First Personalized CAR‑T Shows Mobility Gains in Stiff Person Syndrome
$KYTX Kyverna Therapeutics cell therapy improves mobility in patients with stiff person syndrome. If cleared, the medicine would be first personalized CAR-T therapy for an autoimmune disease https://t.co/B28Zp9IA2O
Daraxonrasib Monotherapy
Eileen O’Reilly’s daraxonrasib monoTx data in 1L PDAC - poster below to save y’all fighting through rows of people to get a view #aacr26 https://t.co/z4yW2apCBf
Avacta Unveils FAP‑cleavable Dual TOPO‑Ii/DDR‑i Payload
Intriguing #AACR26 poster from Avacta w/ CSO Francis Wilson presenting on their dual payload tech. The idea is to release TOPO-Ii + DDRi via FAP cleavage https://t.co/UMeB8y8KaC
Older Adults Often Don’t Need Colonoscopies or Levothyroxine
Many older adults do not need screening colonoscopies or the low thyroid drug levothyroxine: https://t.co/f2C1WrrrN7 #coloncancer #healthcare #seniors #olderadults
ARVN KRAS G12D Preclinical Shows Weak Tumor Inhibition
In the battle of the inhibitors vs glues vs degraders, this one (KRAS G12D preclinical) from ARVN doesn't look too encouraging with little TGI #aacr26 https://t.co/Ng9UWTQcsv
AI Integrates Omics and Lifestyle to Forecast Health Outcomes
A multimodal AI agentic model that integrates electronic medical records, lifestyle, layers of biologic omics data to predict health outcomes and, with perturbations, "what if" scenarios a person improved lifestyle or took a medication @Cell_Metabolism https://t.co/qgVomjkipS https://t.co/JDaeYv0JGu
Aging Mechanisms Are Now Engineerable, Says SynBioBeta
Aging isn't just inevitable decline. It's a set of biological systems that are starting to look engineerable. #SynBioBeta2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK DNA damage accumulates. Protein...
Lilly's Retatrutide Achieves 28.7% Weight Loss, Higher Dropouts
Lilly’s triple G agonist boasts 28.7% weight loss in Phase III trial Lilly is investigating retatrutide in seven other Phase III trials, which are due to read out in 2026. 👨🏻⚕️“Discontinuation rates due to adverse events were 12.2% and 18.2% with retatrutide...
Monoclonal Antibodies Boost Fight Against Infectious Diseases
This is a great conversation w @Invivyd chairman and @politico today on why monoclonal antibodies will enhance our war against infectious diseases.
Cancer Care’s Hidden Burden: 54 Days of Time Toxicity
At Cedars-Sinai, Dr. Khrystyna Levytska reveals underrecognized issue in cancer care: time toxicity Patients spend median of 54 d/yr interacting w/ healthcare As people live longer, we have to improve how they spend that time Solutions: bundle care, expand home-based services https://t.co/4c23jVbBYO
RFK Jr
RFK Jr. says China is 'eating our lunch' in biotech advances - but said Makary’s actions so far have been sufficient - also pledged support for Trump’s CDC nominee https://t.co/LMh0dShbYz
AI Speeds Disease Insight and Treatment Discovery
AI accelerates disease understanding and treatment discovery. https://t.co/pE6ppH5VR8 #sustainability #infrastructure #IoT #AI #5G #cloud #edge #futureofwork @virginia_tech https://t.co/k0Kpc0ATAF
Beyond CAR T: Programmable Immune Cells Shaping Future Therapies
CAR T cells cured patients who had no other options. That was just the opening move. #SynBioBeta2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK The next generation of T...
From Dashboards to Decision‑Making: Voice‑Chat Analytics
The next enterprise advantage will not come from more dashboards. It will come from systems that let executives ask: What changed? Why does it matter? What are my options? What could make this wrong? I’ve wanted to build that for...
Healthcare Leaders Can Pursue Innovation Without Stagnation
Healthcare leaders aren’t choosing between innovation and standing still. Jason Considine lays out the reality many providers are navigating. 👇 🔗https://t.co/oHa2I30o19 @ynhhealth @Experian #RCM #digitalhealth https://t.co/RDA5wMYyRW
Healthcare Must Stop Normalizing Disordered Eating and Privilege
It’s my birthday today and I wish for all healthcare providers to learn about the ways we normalize disordered eating on a daily basis. We need to recognize atypical anorexia and stop encouraging restriction under the guise of health. We...
Daraxonrasib Beats Chemo in Pre‑treated Metastatic Pancreatic Cancer
#ASCO26 LBA5 - Wolpin - Daraxonrasib RAS(ON) multi-selective inhibitor vs chemo in prior Tx metastatic pancreatic adenocarcinoma (mPDAC) - Ph3 RASolute 302 [May 31, 2026] https://t.co/oWEeVo2oyq #NCT06625320 #pancsm #caxtx #PrecisionMedicine https://t.co/adz922fg5z
Ivonescimab Plus Chemo Rivals Tislelizumab in First‑line sqNSCLC
#ASCO26 LBA4 - Zhiwei - Ivonescimab + chemo vs tislelizumab + chemo 1L sq NSCLC - Ph3 HARMONi-6 [May 31, 2026] Zhiwei et al. https://t.co/oWEeVo2oyq #NCT05840016 #lcsm #ImmunoOnc https://t.co/NP2qr2gPuY
Adjuvant Selpercatinib Shows Promise
#ASCO26 LBA3 - Goldman - EFS w/ adjuvant sepercatinib in stage IB-IIIA RET fusion-positive NSCLC: Ph3 LIRETTO-432 trial https://t.co/oWEeVo2oyq #NCT04819100 #lcsm #PrecisionMedicine https://t.co/HWIS9mg57w
Phase 3 Trial Shows Abemaciclib Benefits Advanced Liposarcoma
#ASCO26 LBA2 - Dickson -SARC041: Ph3 DBRCT abemaciclib vs placebo in Pts w/ adv dedifferentiated liposarcoma [May 31, 2026] https://t.co/oWEeVo2oyq #NCT04967521 #scmsm https://t.co/uD6A9JmBCn
Pharma Leaders Leverage Twitter For
A healthcare case study of @ASCO, @Novartis & @Boehringer conversation on twitter [Jan 22, 2015] via @whydotpharma (now @SiljaChouquet ) https://t.co/6xeCaqs8GO #socpharm
Perioperative
#ASCO26 LBA1 - Taplin - Perioperative APA + ADT - prostate CA [May 31, 2026] https://t.co/oWEeVo2oyq #NCT03767244 #pcsm https://t.co/8o91ntAwL9
Two Decades of Evolving ASCO Clinical Trial Trends
Trends and characteristics of clinical trials presented in ASCO plenary sessions (2011–2025) [] Overheu #ASCO26 Abstract # 11024, Poster Bd # 7 https://t.co/JYI0LY7FbU #ClinicalTrials #ctsm @ASCO
Labor Dept Demands PBM Payment Transparency Amid Legal Pushback
The Labor Department wants pharmacy benefit managers to disclose, for the first time, all the different ways they get paid. PBMs are warning this proposal is illegal. Supporters want the proposal to go further. The black box of Rx prices...
Doctor’s Insider Tips to Ease NAD IV Experience
Feel “weird” during an NAD IV? Here are the insider tips from a top doctor, @joseph_purita, to make things smoother:
Scientists Save Billions; CRISPR Cures Sickle Cell
You live in luxury. Without scientists, 6 billion of us would not be alive & the rest would live in hell. Remember that Great choices @brkthroughprize 🏆 Congrats to my colleague @Harvard, Stu Orkin, who won the prize for helping cure...
First Trial Shows Best‑in‑Class NLRP3 Inhibitor Promise
Excited to complete our first clinical trial for BGE-102. Clinical data supporting best-in-class potential, built on new chemistry and a novel binding site targeting NLRP3 - a central driver of of chronic inflammation in aging. On to Phase 2!
Cancer Patients Evolve Into Expert Co‑Navigators
The Rise of the Expert Patient in Cancer: From Backseat Passenger to Co-navigator [Mar 28, 2022] @AndreaAnampaG @JFreemanDaily et al. @DrSGraff @JCOOP_ASCO https://t.co/PO5mhwZ8hh #COSMonc @COSMOCollab https://t.co/zsKBvUprIE
Zero‑Cost AI Agents Will Redefine Radiology by 2026
AI agents near zero cost. Direct patient access to imaging. New roles in follow-up care. This panel with @PocketHealthHQ laid out what will quietly transform radiology in the next 2 years. 👇 https://t.co/GTRAx2un8A #Imaging #PatientExperience
AI Can Streamline Drug Approval, Boost Biotech Valuations
That is an interesting idea. This doesn't seem catered to investors per se, but with two partners in the summer of 25, we explored building an “AI-powered AlphaSense for biopharma” ultimately concluding it was too much work to do as...
From Dorm to $275M: Early Ovarian Cancer Detection Breakthrough
This is my friend Surbhi Sarna. She came to Draper University in 2012. She had painful ovarian cysts as a teenager, but doctors didn’t have tools that could detect cancer without harming the ovaries. She studied molecular biology at UC Berkeley. Then came...
ASCO26 Unveils Pancreatic
#ASCO26 abstract titles were released today: $RVMD RASolute Ph3 study in pancreatic cancer will be presented during the plenary session. Also, Akeso $SMMT ivonescimab HARMONi-6 trial in lung cancer. China-only data.
Muscle Mass Predicts Older Adults' Survival Better than BMI
Muscle mass is a stronger predictor of survival than BMI in older adults Read here: https://www.sciencedirect.com/science/article/abs/pii/S0002934314001387
Military Ends Mandatory Flu Shots, Reversing Centuries‑Old Policy
1/2 The military moving backwards on vaccines (recent announcement making flu vax no longer mandatory) reverses a long history that goes back to Washington and smallpox, and has continued to the (almost) present day - see below from @EvidenceOpen ...
Future Leaders Must Master Supply Chains, Healthcare, AI
Supply chain taught me how systems move. Healthcare taught me what’s at stake. AI is changing what those systems can become. The next era will belong to leaders who understand all three. Excited to speak where that future starts to...
BioAge's Inflammation Drug Shows Best‑in‑class Promise
BioAge says early data suggest ‘best-in-class’ potential for inflammation drug https://t.co/D2owlYxCRa by Kristin Jensen $BIOA $LLY $NMRA
SMMT Spikes as Akeso OS Data Lands Plenary
Summit Thera. $SMMT Well… that answers that. SMMT shares initially popped (as much as ~15%) on today’s release of ASCO abstract titles with the unexpected news that the much-anticipated OS data from Akeso’s HARMONi-6 will be released in a Plenary slot...
RFK Denies Trump Sidelining, Confirms Team Vetted CDC Nominee
RFK says today at @HouseCommerce hearing that it's not true that he's been sidelined by Trump bc of his vaccine views, and that while he didn't talk to Trump about Erica Schwartz's nomination to CDC, his team vetted and...
MRNA Brand Stigmatized by COVID Vaccine Backlash, Says Bhattacharya
That is literally a lie, as Bhattacharya wrote an op-ed trying to explain their move. He essentially was arguing that the "brand" of mRNA is tainted by public backlash to the COVID vaccine. https://t.co/5KXQJtCCxM https://t.co/HDQRvQK0ki
Cancer-Like Microglial Mutations May Fuel Alzheimer's Inflammation
Somatic mutations in microglia brain cells (the same mutations as seen in cancer) are enriched in and may drive the neuroinflammation of Alzheimer's disease @CellCellPress https://t.co/PS7pIBFW4H
Promising Mufemilast Results Unveiled at DDW
Strong mufemilast data being presented at DDW this week for anyone still following the $PALI story. https://t.co/Oi4WI6R0iW
CMS Threatens States with Audits and Federal Scrutiny
CMS will ask states for new health provider audits, Oz says. If states don't take it 'seriously,' they could become targets of further federal scrutiny. https://t.co/IIBNZ8oWrM
AI Misses Primary Diagnosis Over 80% of Time
AI fails at primary patient diagnosis more than 80% of the time, study finds 🔗https://t.co/EauFgd4tJC 🌐 #DHPSP #DigitalHealth https://t.co/VjsiqaFfkS
Pesticide Exposure Correlates with Early‑Onset Colorectal Cancer
Why are we seeing so much early-onset colorectal cancer? The correlation with pesticide exposure and its epigenetic signature, adjusted for all known risk factors. (doesn't establish cause and effect) https://t.co/1UiBiHkgo5
Robotic Cataract Surgery Opens Path for Millions
this is so exciting to see a robot just performed the first complete cataract surgery on a human patient, with no surgeon's hands on the tools and no general anesthesia cataract surgery is where the eye's clouded lens gets swapped for an...
GLP‑1 Therapy Halves Insulin Use in Type 1 Diabetes
I so don't want to add to The Discourse, but I do have to say that the use of a GLP-1 has been a miracle for my Type 1 diabetes (not even the kind that the drugs are made for)....
Distinguish Dilutional Vs. Iron‑Deficiency Anemia in Pregnancy
Almost every pregnant woman's blood work shows anemia at some point. But there are two very different reasons for it and most providers do not distinguish between them. The first is dilutional. Your plasma volume increases by about 50% during pregnancy...
AI Accelerates Small Molecule Synthesis, Says Martin Burke
Small molecule synthesis made faster for the AI era: Listen to Martin Burke on The Long Run. Sponsors: @AlphaSenseInc and Dash Bio. https://t.co/D990phgzg8
AI Could Turn $30B Healthcare Data Into Value
We spent $30 billion digitizing American healthcare. It got used for billing. New Lifers episode with @Farzad_MD, physician, former National Coordinator for Health IT, and CEO of @AledadeACO, on what went wrong, and why AI might finally fix the incentives, with...
UK Bans Cigarettes for Under‑30s, Targeting Smoke‑free Generation
JUST IN: UK bans cigarette sales for anyone born after Jan 1, 2009, aiming to create a “smoke-free generation”