Do Longevity Supplements Really Work?
In this episode of Longevity by Design, Dr. Andrea Mayer discusses the scientific evidence behind multivitamin and mineral supplements, highlighting that they may modestly improve cognition, mood, and blood pressure in at-risk or nutritionally deficient individuals, but show little benefit for healthy people or survival outcomes. She emphasizes a personalized approach—testing nutrient levels and dietary habits before supplementing—and warns of quality issues, noting that roughly one‑third of commercial products contain inaccurate dosages or missing ingredients. The conversation also covers emerging geroprotective compounds like alpha‑ketoglutarate and spermidine, which show modest biological age and inflammation benefits in specific, already healthy middle‑aged groups. Overall, Mayer advocates for targeted, evidence‑based supplementation and stronger regulatory oversight of supplement quality.
259: Dr. Matt Bernstein, Metabolic Psychiatrist: Your Sleep & Mental Health Problems Might Start With Food
In this episode, host Molly Eastman talks with Dr. Matt Bernstein, a psychiatrist and CEO of Accord, about metabolic psychiatry and how diet—particularly ketogenic nutrition—affects mental health, anxiety, and sleep. Dr. Bernstein explains the science behind ketosis, its impact on...
Born to Live Longer? Inside the Genetics and Biology of Centenarians
In this episode, Dr. Paola Sebastiani explains how the genetics of extreme longevity are far more complex than a single "longevity gene," highlighting the growing list of genetic variants—such as APOE, chromosome 9 loci, and inflammation‑related regions on chromosome 6—that...
339. Summary: Nutrients That Help Fight Chronic Fatigue - Life Extension
The Live Foreverish episode hosted by Dr. Mike and Dr. Crystal tackles chronic fatigue syndrome, highlighting how nutrient‑based strategies can alleviate persistent exhaustion. They discuss established supplements such as CoQ10, B‑complex vitamins, and vitamin C, explaining their roles in cellular...
Ep 370 - Calories: Labels vs Reality
In this episode of Iron Culture, hosts Eric Trexler and Dr. Eric Helms dissect a class‑action lawsuit alleging that David protein bars dramatically under‑report calories and fat due to the use of a novel fat replacer (EPC). They explain how...
339. Nutrients That Help Fight Chronic Fatigue - Life Extension
In this episode, Dr. Mike and Dr. Crystal Gossard discuss chronic fatigue syndrome (CFS), outlining its diagnostic criteria, common symptoms like post‑exertional malaise and orthostatic intolerance, and the challenges patients face in getting an accurate diagnosis. They explore potential causes—including...
#385 – AMA #82: Applying the Tools of Longevity in the Real World: Disease Prevention, DEXA Scans, Artificial Sweeteners, Injury...
In this AMA episode, Dr. Peter Atiyah tackles a wide array of practical health questions, covering how health priorities shift across the decades, the hierarchy of chronic disease risk, and the most useful consumer health metrics. He discusses the role...
#385 - AMA #82: Applying the Tools of Longevity in the Real World: Disease Prevention, DEXA Scans, Artificial Sweeteners, Injury...
In this AMA sneak‑peek, Dr. Peter Atiyah fielded listener questions on practical longevity strategies, covering how health priorities shift across the 20s, 40s, and 60s+, the hierarchy of chronic disease risk (cardiovascular, cancer, neurodegeneration, metabolic), and the most useful consumer...
RHR: New Study Challenges the Plant-Based Longevity Myth
In this episode Chris Kresser reviews a new American Journal of Clinical Nutrition study of over 5,000 Chinese adults aged 80+, which found vegetarians and especially vegans were 19‑29% less likely to become centenarians than omnivores, with the effect driven...
Chris Masterjohn: COVID-19 to Mitochondrial Health, Communicating and Applying "the Science"
Chris Masterjohn, a nutritional scientist and mitochondrial biologist, launched Mitome, a consumer‑focused platform for mitochondrial health testing. In a conversation with Razib Khan, he critiqued the COVID‑19 response, alleging authorities overstated certainty and faced attempts at censorship. Masterjohn also argued...
The Gut-Fatigue Connection: Is Your Digestion Making You Tired?
In this episode the host explores the emerging link between chronic fatigue—including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—and gut health, emphasizing how gut dysbiosis may drive persistent exhaustion. They explain the gut microbiome as a complex ecosystem, using a garden metaphor...