Immobilization Studies Isolate Calorie Restriction’s Impact on Muscle
Figuring out whether caloric restriction reduces muscle mass is difficult when physical activity levels are normal because the reduction in bodyweight changes the number of activated fibers in activities of daily life. Immobilization studies provide an answer. https://t.co/F2N3IuCkiY
SMuRF‑less ACS Patients Face Higher Mortality, Receive Fewer Therapies
Higher mortality in acute coronary syndrome patients without standard modifiable risk factors: Results from a global meta-analysis of 1,285,722 patients "Despite lower body mass index and fewer comorbidities, SMuRF-less patients had increased in-hospital mortality and cardiogenic shock. However, despite worse outcomes,...
MappBio's Ebola Antibody MBP-134 Near Outbreak Trial
Wondering where things stand with MappBio's MBP-134 #Ebola monoclonal antibody? The company posted on it today on LinkedIn. And @PeterHorby said Oxford's Pandemic Sciences Institute is working hard to get MBP-134 into a clinical trial in the outbreak zone. https://t.co/1XtbFH1FJg...
Key Takeaways From NAS
🧪⚛️ Summary and thoughts about the outgoing NAS president's State of Science Address 2026. https://t.co/XfRL2xbPNZ https://t.co/tHWrOVnWFG
DBS Reshapes Mood‑related White Matter, Altering Brain Networks
Deep brain stimulation appeared to remodel white matter in a pathway linked to mood, rather than acting only through short-term electrical effects. The changes were accompanied by broader network shifts in the brain. neuroscience
Majorana 2 Delivers 1000× Capacity
And @satyanadella unveils Majorana 2 - 1000x the capacity of Mayorana 1 - in the same form factor - 20 second mean [Qubit] lifetime - 1 microsecond ops - 1/100th of a mm #MSBuild https://t.co/tcNCUUhDpF
Sex and Age Shape Immune Response, Undermining Uniform Treatments
The problem with one-size-fits-all medicine: Biological sex and the aging immune system @BBParis1984 https://t.co/kd5H69wTCZ https://t.co/E3AjzFl0xC
Zero‑G Liquid Storage Set to Revolutionize Space Missions
New Zero-G Liquid Storage System Could Transform Space Missions by @interesting_aIl #SpaceTech #Tech #Technology #EmergingTech #Space https://t.co/WBFRiw6v7C
Mitochondrial Transfer Fuels Cancer Cell Death and Inflammation
Cancer and the mitochondria @Cell_Metabolism Effects of mitochondrial transfer between cells (pathological spelled wrong in figure) and these organelles as a driver of cell death, inflammation https://t.co/vs6b11wwEf https://t.co/4GFjBSLBYf https://t.co/GXl9RxaETU
UMAP Plots Can Mislead—Read Single‑cell Data Wisely
1/ That UMAP plot you’re staring at? It might be lying to you. Let’s talk about why dimensionality reduction can mislead, and how to read your single-cell data without fooling yourself. 🧵 https://t.co/UArMjpZNuU
New Multi-Center Registry Uncovers Hematologic Cancer Biomarkers
AQUARIUS: A longitudinal multi-center molecular biomarker discovery registry for Pts w/ hematologic malignancies - @mtmdphd et al. @TempusAI & IFLI - Instit Follicular Lymphoma Innovation #ASCO26 abstr TPS7105, Poster 599a https://t.co/70G0v1P968 #NCT07154823 #lymsm #cagenome https://t.co/WTLsn97BCx
Specific Molecular Switch Drives Resistance‑exercise Muscle Growth
New in Nature Metabolism: a specific molecular switch that turns resistance exercise into muscle growth has finally been mapped -- and it does not flip after endurance work. (1/4)
Higher Teen IQ Predicts Lower Dementia Risk Later
Adolescent IQ and risk of dementia: a 67-year prospective study 🥳Adolescent IQ is an early life factor associated with a lower risk of dementia in older adulthood. This research highlights the importance of a life-course perspective on brain health.🧠 https://t.co/6AaXKrXEND
Time‑restricted Feeding Restores Metabolic Health in Aging Mice
Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice "These results underscore the potential of TRF as a dietary intervention to mitigate adipose dysfunction and promote metabolic health in the aging population." https://t.co/JgTEjivlCM
Perth Storms Rare, Sea‑level Rise Already Accelerating
Perth storms may be in one in five years, but sea level rise from climate change has been decades in the making, with more to come https://t.co/RV4FKjIDea ICYMI Sunday Times 2007 interview warning on sea level rise in #Broome, #Perth, #Rockingham & #Mandurah...
China Greenlights First Invasive Brain‑chip, Aims Global Lead
China has approved the world’s first invasive brain-computer chip—here’s what’s next The country wants to become a global leader in brain implants. Strong government support is expected to help accelerate that process. https://t.co/B9uOKsHwmE
Adipocyte SLC25A51 Controls Mitochondrial Function and Aging Metabolism
The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging https://t.co/4SuyuA0UsH https://t.co/h1nYczP9Jl
Judge Halts NSF Plan to Close Colorado Climate Center
A judge has temporarily blocked the National Science Foundation from dismantling a globally significant weather and climate research center in Colorado https://t.co/cayo1079vG
High‑Intensity Exercise May Actually Build Cartilage
What if high intensity exercise actually grew cartilage? I have to walk folks off the ledge of fear almost daily in my office. Far too many think that exercise is grinding away their cartilage. The paper we discuss today says...
Speeding Biomarker Translation: From Research to Affordable Care
Fascinating science, but the real question is translation -how quickly can this move from research into something clinically actionable and affordable at scale? We’ve seen promising biomarkers stall before. #health #aging https://t.co/6qUmSulCxJ
Aging Isn't Destiny: 93% Lifestyle, Not Genes
A lot of what we accept about aging is simply wrong. It is not destiny. Chronic disease is not the price of getting older. And genetics decides only about 7-10% of how you age -- the other 93% is epigenetic, programmed...
Doctors Celebrate Breakthrough Pancreatic Cancer Therapy
Doctors stood up and cheered mid-presentation for this historic pancreatic cancer treatment. As a cancer survivor, writing this hit home, but also just amazing. https://t.co/ot4qlBzDyJ via @MarketWatch
Medical Breakthroughs Suggest 150-Year Lifespans Possible
if you're under 50 and you stay healthy, i think you will live to 150 years old minimum the medical singularity is happening. just in the past 2 months alone: > revmed's pancreatic cancer drug (daraxonrasib) doubled survival in the deadliest cancer there...
Mito‑Nuclear Communication Breakdown Drives Alzheimer’s Pathology
Mitochondrial-nuclear crosstalk: A central axis in Alzheimer’s disease 👉Mito–nuclear crosstalk is disrupted in Alzheimer’s disease. https://t.co/grY0fnE0RV https://t.co/ZxSWTOPwg4
Vigorous Exercise Reduces Pressure‑Independent Arterial Stiffness
Intensity Matters: Vigorous Activity is Associated with Lower Pressure-Independent Arterial Stiffness in the UK Biobank 😅"Vigorous activity was consistently associated with lower ASI-PI, suggesting beneficial vascular adaptations to exercise beyond its effects on hemodynamic load." https://t.co/12Dv4bmWOD
Shading Significantly Reduces Vehicle-Integrated Solar Output
On-road tests show strong impact of shading on vehicle-integrated photovoltaics #energysky -- via pv magazine global: https://t.co/eR79lOVxG7
Low CAD Genetic Risk Drives Multigenerational Longevity
Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging https://t.co/mwkzNuRK2D https://t.co/xr1dKT8kjB
World’s Most Efficient Silicon Solar Cell Hits 28.2%
JA Solar, Gold Stone Energy claim world’s highest efficiency for silicon solar cells with 28.2%-efficient back contact device #energysky -- via pv magazine global: https://t.co/aICHkrmTbG
Plasma Dilution Boosts Cardiac Repair and Mobility in Aged Mice
Plasma Dilution After Myocardial Ischemia-Reperfusion Injury Promotes Cardiac Repair, Heart Performance, and Recovery of Motor Function and Endurance in Old Mice https://t.co/gKE6dyzbYJ https://t.co/hjKrU0bPxk
Qualia Reveal Core Mystery of Consciousness, Says Koch
Neuroscientist Christof Koch on how the "qualia" of our experience illuminate the central mystery of consciousness https://t.co/efeENya82s
Sequencing Needed: Polygenic Scores Miss Most High-Risk Carriers
To identify high-risk patients for breast cancer screening, polygenic risk scores are not enough. Sequencing to identify key mutations (PV, pathogenic variants) is necessary. The majority of PV carriers were not picked up as high-risk in this study. https://t.co/8bVdByhKC5 @JAMAOnc @ASCO
Bispecific T‑cell Engager Shows Promising Responses in Refractory
Just published @NatureMedicine and presented @ASCO Advanced, refractory solid cancers treated with a bispecific T cell engager (BiTE, Figure), Phase 1 trial, with or without Keytruda, in 61 patients. Some very favorable responses with "manageable safety profile" https://t.co/MkzQXY1psA
Tunnel Back‑Contact Cell Hits 27% Efficiency, Reduces Silver
DAS Solar, UNSW build tunnel back-contact solar cell with 27% efficiency, lower silver content #energysky -- via pv magazine global: https://t.co/wA6fzbSZQT https://t.co/qDagh4DZd8
Japanese Lab Operated by Robots Revolutionizes Scientific Work
#Robots run this laboratory in Japan — and are changing how scientists work by Rachel Fieldhouse @Nature Learn more: https://t.co/bZ2Ntp8RpM #Robotics #Innovation #EmergingTech #Technology https://t.co/lMcQ4d691b
Historic Data Marks Breakthrough for Pancreatic Cancer
This is a historic data release. A real advance for pancreatic cancer patients, and it shows that our industry goes after the hardest things and can win. #ASCO26 https://t.co/w6F1yAkwK0
New OS Data Reveal Daraxonrasib
A warm #ASCO26 welcome to daraxonrasib and RASolute-302 study in 2nd line metPDAC from $RVMD My story in the post below. Here are the OS curves you haven't seen yet. https://t.co/VoNSu8BH3f
Longevity Linked to Clean Aging, Not Just Slowed Decay
What if extreme longevity is less about avoiding aging and more about aging cleanly? Maria Branyas Morera lived to 117 -- the oldest verified person on Earth. A new multi-omics study in Cell Reports Medicine (Santos-Pujol, Esteller et al) profiled her...
Melatonin Cuts Radiation DNA Damage by One‑third
Melatonin has radioprotective effects☢️ In this 2020 clinical study, 5 healthy males aged 25–35 were given 100 mg of melatonin before exposure to 100 mGy of X-ray radiation (equivalent to multiple CT scans) - 1 hour after radiation: 33% reduction in DNA...
Low Oxygen May Extend Lifespan, Study Suggests
The Role of Hypoxia in Longevity "...Hypoxia, marked by reduced oxygen availability, has emerged as a promising area of study within aging research..." https://t.co/HFODDoSw8a https://t.co/a6VWNP7R6F
Immature Neurons, Not Quantity, Drive Alzheimer Resilience
Researchers found that cognitive resilience in Alzheimer’s disease may depend not on the number of new neurons in the brain, but on how immature neurons adapt and activate protective programs that reduce inflammation and support tissue survival. https://t.co/nQC5dBMeQz
Tabletop EUV Lithography Cuts 3D Patterning to Minutes
A tabletop EUV lithography device cuts semiconductor 3D patterning from days to minutes by printing multiple layers in parallel instead of one layer at a time. For now, it can pattern periodic structures. semiconductors
New Evidence Supports Information Theory of Aging
👏 More exciting evidence for The Information Theory of Aging (ITOA) What is ITOA and why is it a game changer if correct? …
True Longevity Requires Nature, Not Quick‑Fix Vibes
Don't confuse vibes for progress. Nothing you can buy today will get you >1 year of life. We need to engage Mother Nature in a game wits to discover true longevity treatments.
CTA 1 Pulsar Wind Nebula Shows Bent Jet, Perpendicular Torus
Chandra observations of CTA 1 resolve a compact pulsar wind nebula: a southern jet bends toward the southwest, a faint counter-jet extends north, and a torus sits nearly perpendicular to the jet axis. The bend hints at an external influence....
Aging Happens in Two Biological Bursts at 44 and 60
According to a Stanford study, your biology may undergo two major accelerations of aging: - Around age 44 - Around age 60 Dr. Michael Snyder's team analyzed 135,000+ biological markers and found that aging appears to happen in bursts—not a steady decline. Here's what...
Exercise and NAD+ Boost Safety and Function in Friedreich’s Ataxia
Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial https://t.co/1Pll9b0d4q
Global Warming Melts Glaciers, Thaws Permafrost Worldwide
Climate change is leading to the melting of glaciers and the thawing of permafrost worldwide. https://t.co/TPXcO6sAx7
Hindbrain Neurons Directly Sense FGF21, Regulating Appetite
Researchers identified a specific group of neurons in the hindbrain that respond directly to FGF21, acting as a key pathway through which the hormone influences eating behavior and energy balance. https://t.co/ISa30OdrM5
Senescent Cells Misnamed: Time for a New Term
Another impressive study on the physiological functions of senescent cells, another reminder that cellular senescence is a misleading name. What should we call senescent cells instead?
Genomic Test Could Spare Millions of Breast Cancer Patients Chemotherapy
Millions of women with breast cancer could be spared chemotherapy with a groundbreaking genomic test, according to the results of a trial that could transform healthcare guidelines worldwide.