Targeting Inflammaging to Predict and Prevent Chronic Disease
Inflammaging: From Mechanisms to Clinical Implications and Targeted Interventions "...opportunities and limitations of these approaches for identifying individuals at risk for chronic disease..." https://t.co/ClCxPi6sQx https://t.co/Tz6OTxUONS
Pygmy Rattlesnakes Face Heightened Fungal and Lungworm Threats
Pygmy rattlesnakes appeared especially vulnerable in southeastern snake surveys, with higher rates of snake fungal disease and snake lungworm than many other species. Infection risk also shifted with location. snakes
New Therapies Target Age‑related Muscle Loss
Sarcopenia: An overview of emerging therapies and pathophysiological insights in age-related skeletal muscle decline 💪"This consolidated body of knowledge is expected to enhance the formulation of more effective therapeutic strategies aimed at maintaining muscle mass..." https://t.co/MgtFoVtU9F
Butyrate Boosts Lifespan in Mitochondrial‑Deficient Mice
Butyrate extends health and lifespan in mice with mitochondrial deficiency 👉"Overall, our findings highlight the relevance of preserving host-microbiota symbiosis in disorders related to mitochondrial dysfunction." https://t.co/6AKqyNhOS8 https://t.co/QrpIkVYGfN
Tau Determines Long-Term Memory Storage in Mice
Tau appears to shape which brain cells store an experience, helping memories stay stable over time. In mice, it mattered for remote recall more than initial learning or short-term memory. neuroscience
Spermidine Reduces Immune Aging, Enhances Vaccines in Elders
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study https://t.co/0bDkrx4Dbe
Lilly's Verve Gene Editor Cuts Cholesterol, but Delays Loom
Eli Lilly $LLY says Verve’s gene editor lowers cholesterol levels in early, but development timelines have slipped. https://t.co/fuJOPyDwQb via @Jasonmmast
Exercise Rewires Immunity, Influencing Disease and Aging
Exercise doesn’t just strengthen muscles—it rewires immunity. Acute workouts and long-term training reshape immune cell behavior through exerkines, metabolites, blood flow, and even the gut microbiome, with implications for cancer, autoimmunity, and healthy aging. #ExerciseImmunology #Healthspan #Immunology https://t.co/ieYqsZEw96
Proxima Fusion Launches Stellaris, Next‑gen Fusion Reactor
Proxima Fusion Unveils Stellaris, a Next-Generation Fusion Reactor by @spaceandtech_ #CleanEnergy #EmergingTech #Technology #Innovation #Tech https://t.co/UlM883rdW7
Deep‑sea Blue Octopus, Golf‑ball Sized, Studied Intact
A tiny blue octopus found 5,800 feet below the Galápagos was about the size of a golf ball. Because only one specimen was available, its internal anatomy had to be examined without cutting it open. oceanscience
Similar Particles, Different Impacts: Pollution Types Alter Lung and Brain
Within hours, air pollution sources with similar particle levels produced distinct changes in lung function and brain activity. The body did not respond to diesel exhaust, woodsmoke, cooking emissions and limonene-derived aerosol in the same way. airpollution
Boosting TTP Reverses Frailty and Bone Loss in Elderly Mice
New in Aging and Disease: scientists boosted a single protein in elderly mice and the animals got measurably stronger, less frail, and built denser bones. The protein is tristetraprolin, or TTP. Its job is to silence inflammatory messages inside cells before...
BCI Controls Neuroprosthetic Grasps via Surface and Implanted Electrodes
“application of a BCI as a control system for neuroprostheses based on surface (a) and implanted (b) electrodes, respectively. (c) grasp pattern for palmar grasp. (d) grasp pattern for lateral grasp” https://t.co/TUIIbe84hi
Atom‑thin MoSe₂ Enables 4 fJ All‑Optical Switching
An atom-thin MoSe₂ layer paired with a photonic crystal nanocavity enabled all-optical switching at roughly 4 femtojoules. The design is compatible with large-scale photonic circuits, though the threshold may drop further. photonics
EEG‑Driven Hearing Aid Amplifies Desired Voice in Real Time
Researchers used real-time EEG to let a system boost one voice over another, hinting at hearing aids that follow your attention https://spectrum.ieee.org/eeg-hearing-aid-volume-control?share_id=9524874
Epigenetic Editing Advances Toward Safer Gene Therapies
1/Here is an excellent article by @TheEconomist which sheds light on a new and promising Gene Editing modality called EpiGenetic Editing. Unlike its older and more clinically mature Gene Editing “siblings” - CRISPR, Base Editing, Prime Editing and RNA Editing,...
MIT Chemists Isolate Unprecedented Boron‑oxygen Molecule
MIT chemists discover and isolate a new boron-oxygen molecule by Danielle Randall Doughty @MIT Learn more: https://t.co/eVHsoDA64Q #EmergingTech #Innovation #Technology #Tech https://t.co/oNkwpCFHmJ
Study Finds Blood NAD+ Levels Stay Stable with Age
A study published this month in Nature Metabolism showed that blood levels of N.A.D.+ don’t actually fall with age. https://t.co/7tzL70lc5A
Gut FGF15 Shapes Lean Mass, Bone, Bile Acid Changes
Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss https://t.co/bIet15YkyC https://t.co/bMdqiWtLmu
New Study Debunks NAD+ Supplement Anti‑Aging Claims
As a medical school professor, I have watched the NAD+ supplement market explode on the promise that boosting your blood NAD+ slows aging. A new Nature Metabolism paper just punched a hole in the premise. (1/4)
Eating More Can Still Lead to Fat Loss
⚠️Trigger warning: “I ate more calories and lost fat” is not a claim that I broke thermodynamics. It’s a factual statement: one supported by controlled human studies, advancements basic science, and a more nuanced perspective on fuel partitioning, thermogenesis, and...
Individual Training Gains Depend on Multiple Factors, Not Genetics Alone
For those who weren't able to make it to the Inter-Individual Variation in Resistance Training Response Conference in Finland last year, a summary of the conference proceedings has been published in JAP. The conference brought together some of the top...
New Survey Explores Psychedelic Trip Experiences Everywhere
Dear Anyone and Everyone, Planning a trip anywhere and anytime in any way? Check out this Carhart-Harris Lab/UCSF survey study: https://t.co/ZhZbWTtMLQ https://t.co/sdPLjrbr0L
Mitochondrial DNA Stability Crucial for IGF‑1 Longevity Benefits
The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome [ "These observations suggest that mtDNA mutations represent a major barrier to life span extension and that mitochondrial function is required for the successful activation of...
Leukemia Drug HHT Delays Aging, Extends Mouse Lifespan
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice [an FDA-approved anti-leukemic drug; authors found that "HHT treatment delays aging and extends the lifespan in progeroid and aged mice"] https://t.co/LEegM8XUtR
Therapeutic Plasma Exchange Cuts High Blood Microplastic Levels
New research at the intersection of environmental medicine and therapeutic apheresis: https://t.co/i3zVSyYePU A paper just published in the Journal of Clinical Apheresis (Weinstein et al., 2026) reports the first deliberate attempt to remove circulating microplastics from human blood using therapeutic plasma exchange...
U.S. Streamlines Review Process for Fusion Energy
Fusion energy poised for simpler U.S. review https://t.co/DlwoCqRGP4 via @axios with reporting from @WebSummit Vancouver. https://t.co/zg6hM8eYOv
Clitoral Anatomy Mis‑taught Until 1998, Widening Orgasm Gap
The clitoris was not correctly mapped in a peer-reviewed medical journal until 1998. Every gynecologist who graduated before 2000 trained on an incomplete anatomy and passed their lack of knowledge onto you. Most of their patients never knew. It led to not...
Moderate Sex Frequency Minimizes Heart Risk, Extremes Harmful
Americans who had sex 1-3x/week (52–103x/year) had the lowest risk of cardiovascular disease and death. Both very low frequency (<12x/year) and extremely high frequency (≥365x/year) were linked to a higher risk. Low sexual activity might suggest cardiovascular problems (ED), hormonal dysfunction, or...
GLP‑1 Cancer Link Unclear, Dedicated Trials Needed
Whether there is a real impact of GLP-1 drugs on cancer is unresolved. If confirmed, it could simply reflect weight loss or, as seen for other conditions (e.g. heart, kidney), weight loss independent effects. We need dedicated trials to resolve...
Higher Cardiorespiratory Fitness Cuts Depression, Dementia Risk
Cardiorespiratory fitness and risk of mental disorders and dementia: a systematic review and meta-analysis High CRF was associated with a reduced risk of depression (HR = 0.64); all-cause dementia (HR = 0.61) and psychotic disorders (HR = 0.71) in adults. https://t.co/5dNZ0WfU8H
Exercise‑released Myokines Boost Brain, Inactivity Harms Cognition
Muscle talks to the brain. 💪🧠 Exercise triggers myokines & myometabolites that boost cognition, while inactivity sends harmful signals that impair brain function. This muscle–brain crosstalk shapes behavior and resilience to aging and neurodegeneration. @WuTsaiAlliance https://t.co/63skqJToIa
SpaceX Reschedules Starship IFT‑12 Launch for Tonight
SpaceX's website says they are "preparing to launch" Starship IFT-12 today, Friday, May 22, after yesterday's scrub. Same launch window (6:30-8:00 pm ET). https://t.co/WmDymzCeJd
Bridging Four Key Gaps Toward Quantum Advantage
Mind the gaps: The fraught road to quantum advantage Quantum computing is advancing rapidly, yet substantial gaps separate today's noisy intermediate-scale quantum (#NISQ) devices from tomorrow's fault-tolerant application-scale quantum (#FASQ) machines. https://t.co/aSWIa4Z6CA In this perspectives article, @preskill and I identify four related hurdles...
20 Phase‑3 Trials Poised to Redefine Cancer Care
In the wake of the #ASCO26 data drop, we reflect on 20 key phase 3 trials which could make a significant impact. Some of these may make their competitors irrelevant if they change the standard of care: https://t.co/EGtw35EsSk https://t.co/CG0Oe4QxDg
Genomics Predict Venetoclax Response in T(
Genomic Determinants of Clinical Outcomes in Multiple Myeloma with t(11;14)(CCND1;IGH) Treated with Venetoclax [Dec 7, 2024] @MKaddouraMD et al. @lbaughn #ASH24 Abst 249 https://t.co/TLon5bCQ3i #mmsm #PrecisionMedicine
Phase 3 Trial Tests Daratumumab Regimens For
.@SWOG S2213 Ph3 RCT Dara-VC Induction Followed by ASCT or Dara-VCD Consolidation & Daratumumab Maintenance in Pts w/ Newly Diagnosed AL Amyloidosis [Activated: 12/1/23] https://t.co/OizUfJCc2c #mmsm #bmtsm
Sleep's Complex Physiology Links Directly to Dementia Risk
Sleep physiology and dementia, a new 5★ review @ScienceMagazine, gets into glymphatics, blood volume, heart rate variability, vasoactive amines, and neuromodulators. by @MaiNedergaard https://t.co/zBMc1XQZcX https://t.co/eORVYPWmNM
Bright and Near‑Infrared Light Reduce Insomnia in Seniors
Effects of bright light and near-infrared light on insomnia symptoms in community-dwelling older adults: a randomized clinical trial https://t.co/NmZvFlV7qy
Scientists Fear New Methane Rules Won’t Cut Emissions
“Why are scientists worried about the new global methane rules and emission goals?” | Article by Basudha Das for @business_today: https://www.businesstoday.in/science/story/why-are-scientists-worried-about-the-new-global-methane-rules-and-emission-goals-532537-2026-05-21
AI‑Designed PE8 Editors Boost Prime Editing Efficiency
Today in @NatureBiotech we report a new suit of PE8 prime editor proteins. PE8 variants were developed from laboratory-evolved PE6 proteins using AI-guided protein redesign. This approach combines recent advances in computational protein design and directed evolution to increase prime...
Fructose: Evolutionary Signal Turned Modern Health Hazard
Fructose: metabolic signal and modern hazard https://t.co/o8nnUaiQP0 Fig. 6: The fructose survival hypothesis. 👇👨⚕️ https://t.co/YFnpttINx2
Muscle Hormone Irisin Shields Brain Cells in MS Model
An exercise hormone derived from muscle—irisin— is neuroprotective, preventing brain cell loss, as seen in the experimental model of multiple sclerosis @NatMetabolism https://t.co/CC4KDOJTn1 https://t.co/9bbcLpW4g6 https://t.co/6NP0sKx3Yr
Centenarians Retain Youthful Immune Profile, Hinting at Longevity
Centenarians show immune function found in younger individuals. Their immune system show reduced inflammatory signaling, enhanced autophagy, and controlled cellular senescence. They have low or no autoimmune disease, robust immunity against cancer and a distinct immune cell profile. Together, these...
Chernobyl’s Exclusion Zone Outperforms Small Reserves in Mammal Diversity
In northern Chernobyl, the exclusion zone and a nearby reserve had the highest mammal diversity and occupancy rates. Smaller protected areas often looked much closer to unprotected land than to these low-disturbance refuges. biodiversity
Preservatives Linked to Hypertension and Cardiovascular Risk
The link between chronic exposure to several preservative food additives and hypertension, along with risk of cardiovascular disease https://t.co/FIm02gPv3f
Scientists Say Livestock Industry Obscures Emissions with Fuzzy Math
"Top Climate Scientists Accuse the Livestock Industry of Pushing Fuzzy Math to Downplay its Climate Warming Emissions" by @Georgina_Gustin for @InsideClimate News: https://t.co/8TX7oX9ckO
Exposome Patterns Across Life Predict Aging Brain Health
Exposome-wide patterns predict brain health in aging (spanning biomedical, environmental, lifestyle, socio-affective, and early life domains) 👨⚕️ https://t.co/VtpdjLtda0 https://t.co/CpX8mPF7LP
Low‑risk Pancreatic Cysts Raise Cancer Risk 14‑fold
Low-risk pancreatic cysts were linked to about a 14-fold higher pancreatic cancer risk than the general population. Risk increased with larger cysts, older age, and main pancreatic duct dilation, while some cancers appeared only after five years. pancreas
Canada Slows Carbon Price Hike to Accommodate Alberta
Canada is applying a slower escalator for its national carbon price to match a deal it struck with the oil-rich province of Alberta, according to an updated government website https://t.co/ZtHUcEJQ0Q