Expert Wei Debunks PRME Failure Claims with CRISPR Insight
Here is a great overview by one of the most educated & knowledgeable people on 𝕏 and a personal friend - @zhaoweiasu, in which he rebutted the argument that $PRME has failed to deliver on its business model. As an expert on CRISPR, Prime and Base Editing $BEAM - Wei’s perspective is super interesting.
Geroscience Drives Precision Geromedicine and Targeted Therapies
Beyond disease treatment and prevention: From geroscience and molecular hallmarks to gerotherapeutics and precision geromedicine https://t.co/cXkWAyj3Cd
Katherine Johnson Stresses Math's Vital Role in Space
Katherine Johnson, the brilliant mathematician who helped @NASA put a man on the Moon talks about the importance of math https://t.co/bgRPTeCXVc
CRISPR Shifts to DNA‑guided RNA Targeting
Expanding the CRISPR genome editing toolkit: A flip from RNA-guided DNA targeting to DNA-guided RNA targeting @NatureBiotech https://t.co/GxKVthgbxh https://t.co/UIifna0nsF https://t.co/2ZB1eJzpCe
Polyphenol‑rich Foods Slow Cardiovascular Aging
Berries, Tea, Coffee - and a Slower Cardiovascular Aging Curve As a medical school professor, I teach that cardiovascular risk climbs with age. What I am updating is how much of that climb is negotiable. A 10-year study from King's College London,...
Gut E. Coli Toxin Linked to Rising Colon Cancer
We don’t know exactly why but some evidence is emerging that a toxin produced by a strain of e coli we have in our colonic microbiome may be the cause of rising cases of colon cancer
Potassium Sorbate Alters Fly Development, Microbiome, Reduces Toxicity
Potassium sorbate induces developmental and microbiome changes in Drosophila melanogaster with attenuated trans-generational toxicity https://t.co/tw1i5Su5Xu https://t.co/07dJg0P29F
Latest Ebola and Hantavirus Updates From Experts
TAKING SHOTS with Dr. Angela Rasmussen & Jessica Malaty Rivera: Ebola and Hantavirus Update https://t.co/248bGuZMda
Repeated Psilocybin Doses Show Safety, Promise for OCD
A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive–compulsive disorder 🍥"Administration of up to eight doses of psilocybin in a clinical research setting appears to be safe and potentially effective for patients with OCD. Larger trials...
Gut “Species” Are Actually Multiple Strains Tied to Disease
Researchers found that many gut bacteria thought to be single species actually contain distinct populations that have evolved to thrive under different conditions in the human gut. Some of these bacterial groups are linked to aging, inflammatory bowel disease, colorectal...
TP53 Classification Uncovers Three Pan‑Cancer Mutation Patterns
TP53-based tripartite classification reveals three distinct mutation patterns across pan-cancer [May 26, 2026] Ma & Dong @CellReports https://t.co/ZDG6Nl2Mxm #PrecisionMedicine https://t.co/Bgye42RPFT
Low‑dose Creatine Shields Cognition During Sleep Loss
A lower single dose of creatine still protects cognitive function during sleep deprivation. A single 0.2 g/kg dose of creatine reduced the decline in logical and numerical reasoning, language-related processing speed, and psychomotor vigilance during 21 hours of sleep deprivation. The...
Brain Holds 3,000× More Microplastics Than Blood
This new perspective study reports that our brains are carrying 3,000x more microplastic than our blood. Microplastic burden of the human brain rose ~50% between 2016 and 2024. The average brain now carries roughly: > 11x the load of the liver > 11x...
Sample Handling Critically Impacts NAD+ Aging Biomarker Accuracy
How you handle blood 🩸samples may dramatically distort NAD+ measurements. Freezing, freeze–thaw cycles, and dried blood spots caused major NAD+ loss. Methanol-based preservation largely stabilized levels—highlighting how pre-analytical methods can shape aging biomarker data. #Metabolism #Aging #NAD https://t.co/BVXXJgT344
Antibody‑Drug Conjugates Surge in Cancer Clinical Research
The progress and intensity of clinical research efforts with antibody-drug conjugates vs cancer is remarkable A new @CellCellPress review https://t.co/bkaJ2OOt63
Low Cerebral Blood Flow Predicts Accelerated Brain Degeneration
Lower cerebral blood flow (CBF) may quietly shape brain health and brain aging. In a well-studied cohort, reduced CBF at baseline was linked to worse brain microcircuitry and also steeper worsening of white & gray matter integrity over time—highlighting CBF...
Universe’s Age Varies Slightly Across Observers
Ask Ethan: Is the Universe the same age everywhere? Does our 13.8 billion year figure for the Universe's age apply to any observer anywhere as far as "now" goes? Several scientific effects say otherwise, but quantitatively, not by much. https://t.co/eIBcSVxmFR
Seeking Must-See ASCO26 Abstracts for May 21
Hey BioXers who pay attention to cancer: Are there data coming out on May 21 in #ASCO26 abstracts (not late breakers) that you deem must see? I'm trying to figure out what needs to be covered on May 21 when...
Successful Hookworm Vaccine Trials Aim for Global Low‑Cost Scale
No need to bother our friend @grok the answer is yes, our vaccine group was funded by Gates Foundation for a hookworm anemia vaccine although the funding stopped a decade ago. But we just published in @TheLancetInfDis that the vaccine...
New Math Method Cuts Earth‑Moon Fuel Use by 58 M/S
A new mathematical method mapped a more economical route between Earth and the moon’s orbits, cutting fuel use by 58.80 m/s. The route came from exploring far more trajectory options than earlier work. space
Blind Quantum Computing Achieved on Modular Superconducting Processor
Do you wonder how you can execute a #quantum algorithm on a quantum server in a way that the operator of the server does know neither the task nor the result? Here we conceptually demonstrate blind quantum computing using ...
SIRT6 Overexpression Reverses Liver Chromatin Aging
SIRT6 overexpression counteracts chromatin aging in the male murine liver “Furthermore, AAV-mediated SIRT6 overexpression in aged male mice demonstrates that SIRT6 not only slows age-related chromatin changes but can also reverse them, rejuvenating chromatin accessibility to a youthful state.” https://t.co/fpGJtiOjvL @NatureComms
Post‑meal Exercise Better Controls Blood Sugar Than
After Dinner Rest a While, After Supper Walk a Mile? A Systematic Review with Meta-analysis on the Acute Postprandial Glycemic Response to Exercise Before and After Meal Ingestion in Healthy Subjects and Patients with Impaired Glucose Tolerance https://t.co/XdiAkCbLhs
Thymus Role in Health Across Lifespan Redefined
Challenging medical dogma, our understanding of the thymus and its impact on our health throughout lifespan has been completely revamped w/ @HugoAerts @TheLancet https://t.co/Wx4n7zeJwp https://t.co/wq2sgYd5X6
AUV Maps Coral Reef Biodiversity Hotspots Using Sight‑Sound Tracking
An #autonomous underwater vehicle equipped with a new framework can follow sights and sounds to detect and map #biodiversity hotspots in coral reefs. @WHOI Learn more in Science #Robotics: https://t.co/mNiv2IQkAf https://t.co/ThfGr9IXRJ
Retina Scans Reveal Osteoporosis Risk Across the Body
Our retina image is so rich with information, a gateway to the whole body, well beyond the eye. Today add osteoporosis to the list. https://t.co/wUUsOziecv This adds to what I recently wrote about at Ground Truths https://t.co/fOsjLgAyvU
250+ Peppermint Mutants Boost Flavor, Disease Resistance
Over 250 new peppermint variants, created through induced genetic mutations, offer potential for enhanced flavor and improved disease resistance, providing a non-GMO pathway to strengthen clonal crops. plantgenomics
BCLXL-PROTAC Clears Senescent Cells, Offers COPD Hope
Clearance of Senescent Cells by BCLXL-PROTAC: A Novel Approach to Treat COPD? "These findings demonstrate that BCLXL-PROTAC is a potent and selective senolytic agent that may promote lung cell rejuvenation, supporting its potential as a novel therapeutic strategy for age-related diseases,...
Modular Quantum Processor Simulated to Factor 2048‑bit RSA
A little behind on this, but an arxiv paper came out last week on factoring 2048-bit RSA integers with a modular atomic processor. It's an end-to-end analysis of distributing Shor's algorithm, which is needed for the modular roadmaps. Key point: •...
Evolutionary Theories Explain Persistence of Homosexuality
A FAQ: Why are some people gay given that it reduces reproductive output and hence should have been selected out long ago? (The puzzle isn't homosexual attraction or sex, but avoidance of heterosexual mating opportunities.) Steve Stewart-Williams reviews the theories...
Yale Turns Research Into Real-World Solutions
Translating academic research into things people can use is among the most consequential work a university does. This week on Health & Veritas, @thehowie and I sit down with @JoshGeballe, who runs the part of Yale built for that work....
Plant Leaf Becomes Graphene Neural‑network Sensor
What happens when a graphene transistor, a Monstera leaf, and a neural network become the same thing? https://spectrum.ieee.org/graphene-sensor-plant-neural-network?share_id=9493662
Perfect Spacewalk Glove Fit Requires Custom Modeling, Trimmed Nails
Testing the fit of spacewalking gloves. My hands are in a low-pressure chamber, to see if the gloves will bulge too much during a spacewalk. I was lucky - when @nasa was making the new gloves, my hands were used...
Chemo-Free Padcev‑Keytruda Shows Promise for Cis‑eligible Patients
$AZN Volga might have matched $MRK $PFE KN-905 in cis-ineligible patients, but here comes chemo-free Padcev + Keytruda in the cis-eligible setting. Via @ApexOnco -> https://t.co/KmwCfgZLBm
RGNX Shows 71% Microdystrophin, Eyes 2027 Approval
$RGNX Duchenne gene therapy study results are out: microdystrophin expression reached an average of 71% of normal across all 31 boys at 12 wks. Functional improvements in a subset of boys followed for one year also seen. The big question...
Faster Biological Aging Predicts Rapid Multimorbidity, PhenoAge Leads
Accelerated biological aging is associated with faster multimorbidity progression: a UK biobank study "...with PhenoAge acceleration achieving the highest predictive performance.."" https://t.co/W7vZS00rw7
Leaffooted Bugs Need Rapid Symbiont Acquisition for Survival
Leaffooted bug nymphs must quickly acquire essential bacterial symbionts from their environment; delays in this process sharply reduce survival and slow development, highlighting a critical window for symbiotic partnership. symbiosis
Rectal Cancer Deaths Surge, May Outpace Colon by 2035
Rectal cancer deaths rising rapidly among millennials: 'It's a medical crisis.' By 2035, rectal cancer death rates could exceed deaths from colon cancer, new research suggests. https://t.co/T4G4BGx8yl https://t.co/9WPzumcTcV
Roman Telescope: Wide‑field Cosmic Survey Complementing JWST
No big deal, I’ve just got the future of astrophysics right behind me 🔭 Meet the Nancy Grace Roman Space Telescope. This powerful telescope has 300 megapixel wide-field camera and 100x the field of view of Hubble. Think of it this...
LLM‑assisted Breakthrough Improves Depolarizing Channel Bound
A nice application of LLMs (Codex with gpt5.5 here) for research. Yesterday, a paper appeared on arXiv with an improved lower bound on the capacity threshold of the depolarizing channel, one of the most frustrating open problems in quantum information...
NASA Details Artemis III Plan: Spacer, Longer Orion Stay, HLS Docking
NASA Outlines Preliminary Artemis III Mission Plans. https://t.co/qhj0gZvuhe Will use a "spacer" in place of ICPS, circular low Earth orbit, crew will spend more time in Orion than Artemis II, dock with both HLS "pathfinders," maybe enter one. Maybe cubesats.
Lithium in Drinking Water Linked to Lower Suicide Rates
"There is a protective (or inverse) association between lithium intakes from public drinking water and suicide mortality at the population level." whoa https://t.co/ZnWTB5Q9Uz
Adenine Base Editing Reverses Dravet Syndrome in Mice
Today in @ScienceTM, we report the use of in vivo adenine base editing to correct a variant causing Dravet syndrome, a severe childhood epilepsy and neurodevelopmental disorder, substantially ameliorating disease symptoms and extending lifespan in an animal model. 1/13 https://t.co/uQEwWvj94y
Carotid Bodies Drive Adaptation to Altitude and Space
Alpinists and astronauts endure surprisingly similar physiological challenges. We show that carotid body chemoreceptors are central to the mechanisms of adaptation to both high altitude and microgravity. 🙏David Andrade et al. 🇨🇱 @physiol_journal https://t.co/RkOxALyV7I https://t.co/BQirYEBQGm
Laser Links Carry Data, Radio Secures Safety for Artemis2
Laser data links handled all the HD video and science data during NASA's recent #Artemis2 mission. This freed radio to be devoted to safety-critical telemetry connections. The two systems' division of labor is the blueprint for future deep-space missions. https://spectrum.ieee.org/free-space-optical-communication-artemis?share_id=9491502
Quantum Computing Leverages Interference, Not Parallel Evaluation
It's the line you'll see in nearly every popular explainer: "a quantum computer evaluates all possibilities in parallel." It's wrong. Qubits, superposition, measurement, entanglement. We have quantum systems, ok. They can hold many states at once and link those...
Testing Metformin, Fisetin, Spermidine Boosts Elder Resilience
Excited to collaborate in this clinical trial in healthy older adults 🚀 Three geroprotectors (metformin, fisetin, and spermidine) will be tested for resilience promotion after a three-week intervention. Looking forward to seeing how this study unfolds @InflamAge_UoB @news_ub
Metformin Shows Potential to Prevent Esophageal Cancer
Metformin Use and Development of Esophageal Squamous Cell Carcinoma "These findings suggest metformin use may have preventive potential against ESCC, which warrants further evaluation," [though this is a case-control study, would benefit from prospective design] https://t.co/w5QmYd9i55
Moderna Tops TIME's 2026 Most Impactful Companies List
This week, @TIME ranked @moderna_tx #1 on its list of the World’s Most Impactful Companies of 2026. To create the ranking, TIME and @StatistaCharts analyzed economic and scientific data to determine which companies most effectively turn resources into value for people...
NAMPT Loss Disrupts Mitochondria, Triggers Hippocampal Neuron Death
The Depletion of NAMPT Disturbs Mitochondrial Homeostasis and Causes Neuronal Degeneration in Mouse Hippocampus https://t.co/g101jOJQpn