your brand doesn't need to make sense to everyone
1/ The Back Door Is Open How Acute Infection Could Make Anti-Infectives Investable Again Anti-infectives never died. The business model did. Low prices. Short courses. High resistance risk. Pharma walked. Now look at Alfasigma stepping into HSV encephalitis. Small deal. Narrow indication. Big implication....

Let's finally make LLMs work for you instead of against you, so your drafts stop sounding generic and start sounding like you. We’ll break down how to spot and remove “AI slop,” fix the generated-looking structure that gives it away, and...
What nobody tells first-time founders Clip from my chat with Sam Lessin : https://lnkd.in/gN3JzMXv
Humanoid robot assembling humanoid #Robots for factory work via @ZappyZappy7 #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/b2ClEryVoi
Me: "our brand positioning is audience research for marketers." Google: "ha ha ha... your brand is whatever we say it is." My advice: Step 1 - monitor your search console ratio on branded terms, keeping a special eye on those...
NAUT Brings Scalable, Plug-and-Play Autonomy to the Oceans via @WevolverApp #EmergingTech #Technology #Innovation #Tech https://t.co/cG7uUBfixg
Your timeline is probably full of people shouting that they’ve cured cancer and achieved world peace using Claude Code.... so maybe you've had enough. But I can’t help being incredibly excited about it, so I wanted to share my experience...
The Senate has passed the minibus that includes CJS, which in turn includes NASA. Now to the President.

Understanding Mixture Of Experts: Scaling #AI Capability Without Scaling Cost Or Risk by @davidwsilva_ @Forbes Learn more: https://t.co/5Rr1mQdG3g #ArtificialIntelligence #MachineLearning #ML https://t.co/EWjt6DtUSo
Sumo.com - soft launched something new there today. 👋 Love your feedback 👋
Most managers avoid feedback because it feels uncomfortable. On the Duct Tape Marketing Podcast, Ashley Herd and I talk about shifting feedback away from yourself and toward the person you want to help. That is how trust is built. Tune in-> https://t.co/elDGv0XGYO
Higgsfield built itself by having a lot of AI influencers talking about them. It was a brilliant marketing move, and it's paying off.
All year long, the robot demos are going to get better and better and better. The world models are starting to come together and, here we go, running in the world model. I used to run marathons at about this pace....

China's 2nd launch of the day & 4th of the year: a Ceres-1 solid rocket lifted off from a barge off the coast of Shandong province at 2010 UTC (Jan. 15), successfully sending 4 Tianqi Constellation satellites into 850 km,...

Why Google Will Win the AI Search War (And ChatGPT Will Have to Be Content With Silver) - Interesting analysis from @gfiorelli1 going through data: * Google processes 373 times more searches than ChatGPT, controls 90%+ of mobile search, and...
AI revolutionized building web apps, but not so much mobile... until today. In 2013, I joined Meta because I was excited about the potential for mobile and the internet to connect the world. I quickly found that building mobile, being a closed...
This is why I have been sharing this (and other) checklists in all my talks about AI search. So much of it is just saying the things that you’d want an LLM to say about you, directly and concisely on your...
What if your media bids were optimized for profit, not just conversions? And personalization actually reflected real intent, not guesswork? That’s the edge of an open schema — data that adapts as fast as your customers do. Check out Nicholas...

.@Eutelsat signs multi-launch contract w/ startup @MaiaSpaceOff for launches of OneWeb satellites starting in 2027. Maia says contract can secure the majority of its order book for 2027-2029. @Armees_Gouv @CNES @esa @AirbusSpace. https://t.co/LChx5fuH4S https://t.co/bj85cV7pwa

Just had Claude Code build me a full health projection based on one year's worth of daily scale data. I have hundreds of data points on my weight, body water, skeletal muscle, metabolic age, and a whole bunch of statistics...
When #Robot Dogs Learn to Speak: #AI Gives Machines a Voice by @HiwonderSteam #Robotics #ArtificialIntelligence #MachineLearning #ML #MI #Innovation https://t.co/8w2bf5AFrV
Today's Thought: The "Blue Link" Era is Over. Is Your Growth Plan Stuck in 2010? For decades, we’ve told Marketing: “Rank on page one.” We’ve told Sales: “Don’t worry, the leads are coming from search.” But the seismic shift to...

How does obesity lead to immune system dysregulation and chronic inflammation? Macrophage metabolism is rewired, with activation of the NLRP3 inflammasome @ScienceMagazine https://t.co/bkAUgOE1c2 https://t.co/It6YaXT1b5
When I started using @Replit last summer, agent v1, you didn’t really know if anything you told the agent to do … would really work in practice when it created the code. You hoped. But you just didn’t...
Scientists have designed a framework that enables a humanoid robot face to produce realistic lip-audio synchronization across 12 different languages, including English, Russian, Korean, and Arabic. @hodlipson @Yuhang__Hu Learn more in Science #Robotics: https://t.co/Sk4UElC3o8 https://t.co/LdVokZgeB3
“Why would you spend weeks building a presentation to explain your idea to leadership, when you can now spend 10 minutes ‘vibe coding’ it and just SHOW them the working product?”

Back in the day, folks talked about Sand Hill VCs going to Bucks and doing deals over breakfast But the hipper VCs were in Palo Alto. And they did breakfast at Il Fornaio Another one that couldn’t make it in...

New @ScienceMagazine A thoughtful and comprehensive review on how multimodal AI can transform mental health, with emphasis on a patient-centric approach "The successful translation of AI into clinical practice will require robust validation" https://t.co/xSACrFI0tW https://t.co/8jiV6P1vdj

.@Arianespace plans 7-8 Ariane 6 launches this year, including 2-3 for @Amazonleo, the first in Feb; waiting on @defis_eu #Iris2 schedule and details of @BMVg_Bundeswehr constellation. @EutelsatGroup. https://t.co/HS7JE8spxw https://t.co/XoYUqcJMvK
CFO's really want to use AI this year. But it still comes back to data quality and structure. Shocker. I'm holding a live session next week to help CFO's and Controllers assess their AI readiness. I'm teaming up with the...
I’ve sat in a lot of pipeline reviews where content looked like it was doing its job. At first glance, everything looks healthy. Pages are getting published. Rankings improve. Traffic trends upward. Then the conversation turns to which pieces actually...

This diagram nails it. Modern AI isn’t one thing — it’s 5 interacting pillars: GenAI • LLMs • RAG • Agents • Agentic systems The edge isn’t tools. It’s how you connect, control, and govern them. Miss one layer → fragile AI. https://t.co/N16xAu6RwO

This company will now let you spend $1,000,000 to reserve a hotel room on the Moon, yes seriously… #space #moon #science #physics #astrokobi
Cloud computing for the AI world. I visited @gmi_cloud's headquarters on Monday. This is a company that only hosts GPUs for many companies building, and running, AI models. I worked for Rackspace for seven years back when it was a hot...
The history of software is really the history of how humans interact with computers. A (partial) history of user interfaces: TUI: (Terminal User Interface): Type & Read GUI (Graphical User Interface): Point & Click MUI (Mobile User Interface): Touch &...
Looks like YC-backed Stripe may have cut off merchant acquiring for YC-backed Venezuelan sanctions evasion app Kontigo (English: the main use I gave to @kontigo_app died yesterday. It seems like @stripe stopped their card processor.)

Your Prompts Aren’t the Problem❌ A full guide to getting consistently better answers from AI👇 When you use an AI assistant and think “Why is it suddenly confused?” Or “Why did this work 5 minutes ago but not now?” It’s rarely about wording. It’s about context. What the...

How To Create #AI-Fluent Employees Through A Culture Of Curiosity by Bryan Gernert @Forbes Learn more: https://t.co/xyDtdHqF8g #ArtificialIntelligence #MachineLearning #ML #MI https://t.co/9qfA9Q00mh
If people don't talk about your product after buying it, you have a product problem. The best ad channel is word of mouth.
Dear Sales Professional, If you would like to lose a ton of deals you should have closed, keep attempting to resolve concerns over text messages instead of calling the person directly and having a real conversion. Sincerely, A Friend Who...
Christos Makridis and I have a new article published by The Brookings Institution on "Counting AI: A blueprint to integrate AI investment and use data into U.S. national statistics". Christos has a great summary below. What do you think?

Turns out just copying Shopify works. Made our AppSumo cart and checkout pages more similar ro them. Improved conversion 13.01%. https://t.co/dSwVWHYMW4

Churned customers don’t disappear. They always come back to check on you. The question is whether you notice… https://t.co/2uqVT1n4Q9
This is also true with GTM agents The very best agents for sales, marketing, support, post sales can also function as strong general agents with just a bit of work That means all are going to compete with each other to win...
I recently sat down with @PaloAltoNtwks CEO @nikesharora on Long Strange Trip, and we spent a lot of time talking about M&A – from the buyer’s side. I mulled on that for awhile and came up with my (hopefully non-obvious)...

🚨 You have until tomorrow to enter for a complimentary #brightonSEO US day pass to the world’s leading search marketing conference. Enter Jan 14 - 16 for access this September 2026 at the San Diego Convention Center. Do it here 👉 https://t.co/M45hlmvMt9...
"You're Likely Screwing Up AI Adoption..." & more in today’s Operator Links, full post + sources in the comments.
Qilu appears to be aping $JNJ in trispecific T-cell engagers. First BCMA x GPRC5D, now CD79b x CD20. Via @ApexOnco -> https://t.co/d4pBcl0MuF
AI: Future of Defense & Warfare w US Under Secretary of War Emil Michael @emilmichael for @NoPriorsPod *Innovation Priorities for the DoW *Autonomous Defense Technologies *Architecting https://t.co/NVUvKPe1OY *Future of Warfare *Rebuilding the US Industrial Base https://t.co/Z1LbVotQeO