Claude + Excel Eliminates Need for Quickbooks
Holy crap we literally don't need Quickbooks anymore because of what happens when you combine Claude and Excel
Share Your Health Data Instantly, No More Paper Forms
pumped for @flexpa. flexpa ensures you never have to fill out another clipboard at a doctor's office again. it's your health data, and now you can share it with any application you want in a few clicks or with just...
Deepfake Reagan Highlights Need for Human Verification
At a Tools for Humanity (ie Sam Altman’s eye-scanning orb company) event in SF this morning where they are announcing a bunch of upgrades to their “proof of human” identity service World ID. The event opened with a video of...
Agents Accelerate Work, Scheduling PRs Prevents Overload
My coworkers are moving at human speed. I'm using agents to run ahead and do next week's work in branches. Then I'll schedule PRs to drip out at a regular pace so I don't overwhelm the process. This...
Xbox Mode Arrives in Windows 11 Release Preview
Microsoft’s Xbox mode is now rolling out to Windows 11 Release Preview, so not long until everyone gets it https://t.co/tqVkRwFRFr
Global Rocket Race Accelerates with New Tests and Launches
In this week's rocket report: • Starship V3 test-fired in Texas • Blue Origin gets new launch pad at Vandenberg • Third New Glenn launch on tap this weekend • Europe's tentative step toward crew launch • China nears debut of another reusable rocket https://t.co/mGrHsnxzOC
Cincinnati Converts Former Landfill Into Solar Power Hub
Cincinnati to turn an old landfill site into a solar power producer #energysky -- via Solar Power World: https://t.co/Hq0P5iTdG3
AI Becomes the Ultimate AI Operations Whisperer
AI is better than you at working with AI. It's better at generating prompts for AI, teaching skills to other AI agents, coordinating messaging between AIs. AI is an AI ops whisperer. Think like a PM: go through the journey...
AI on PC Cuts Energy Use by 80%
Tech Breakthrough: Running AI on Your Computer Uses 80% Less Energy Startup Refiant AI's new algorithm = major benefits for energy and water use, data sovereignty, and privacy. Interview w/co-founder Mathew Haswell. #AI #ArtificialIntelligence https://youtu.be/NE9gm7ww3Ww
China's Robotic Beasts Blend Engineering with Imagination
Engineering Meets Imagination: China’s #Robotic Beasts Take Shape by @China_Fact #Robotics #MachineLearning #ArtificialIntelligence #ML https://t.co/wgddqXvbDj
AI Redefines TSMC’s Capacity and Global Strategy
In other words, TSMC is no longer dealing with a normal semiconductor cycle. It is dealing with a structural reallocation of capacity. AI is reshaping the logic of semiconductor capital spending, extending the lifecycle of leading-edge process nodes, and even changing...
Anker Solix Unveils 7 kWh Plug‑In Battery for Rooftop Solar
Anker Solix launches 7 kWh plug-in battery targeting rooftop solar retrofits #energysky -- via pv magazine global: https://t.co/Pd8whB8AAq
User Claims Opus 4.7 Sounds Condescending, Demands Fairness
Opus 4.7 is the first model that feels like it is openly condescending towards me, as the customer with certain prompts. Whatever Anthropic did: I don't like it. If the model is condescending: I shouldn't be paying you to use it;...
AI Threatens Tech Moats, Future Cashflow Valuations Collapse
If AI lives up to the hype, it will erode the traditional long term moats of technology companies. As a result, no one with a brain wants to pay for cashflows far in the future. These multiples cannot come back unless...
Demanding 1,200 Benchmark Test Before Claiming SOTA
Until they test it in @InSilicoMeds benchmarks (1,200 benchmarks), I will not believe that this is anywhere close to SOTA. Let's benchmark it folks. Whoever has access and would like to benchmark - let's collaborate
Orion Reentry Hints at Unreleased Public Disclosure
On Orion’s reentry: “And then there was a point—there’s something that I feel that I am not ready to say to the public yet.” https://t.co/HGK65yHVNJ
Open‑weight AI Keeps Competition Alive, Prevents Monopoly
It's incredibly hard to stop open weight AI developers from distilling knowledge out of frontier models. Another reason to believe AI will remain hyper-competitive and not monopolized. Economics from @dwarkesh_sp newsletter this morning. https://t.co/KKocBrLgNs https://t.co/swXubgHvbM
JNJ's HLD-0117 Enters Phase 1, Target Unreve
Second $JNJ ex-Halda "riptac", HLD-0117, goes into phase 1. Previously only known as "breast cancer riptac", target still undisclosed https://t.co/aJRe55AgYH
Upload Updated Contract, AI Amends It Instantly
Renegotiated a contract? In JustPaid, upload the updated version to amend it in seconds AI handles the rest. https://t.co/Fl423xNbMo
House Science Committee Schedules NASA FY2027 Budget Hearing
House SS&T will hold a hearing on NASA's FY2027 budget request on Wednesday, Apr 22, at 10:00 am ET, with Isaacman.
Scaling Bio‑Products: Funding, Forecasting, and Partnerships
Getting from pilot plant to commercial scale is where most bio-based products die. The science works. The economics don't. Or the capital isn't there. Or the supply chain can't handle the volume. This session at @SynBioBeta 2026 brings together people who've actually...
Leverage Competitor Success to Win New Prospects
Want instant credibility with a new prospect? Don't talk about yourself. Talk about their competitor. "We helped [similar company] solve [exact problem you suspect they have]." Now they're leaning in. Not because of you. Because of the fear of falling behind.
Seeking Beta Testers for New Robotics Dataset Hosting
Looking for some beta testers for our new robotics dataset hosting features. Who's currently hosting large robotics datasets and would be down to try? 🤖🤖🤖
Colorado Invests $12.4M to Scale Campus Geothermal
$12.4M invested to expand geothermal in Colorado—cutting costs, reducing emissions, and building a cleaner energy future. https://www.colorado.gov/governor/news/polis-administration-awards-124-million-further-develop-geothermal-energy-colorado New CU Boulder research shows it can power campuses and scale statewide. https://www.govtech.com/education/higher-ed/study-finds-geothermal-energy-feasible-for-cu-boulder Colorado is turning innovation into real solutions that save people money.
WOZCODE Slashes Claude Code Costs by 54%
Someone built a plugin that cuts Claude Code's cost by 54% on the same task, same model. Not a different model. Not a different harness. Just smarter tools underneath. It's called WOZCODE and the benchmark numbers are genuinely CRAZYYYY. https://t.co/OUoCq9J5ep
Solar Asset Managers Highlight AI Solutions for System Losses
Solar asset managers talk underperforming systems, catastrophic losses and AI at SAMNA 2026 #energysky -- via pv magazine usa: https://t.co/mcEfHXXqoF
AI Risk Lies in Agents' Actions, Not Model Statements
The New #AI Risk Isn’t What Models Say. It’s What Agents Do by Tyler Akidau @Forbes Learn more: https://t.co/nVK1YaBgb4 #ArtificialIntelligence #MachineLearning #ML #DL https://t.co/Fp5k8v0NUM
China’s Drug Innovation Surge Defies Industrial Policy Narrative
China Is Now a Global Drug Innovation Powerhouse. Industrial Policy Had Little to Do with It. .....industrial policies like Made in China 2025 played a negligible role... https://t.co/MKyZ6auvAS
AI Generates Claude Design Video From Blog and Tweets
Made this 30 second video of Claude Design just by pasting in the Claude Design blog post and some tweets from @AnthropicAI employees Kinda speechless. https://t.co/9uFxO3LKzf
Use YOLO, Not Opus, for Fast Accurate Detection
Don't use Opus 4.7 for computer vision. It's the wrong tool. I ran a simple pointing task on both Opus 4.7 and GPT 5.4: find the cars in an aerial image. Both took several minutes. That alone should...
Chinese Pharma Leads Speed, Insilico Wins on Novelty
Very insightful article in China Daily. There is a big delta between the AI CRO model and AI Biotech model. At Insilico, we do not compete with Xtalpi or other local companies. The most hardcore competitors now are the large...
HeyGen Now Powers All My AI Agents
HeyGen just put itself inside every agent I use. This is awesome. Check it out:
Cloudflare Logs Its Biggest Performance Jump Yet
One of my favorite things about Cloudflare Innovation Weeks is we force ourselves to check in on how our performance stacks up against competitors. This week we document the biggest jump we’ve ever made: https://t.co/PwLeiKKEUf
Experts Slam Non‑specialist Analogies in AI Debate
I love it when podcast hosts and newsletter compilers cite other non industry or non expert sources on a complex issue to try and dispute one of the architects of the entire AI revolution... Jensen on nuclear weapons analogy: "Comparing...
Blood Test Identifies Molecules Predicting Short‑term Survival
New Blood Test Signals Who is Most Likely to Live Longer, Study Finds Research finds tiny molecules in blood strongly predict short‑term survival in older adults https://t.co/8bv3I5CCXE https://t.co/IdZ5eYOmwe
Integrate AI, Triple Margins; Pure AI Startups Fail
90% of the 'AI wrapper' startups are going to die in 12 months. but the founders who integrate AI into their existing businesses are going to 3x their margins. i'm not building an AI company. i'm building a company that happens...
New 2.7GW Data Center Emits 14 Mt CO₂
Another day, another massive Petrotech fossil-fuelled data centre. The "Kilby power plant", 2.7 GW of fossil gas, will be pumping out 14 megatonnes of CO2-e a year (about 4.3 million combustion cars worth). Still waiting for AI to solve climate...
AZD4956
Just disclosed in #AACR26 abstracts: $AZN AZD4956 = DNA pol theta inhibitor. My story from when it entered phase 1/2 Parthenon study +/-saruparib -> https://t.co/bHoOKqd7da
Authentic Thought Beats Futurist Lies
The Future of Everything is Lies, I Guess https://aphyr.com/posts/420-the-future-of-everything-is-lies-i-guess-where-do-we-go-from-here "Refuse to insult your readers: think your own thoughts and write your own words." - Gonna be quoting this for a long while
Intel’s DP‑Alt Mode Works Seamlessly with Apple 6K XDR
One nice thing about being on Intel is that DP-alt mode Just Works. Never was able to get any AMD laptop to work consistently with Thunderbolt and the Apple 6K XDR. There were hacks you could do, special cables etc,...
Samsung's Crazy Buds Cases Spark Weird Accessory Craze
Samsung just released some truly absurd cases for the Galaxy Buds 4 / Pro 4 and I'm extremely here for it. More weird accessories please, Big Tech.
AI Agents Will Flood Networks—New Strategies Needed
Given how much more Internet traffic AI Agents are going to create, we need new strategies to ensure the network can keep up. Here’s one…
AI Mode Now Orders Nearby Items via Voice
Expanding from Search to AI Mode -> AI Mode can now call nearby stores for last-minute shopping "This tool launched directly on Search last November, and it’s rolling out in the coming weeks on AI Mode in the U.S." "Just describe what...
Omnidirectional Drone Glides Effortlessly in All Directions
This #Drone Can Glide Effortlessly in Any Direction via @ZappyZappy7 #Technology #Innovation #EmergingTech #TechForGood https://t.co/CCWWw0uqyY
Agentic Web Arrives: 5 Key AI Search Shifts
The Agentic Web is Here: 5 AI Shifts I'm Discussing with Clients about AI Search - Marie Haynes https://buff.ly/VRW47KT
Balance Brand Identity with Performance-Driven Creative Testing
Brand Creative /= Performance Creative This is one of the biggest hurdles when working with brands looking to scale is they want things "on brand" but "on brand" typically doesn't convert as well as performance driven creative. You have to be willing...
Tesla FSD Spots Road Debris Before Driver, Intervenes
I wasn't sure what this was (it was rather large) but Tesla's FSD saw the debris in the road sooner than I did and took aggressive action to ensure I didn't run it over.
Minibinder Data for $149—Custom Assays Available
Get data on your minibinders for $149! Sequence in -> data out. Let us know other assays or protocols you'd like to see and we're happy to add to Ginkgo Cloud Lab.
Epic's AI Suite Crowds Out Third‑Party Tools in Healthcare
My new Substack: Epic, the leading EHR vendor, has released >100 AI tools. Choosing them over third-party tools has become the safe choice for many health systems. I explore why, and the bigger questions: can – and should – something be done about...
Personal, Tangible Gestures Outlast Automated B2B Outreach
A few years ago, someone sent me tiki cups. Not branded cups. Not a box with a company logo slapped on the side. Just a set of those fancy ceramic tiki mugs — the kind you’d get at Trader Vic’s...