Science Social Media and Updates
Science Social Media and Updates
Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis? 🗣️"We will describe how SIRT1 can represent a key molecular link and an appealing target to harness microglial neuroprotective potential as a preventive strategy during the key time frame of pre-symptomatic AD. We conclude with a brief summary of the up-to-date evidence on the benefits of natural SIRT1 inducers that act on the inflammation-energy axis." https://t.co/TRB8tExiLa
Heart-Brain Axis Atrial fibrillation leads to reduced brain glymphatic flow, decreased washout of waste metabolites. https://t.co/2PNjoDl4Om Today #ACC26 @JAMACardio Serum Neurofilament (sNfl), a marker for brain cell injury, is associated with adverse CV events and mortality in patients with atrial fibrillation https://t.co/fWNg8zks0C
$TENX $TECX 🤔 $MRK sotatercept high dose *missed* stat sig on 6MWT in P2 (and it wasn’t particularly close). The low dose hit stat sig (barely) and was the dose taken to P3. What to make of a...
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative Lay Summary: "The role of interleukin-6 receptor (IL6R) blockade in reducing chronic-disease risk and improving longevity is uncertain. In a study of 38 807 postmenopausal women followed for...
🧪⚛️ Science items for the week, including causal uncertainty in quantum mechanics, magnets, the reverse sprinkler problem, and some funding talk. https://t.co/93lsIoh8xP
The list of conditions for which GLP-1 drugs provide benefit independent of weight loss keeps growing. Add psoriatic arthritis #AAD26 @AADskin https://t.co/kJej6osXTS
Is this bird extinct? The Ivory-billed Woodpecker hasn’t been seen since 1944, despite numerous claims over the decades. All claims can only be deduced to people mistakenly identifying its close cousin, the Pileated Woodpecker. Every year, thousands of eager birders flock...
SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice “The beneficial effects of SGLT2i treatment in gKO mice conclusively demonstrate that in a physiologically relevant preclinical model of HFrEF, SGLT2i can exert therapeutic benefits via off-target pharmacology.3...
“There is no such thing as proof in biology… 🤔 …at any given moment we’re just one well-designed experiment (or one we’ll-phrased question) away from having to completely reevaluate the way we see the world.” 🔬 - @DrRagnar 🧠
You guys liked the last batch of Ring photos so much, here’s a couple more from another angle. Standard Sam wasn’t in frame, so we’ve added in Ghostly Jane for reference. https://t.co/a5vqFxvfgc
Here’s an engaging X (Twitter) post tailored to that specific BfR article: Is your apple really “poisoned”? 🍎 A compelling read from German Federal Institute for Risk Assessment unpacks the myth vs reality of pesticide residues—reminding us that “the dose makes the...
Artificial Biological Intelligence (ABI) In a post-Darwinian era of being able to write genomes, the implications—both for good and harm—are profound. In conversation with @AdrianWoolfson on his new book On the Future of Species https://t.co/2OahzzxAAa
Generically, it’s an IT arch that distributes computing so processing is closer to where the data is generated, which makes data xport more efficient and versatile. In this case, it means processing data in space, on the Ring, vs dumping...
You can publish a paper with wrong data. You can't make a working drug with a wrong experiment. I wrote about HeLa contamination a few days ago. Then an Oxford researcher told me his story. https://t.co/77vvQQ8kq0
Joining @BloombergTV This Weekend at 9:45amET to talk about Artemis II and my trip to Florida/KSC @davidgura @EenaRuffini @LisaMateoTV
Fraunhofer CSP warns some cleaning agents may reduce PV module performance by up to 5.6% #energysky -- via pv magazine global: https://t.co/yfOWVCOjSx https://t.co/PM69r9Hgdg
Two Artemis II media events today (Sunday, Mar 28): 11:30 am ET with the crew, 2:00 pm ET status update. Watch on NASA's YouTube channel.
How AI foundation models are moving from language into the biology of living systems and plant science. https://t.co/8WoCYGs5Fg
Internal waves transport energy thousands of miles across the Southern Ocean, with tidal forces driving over 80% of the flux poleward and wind-driven waves carrying a smaller, equatorward component, influencing ocean mixing and climate dynamics. oceanography
Climate has almost disappeared from our conversation. But it remains the most pressing challenge of our times. Last week the WMO said the planet is “more out of balance than at any time in observed history.” Energy security and climate security are...
Concur that COVID was very likely zoonotic in origin. That's always been the most likely scenario, and the evidence has just grown stronger. (See below.) From a policy standpoint, I don't think it matters much. 1. Some past pandemics have originated...
Hematopoietic (stem) cells—The elixir of life? "In this perspective article, we discuss the evidence that supports that rejuvenating or delaying aging of the blood system has a beneficial and systemic impact on human health..." @FEBS_Letters https://t.co/Y9sYcwXp1A @FEBSJournal
Really interested in seeing how the supposedly smartest people rationalize ignoring a mountain of evidence that we’ve been talking about and publishing in top journals on for years
MIT’s Insect-Size #Robot Flies Like a Bumblebee by @IntEngineering #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/xGQ1Fkrbd7
Loss of epigenetic information as a cause of mammalian aging “we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA...
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target 👉 “By providing mechanistic clarity on how epigenetic dysregulation drives ageing phenotypes, we aim to enable rational design of therapeutics that target the epigenetic systems that fail during ageing,...
I wonder if we could find similar signatures in chronic diseases, such as diabetes, chronic infections, or autoimmune diseases? Would the Information Theory of Aging also rationalize these diseases equally based on equivalent observations?
The results of this first phase 2a clinical trial of intranasal 5-MeO-DMT administered adjunctively to SSRIs demonstrated acceptable safety and tolerability with promising improvements in depressive symptoms. https://t.co/m15DkPP4qX
Senescent immune cells protect against damage, inflammation and disease 🤯 In mice, p16-expressing immune cells delay age-related organ deterioration and preserve tissue homeostasis. More evidence of the physiological roles of senescent cells? https://t.co/UtBKDF00P1
This paper took us 13 years and is one of the longest papers ever in Cell. Check it out & judge for yourself https://t.co/Ra0CX1i5zt https://t.co/LbGXx2u4cq
The Hib vaccine protects against Haemophilus influenzae type b (Hib) bacteria, which can cause severe illnesses like meningitis, pneumonia, and epiglottitis. Th
"Ten Unsolved Mysteries of the Brain" in Discover Magazine. I wrote this article 19 years ago. Amazingly, these are still the mysteries we face. https://t.co/SIfEB8VkUv
The researchers I know are far more likely to love this than hate it. You really think people enjoy the process of writing papers vs the actual hypothesis generation and designing & steering the research? Automate everything that can...
When I started Don't Die in 2021, we evaluated all the scientific evidence for the most powerful anti-aging therapies. Psychedelics were no where to be found. A wild turn of events that they're now front and center for us....
Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial "Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats.." https://t.co/Y6fmNYStmZ
In a randomized trial of a PCSK9 inhibitor [for LDL cholesterol lowering] vs placebo for patients with diabetes and no known heart disease, there was significant reduction of major cardiovascular events including deaths #ACC26 @JAMA_current https://t.co/mzuI79c4IN https://t.co/16Cpxf7IBx
Supercomputer simulations of a two-million-atom human cell model have mapped the dynamic motions of the spliceosome, offering detailed insights into gene splicing mechanisms and informing future drug development. computationalbiology
A new Science #Robotics study highlights Saranga, a deep neural network that can denoise ultrasound echolocation signals to improve aerial navigation even in dense fog, snow, or darkness. @nitinjsanket https://t.co/utyw7UGfJ9 https://t.co/ElinoMN830
Validation of aggressive LDL lowering to reduce major adverse cardiovascular events, a randomized trial targeting LDL < 55 mg/dl. In participants with atherosclerotic cardiovascular disease (secondary prevention) @NEJM #ACC26 https://t.co/oLnkqhawOd
Ancient DNA analysis shows that domesticated dogs lived alongside humans in Western Eurasia over 14,000 years ago, sharing diets and forming close bonds long before the advent of agriculture. archaeology
Now @NASA Unveils Its $20 Billion Moon Base Plan—and a Nuclear Spacecraft for Mars by @EddyTheGent https://t.co/2xGqkZeZyd https://t.co/N24jKsM0AN
AI needs data. And biology is finally generating it at scale. I spoke with @10xGenomics CEO Serge Saxonov about the single-cell and spatial biology revolution — and why the convergence of AI + biological measurement could transform medicine. Read the full profile...
Adam, I used to think this way. Then gene therapy & IO worked. IL2 has consumed a lot of hope; but new variations make it hard to quit. Abeta worked. And synergy: combine modest drugs, unlock big benefits. Invest or...
A comprehensive atlas now defines all human E3 ligases, resolving decades of inconsistencies and providing a unified framework to advance research and therapeutic development for diseases linked to these essential enzymes. biotechnology
Molecular anchors have been shown to stabilize perovskite solar cells, significantly reducing performance loss during rapid temperature changes and enhancing their durability for long-term outdoor use. solarenergy
A new paper says lifespan gains will be small due to our biology That’s true - if we don’t change. But if we can change our biological age, the equation changes In 1700, we couldn’t imagine moving faster than a horse. Biology...
A lab-based mini-atmosphere experiment demonstrates that energy and angular momentum cascade differently across scales, revealing behaviors in turbulent flows not captured by current atmospheric models. atmosphericphysics
Scientists in Spain kept a donated human uterus alive for 24 hours using a machine that mimics the body's circulatory system, pumping modified blood through the organ.
Obesity (in the US) is much more common than prev thought: 69% vs. old 43% stat Based on new better definition that uses not only BMI but also anthropomorphic measures such as waist & ratios of it, which more accurately shows higher...
Using a 20-year period to compare methane the CO2 is a terrible idea. It heavily discounts the future and locks in greater warming. New York should move away from it, and instead set separate targets for CO2 and short-lived climate...
