Software Sector Sees Broad Sell‑off, 73% Down
Is there a broad cycling out of software? 73% of public software companies fell today. Median decline: -4.7%. Biggest drops: - Smartsheet -12.6% - Atlassian -12.2% - ServiceNow -11.9% - Microsoft -11.7% - HubSpot -10.7% https://t.co/cLD4hrhCg2
Leaked Data Reveals Mechanisms of JNJ and MRK ADCs
With a tipoff from a friend, and some info that probably shouldn't have been posted in a trial registry, the mechanisms of ADCs JNJ-95437446 $JNJ & SKB571/ MK-2750 $MRK have been revealed. Quite amazing given the recent $GMAB news. Via...
Wrong Leaders Cost Years of Lost Potential
Picking the wrong VP reverberates for 2+ years Picking the wrong cofounder reverberates for 10+ years You don’t fail, it’s just you could have done so much more. And that compounds, too.
SNY Drops Alphamedix, Opening Window for CATX
Looks like $SNY discontinued Alphamedix/ SAR447873, licensed in Sep 2024 from Radiomedix & Orano Med, h/t B Riley. @ByMadeleineA covered it at #Esmo25 and flagged dysphagia & renal tox. https://t.co/6L2O0c5cOA Good news for $CATX?
Introverts Can Thrive in Content Strategy Too
If your content strategy depends on being an extrovert, it’s a bad strategy. Quiet people sell too.
Apple's iPhone Privacy Shield Lacks U.S. Carrier Support
Apple’s new iPhone security feature limits cell networks from collecting precise location data, but appears to have very limited support in the U.S. at the moment. Here’s to hoping all the big carriers get on board too. https://t.co/tCJT63yJO3 https://t.co/PK9jhIlU18
Stop DIY Taxes—Automate with Anrok for Scale
4 signs you should not be going it alone, tax-wise: 1. You are not, in fact, an accountant. 2. You crossed the $1M annual sales mark and your tax filings went from 2 --> 40, overnight. 3. You did not...
Anti‑vax Groups Target State Vaccine Mandates After CDC List
#CDC sets the list of vaccinations recommended for all kids. But decisions about which inoculations kids require for school entry are made at the state level. Anti-vax forces are shifting their focus there @danielpayne.bsky.social & @isabellacueto.bsky.social report. https://t.co/9VPajcWzdI
Vaccines Strain Pediatric Practices, Not Boost Doctor Profits
People who oppose #vaccines often claim that doctors push them because they're paid to by Pharma or that vaccine administration is a big revenue source for doctors. The reality: Delivering vaccine puts an economic strain on many pediatric practices. https://t.co/cyJj1M2SPB
Apple’s iPhone Voice-to-Text Still Mishears “How AI”
I just used voice-to-text on my iPhone for a text message in which i spoke, “how AI.” My iPhone typed “Howie.” I feel like that about sums up Apple’s current AI capabilities on the iPhone.
Understanding Login vs Interactive Shells in Bioinformatics
Bioinformatics is more about biology and code. It's shells and sessions, exports and environments. Ever been confused by “login shell” vs “interactive shell”? This thread is for you. 🧵 https://t.co/DfB8BEztiD
Posting Too Much? It's a Burnout Warning
If you’re posting 10 times a day but you feel fried, it’s not a flex. It’s a warning.
2026 Still Stuck Using Outdated Microdeposit Verification
Literally insane anyone still needs to do microdeposits for bank account verification in our year of the lord 2026 https://t.co/jubY3sc9qB
AI Training Could Double Worker Productivity, Study Finds
Does AI training double worker productivity? What's your reaction to this study from Microsoft? Follow for more.
B2B Marketers Shift From Paid Ads to Events, Partnerships
The great paid ads pullback of 2026 is here. We surveyed 50 mid-market B2B marketing leaders with Wynter. The data is violent. 72% are actively slashing budgets for paid ads, content syndication, or agencies. This isn't a "hot take." It is a capital...
Automate Your Content: Thrive Offline and Online
If you want a life and a business, you need content that runs even when you’re offline.
Banks Need Modern Back Offices to Scale Efficiently
[New Episode] Banks Can’t Scale Without a Modern Back Office. With guests, Richard Ullenius and @BrandonSailors from @csg_i. Watch the latest episode: https://t.co/n0Vuv4oh4u https://t.co/8vX6TWAPDB
All Strategies Work—Pick One and Stop Paralyzing
Today a journalist emailed me one of those questions that looks innocent and absolutely isn’t. What unexpected opportunity came from starting your own business and what advice would you give others about recognising opportunities. Which is really asking, what did...
Biopharma Sentiment Surges, Fueling M&A and IPO Boom
Biopharma sentiment just snapped higher $XBI BPSI index jumped 78 to 90 in Q1. That is not a grind. That is a turn. Under the hood: >Current Conditions surged 58 to 75. Pain is easing now, not someday. >12-month Expectations hit 100 for the first...
Robotics Teams Lose Time Rebuilding Infrastructure, Not Algorithms
🎙️ Stephen James is the founder and CEO of Neuracore , and Assistant Professor of Robot Learning at Imperial College London: In this episode, Stephen shares his path from growing up in Wales to spending a decade at Imperial, a...
China’s 15th Five-Year Plan Unveils Ambitious Space Agenda
An early insight into China's plans for space in its 15th Five-year plan, & it's certainly ambitious & long-term. Areas include: - Space resource development (Inc. feasibility studies for "Tiangong Kaiwu" (below)) - Space tourism - Space-based digital infrastructure - STM
Attention Without Sales Means Missing the Conversion Bridge
If your content is getting attention but not buyers, you’re building interest without a bridge.
Robotics Demos Lag Far Behind Real-World Production
there is massive arb between robotics demos you see on twitter and what very few companies have in large-scale production today and no, the gap isn't in favor of the twitter demos.
Cyber InsurTech Hits Turning Point with Massive Funding
Cyber InsurTech at a crossroads ? → https://t.co/lkwru1czZC This reflects the largest round announced recently, which happened to come from a cyber InsurTech startup. https://t.co/NIanaOZPp2
Authenticity Beats High Production Value Every Time
I spent $20k on a brand photoshoot with models and studios. Competitor shot iPhone videos in their bedroom. Their content got 4x more engagement. Production value doesn't matter. Authenticity does. Test everything.
Germany Rushes BRDBND Satellite, Tests Industrial Capacity
German defense: We're moving fast on brdbnd constellation; it'll be interoperable w/ @defis_eu #Iris2. Goal: Strengthen @NATO &EU alliances. Can German industrial base can digest the massive govt investment so quickly? #EuropeanSpaceConf @bundeswehrInfo.https://t.co/X4UYXIDL4C https://t.co/G7lKeNKBIK
QMD Launches Native Query Extender, Boosting Expansion Performance
QMD now has its own natively trained query extender model https://t.co/b89CmKIknV Seems to do much better at query expansion in my tests. try it out.
Rolv's AI Speed Breakthrough Shows Promising Results
Months ago I shared Rolv with you and he shared that he had a major performance breakthrough for running AIs. His breakthrough is proving itself. Will share the final results when it's up, but his math is working out to...
Brayden's Architecture Beats ChatGPT for Molty Reports
The second "Ultimate Molty Report." Thanks @blevlabs. If it weren't for Brayden's cognitive architecture these reports wouldn't be nearly as good as if I used, say, Grok or ChatGPT to write them.
Timing Amplifies Good Content, Can't Rescue Bad Messages
Posting times won’t fix a bad message. But good timing can absolutely multiply a good message.
New AI Releases and Viral Moltbot Report Incoming
Tomorrow morning @higgsfield_ai and @AnthropicAI will drop something crazy. And I'm about to drop another @moltbot report. My first one got viewed hundreds of thousands of times.
AI Agents Improve Instantly with Each Compute Boost
We've had a pretty wild new AI Agent feature that we've almost released twice, but then right as we get close, a new technical breakthrough makes the agent substantially better than before. The pace of new best practices emerging in...
Master Your Pitch, Meet Top VCs, Secure Term Sheets
- Know your worth - Hone your pitch - Meet the best VCs - Collect term sheets That's SaaStr AI VC -> https://t.co/XzJ5d0OqGr https://t.co/qulPugatLR
VCs Can't Fund Ex‑OpenAI Founders Indefinitely
“VCs can’t just keep giving OpenAI employees billions of dollars to start a new company forever” VCs: https://t.co/lVyo5wnDoI
Team Achieves Safe Age‑Reversal Breakthrough at LiFE BIOSCIENCES
Meet the LiFE BIOSCIENCES team, from L to R, Dr. Michael Ringel (COO), Dr. Sharon Rosenzweig-Lipson, (CSO) and Jerry McLaughlin (CEO). Not pictured Amit Shashank (CAO) and my co-founder and founding CEO, Tristan Edwards. A shout out to my lab...
Create a Content Machine That Honors Your Life
Build a content machine that respects your life. Not one that requires you to pretend you don’t have one.
Scaling AI Developer Infrastructure: Lessons From Meta’s Internal Agent
Office Hours: Building Developer Infrastructure at Scale with Jim Everingham In the world of AI, how do the very best companies build their developer infrastructure? To answer that question : On Tuesday, February 24, I’ll be hosting an in-person fireside...
Reviving BabyAGI Amid Surge of Build Energy
it’s been so fun watching the build energy this past week, i had to start rebuilding babyagi again last night :)
Regulation Relief Fuels SaaS Boom in Cannabis Retail
Here’s how increased access to cannabis led to Sparkplug’s explosive growth… The startup — a LAUNCH portfolio company — offers a SaaS product that educates and rewards and benefits the dispensary clerks and “budtenders” who actually sell cannabis to clients,...
Master Depth, Volume, Live to Boost Followers
Depth Volume Live The DVL discipline will change the outcomes so many of you strive to …. Depth - so many of you want more followers and sales but don’t reply To a single dm or comment .. from 2007-2011 I...
AI Brand Rankings Unreliable; Track Mention Frequency Instead
Ranking position in AI responses is meaningless. Across repeated runs of the same prompt, LLMs almost never return the same list of brands in the same order. In many cases, they don’t return the same list at all. New research...
Chris Petty Advances Cell Age Reset, ER‑100 Trials Near
PhD student Chris Petty presents his latest results to the lab. His project is to uncover the mystery of how it’s possible to reset the age of a cell. Where does the back up lie? It’s one of the biggest...
Azure Hits $103B Run Rate, up 38% YoY
Azure at a ~$103B run rate growing 38% constant currency Quarterly YoY growth trends below
ChatGPT Could Power Universal Price Comparisons via Shopify Catalog
I saw a Q&A that mentioned @Shopify's Catalog MCP provides a "List of shops selling the product with specific prices" along with a Universal Product ID. Does that mean a shopper could use chatgpt for easy price comparison shopping across...
Prioritizing Guided Onboarding for Complex Data Platform
I spent 2025 building out the best product I could for brand and category tracking, and my current next product focus is making sure that I surround it with a strong onboarding and training experience. The double-edged sword of adding...
Intercom's AI Pivot Redefines SaaS Economics
Intercom has pivoted from traditional SaaS to AI better than any company I can think of. I spoke to the CFO behind the customer support juggernaut, and the outcome based product Finn. Dan Griggs is mastering the new economics of...
Upgrade to a 5‑Email Welcome Series for Real Conversions
Most brands build a 3-email welcome series and never touch it again. Here's the 5-email flow that actually converts: https://t.co/mDwary7P4f
Nori AI: Simple, All‑In‑One Family Planner
Clawdbot, now called @moltbot, is hot, but sometimes you just want a simple family planner, and don’t want to buy a new Mac Mini and nerd out for the weekend just to get a family planning system running. Nori is...
Leaders' Excuses Limit Teams; Ask, Don’t Assume
"The team won't do it" is rarely about them. It's about you. We were talking about having CSMs tell customers when they're getting in their own way. Not being rude. Just direct. "We can only help you if you do...
Bout-and-Glide Swimming Proves More Energy Efficient
A new Science #Robotics study uses a #bioinspired robot to demonstrate that “bout-and-glide" swimming, seen in aquatic animals such as zebrafish and humpback whales, is more energy efficient than continuous swimming. https://t.co/8EWURPmuCh https://t.co/UJWVkzvaRk