'A Second Set of Eyes': AI-Supported Breast Cancer Screening Spots More Cancers Earlier, Landmark Trial Finds
A prospective, population‑based MASAI trial in Sweden screened over 100,000 women using a commercially available AI system alongside radiologists. The AI‑assisted workflow identified more clinically relevant breast cancers and cut interval‑cancer rates without raising false‑positive alerts. Radiologists read AI‑flagged cases with a single‑reader model, reducing workload while maintaining diagnostic quality. The findings mark the first evidence that AI can improve patient outcomes in routine mammography screening.
Scientists Identify SARS-CoV-2 PLpro and RIPK1 Inhibitors Showing Potent Synergistic Antiviral Effects in Mouse COVID-19 Model
Scientists have identified two small‑molecule inhibitors—SHY1643 targeting the SARS‑CoV‑2 papain‑like protease (PLpro) and QY1892 targeting the host kinase RIPK1—that together produce a potent antiviral effect in a mouse COVID‑19 model. Individually, each compound modestly reduced viral loads and inflammation, but...
McKinsey Vet Franck Le Deu Joins Nisa Leung’s New Fund; Plus C-Suite Shuffle at Bicycle
Former McKinsey senior partner emeritus Franck Le Deu has joined Aulis Capital as a venture partner. Aulis, the Hong Kong‑based fund launched by veteran Chinese VC Nisa Le Ung, will back emerging biotech and health‑tech companies across Asia and the West. Le Deu, who...
Multidisciplinary Evidence-Based Guidelines for Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease
A new multidisciplinary, evidence‑based guideline set recommends therapeutic drug monitoring (TDM) for biologic therapies in inflammatory bowel disease (IBD). The recommendations integrate pharmacokinetic data, disease activity metrics, and patient‑specific factors to optimize dosing of anti‑TNF, anti‑integrin, and anti‑IL agents. The...
Series A Companies: Biotech’s Class of 2025
After four years of falling series A activity, biotech start‑up financing stabilized in 2025. The number of companies raising series A remained flat versus 2024, while total dollars raised increased. BioCentury’s analysis shows a broader revival, with round sizes, investor profiles, and...
FDA Clears First Human Cellular Reprogramming Trial
Fascinating interview with Chief Scientist Sharon Rosenzweig-Lipson about working with the FDA, prepping for clinical trials, and what's next lifespan.io/news/first-human-cellular-reprogramming-trial-cleared-by-the-fda/
Inspect Your P‑value Histogram After DESeq2 Analysis
How is your p-value histogram look like? chatomics blog post: Downstream of bulk RNAseq: read in salmon output using tximport and then DESeq2 https://t.co/zGjobde9TO https://t.co/aCJaxto5tS
Structure-Guided Development of Picomolar Macrocyclic Inhibitors Targeting TRPC5 Channels with Antidepressant Effects
Scientists have created a new class of macrocyclic inhibitors that target the TRPC5 ion channel with picomolar potency. The lead compound JDIC‑127 achieves an IC₅₀ of 374 pM, roughly 200‑fold more potent than the previous benchmark HC‑070, and demonstrates high selectivity...
Circulating Mitochondrial and Cellular Damage Markers in Long COVID: Links to Cognitive Function, Psychological Distress, and Inflammation
A recent Molecular Psychiatry study measured circulating mitochondrial DNA and other cellular damage markers in individuals with long COVID and found them significantly elevated compared with recovered controls. The analysis revealed strong correlations between higher mtDNA levels and reduced performance...
A Color-Changing Microneedle Sensor Made From Food Ingredients Can Detect Spoilage Through Sealed Packaging
Researchers have created a food‑safe gelatin microneedle sensor that pierces sealed packaging and changes color as protein‑rich foods spoil. The device embeds red‑cabbage anthocyanin, shifting from purple to blue when pH rises, providing a visual spoilage cue. Mechanical tests show...
US Calls for DOJ Investigation of Hims over GLP-1 Drugs
The U.S. government has referred tele‑health firm Hims & Hers to the Department of Justice for a formal investigation into its GLP‑1 weight‑loss program. Hims, which recently launched a compounded version of GLP‑1 drugs to compete with Novo Nordisk’s market‑leading injectables, is...
Sanofi Misses in Fabry: Is It Time to Move on From GCS Inhibition in the Indication?
Sanofi announced that its glucosylceramide synthase (GCS) inhibitor for Fabry disease failed to meet the primary efficacy endpoint in a late‑stage trial. The double‑blind study enrolled roughly 280 patients and showed no statistically significant improvement in key renal or cardiac...
Regulators Target Hims After Misleading GLP‑1 Ads
Coincidence that $HIMS has suddenly taken down all ads touting “the same active ingredient as Wegovy”? $HIMS may have finally called enough attention to their bullshit antics to get regulators to finally crack down on them. This could...
Study Reveals Modulated UV-C Light Extends Guava Shelf Life
A recent study demonstrates that applying modulated UV‑C light to harvested guavas can significantly prolong their shelf life. The researchers found that pulsed UV‑C treatment suppresses microbial growth while using roughly 30% less energy than continuous exposure. Shelf life extensions...
Flu B Surge Kills 8 More Children, 90% Unvaccinated
1. Some news about #flu & #measles in the US: 8 more kids have died from flu this winter. That brings the pediatric death toll to 60 & flu season isn't over. Flu B activity seems to be increasing & flu...
TrumpRx Launch Falls Flat for some, Citing Generic Access
President Donald Trump unveiled TrumpRx, a direct‑to‑consumer drug platform promising to let Americans purchase prescription medicines without traditional insurance intermediaries. The rollout was framed as a fulfillment of broken political promises to lower drug costs. However, early feedback highlights that...
New Discovery Reveals Why Ovarian Cancer Spreads Rapidly in the Abdomen
Recent research highlights AI‑driven discovery of tetrahydrocarbazoles as click‑activated, broad‑spectrum antitumor agents, while a plant‑derived limonoid, DHL‑11, targets IMPDH2 to inhibit triple‑negative breast cancer. A U.S. survey shows patients still favor in‑clinic cervical cancer screening over home tests, and a...
New Study Uncovers Mechanism Behind Burn Pit Particulate Matter–Induced Lung Inflammation
Researchers at National Jewish Health published a study showing that particulate matter from military burn pits provokes markedly stronger inflammatory and oxidative responses in lung macrophages than ordinary desert dust. The work identifies Toll‑like Receptor 2 (TLR2) as the primary sensor...
Arguing for a Higher Heritability of Human Longevity
A new open‑access study re‑examines human longevity heritability, arguing that previous estimates were biased low because they ignored extrinsic mortality and arbitrary age cutoffs. By modeling and correcting for these factors, the authors find intrinsic lifespan heritability rises to roughly...
HHS Drops Legal Fight over Blocked 340B Rebate Pilot
The U.S. Department of Health and Human Services has abandoned its legal challenge to a federal court’s injunction that halted a proposed 340B drug‑price rebate pilot. The pilot, designed by the Trump administration to test new rebate mechanisms for hospitals...
Orphan Drug Tweak in US Spending Bill Will Make Life Easier for the FDA
President Donald Trump signed the federal spending bill preserving the FDA’s ability to grant a seven‑year exclusivity period for orphan drugs that receive new indications. The provision reverses earlier suggestions to shorten the exclusivity term, embedding the policy in the...
Study Strengthens the Potential of Mycoprotein as an Alternative to Meat
A doctoral thesis from the University of Borås demonstrates that mycoprotein is digested as efficiently as chicken and fish, with amino acid profiles meeting human nutritional needs. Simulated INFOGEST digestion revealed iron is more bioavailable because mycoprotein lacks phytate. The...
Insilico Medicine Welcomes Dr. Halle Zhang as New Vice President of Clinical Development for Oncology
Insilico Medicine has appointed Dr. Halle Zhang as Vice President of Clinical Development for Oncology, bringing over two decades of oncology experience from BMS and other biotech firms. Zhang will lead global clinical strategy for Insilico’s AI‑driven oncology portfolio, spanning...
FDA Grants Priority Review For Pfizer’s Marstacimab for Hemophilia A or B
The FDA granted priority review for Pfizer’s marstacimab, marketed as HYMPAVZI, to broaden its label to patients aged six and older with inhibitors and to children 6‑11 without inhibitors. Marstacimab is a weekly subcutaneous anti‑TFPI antibody, the first of its...
Navigating the Gut: The Role of Formic Acid in the Microbiome
Recent research highlights formic acid as a pivotal microbial metabolite that shapes gut ecosystem dynamics and host physiology. The study shows that specific bacterial strains generate formic acid, which modulates intestinal pH, nutrient absorption, and immune signaling. In murine models,...
Nivolumab and Ipilimumab: Key Insights From BIONIKK Study
Researchers from the phase‑2 BIONIKK trial published an exposure‑response analysis of ipilimumab and nivolumab in metastatic clear‑cell renal cell carcinoma. By correlating drug concentrations with patient outcomes, the study identified optimal dosing windows that balance efficacy with toxicity. The findings...
Neonatal Nutrition’s Impact on Body Composition
A 2026 study by Modi published in Pediatric Research demonstrates that neonatal body composition, measured with advanced techniques such as air‑displacement plethysmography, is a more informative health metric than weight alone. The research shows that specific macronutrient and human‑milk‑based feeding...
Acetylshikonin Eases Gouty Arthritis via Sirtuin1 Boost
Researchers led by Wu, C. demonstrated that acetylshikonin, a plant‑derived molecule, markedly increases SIRT1 expression in gouty arthritis models. The up‑regulation of SIRT1 coincided with significant drops in IL‑1β and TNF‑α levels, curbing joint inflammation. In parallel, the compound boosted...
IMMX Poised for Rise After Feb ’26 Enrollment Completion
$IMMX looks like it wants to move higher. Enrollment completion in Feb ’26 is the next key catalyst, setting up the path toward a filing-grade dataset in AL amyloidosis. Market starting to sniff it out. Check out the AL Amyloidosis success story here: https://t.co/1ei6kat25y
STAT+: A Sign Biotech Is Back? Four Drugmakers Go Public, Raising Nearly $1 Billion in All
Four biotech firms—Agomab Therapeutics, Eikon Therapeutics, Spyglass Pharma, and Veradermics—went public this week, collectively raising close to $1 billion. A fifth company, Generate Biomedicines, filed IPO paperwork, signaling renewed confidence in public markets. The wave follows a prolonged downturn where only...
Maturing Heart-Lung Sync Reveals Preterm Infant Health
Researchers have identified cardiopulmonary phase synchronization as a robust biomarker for autonomic nervous system maturation in preterm infants. By applying Hilbert‑transform‑based signal processing to continuous ECG and respiratory waveforms, the study mapped a clear maturational trajectory that correlates with gestational...
White House’s Online Service for Drug Sales Debuts with Limited Impact on Prices
The White House launched TrumpRx, an online portal selling about 40 prescription drugs from manufacturers such as Pfizer, Eli Lilly, and Novo Nordisk at discounted rates. The platform targets cash‑pay consumers, offering "most‑favored‑nation" pricing that mirrors low overseas prices. While the service...
Simulation Finds Grass2Gas Biogas Systems May Reduce Dairy Emissions by over 20%
A Penn State-led simulation of the Grass2Gas system—combining year‑round cover crops with anaerobic digestion of manure and biomass—shows an average reduction of more than 20% in the carbon footprint of milk from a typical Pennsylvania dairy. Life‑cycle assessment reveals that...
How CDMO Alliances Can Provide End-to-End Service that Reduces Drug Development Time and Costs
Integrated CDMO networks are reshaping drug development by offering end‑to‑end expertise, especially for complex modalities such as antibody‑drug conjugates (ADCs). Partnerships between specialist CDMOs allow small and mid‑size biopharma firms to access high‑potency handling, bioconjugation, and lyophilization capabilities without building...
Researchers Uncover Novel CDK12-FOXA1 Pathway Driving Prostate Cancer Progression—Team Led by Professor Jun Pang at Sun Yat-Sen University Reveals New...
Researchers led by Jun Pang at Sun Yat‑Sen University identified a CDK12‑FOXA1 signaling axis that drives prostate cancer progression. CDK12 phosphorylates FOXA1 at serine 234, enhancing its transcriptional potency and up‑regulating MDM2, which in turn degrades the tumor‑suppressor p53. Inhibiting CDK12 with...
Identification Methods for Drug Repurposing: Case Studies in Neurodegeneration
The article outlines modern methods for identifying drug repurposing opportunities, focusing on neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It highlights computational screening, network pharmacology, and real‑world evidence as core techniques, and presents case studies where existing drugs showed disease‑modifying...
Light’s Speed Mismatch Weakens Advanced Medical Scans, Researchers Find
Researchers identified intrinsic unbalanced group‑velocity dispersion in nonlinear interferometers as a major source of axial resolution loss for undetected‑photon optical coherence tomography (OCT). The dispersion stems from non‑degenerate optical parametric down‑conversion, making physical compensation difficult. By extracting phase from high‑precision...
Hovione’s Strategy for Complexity, Speed, and Regional Supply Chains
Marcio Temtem, Hovione’s VP of Strategic Business Management, highlighted three industry shifts: growing small‑molecule complexity, faster development cycles driven by AI, and the regionalization of supply chains. Hovione counters these pressures with its amorphous solid dispersion platform, continuous flow and...
Dropping Vaccines Revives Disease Risk in Schools
The danger of adopting a Danish-style vax schedule: "When we remove a vaccine like the meningococcal shot from the routine schedule, we aren’t just changing a line on a chart. We are inviting previously well-controlled diseases back into our high...
Neutrophil Phenotypes and Spatial Layout Mapped in Colorectal Cancer
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer https://t.co/0FLusa7vuB https://t.co/ETU87KRDXd
Editors Bridging Science: From Desk to Lab
The role of scientific journal editors is evolving from pure gatekeeping to active participation in laboratory research, as highlighted by Guo and Ding’s analysis in Light: Science & Applications. By immersing themselves in cutting‑edge fields such as photonics and quantum...
AI Diagnoses Cervical Spondylosis via Multimodal Imaging
Researchers led by Song, Li, and Ouyang introduced a multi‑task deep‑learning model that simultaneously analyzes MRI, CT and X‑ray scans to diagnose cervical spondylosis. Trained on thousands of annotated multimodal images, the system captures bony, disc and neural pathologies with...
UniQure Pauses Higher Doses in Fabry Study; Aro Shares Pompe Data
UniQure announced a pause on the mid‑ and high‑dose cohorts of its Fabry disease gene‑therapy trial after two participants receiving 4×10^13 genome copies per kilogram experienced safety concerns. The low‑dose arm will continue while the company conducts a detailed safety...
AI Tools Like Claude Code Transform Bioinformatics Development
Are bioinformaticians losing their jobs because of AI? After using Claude Code for a couple of months, I'm truly impressed by its ability to write and optimize bioinformatics tools. https://t.co/ojh5bv09fI
How AI Is Helping Solve the Labor Issue in Treating Rare Diseases
Biotech firms Insilico Medicine and GenEditBio are leveraging artificial intelligence to overcome the talent bottleneck that has left thousands of rare diseases untreated. Insilico’s new MMAI Gym trains large language models to perform multiple drug‑discovery tasks, while its platform automates...
Weill Cornell Physician-Scientists Honored with ASCI Early-Career Awards
Weill Cornell Medicine announced that Dr. Semra Etyemez and Dr. Jesse Platt received the American Society for Clinical Investigation’s 2026 early‑career honors. Etyemez earned the Emerging‑Generation Award for her work identifying biomarkers of perinatal mood and anxiety disorders, while Platt...
Texas Children’s Establishes National Benchmark in Pediatric Organ Transplantation
Texas Children’s Hospital reclaimed the national lead for pediatric organ transplantation by completing 144 transplants in 2025, a 22% rise over its 2021 record. The hospital now tops the United States in liver and kidney transplant volume and shares the...
Leqembi Starts to Deliver for Eisai and Biogen
Biogen and Eisai reported a 54% jump in fourth‑quarter sales of their Alzheimer’s drug Leqembi, reaching $134 million, with $78 million generated in the United States. The increase follows the FDA’s approval of a once‑weekly subcutaneous injection, offering a less‑burdensome alternative to...
Bioinformatics Mastery Stalls Due to Undocumented Tacit Knowledge
1/ Bioinformatics takes years to master. Not because it’s hard. But because so much of what matters… no one writes down. Let me explain https://t.co/EEboWOxB5C
Tandem Repeat Evolution Under Selfing and Selection
A new study by Sudbrack and Mullon shows that partial self‑fertilisation dramatically reshapes the evolution of tandem repeat (TR) sequences. Selfing increases homozygosity, amplifying variance from unequal recombination and strengthening selection across four regimes, resulting in lower genetic load despite...