. It's much worse than that. Six months was last week’s timeline. This morning, Anthropic released Claude Design, a tool that turns a sentence into...

Robotics Streamline Warehouse Automation for Faster Operations
How to #Automate Your #Warehouse with #Robotics by @antgrasso #Robots #RPA #ArtificialIntelligence #Innovation #Technology https://t.co/LYCHsW7agp
Future AI Wins by Seeing, Not Just Talking
Most AI today can read, write, and talk, but struggles to reliably understand the real world through vision. The next wave of winning AI will come from systems that can see, interpret, and act in real environments, not just generate...
LLMs Require Fat Skills, Not Solo Effort
Logical fallacy: Kyle Kingsbury assumes the LLM must do all the work alone naked No dude, that is what fat skills (markdown that tells the model how to do it like a human would) and fat code (literally deterministic Turing machines)...
Self‑Driving Tech Will Define Trucking Competitiveness in Five Years
Big flex from @chris_urmson, ceo of @aurora_inno onstage at @humanxco last week discussing how the self-driving truck co is going from R&D to profitable business. "Within five years, if you're not using our technology, I expect you won't be competitive...

Decade Reset: New Social Selling Rules for 2026
The Decade Reset: Why we Rewrote the Social Selling Rules for 2026 by @Timothy_Hughes https://t.co/aRvIFwO3qi @DLAIgnite #SocialSelling #DigitalSelling #Sales #SalesTips #SalesLeader #Salesforce #Marketing #Leadership #MarketingStrategy #MarketingSuccess https://t.co/gGMyaSde0i
Gemini 3.1 Flash TTS Sparks Realistic AI Voice Boom
These Gemini 3.1 Flash TTS demos I've seen floating around are so darn awesome. @glaforge built a cool one with our Gemini Interactions SDK for Java. Are we about to see an explosion in realistic AI voices? https://t.co/RFLF4TyuoU