Automate Portfolio Pipelines & Coaching in 5 Minutes
My colleague at Stage 2 Capital, Mandy Cole , is using this #Claude skill to automate each portfolio company's pipeline and translate the analysis into coaching priorities. The skill generates: 📊 A pipeline health spreadsheet (stage conversion rates, velocity, at-risk deals, rep breakdown) 📈 An interactive dashboard (funnel visualization, coverage ratios, quota vs. actuals) 🎯 A coaching priorities doc (the 5 deals most likely to slip + specific talk tracks for 1:1s) 👇 It takes 5 minuites to setup. Full guide linked in comments.
RFK Jr. Defends FDA Chief Amid Industry Backlash
RFK Jr. defends FDA, Makary following Republican questions - also defends the $REPL CRL: "Marty made the correct decision to not approve that drug. But everybody goes after him because the industry is so powerful." https://t.co/CuEeNFCYpp
ITAR Restrictions Pose Risk, Not Deal‑Breaker, $100M Spend Continues
.@Thales_Alenia_S: US #ITAR, #DPAS space tech export restrictions are a risk, not a showstopper. We still spend $100M or more per year on US components. @voyagertech_ @SpaceSymposium @Starlab_Space.https://t.co/GsZ51fq6T8 https://t.co/UfdSaAZ784
Apple’s $599 MacBook Neo: Recycled, Affordable, Not Junk
The MacBook Neo Guide — first edition. In 2008, Jobs said Apple couldn't make a $500 computer that wasn't junk. In 2026, they made a $599 one out of iPhone parts, binned chips, and recycled aluminum. It's not cheap....
Loved PyCon DE: AI Community, Now on Family Break
Had a great time at PyCon & PyData DE. Highly recommend it. Great open-source, community-focused conference with lots of builders in the Python AI, LLM and agent space. Taking a short family break, my first "vacation" in years (hopefully, I won't...
OpenAI Debuts GPT‑Rosalind, Entering Biopharma After Anthropic
NEW: OpenAI is the latest tech giant to move into biopharma, launching Thursday GPT-Rosalind, a life sciences-tailored version of its LLM Trails behind the very similar launch of Anthropic's Claude for Life Sciences by ~5 months. More here: https://t.co/zkXDwY0BBI
Army Looks to Drone Tankers for Cheyenne II Refuel
Army Eyes Drone Tankers To Refuel Its New MV-75 Cheyenne II Tiltrotors The Army and Bell have pointed to the U.S. Navy's MQ-25 Stingray drone tanker as an example of what could be on the horizon. https://t.co/e6RXASGLjJ
Salesforce Headless 360 Opens Full Platform to APIs
Why @Salesforce Headless 360 matters https://t.co/8kJu9uJnjn Salesforce launched Salesforce Headless 360 in a move that makes its entire platform available via APIs, Model Context Protocol, and CLI commands for humans and AI agents. https://t.co/K2sl5HQ1DL
From Internal Tools to an Agent Factory
I started by building agents because of internal product work and OpenClaw. Now, it feels like I’m building an agent factory.
Xiaomi 17 Ultra Proves “Leica Phone” Concept Viable
Until recently, I'd have called it a cynical cash grab – but after two weeks with this special-edition Xiaomi 17 Ultra, the idea of a "Leica Phone" finally makes sense to me. Join me in the live chat for my first...
Flawed Study Groups Failed and Successful Alzheimer Drugs Together
This new analysis of Alzheimer's drugs is such a good example of why we can't make any headway as a society. There is probably a good debate to be had on whether the risks and costs of the two approved beta...
MediaPipe Gives 3D Single-Person, YOLOv26 Multi-Person 2D
MediaPipe Pose vs YOLOv26 Pose — two differences that change everything: → Single person vs multi-person → Relative 3D vs 2D only MediaPipe: locks on one person, gives 3D landmarks, runs on phones. YOLOv26: detects everyone, but 2D keypoints only. Same task. Different philosophy. #ComputerVision #PoseEstimation...
JetSnake Robot Tackles Dangerous Tunnel Maintenance Tasks
Snake-Arm #Robot “JetSnake” Takes on Hazardous Tunnel Maintenance Tasks by @IntEngineering #Robotics #Engineering #Innovation #Technology https://t.co/xrjfym04IA
AI Accelerates Mid-Market Data Integration for Faster Decisions
Contributor Spotlight: Henry Park (p. 33): AI makes mid-market data integration faster and more accessible - connect systems, improve insight, speed decisions. https://t.co/YrxFqMpTXp #AI #Data #SIOP https://t.co/l3pRT7Y3Zz
New Multi‑Region Endpoint Boosts Availability, Preserves Data Residency
You want @AnthropicAI Claude Opus 4.7 served from a single @googlecloud region? Got it. Oh, you want the global endpoint for max availability? Do that. What's new is the multi-region endpoint with more availability, but respecting data residency. https://t.co/CSUJhvOCMX
Boost Productivity with Opus 4.7: Proven Tips
Dogfooding Opus 4.7 the last few weeks, I've been feeling incredibly productive. Sharing a few tips to get more out of 4.7 🧵
AI's Transparency Gap Hinders Theory Verification
The problem with AI right now is that we do not have enough transparency to prove or disprove this theory. I just wrote about this. I don’t know what the real issue is or hopefully was.
From One AI-Generated Page to Cohesive Websites
You can get AI to write a page in seconds. The hard part is making the next five pages feel like they belong. Tomorrow at 10am PT I’ll show the exact workflow I use to go from one strong page...
Agentic AI Security Needs Layered, Integrated Defenses
We keep asking how to solve agentic security as if there is a single answer, but most of the conversations I am having suggest it is a combination of least privilege, access controls, monitoring, and good architecture. The question might not...
High‑Resolution TORC2 Structure Opens Path to Age‑Related Therapies
Activating TORC2 holds potential in medicine for treating age-related memory & hearing loss. New study out today @MolecularCell reveals the structure of TORC2 in highest-ever resolution - which is good news for drug developers & all of us who age...
New AI TUIs May Expand Attack Surface via React
I know there are some new TUIs coming out for AI development but I’m concerned about increasing the attack surface with web technologies like react. Securing AI is hard enough as it is.
CIOs Must Rethink Talent Pipelines for AI-First Era
#CIOChat Q4: Looking ahead, how should CIOs rebuild the talent pipeline in an AI-first world: Formal apprenticeships, simulation labs, AI-assisted learning, or something entirely new? What does the next generation of enterprise technologists look like? https://t.co/ERYwrw74Km
New GStack Gate Stops AI Guesswork at Critical Forks
Karpathy's Confusion Protocol is now in GStack Karpathy called it: the #1 AI coding failure mode is the agent confidently picking the wrong path at an ambiguous decision point. You lose 10 minutes of work and have to start over. gstack now...
Drug Discovery Expands Beyond AI to New Frontiers
The marked expansion of paths and methods for new drug development including and beyond AI @Joseph_C_Wu @james_y_zou @WuXuekun @ScienceMagazine https://t.co/hTJ4Rt181n https://t.co/H3U5BNR1ER
Slash Raises $100M Series C, Hits $1.4B Valuation
🚨 JUST IN: @slashapp raised $100M Series C at $1.4B to build a Ramp competitor $250M ARR. 60 employees. Valuation quadrupled since May. The headline is the round. The story is everything else 🧵 https://t.co/SzLfFk3ZuB
Orbiting Needs Speed, Not Height: Artemis II Curve Explained
Why does the @nasa Artemis II curve so much on launch? Getting into orbit is more about going fast than going up. For low Earth orbit, it's over 80 percent kinetic energy. https://www.instagram.com/p/DXMmMxrAOtJ/?img_index=1
AI-Driven Traffic Spikes 393% and Lifts Retailer Revenue
AI traffic to US retailers rose 393% in Q1, and it’s boosting their revenue too https://t.co/4s4yDglDSH
Most Users Doubt AI Search, Demand Verifiable Links
https://t.co/pg3z88Zezd Only 15% of people trust AI search platforms, w/ 63% double-checking the results against trusted sources like news websites. They want easy access with clear links so they can verify content, something we're seeing less and less of in AI...
AI Is a Tool, Not a Shortcut—Be Action‑oriented
I stole this framework, and it has genuinely been one of the most helpful hiring and onboarding guides my team uses. Being AI-first means nothing without solving real business problems. It's not enough to just use AI. I know plenty...
Starship V3 Set for First Test Flight Soon
Starship V3 booster & ship will be ready for their first test flight in a few weeks
Qwen Image Edit Delivers Precise, User‑Guided AI Editing
Qwen Image Edit: Bringing Precision and Control to AI-Powered Image Editing In this episode of Artificial Intelligence: Papers and Concepts, we explore Qwen Image Edit, a multimodal system designed to make image editing more precise, controllable, and aligned with user intent....
AI‑Driven Scorecard Streamlines Product Research & Validation
I use AI for product research before I use it for anything else. Here's my exact workflow (and prompt) you can use: > Find competitor URLs using a product research tool > Plug them into a deep research prompt on Gemini or ChatGPT >...
π0.7 Demonstrates Emergent Compositional Generalization via Instructions
We finished evaluating π0.7, our new model at Physical Intelligence. What I'm most excited about with π0.7 is that it's starting to show some surprising emergent compositional generalization, being able to both perform complex tasks and learn new tasks just...
Opus 4.7 Launches on Bedrock; Kiro CLI Integration Pending
Taking a bit of a break today because Opus 4.7 is already available in Amazon Bedrock and hoping it will be in the Kiro CLI today as well (or soon).
New AI Model Sparks Fresh Hedonic Treadmill Rush
I am embarrassingly excited about Claude Opus 4.7. We are so spoiled. We get used to these tools, start cursing them for their flaws, and then a new model drops and it feels like a mini holiday. I know in...
Entry-Level IT Jobs Vanish as Automation Takes Over
#CIOChat Q1: Entry-level IT work (troubleshooting, documentation, basic coding, ticket triage) is increasingly handled by copilots and IT automation. Are you already seeing the vanishing talent pyramid in action? What key junior roles are disappearing first in your org? https://t.co/TM6E5WJnrm
Exploring AI's Broad Impact Across Industries Today
Looking forward to a great panel discussion this afternoon with Springer discussing the wide ranging applications of AI across different industries and economic sectors @LehmanPresident @LehmanCollege @silvapuras @CUNY @ny_cpasociety https://t.co/40uh7Gz4ql
1q22 Gain Predicts Poor Prognosis in Myeloma
Prognostic significance of acquired 1q22 gain in multiple myeloma [Oct 28, 2021] Hadiyah Y Audil et al. @myelomaMD Am J Hematol https://t.co/qUKCUdnZPH #mmsm #PrecisionMedicine #oncopath HT @EagleMyeloma https://t.co/vd0BVZ6bRq
Debating Machine Consciousness: Confident Denials Meet Ongoing Philosophy
Amazed at how many people will confidently assert machines will never be conscious. It's maybe the most contested question in all philosophy.
Most Philosophers Think AI Could Be Conscious, 11% Remain Agnostic
On AI consciousness: 1. Functionalism is the most popular view of philosophy of mind, which basically says sufficiently complex machines *will* be conscious. 2. Most other views are also compatible with AI consciousness (e.g. identity theory, panpsychism). 3. Eliminativists say humans...
AI’s Future Mirrors Early‑electricity’s Regulated Monopoly Era
In thinking about the right historical analogy for AI, I've become very interested in the early history of electricity in the early 1900s. With early 20th century electricity, you had: - famously feuding private inventors creating/scaling the early technology (Edison, Tesla,...
Trump Jr.’s Advisory Role Sparks 22x Valuation Surge
"To put numbers on it: when Trump Jr. joined Kalshi as a paid adviser in January 2025, Kalshi was valued at roughly $500 million. By December 2025, it was valued at $11 billion — a 22x increase in under a...
1q Abnormalities Define Distinct Proteomic Landscape in Myeloma
Proteomic profiling revealed unique disease biology associated with 1q abnormalities in multiple myeloma [Apr 14, 2026] Mangalaparthi et al. @Nature_NPJ https://t.co/XTcJZIGFh6 #mmsm #PrecisionMedicine HT @Myeloma_Doc https://t.co/XyrxJ29elO
U.S. Grid‑Battery Output to Power All Renewables by 2026
U.S. grid-battery production has gone from 0 in 2024 to 145 GWh/year by the end of 2026, enough to provide batteries to support all wind and solar in the U.S. https://t.co/faeAUzMjZ8
AI Firms Devour NYC Office Space, Leasing Data Shows
My friend and broker from the Breather days, Ramsey Fehrer at CBRE, shared NYC tech leasing data they pulled for a client recently. AI is eating NYC office space. https://t.co/tEdfzI97NT
Mobile Launcher Returns to VAB for Artemis III Prep
The Mobile Launcher is on its way back to the VAB today to start getting ready for Artemis III. Departed the pad at 8:11 am ET. https://t.co/ZeDzYf5S67
NASA Greenlights ROSA Support for ExoMars Rover
NASA has given approval for the Rosalind Franklin Support and Augmentation (ROSA) project to begin implementation. This is the addl support NASA is providing to ESA to get the ExoMars Rosalind Franklin rover w/drill to Mars. https://t.co/mBPdDblJzg
AI Is Not Alien, It's Anti‑Intelligence Opposing Human Thought
Hariri is close, but I think he misses the point by calling AI alien. It's better to think of AI as anti-intelligence--intelligence that is antithetical to human cognition. https://t.co/m1ErdtsBgs
Russell Gold Swaps WSJ for Solar Industry Insight
I think I may have accidentally gotten Russell Gold to leave the Wall Street Journal for the solar industry. On the latest episode of Energy Empire, he explains why. https://t.co/LerdxNAL7J
AI Learns Scientific Laws, Not Just Memorized Answers
With Sim2Reason, AI moves closer to how science itself progresses: not by memorizing answers, but by discovering the laws that generate them. 🚀🧠 Read more about the team’s work: https://t.co/CSFqdns1er