The MIT professor who has been appointed by Robert F Kennedy Jr to review the safety of Covid-19 vaccines has failed to meet basic scientific standards in his own research on the topic, according to more than a dozen scientists and public health experts. https://t.co/y1rJQqoWDZ
Outstanding WSJ story on the explosion of ABA/autism therapy -fueled by lax Medicaid payment and often non-existent compliance policies, $20/hr RBTs credentialed after a 40-hour online course, and annual staff churn of 50–100%. Our “pay and chase” reimbursement system assumes...
This is the exact same tradeoff people who do not mask are making with our lives and children’s lives rn. Our lives in exchange for not having to mask and stop the spread of disease. Anti vaxxers are awful, but...
In perimenopause, even elite athletic women report this: More sleep disruption. More physical and mental exhaustion. More musculoskeletal pain. All of it directly undermining training and recovery. This is a hormonal architecture problem not a motivation or consistency problem. And it has...
Lab-grown teeth might become an alternative to dental fillings by @Khulood_Almani #HealthTech #Healthcare #Technology #Innovation #TechForGood https://t.co/S4x8tYCjaq
A randomized controlled trial demonstrates that the digital therapy attexis leads to a clinically significant reduction in ADHD symptoms and improvements in daily functioning for adults, showing comparable effects to face-to-face psychotherapy. digitalhealth
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis 🫀 Author conclusion: Melatonin supplementation “significantly ameliorated” multiple Cardiometabolic Risk Factors. https://t.co/SapRrA0RDa
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial https://t.co/Xt9HqmmyGi

Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases https://t.co/kp4LZEbZzN https://t.co/boWzW7fcjM

It’s Colorectal Cancer Awareness Month, so I wanted to pop on here with a gentle reminder: if you’re 45 or older, it’s time to schedule your colon cancer screening. I had mine done last year, and because I had plenty of...
Wireless EMG-Controlled Bionic Hand with Independent Finger Movement by @CyberRobooo #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/7zrAgN3ahU
So many women feel emotionally flat after birth. Not full postpartum depression, but just off. Low energy, foggy, no motivation, etc. Too often the conversation jumps straight to medication. But nobody asks about their gut. Pregnancy wrecks your gut....
Women with PMDD: Have you wondered about the genuine clinical evidence behind supplements that may help with symptom relief? These are worth a conversation with your medical provider 👇

One new trial is underway to teach future doctors how evidence is generated and evaluated. https://t.co/UaDJW1e28g #sustainability #infrastructure #IoT #AI #5G #cloud #edge #futureofwork https://t.co/lETrJfupXu
Put a camera on your toilet? I have two of these. The freakiest product of my life. But once you get over that you have a camera aimed at your poop it might save your life. My best friend died at...

"AI will not replace biological reasoning, but it may become indispensable for navigating biological systems whose complexity exceeds human intuition." A perspective on future applications for cancer neuroscience https://t.co/TnDFZ7NRFN @scisignal https://t.co/ijbhfbjXcs
AI adoption is everywhere. AI strategy is not. 98% using it 7.5% with a roadmap Adam Turinas on the healthcare AI maturity gap... https://t.co/YWIbRTtFT9 #HealthLaunchpad #AIforMarketing #hcmktg https://t.co/pGsi557iIJ
This is actually good news for health-tech. TALK’s takeout multiple of ~3.0x revenues actually represents a fairly healthy premium to the recent digital health average (recall ACCD was taken out at ~1x). https://t.co/4FyXzAiny4

Study shows nearly half of weight loss participants reduced alcohol use after starting anti-obesity medication (GLP-1 agonists, metformin, naltrexone). https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827069 https://www.gatlan.com/ @GatlanHealth

Physician burnout isn't an empty battery. It’s an engine revving while stuck in park. 🏎️💨 It’s not just exhaustion; it’s blocked energy. When your moral agency is stripped away, your "aliveness" turns into cynicism. It’s time to reframe the problem. 🧵 👇 Link...
Last fall the administration was talking about leucovorin as a potential treatment for large numbers of people with #autism. Today's approval suggests the evidence supports its use in a much smaller group of people, @rosebroderick_ reports. https://t.co/NlJR8KlaqP
In my recent @BakerInstitute article, “reframing autism,“ I debunk the nonsense around vaccines, Tylenol, and leucovorin https://t.co/pxLaDLInlf
BioNTech founders to step down and helm new mRNA startup https://t.co/yjvsVRQH2D by @Lilah_Alvarado $BNTX - 20%
Xenon hits a ‘home run’ in epilepsy; FDA restarts review of Duchenne cell therapy https://t.co/l40xYeW2Xh $XENE $CAPR + 15% $REGN $PFE $ABBV $GSK #biotech
Can it run inside your hospital? Taiwan’s debut pavilion at #HIMSS26 showcases AI built for integration, uptime & scale. Booth #6035. Mixer TODAY | 1:30 PM. Get the info: https://t.co/YmpW6r2H5Y #TaiwanExcellence #HITSM
$BBIO $ALNY moving higher on apparently good news re: Pfizer's tafamidis patent defense. If you have access to Umer Raffat's research, he has all the details.
🚨 @NPR spotlights our new JAMA Network Open study: One psilocybin dose + therapy gives 6X better odds of quitting smoking vs. nicotine patch + therapy. Game-changer for tobacco smoking addiction?

Comparison of AI and primary care physicians for 100 patients in a prospective real-world assessment —The physicians outperformed AI [AIME] for practicality and cost-effectiveness —AI was comparable for diagnosis, management plan, appropriateness and safety @AdamRodmanMD @alan_karthi @PeterBrodeurMD @googledeepmind https://t.co/FNWYoHVkkw

Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70 https://t.co/aOActAUN27 https://t.co/Bxl2YZxnlf
But hey, it’s all in our heads, amirite? (And for those who think this is all vax-induced: Bear in mind that the majority of long-haulers came from wave one, pre-vaccine.) https://t.co/wykHr4y0tX
3 new reports and an editorial @NatureCancer reinforce the benefit of AI for breast cancer screening https://t.co/MlFns7M0yB https://t.co/MF3fj0CuIE https://t.co/a436srKDaD https://t.co/1XTMIsAPfg
DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma https://t.co/v39bOreJwu
On the latest episode of Lifers, I’m joined by @MSFTResearch President @peteratmsr. We dive into the evolution of AI and his bold predictions for the future of healthcare. Timestamps: (00:00) Preview (01:23) Intro (02:54) Evolution from deep neural nets to modern AI (04:30) Demystifying model...
Correction: I took down a post about Thursday's #VRBPAC meeting because it contained an error. #FDA has named 6 temporary voting members (not 2), which will bring the number for the meeting to 9. The temps are all former members....
$CAPR resubmission of the deramiocel application accepted by the FDA. New decision date: Aug. 22. https://t.co/mWSyyXg8di
This morning's BioNTech news strikes me as very odd. Certainly, founder Ugur Sahin and Ozlem Tureci shouldn't feel compelled to run the company forever, and they may not be the right people to manage both the continued decline of Covid-19...
How CRISPR works (in nature) and how it’s being leveraged as a tool for gene editing to cure and prevent diseases. Dr Alex Marson MD PhD of UCSF on the Huberman Lab podcast out now. https://t.co/fiL48JHxSL
“Overpayments to Medicare Advantage insurers increased Part B premiums by $13.4 billion in 2025, the committee said, a cost mostly borne by seniors.”
$GSK is ostensibly the "sponsor" that won the approval but is once again saying it won't produce the drug.
Sticking with the science. I find that really impressive. BioNTech founders Uğur Şahin and Özlem Türeci are leaving the biotech they founded to start a new one. Maybe by the time they have something for the clinic, the FDA will...

Every week, I track the signals that show where medicine is really going from the latest AI breakthroughs and digital health tools to the cultural shifts redefining patient care. The Medical Futurist Newsletter brings you: ✅ Curated insights on the most impactful...

Today, I gave a virtual talk to a leading pharma company's team about the future of oncology. As they asked me to focus on AI's role in that, I'll describe real-life and some hypothetical examples of how the 5 levels...
https://open.substack.com/pub/pauloffit/p/the-v-word?utm_campaign=post-expanded-share&utm_medium=web More than one year passed before a public health official said the "V" word during a recent measles epidemic. Why?

Great evening with Frontera’s mgmt team and Denver area founders. Frontera is using AI to impact behavioral disorders, esp Autism. No holds barred panel w/ friends Ben Hemani (Bison Ventures, ex Gates Ventures), Galym Imanbayev (Lightspeed) and Amol (Frontera, ex...
Another example of how RFK Jrs version of MAHA is totally incoherent. --> he wants to end 'GRAS' chemicals in food (generally regarded as safe) --> his FDA opens door to flavored e-cigs (which use GRAS chemicals - NEVER TESTED FOR INHALATION...
Trump has collapsed cancer research. —> The National Cancer Institute hasn’t made a single grant this fiscal year https://t.co/3mKjoMua8Q
PAIN takes PATIENCE It takes years to develop chronic pain. We can’t fix that in two months. 
Actually he has it a bit backwards, those vaccinated with IPV can still acquire poliovirus and shed virus, but it prevents the virus from entering the bloodstream + protects almost 100% paralytic polio, just like the Covid vaccine protects 80-90%...
Vertex $VRTX says its drug successfully reduced marker of kidney disease in late-stage trial https://t.co/TbEkcHVYBB via @Jasonmmast
Oracle isn’t just working to keep pace with industry change. We’re setting the standard by delivering intelligent and secure solutions that can directly impact patient care and boost efficiency across the healthcare ecosystem. Here’s what you can expect this week at...