APOE Ε4 Predicts Early Cognitive Decline in Midlife Adults
APOE ε4 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults 🗣️” In this study, APOE ε4 carrier status was associated with early cognitive decline, highlighting midlife risk awareness and lifestyle interventions, while non-APOE polygenic risk may require longer follow-up to manifest….” https://t.co/s3X2rsGN7s
Rare Measles Complication Kills Child Years After Infection
Subacute sclerosing panencephalitis is a rare but fatal side effect of #measles infection, which manifests years after a kid recovers. This story of a family who lost a 10-year old to it is heartbreaking. Renae was too young to be...
Regulatory Hurdles, Not Tech, Slow Biotech Breakthroughs
"We need 6 'AlphaFold' moments to compress the drug delivery timeline from 10yrs to a few months" -Demis Yes and the FDA will still take 10yrs to approve it. Safetyism has throttled biotech unnecessarily and the only way to accelerate is to...
Inflammation, Not Cholesterol, Fuels Heart Disease
As a medical school professor, I have been saying this for years. Now Scientific American put it on the cover. "Your Heart In Flames" -- May 2026 issue. The argument: chronic inflammation, not cholesterol alone, is the real driver of cardiovascular disease. Up...
Self‑Experiment Shows High‑Dose Statins May Reduce Exercise Performance
1/2) Given emerging literature I decided to test, in a randomized, placebo-controlled crossover experiment conducted on myself whether high-dose statins would impair my exercise performance.
Nicotinamide Riboside Blocks Lasting Mitochondrial Damage Post‑asphyxia
Long-term region-specific mitochondrial respiration impairment after perinatal asphyxia is prevented by the NAD⁺ donor nicotinamide riboside: A real-time organotypic metabolic profiling approach https://t.co/ZGyAxcnNAC https://t.co/w0VJkAmlHT
Patients Seek Google First, Doctors Become Last Resort
A mother once came to me with her 8 year old. First thing she said wasn't the symptoms. It was "Doctor, I read online that it could be... She had already diagnosed her child. Already half-decided the treatment. She just needed me...
MyChart’s 250 Deep Links Reveal Limits of Data‑Only Portals
Everyone has strong opinions about MyChart. I decided to stop speculating and take a look under the hood. The MyChart APK declares roughly 250 deep links covering everything from geofenced appointment check-in to payer-to-payer data exchange to bedside tablet pairing. The...
UnitedHealth's Profit Strategy: Deny Patients Needed Medication
UnitedHealth just told Wall Street their plan for more profits is to deny more medicine to people. https://t.co/JYysdCAPBw
Tortugas Neuroscience Launches to Develop Brain Disorder Drugs
Tortugas Neuroscience launches with hopes to develop drugs for brain disorders, other conditions https://t.co/zoM69VEQtV via @ADeAngelis_bio
Trump Order Boosts Psychedelic Biotech Stocks
Trump executive order lifts psychedelics biotechs https://t.co/3H00cxuF4A by @realJacobBell $GHRS $HRELP $DFTX $ENVB $COMP $ATAI #biotech
Metabolic Health Drives Knee Osteoarthritis Progression
Knee Osteoarthritis Thread 4: Metabolic Health and the Knee. Your metabolic health will directly impact how your knee feels more than you can imagine. Your metabolic health directly influences how quickly your arthritis progresses and how your cartilage responds to...
Serif Targets Revolutionary Genetic Medicine Platform
Serif, Flagship’s latest biotech, aims to make a new kind of genetic medicine https://t.co/kvmbF3xYKu by @gwendolynawu #biotech #startups @FlagshipPioneer
Endless ER Wait Leaves Mom Still Unattended
Spent the whole evening in the ER waiting room and we’re still waiting so that my mom gets medical attention 🫠
Celastrol Disrupts Hsc70‑Bim to Boost Longevity, Reduce Fibrosis
Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis https://t.co/Iv51QlhH5l
Cerebral Palsy Doctor Explains Real Impact of Policy Cuts
I have cerebral palsy and I’m a doctor. Here’s what policy cuts mean for patients like me. [PODCAST] http://dlvr.it/TS7zmV Podcast #PublicHealthPolicy
Group Coaching Boosts Mental Health in Seniors
Community as Medicine: A Qualitative Study of How Group Health Coaching and Social Connection Improve Mental Well-Being in Older Adults https://t.co/U8mo1sYgt1 @MDPIOpenAccess https://t.co/2HCt6wBBSm
Resistance Training Cuts Fat and Boosts Grip Strength
Exercise, nutrition, physical agent therapy in older adults with sarcopenic obesity: a systematic review and network meta-analysis RT can reduce BF% while simultaneously improving grip strength, representing an effective management strategy for sarcopenic obesity. https://t.co/p0wR2R5M1E
Four Overlooked AACR Early-Stage Agents Worth Watching
While everyone was watching KRAS, some of AACR’s promising early stage pipeline agents were easy to miss. Here's an analysis on four examples which caught my eye and are well worth watching to see how they develop in the...
ER Doctors Question Band‑Aid Role Amid Systemic Failure
An ER physician with 35 years of experience said it out loud: "Have I been part of the problem rather than part of the solution? Have I just been a band-aid?" That is Kenneth Ro, and it is the quiet...
Irregular Bedtimes Double Risk of Major Cardiac Events
Sleep timing irregularity in midlife: association with incident major adverse cardiac events and cardiovascular disease mortality over a 10-year follow-up 🫀Individuals with irregular bedtimes had a 2-fold higher risk of MACEs compared to those with regular bedtimes Irregular sleep midpoints? Also a...
Patients Now Save Money Using Weight‑Loss Injections
So I saw a Threads post yesterday and it was an interesting topic. I've spoken to my Aussie patients about this too. Dulu ingat weight loss injection = mahal. But ramai patients during consults now cakap benda sama: “Dr Dinar, I've actually been...
Tenofovir Alafenamide Cuts Biological Age in Adults
An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics 💫 https://t.co/FFvTmJv2zv https://t.co/DHHQ18nAmy
HDAC7 Loss Predicts Poor DLBCL Outcomes; Restoration Stops Tumor
Loss of the HDAC7 protein in diffuse large B cell lymphoma is linked to poorer outcomes, while restoring HDAC7 in cancer cells halts tumor growth, highlighting its potential as both a biomarker and therapeutic target. bloodcancer
Gene Therapy Works Best for Deaf Children Aged 5‑8
AAV gene therapy for autosomal recessive deafness 9: a single-arm trial 🌟“Gene therapy for congenital deafness has shown promising results in children but lacks data in older populations… . An age-dependent therapeutic effect was observed, with optimal outcomes in 5- to...
Getting a Tetanus Shot Before Unexpected Nail Mishaps
called a general appt line to get a tetanus shot operator: is there a specific time that you need this done by? me: i mean, i guess before i step on a rusty nail, i mean, im not looking to self harm...
China Debuts Pharmacy Robot Processing 370 Orders Daily
China Launches First Pharmacy #Robot Handling 370 Orders a Day by @CGTNOfficial #MedTech #HealthTech #Tech #Healthcare https://t.co/DjZ0teE6fF
Vaccinated Donor Plasma Contains No Spike Proteins or mRNA
One of the top questions I get about young plasma exchange (YPE): “What if the donor was vaccinated? Does that mean I’m getting spike proteins or mRNA injected into me?” Short answer: No. Here’s the breakdown... https://t.co/JDoAi2yPmR
Anktiva Needs Trial Data Before FDA Approval
For the umpteenth time, these posters have zero relevance to Anktiva unless, or until, $IBRX conducts/completes randomized clinical trials that demonstrate the drug improves outcomes for cancer patients w/ lymphopenia. @LoriMills4CA42 and the rest of you can idolize @DrPatrick ...
GLP‑1 Drugs Aren’t a One‑size‑fit Solution
Should everyone be taking a GLP-1 medication? From my discussion with @RealDoctorMike on his podcast https://t.co/d3M8cFHggz
Higher Muscle Strength Cuts Mortality Risk in Elderly Women
Muscular Strength and Mortality in Women Aged 63 to 99 Years 👉 “this study of ambulatory older women, greater muscular strength was associated with lower mortality even when controlling for accelerometer-measured PA and sedentary time, walking speed, and systemic inflammation.” https://t.co/xi913FibKy
AI's First Use Turns Skeptical Radiologists Into Advocates
In healthcare, you only understand how game-changing AI is once you use it. What strikes me most is how reliably opinions flip. The skeptic radiologist goes from “I don’t need this” to “I can’t imagine working without it.” Not occasionally. Almost every time.
GLP‑1s Preserve Muscle Better Than Diet‑Only Weight Loss
Summary for patients on GLP-1 drugs and non-drug weight loss re: muscle mass impact @AnnalsofIM https://t.co/pSDhbKkXwb https://t.co/qM7OgVJwQg
Garlic-Derived DAS Outperforms Metformin, Extending Mouse Lifespan
👉 “Chronic treatment with DAS (found in garlic 🧄) freshly added to the diet weekly revealed geroprotective effects, since it extended lifespan and improved metabolic homeostasis, locomotor function, and relevant cognitive parameters in wild-type male mice fed with an STD....
NIH Grant Funding Slashes, Women’s Health Projects Plummet
Elections have consequences.... The number of competitive grants awarded by the NIH is down by more than half compared with the same period last year. Overall, the NIH supported over 2,700 fewer scientific projects in fiscal 2025, about a 15%...
Measles Outbreak Could Cost $7 B, Anti‑Vax Shift
Two Bloomberg measles stories - $7 billion in potential costs and some anti-vaxers coming to their senses: https://t.co/oLkHtaLjmY https://t.co/qXAG8FfXIx
CRISPR Advances Outpace Ethics in Germline Editing Debate
In 2018, He Jiankui edited the genomes of two human embryos, brought them to term, and went to prison for it. The babies are now children. We don't know how they're doing. Seven years later, base editing and prime editing can...
Free Virtual Summit on Multiomics & NGS – Register Now
Join @julemieux1 and as we co-host THE STATE OF MULTIOMICS & NGS @Genbio virtual summit next Wednesday, April 29th: Sponsored by @illumina - registration is free. https://t.co/NJErGGe5qb https://t.co/dJuRqy8Np7
Blood and Fat Markers Forecast Heart Disease Risk
Neutrophil-to-Lymphocyte Ratio, Bone Marrow, and Visceral Fat Metabolism as Predictors of Future Cardiovascular Disease in an Asymptomatic Healthy Population https://t.co/Oq1a3fH5qa
Combine Meds and Lifestyle for Equitable Hypertension Control
Healthy Lifestyle After Hypertension—A Call to Action 💡Integrate antihypertensive medication use and lifestyle modification to deliver more effective and equitable population-level hypertension management and cardiometabolic disease prevention. https://t.co/wENgycQ8hz
LLY's Second in Vivo CAR‑T Deal via Kelonia Buyout
Kelonia turns #ASH25 late-breaker into buyout, with $LLY's second move into in vivo Car-T. Via @ApexOnco -> https://t.co/NPhdnuhPu3 $AZN $GILD
Oracle Health Joins CMSGov Aligned Networks to Boost Data Access
For decades, the @OracleHealth team has been committed to making sure patients have access to and remain in control of their health data. Our participation in the @CMSGov Aligned Networks underscores this commitment, and will help improve how clinicians and...
Key Overlooked Factors in Clinical Trial Design
New presentation on things we often forget to consider when designing a clinical trial: https://t.co/BVlSCIHdLu #Statistics #clinicaltrials
Deadliest Cancers Receive the Least Federal Funding
The worst cancers with respect to lethality get the least federal funding support https://t.co/uCJXYgpB3c https://t.co/woqbMo1oYp
Inside the $3.25B Eli Lilly Acquisition: Memo and Deck
Read the memo and slide deck that led to th creation of the company Eli Lilly bought for $3.25 billion today https://t.co/cNoTs7M4YM
Nektar Jumps as Alopecia Drug Shows Promise
Nektar surges again as alopecia drug shows new promise in extension study https://t.co/UV0ccY4HiR @ByJonGardner $NKTR + 25% $LLY
First Gut Microbiome Signature Predicts Parkinson’s Risk in Healthy Carriers
We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition @NatureMedicine https://t.co/oDTItnis5L
2018 Study Predicts Psilocybin Should Move to Schedule 4
The psychedelic executive order requires government to "initiate and complete review of any product containing a Schedule I substance that has successfully completed Phase 3 clinical trials ... so that rescheduling ... may proceed as quickly as practicable". My 2018...
AACR 2026 Unveils Merck Breakthrough and Lung Cancer Hope
AACR 2026: Revolution’s next prospect, Merck’s reveal and a lung cancer battle https://t.co/u2iwCd3DKv #AACR26 $RVMD $MRK $NUVL $NUVB
Biotech Must Prioritize Collaboration, Not Nationalism, for Patients
After a week in Washington DC at one of the best new annual events by @semafor , I came to China for just 2 nights to meet some of my friends from Washington. I even had to skip this year's...