Monitoring Beer Fermentation at the Single-Cell Level with a Novel Raman Method
Scientists at the Qingdao Institute of Bioenergy and Bioprocess Technology have introduced “process ramanomics,” a single‑cell Raman spectroscopy workflow that monitors beer fermentation in real time. By capturing Raman fingerprints from individual yeast cells, the method accurately predicts 19 extracellular metabolites, including key alcohols, esters, and sugars, matching conventional lab assays. The approach also maps cell‑to‑cell heterogeneity, offering insights into metabolic dynamics that bulk measurements miss. An auxiliary tool, Intra‑Ramanome Correlation Analysis, links intracellular spectral features to extracellular product formation, deepening mechanistic understanding.
US Must Shift to Robotic Labs to Stay Competitive
This is happening because scientific research in the US is done by hand at the lab bench. China is very good at having lots of skilled, manual labor. We need to move our paradigm for doing science off the lab...
J&J Builds Case for Earlier Tecvayli Use in Multiple Myeloma
Johnson & Johnson reported that Tecvayli (teclistamab) monotherapy cut overall survival risk by 40% in the MajesTEC‑9 trial for patients who had received one to three prior lines of therapy. The same study showed a 71% reduction in progression‑free survival...
FDA Delays Decision for Lilly’s Obesity Pill Orforglipron, Other Priority Voucher Awardees: Report
The FDA announced it will postpone its action date for Eli Lilly’s oral obesity drug orforglipron to April 10, 2026, extending the review timeline for the medication. The agency also delayed decisions for three other Commissioner’s National Priority Voucher recipients—Sanofi’s Tzield, Disc Medicine’s...
Compounder Sues Lilly, Novo, Claims Coordinated Crackdown
Arizona‑based Strive Compounding Pharmacy has filed an antitrust lawsuit in Texas against Eli Lilly and Novo Nordisk, accusing the two giants of coordinating with telehealth firms to block compounders from filling GLP‑1 prescriptions. The complaint alleges that the pharma companies restrict payment...
Jazz Sells Priority Review Voucher for $200M as Program’s Renewal Languishes in Senate
Jazz Pharmaceuticals sold a priority review voucher for $200 million, the highest price in nearly a decade, during its J.P. Morgan Healthcare Conference presentation. The voucher stemmed from the FDA’s August 2025 approval of Modeyso, a rare‑brain‑tumor drug acquired through Chimerix. While...
JPM Day 3: Rare Disease in the Spotlight
Rare‑disease therapeutics dominated day three of J.P. Morgan Healthcare, with five companies outlining 2026 roadmaps. Rocket Pharmaceuticals announced it will resume dosing three Danon disease patients in the first half of 2026 after an FDA hold, while also awaiting a...
Possible Coordinated Fake Biotech Tips Manipulate OCUL Stock
Is there a single person feeding La Lettre fake biotech takeover tips, or is this a group effort? The stock manipulation is brazen. First, we learn all the $ABVX $LLY French Ministry speculation was fake, now today it's $SNY $OCUL...
Ocugen Touts Phase 2 Data for Eye Disease Gene Therapy
Ocugen announced positive interim Phase 2 data for its geographic atrophy (GA) gene therapy, a leading cause of vision loss in age‑related macular degeneration. The trial, though limited to a small patient cohort, demonstrated measurable improvements in retinal function and...
Cellares Inks Long-Term Lease for IDMO Smart Factory at Leiden Bio Science Park
Cellares has signed a long‑term lease for a 9,741 m² site at Leiden Bio Science Park, designating it as its European headquarters and a new IDMO Smart Factory. The facility will host the company’s automated Cell Shuttle manufacturing platform and Cell...
Novartis Issues a Life Sciences Warning in a 'G-Zero' World
Novartis has sent an open letter to governments in the EU, Canada and Japan warning that fragmented regulation, unpredictable pricing and blunt cost‑control tools are causing Europe to lose life‑science ground to the United States and China. The company, together...
Advancing Human-Machine Interfaces with Memristive Technology
Researchers have unveiled a new memristive architecture that dramatically improves human‑machine interfaces (HMIs). The technology leverages analog resistance states to store and process data directly at the sensor level, cutting latency and power draw. Early prototypes demonstrate real‑time pattern recognition...
J&J Reports Positive Phase 3 Data for Tecvayli in Earlier Blood Cancer Setting
Johnson & Johnson announced that its bispecific antibody Tecvayli (teclistamab) achieved a statistically significant overall survival benefit in a Phase 3 trial evaluating an earlier‑line setting for multiple myeloma. The study reported a hazard ratio of 0.68 for death and extended...
DIY Botox: Why Self-Injecting a Neurotoxin Is a Terrible Idea
TikTok and other platforms are fueling a surge in DIY Botox, where consumers purchase unapproved botulinum toxin online and self‑inject it. In late 2025 the FDA issued warning letters to 18 websites selling counterfeit or misbranded products, citing adverse events...
Investigating the Epigenetics of Cellular Senescence in T Cells
The paper examines epigenetic regulation of senescence in CD8+ T cells from younger and older donors, revealing that the senescent state, rather than chronological age, drives the majority of epigenomic and transcriptional shifts. Approximately 40% of detectable transcription factors are...
A Beneficial Function of TGF-Β in Aging
Researchers discovered that transforming growth factor‑beta (TGF‑β) signaling in microglia acts as a protective checkpoint for myelin integrity in the aging spinal cord. In aged mice, the dorsal column showed pronounced myelin degeneration alongside heightened TGF‑β activity in resident microglia....
True Colours
The article outlines the gold standard for spectroscopy in pharmaceutical labs, emphasizing that precise colour and turbidity measurements underpin brand integrity, product identification, and patient safety. It profiles six manufacturers—HunterLab, Shimadzu, PerkinElmer, Thermo Fisher Scientific, Agilent, and Mettler Toledo—detailing flagship...
MARS Bioimaging Closes $15M Series A Funding
Medical device startup MARS Bioimaging announced a $15 million Series A round, led by Pacific Channel. The financing was delivered in two tranches—$7.6 million initially and $7.4 million later in 2026. The capital will accelerate deployment of its portable spectral photon‑counting CT scanners across...
Oxford BioMedica Confirms Private Equity Takeover Talks
Oxford BioMedica, a UK contract development and manufacturing organisation specialising in cell and gene therapies, disclosed an unsolicited cash approach from Stockholm‑listed private‑equity group EQT. The news sent the shares up 15% intraday and over a third higher year‑to‑date, reflecting...
A Protein Found in the GI Tract Can Neutralize Many Bacteria
Researchers at MIT have identified intelectin‑2, a lectin produced in the gut, as a broad‑spectrum antimicrobial protein. The molecule binds galactose residues on both mucins and bacterial membranes, reinforcing the mucus barrier and trapping microbes. Trapped bacteria eventually disintegrate, showing...
Novo Nordisk Foundation to Inject $850M+ Into BioInnovation Institute Through 2035
The Novo Nordisk Foundation announced a commitment of 5.5 billion Danish kroner (approximately $857 million) to the BioInnovation Institute, a life‑science and deep‑tech incubator, with funding extending through 2035. The pledge aims to bolster the institute’s capacity to nurture early‑stage biotech and...
JPM26: As Capital Concentrates, VCs Scrutinize Founder Pedigree and CEO Fit in Early Biotech
At the J.P. Morgan Healthcare Conference, venture capitalists highlighted a tightening funding environment for early‑stage biotech firms, driven by a hyper‑concentration of capital among a few investors. VCs now scrutinize founder and CEO attributes, emphasizing regulatory know‑how, market insight, and...
11 Companies Hiring Manufacturing Professionals Now
Big Pharma is accelerating domestic manufacturing hiring as 2026 begins, highlighted by Johnson & Johnson’s plan to add 500 jobs at a new North Carolina plant and AbbVie’s $100 billion ten‑year commitment to U.S. R&D and capital projects. The surge creates...
Spaceflight Study Links Astronaut Biology to Reversible Shifts in Epigenetic Age
A recent Buck Institute study analyzed blood from the four‑person Axiom 2 crew, revealing that a 10‑day spaceflight accelerated epigenetic age by roughly 1.9 years by day 7. Serial sampling showed the acceleration reversed after landing, with older astronauts returning to baseline and...
Chlocarbazomycins: Promising Adenosine A1 Receptor Antagonists
Researchers have identified a new class of natural products called chlocarbazomycins that act as potent antagonists of the adenosine A1 receptor. In preclinical assays, these compounds bind with nanomolar affinity and demonstrate functional activity, lowering heart rate and improving neuronal...
N1-Methylpseudouridine Shapes Translation Dynamics
Researchers have demonstrated that incorporating N1‑methylpseudouridine (m1Ψ) into synthetic mRNA reshapes ribosomal translation dynamics. High‑resolution ribosome profiling shows accelerated elongation rates and altered codon‑specific pausing compared with unmodified uridine. The modification also dampens innate immune sensing, leading to higher protein...
China’s JNBY Group Is Making a Case for Faux Fur, as the Real Thing Falls Out of Fashion
China’s JNBY Group introduced a plant‑based faux‑fur vest for its Croquis menswear line, marking the first large‑scale retail rollout of BioFluff’s Savian material. The collaboration leverages JNBY’s vertically integrated network of over 2,100 stores, allowing the eco‑fur product to reach...
U.S. Leverages Drug Spending Power to Block Chinese Biotech
Yep. Truth from @zavaindar Though unlike cars, phones, solar panels, etc, US controls the biotech market because we are only ones who pay fair price for drugs (70% of profits originate from US consumers). So we can stop...
Apply NMF to Single‑Cell RNA‑seq with Our Tutorial
Non-negative matrix factorization is a commonly used technique in genomics data analysis. Read my tutorial on how you can use it for single-cell RNAseq data https://t.co/2SA1JdLfkT https://t.co/6kI1gcqyOe
KLHL6 Ubiquitin Ligase Fuels CD8+ T Cell Resistance
Researchers have identified the ubiquitin ligase KLHL6 as a critical driver of CD8+ T‑cell resistance in cancer. KLHL6 promotes degradation of the inhibitory receptor PD‑1, thereby sustaining T‑cell activation within the tumor microenvironment. In mouse models, genetic ablation or pharmacologic...
Twitter Transformed My Bioinformatics Career and Keeps Me Current
Bioinformatics is a fast-moving field, how to stay current? 👇 The answers are different in different times. I read Stephen's post around 2012 and I hopped on Twitter; followed a bunch of bioinformaticians, Journals and professors. It changed my career trajectory. https://t.co/QYV5vKFQgP
AI Explains Single‑cell Clustering, Not Just Runs It
1/ I've analyzed dozens of single-cell datasets. I still google "Seurat clustering parameters" every single time. Last week I tried something different. I asked Claude Code to explain my clustering results instead of just generating them. https://t.co/AMQpheqhYC
Psychotropic Medications and Their Interactions with Subcortical Brain Volume in Bipolar Disorder: An ENIGMA Mega-Analysis
The ENIGMA Bipolar Disorder Working Group pooled MRI data from 6,729 participants to examine how psychotropic medications influence subcortical brain volumes in bipolar disorder. Lithium use was associated with larger hippocampal and thalamic volumes, whereas antipsychotics and valproate correlated with...
He Jiankui Returns, Society Still Unready for Embryo Editing
The reckless human embryo genome editor, He Jiankui, known as China's Dr. Frankenstein, is back at it. "People were not yet ready to accept what I was doing." We're still not. https://t.co/UYIwWj0qf1
Poll: Which Company Should I Thread Next?
So far I have finished writing two comprehensive 🧵which covered both $BEAM & $PRME #JPM26’s presentations. $XBI Before I continue to write additional #JPM2026🧵’s I’m interested in hearing your thoughts about which company - if at all - would you want...
Associations Between Mosaic Loss and Schizophrenia or Bipolar Disorder of Young Age
Recent genomic studies reveal that somatic mosaic loss, particularly mosaic chromosomal alterations, is significantly associated with early‑onset schizophrenia and bipolar disorder. Analyses of over 12,000 schizophrenia cases identified recurrent somatic copy‑number variants disrupting NRXN1 and ABCB11, while prenatal mutational signatures...
Long COVID Linked to Elevated P‑tau181, Alzheimer Risk
Not good to see the rise in p-tau181, a blood biomarker of brain inflammation tied to increased risk of Alzheimer's disease, in a prospective cohort (mean age 56 years) with #LongCovid and neurological symptoms https://t.co/XTd5qeN24e @eBioMedicine https://t.co/B1fkhoydFI
GLP‑1 Therapies
A 5★ new review of the GLP-1 drugs, what they have achieved, and where the field is headed with so many new molecules and combinations @TheLancet https://t.co/E1Xa15fk1q https://t.co/Jjmw01L5KM
PROTAC Bottleneck Breakthroughs
The latest generation of intracellular PROTACs now offers precise spatial activation, tunable persistence, and expanded ubiquitin‑ligase recruitment, addressing the pharmacokinetic and toxicity hurdles of earlier candidates. Chinese research groups have pioneered formulations that release the degrader only within target cells...
EMA and FDA Collaborate on Framework for AI Use in Drug Development
The U.S. FDA and Europe’s EMA have jointly published ten guiding principles for the use of artificial intelligence across the drug development lifecycle. The framework covers human‑centric design, risk‑based validation, data governance, multidisciplinary expertise, and clear communication of model performance....
Smartphone Measures Vasomotor Function via Fingertip Elasticity
Researchers published a study demonstrating that a standard smartphone can assess vasomotor function by measuring fingertip arteriolar elasticity using green‑light photoplethysmography combined with a volume‑oscillometric method. The technique captures blood‑volume oscillations to infer arterial pressure changes, offering a non‑invasive proxy...
Measles Cases Surge, Adult Infections Now Dominate
#Measles cases continues to climb. The 2025 tally has now hit 2242 & there've already been more confirmed cases in 2026 — 171 — than were logged in most years from the late 1990s to 2023! Interesting to see the age...
Improved Survival and Return-to-Play Guidelines for Athletes
An excellent @NEJM review of sudden cardiac death in athletes with what constitutes the appropriate workup, potential for returning to sports, and very good trend for survival over the years https://t.co/PgoBaEcbZI
Cryo-EM Maps Autoantibody Hotspots on NMDA Receptors in Autoimmune Encephalitis
A study in Science Advances used cryo‑electron microscopy to map the exact binding sites of anti‑NMDAR autoantibodies on the GluN1 amino‑terminal domain of NMDA receptors. The researchers showed that mouse‑derived antibodies bind the same two hotspots as those isolated from...
Project Prometheus Expands VC Bob Nelsen Beyond Healthcare
Secretive Project Prometheus takes VC Bob Nelsen beyond just health care https://t.co/iRuv6MP3bW via @ADeAngelis_bio #JPM26
Scribe Therapeutics Plans to Test Cholesterol-Lowering Therapy This Summer
The request does not contain the full text of the article titled “Scribe Therapeutics plans to test cholesterol‑lowering therapy this summer,” only a brief placeholder and a sign‑up prompt. Without the substantive content, no executive summary can be generated.
Ultrasound-Activated Nanoparticles in Immune Cells Trigger Targeted Inflammatory Response
Boston College scientists demonstrated that barium titanate piezoelectric nanoparticles internalized by macrophages can be remotely activated with ultrasound, prompting M1‑type inflammatory polarization. By tuning ultrasound intensity they avoided cytotoxicity, while higher power levels selectively killed nanoparticle‑laden cells, hinting at a...
STAT+: Secretive Project Prometheus Takes VC Bob Nelsen Beyond Just Health Care
Venture capitalist Bob Nelsen is spearheading Project Prometheus, an AI‑driven venture that fuses artificial intelligence with physics. The startup is co‑led by Amazon founder Jeff Bezos and former Foresite Capital AI chief Vik Bajaj, with renowned scientist Rick Klausner on board. While...
Manufacturers Benefit as Pharma Customers Invest Back in US
Recent tariff and trade policy shifts that unsettled pharmaceutical firms in 2025 are now creating upside for U.S. manufacturers. Pharma companies are redirecting capital toward domestic production, spurring demand for contract manufacturing and equipment. This investment wave is expected to...
Future Outlook: SARS and COVID-19 Explained
The article offers a forward‑looking comparison of SARS and COVID‑19, detailing their virological differences, transmission dynamics, and the evolution of public‑health responses. It highlights how early containment strategies for SARS informed later COVID‑19 policies, while also exposing gaps in surveillance...