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Uterine Immune Cells Differ; Blood Tests Miss Pregnancy Tolerance

Pregnancy is an immunological paradox. Half the baby's DNA comes from someone else. Your immune system should reject it the way it rejects a transplant. But it doesn't. Your body pulls off this precise immune shift where the immune cells in your uterus are completely different from the ones in your blood. Rather than attacking the embryo, they remodel the blood vessels to feed the placenta. When this immune tolerance breaks down, it's linked to recurrent miscarriages, preeclampsia, and implantation failure. Yet most fertility clinics never test for it. The standard NK cell test measures immune cells in your blood, which are completely different from the ones in your uterus. So the test is measuring the wrong thing. And instead of developing a better test, the governing bodies (ASRM, RCOG) just said stop testing altogether. Reproductive immunologists have been saying for years that the field is starved of research funding. ASRM says "don't test until we have evidence." Researchers say "we can't get evidence without funding for proper trials." Classic catch-22. Meanwhile women keep miscarrying and nobody's looking at their immune system.