Lymphatic‑Targeted Prodrugs Boost Neuropsychiatric Oral Absorption
Loved getting these pictures. Full house w/ hundreds attending our oral presentation “Unlocking Medicines for Neuropsychiatry by Enhancing Oral Absorption Using a Lymphatic-targeting Prodrug Technology” at the American Society of Clinical Psychopharmacology annual meeting https://t.co/hylVMd1IWW
Study Shows Mechanism, Not Creatine Risk for Endometriosis
Creatine promotes endometriosis” is making the rounds. That’s not what the paper shows. It’s a mechanism study in cells and mice. Here’s why it says nothing about your creatine tub. 🧵
Prototype Antenna Goes Skyward, Paving Path for 244‑Dish ngVLA
A single prototype antenna just shifted from construction to sky testing; see how it sets the stage for a 244-dish ngVLA. https://spectrum.ieee.org/ngvla-radio-telescope-vla-astronomy?share_id=9577419
GLP‑1 Drugs Cut 8‑year Knee Replacement Risk by 5%
New in Regional Anesthesia and Pain Medicine: three years of semaglutide or tirzepatide was linked to a nearly 5 percentage point lower 8-year risk of knee replacement in adults with osteoarthritis. University of Maryland compared ~42,000 GLP-1 users to ~42,000 matched...
MyHC‑slow Loss Drives Insulin Resistance; Sulforaphane Rescues
Muscle contraction and metabolism are more connected than we thought. Loss of the slow-twitch motor protein MyHC-slow (Myh7) triggers muscle dysfunction, insulin resistance, and impaired glucose uptake via disrupted NRF2 signaling and mitochondrial health. Sulforaphane reversed many of these effects,...
Graphene 2026: Premier Global 2D Materials Conference in Barcelona
GRAPHENE 2026 in Barcelona late june THE Key international event of Graphene, 2D materials and co....https://t.co/Lu3IT29eLw https://t.co/a8bFyr4kV3
Post‑Black Death Oak Expansion Hits Islands and Mountains
Ancient Mediterranean oak forests show a strong wave of tree establishment beginning in the early 1400s, shortly after the Black Death. The same signal appeared in both island and mountain settings, but not at the same pace. ecology
Ancient Deer Held Genetic Diversity Lost in Modern Populations
A 120,000-year-old fallow deer population in central Europe held as much genetic diversity as today’s deer across Eurasia. Modern animals appear to preserve only a narrow slice of that earlier range. paleogenetics
Moderate Emissions Keep Earth 3‑4°C Warmer by 3000
We are in the Age of Humans - the Anthropocene. Our new article (open access) shows how even with a moderate future emissions scenario, global temperature will still be elevated by 3-4°C in the year 3000! Lifetime of our CO2 in the...
Senescent Tumor Cells Kill Neighbors, Fueling Growth
Some tumor cells with abnormal chromosome numbers enter senescence, then send signals that suppress and kill nearby healthy cells. In fruit flies, that damage helped the tumor keep expanding. cancerbiology
Time‑Restricted Eating Boosts Health, Sparks Intermittent Fasting Era
Fourteen years ago today, our lab published the first definitive evidence that simply restricting when mice eat—without changing the amount or quality of food—can deliver profound health benefits. That discovery helped launch a new era of circadian nutrition research and...
Gravity, Crust Flexing, and Earth's Wobble Drive Sea‑Level Changes
Sea level is shaped by more than melting ice and thermal expansion. As ocean mass shifts, gravity, crust flexing, and a slight rotational wobble can amplify rise along some coasts while parts of the deep ocean drop. sealevel
Future Heart Disease Prevention Targets Inflammation, Not Lipids
The next frontier for prevention of heart and vascular disease isn't targeting lipids. It's about blocking inflammation. These are some of the ongoing clinical trials @NatureMedicine https://t.co/DSLMoPFqs7 https://t.co/RDoVUXKjBl
Semaglutide Slows Biological Aging in HIV Patients
One of the lies I taught in medical school: aging is a separate disease from metabolic disease. A new RCT just complicated that. UC San Diego + TruDiagnostic, randomized double-blind placebo-controlled (Nature Communications, June 2026): adults with HIV on semaglutide showed...
Star Mass Distribution Varies: New Reason Uncovered
Starts With A Bang podcast #130 – the initial mass function of stars Give the Universe a massive enough cold cloud of gas, and it'll give you a spectrum of stars of all different masses. But that spectrum isn't universal, and we...
Folded
A folded right-angle linker let four planar π-conjugated panels assemble into square macrocycles, overcoming a long-standing geometry problem. The same imine bond also enabled reversible acid-triggered color change and recovery of starting monomers from byproducts. chemistry
3D Retinal AI Beats 2D Models, Detects Six Diseases
A new AI system built for 3D retinal scans identified six of eight retinal diseases more accurately than a model trained on 2D images. The improvement held across multiple clinical sites and imaging methods. ophthalmology
TLR5 Deficiency Links Lung Microbiome Shift to Fibrosis
A faulty TLR5 receptor may help drive idiopathic pulmonary fibrosis by disturbing the lung microbiome. In people and mice, TLR5 deficiency aligned with lower bacterial diversity and more proteobacteria. lunghealth
CRISPR Embryos and Self‑learning AI Now Real, Risks Looming
Two of the most powerful technologies we've ever known—CRISPR human embryo editing and self-improving A.I.—are getting actualized, and carry known and unforeseen risks https://t.co/yQY4KqCIhy https://t.co/08ZSvxZ07k @AnthropicAI https://t.co/RLM7Pj93Y7
Kids Detect Intent in Human Eyes, Not Robots
Children Read Intent in Human Eyes but Not in #Robots by Nicola Cerbino @NeuroscienceNew @Unicatt_en Learn more: https://t.co/EU9R1qaDEf #Innovation #Technology #EmergingTech https://t.co/P3xQST5gFj
Massive Cell Counts: Insight or Just Bigger Numbers?
1/ Another single-cell study drops. 500,000 cells sequenced. More UMAP plots. More clusters. But here’s the question: Are we learning more—or just counting better? 🧵 https://t.co/0MteDjplVz
Timed Antioxidants Restore Redox Rhythms, Rejuvenate Aged Mice
Aging disrupts daily redox rhythms across tissues, contributing to metabolic and functional decline. In aged mice, timed antioxidant/pro-oxidant interventions restored redox oscillations, improved glucose metabolism and motor performance, and partially rejuvenated liver and muscle programs. #Aging #CircadianBiology #Longevity https://t.co/s5qZVYxvWq
Deep Antarctic Meltwater Reveals Hidden Coastal Reservoir
Antarctic glacier meltwater showed up well below the surface in coastal waters along the Western Antarctic Peninsula. In sheltered bays, the freshwater signal extended beyond 90 meters, hinting at a hidden reservoir in the water column. climate
ETH Zürich Introduces HELIOS: Four‑armed Humanoid for Space
ETH Zürich Unveils HELIOS: A Four-Armed Humanoid #Robot Built for Space Operations by @orbitrobotics #Robotics #EmergingTech #Technology #Innovation https://t.co/Mjtew0hlfa
Many STEMI Patients Lack Traditional Risk Factors, Outcomes Similar
ST‐Segment–Elevation Myocardial Infarction (STEMI) Patients Without Standard Modifiable Cardiovascular Risk Factors—How Common Are They, and What Are Their Outcomes? https://t.co/ntbIex0nOp
Prenatal Zika Causes Hidden Developmental Delays Unpredicted by Biomarkers
Prenatal Zika exposure was tied to subtle vision, hearing, and social changes in infants that appeared healthy at birth. Common maternal biomarkers did not predict which infants would later show developmental differences. zika
New Gene-Editing Tool Enables Precise Human Embryo Modifications
When scientists used CRISPR to edit the DNA of human embryos, it made catastrophic mistakes. But now they've used a newer tool to make far more precise edits. Here's my story about how this changes the germline engineering debate. Gift...
Microglia Shift Determines Alzheimer’s Progression in Elderly
Identifying an inflection point for Alzheimer's disease from the brains of 80 and 100 year old individuals. Microglia transition is key; initially it is protective vs inflammatory changes triggered by amyloid. But microglia can turn destructive linked to tau. Resilience in...
Quit Smoking Cuts Dementia Risk, Especially Without Weight Gain
A new Neurology study found that quitting smoking significantly lowers the risk of dementia and cognitive decline, with the greatest benefits seen in people who avoid substantial weight gain after quitting... https://t.co/RNIIAPhuyQ
Agriculture Drives 94% of Global Tree Cover Loss
Nearly all of that permanent loss (94%) of global tree cover between 2001 and 2025 is linked to the removal of trees for agricultural activities. https://www.wri.org/news/release-tropical-rainforest-loss-drops-36-2025-fires-threaten-global-progress
1927 Solvay Conference: Quantum Debate Among Future Nobel Legends
The Fifth Solvay International Conference on Physics, held from October 24 to 29, 1927, in Brussels, is widely considered one of the most significant events in the history of science. Its primary focus was "Electrons and Photons," but it is...
Orexin‑Target
Modafinil, the “Limitless drug” I talked about on Nightline years ago, was the first medication that increased alertness without acting like a traditional stimulant. It works through orexin pathways, which is why researchers had to create an entirely new category for...
Black Hole Wind Carves Cone Cavity Near Sagittarius A*
Near Sagittarius A*, a cone-shaped cavity missing cold gas points to a black hole wind. The hollowed region aligns with bright X-rays, while nearby stars appear unable to supply enough energy to make it. astronomy
Blood Filter Trapped Ebola Particles in 2014—Could It Help Today?
In 2014, doctors used a blood-filtering device to trap millions of Ebola particles from one patient's blood. Could it work in today's outbreak zones? https://spectrum.ieee.org/ebola-hemopurifier-blood-filter?share_id=9572300
Tart Cherry Boosts Muscle Recovery and Adaptation
Tart cherry may enhance muscle adaptations to exercise 🍒 This new study investigated the effects of tart cherry supplementation on recovery from exercise-induced muscle damage 🔍 Participants either consumed… 1️⃣ Tart cherry (high-dose) 2️⃣ Tart cherry (low-dose) 3️⃣ Placebo …for 7-days prior to muscle damage....
AMOC Collapse Threatens Northern Europe's Food Security
I often get asked: what impacts would a shutdown of the Atlantic ocean circulation #AMOC have? A short overview is found in this expert report. Impacts include e.g. widespread domestic food insecurity in Northern Europe and strain on global food...
Older Fathers Reduce Offspring Reproductive Success, Study Finds
Older fatherhood might lower evolutionary fitness in the children. A study of 1.4 million+ people found that having a child at 45 instead of 35 was associated with roughly 3–8% lower reproductive success in the offspring. The likely explanation: more mutations accumulate...
Tiny Space Laser Sidesteps Cable Vulnerabilities, Reshapes Connectivity
World's smallest space laser station is changing global connectivity by bypassing 'vulnerabilities associated with terrestrial and subsea cables' https://t.co/wEtJJJsP9x
PurIST Classifier Validated for Therapy Selection in Pancreatic Cancer
Real-World Validation of the Purity Independent Subtyping of Tumors Classifier for Informing Therapy Selection [PurIST @TempusAI] in Pancreatic Ductal Adenocarcinoma [Sep 4, 2025] @stephwen et al. @JCOPO_ASCO https://t.co/R24DErvaB4 #pancsm #PrecisionMedicine
Atom Computing Achieves Fault‑tolerant Quantum Breakthrough, Gets $100M Support
Massive step closer to fault tolerant #quantum computing by @DCVC-backed @Atom_Computing—a world first on a neutral atom system at this scale. This proof, on commercially viable Atom systems capable of over 1000 qubits (with a clear, near-term roadmap to orders of...
Experiment Confirms Only 100% WWS Solves Climate
The experiment is over–we know what does & doesn’t work to address climate Video https://www.youtube.com/watch?v=OTeXp8RP_Dc WWS system https://web.stanford.edu/group/efmh/jacobson/Articles/I/WWSDiagram.pdf 2009 100% WWS paper https://web.stanford.edu/group/efmh/jacobson/Articles/I/sad1109Jaco5p.indd.pdf Book https://web.stanford.edu/group/efmh/jacobson/WWSStillNMN/StillNMN.html
NewLimit Secures $435 Million, Valued Over $3 B
NewLimit, one of the 'epigenetic reprogramming' companies, raised $435 million. Very big number. Second biggest after Altos. Claims payload will be RNA to the liver. Presumably its 1 or more transcription factors carried by LNPs. New valuation >$3 billion....
NASA Holds Today’s MAVEN Loss Briefing at 2 PM ET
NASA will have a media bfg TODAY (June 3) at 2:00 pm ET about MAVEN. The Mars orbiter was last heard from on Dec 6 when it didn't reestablish contact after its orbit took it behind Mars. The press...
Parental Exercise Pre‑Conception Programs Offspring Metabolism
Exercise benefits may begin before conception. In mice, parental physical activity before mating shaped offspring body composition, hypothalamic gene expression, and early-life metabolic programming—with effects influenced by parental age and potentially mediated through changes in breastmilk composition. #ExerciseScience #Epigenetics #MetabolicHealth...
Calorie Restriction Cuts Human Biological Aging by 2‑3%
Slowing aging is not theoretical. In humans, calorie restriction measurably slows biological aging pace by ~2–3% over 2 years https://www.nature.com/articles/s43587-022-00357-y
Cognitive Resilience Lets some Avoid Dementia Despite Alzheimer’s
Not all Alzheimer’s leads to dementia "Why do some people experience memory loss and cognitive decline as Alzheimer’s builds up in their brain, while others stay mentally sharp? This question lies at the heart of new research into “cognitive resilience”, a...
Engineered Hookworm Delivers Anti‑Tetrodotoxin Antibody In Vivo
A genetically modified human hookworm produced an antibody against tetrodotoxin inside an animal host and secreted it into the bloodstream. The neutralization was partial, but the delivery route worked end to end. biotech
Immobilization Studies Isolate Calorie Restriction’s Impact on Muscle
Figuring out whether caloric restriction reduces muscle mass is difficult when physical activity levels are normal because the reduction in bodyweight changes the number of activated fibers in activities of daily life. Immobilization studies provide an answer. https://t.co/F2N3IuCkiY
Dense Tumor Stroma Causes Highly Uneven Antibody Delivery
A single-cell platform tracked an antibody drug through pancreatic and head and neck tumors and showed sharply uneven delivery from one region to another. Dense surrounding tissue appeared to block access in parts of the tumor. cancerbiology
SMuRF‑less ACS Patients Face Higher Mortality, Receive Fewer Therapies
Higher mortality in acute coronary syndrome patients without standard modifiable risk factors: Results from a global meta-analysis of 1,285,722 patients "Despite lower body mass index and fewer comorbidities, SMuRF-less patients had increased in-hospital mortality and cardiogenic shock. However, despite worse outcomes,...