Sex Chromosomes Drive Cancer, Autoimmunity, and Brain Disease
Our X and Y chromosomes play a bigger part in health than acknowledged, including cancer, autoimmunity, and neurologic conditions. A new @nature feature https://t.co/IjVNbXzBPB
New Receptor Enables Bat Alphacoronavirus Entry Into Humans
Discovery of a new receptor by which alphacoronavirus from bats can get into human cells and the potential for transmission https://t.co/LE5sTVyfkS @Nature https://t.co/aszqnDMQqE @NatureNV https://t.co/ejnvrvr6BO
Redefining ‘First‑in‑Class’ Amid Faster Competing Therapies
How do we define “first in class” when there are others further ahead? This example is from Atheron Therapeutics w/ a CCNE1 degrader #aacr26 https://t.co/s22biREUrt
Wet AI Using Brain Cells Could Outperform GPUs
Here's our story on The Biological Computing Co. It's an inside look at how it's using human and rat brain cells to help discover new AI processing algorithms that mimic how neurons actually behave and learn. Will the "wet" AI...
Tiny Data Center Gas Projects Outpace Morocco’s Emissions
"New gas projects linked to just 11 data center campuses around the US have the potential to create more greenhouse gases than the country of Morocco emitted in 2024." -Wired There's a better way. At Firma Power we're chatting that way...
Longevity Linked to Ion Transport, Not Cell Division Genes
Why some species age slower than others remains a mystery. This is an impressive analysis of genes linked to longevity evolution in mammals. Genes associated with cell division & DNA repair show negative correlations with lifespan evolution, while positively correlated genes are...
Understanding Broad Aging Slowdown vs Targeted Rejuvenation
The 2 Longevity Fields... New post on a topic of great importance. Long, but something I feel strongly about. Broadly Slowing Aging vs. Divide-and-Conquer Rejuvenation: How to tell the difference and why acknowledging both matters (link in next post) https://t.co/khHlClSAWo
Sleep: A Modifiable Key to Aging and Alzheimer’s
“If sleep is a missing piece in the explanatory puzzle of aging and Alzheimer’s disease, then maybe we can do something about it. Sleep is a modifiable factor.” — Dr. Matthew Walker Listen to my interview with sleep expert Dr. Matthew Walker:...
Oxygenated Water Boosts Cycling Performance, Study Shows
Can oxygenated water improve athletic performance? In this blog, Dr Nick Tiller and I discuss findings from a study showing oxygenated water improves cycling performance... Read here: https://t.co/pqgFyUWJSv https://t.co/qNDIecK4Pj
Quantum Gravity Corrections Could Explain Dark Matter, Energy, Decoherence
A new theoretical framework suggests that dark matter, dark energy, and decoherence may emerge from quantum corrections linked to gravitational effects, potentially eliminating the need for hidden substances or modifications to established physics. quantumgravity
CDC Withholds Report Showing Vaccines Reduce Hospitalizations
Can't hide from science. CDC won’t publish report showing covid shots cut likelihood of hospital visits https://t.co/zajDCiaaAJ
Helium Powers Chips, Not Just Party Balloons
How many people know that Helium is more important to the semiconductor industry than it is to birthday balloons…? 🤔
Hooke's Micrographia Sparked Curiosity, Igniting the Scientific Revolution
When Robert Hooke published “Micrographia” in 1665 it immediately became a best seller. The book included stunning drawings of Hooke's microscopic observations, showing intricate details of plant and insect structures, among other objects. One of Hooke's most famous illustrations is of...
Belief in Treatment Lowers Brain Pain Activity
Simply believing you’re being treated can measurably reduce the brain’s pain processing. MRI scans across 20 studies show that placebo treatment reduces activity in pain-processing brain regions. The effect is small, but consistent. Full video on placebo: https://t.co/l1PV2LNyhA Study: PMID: 33654105
New DNA Region Ties Frailty to Brain, Immunity
A newly identified DNA region and two related genes link frailty to both brain and immune function, offering fresh insight into the biological mechanisms that shape aging risk and potential pathways for early detection. genetics
Postural Slow‑twitch Muscles Atrophy Faster when Immobilized
Slow twitch muscles (like the calves) atrophy more during immobilization. This might be explained by their postural role, since they tend to contain more hypertrophied fibers due to the activities of daily life, leading to greater atrophy during disuse. https://t.co/lDSyXbYdC3
Tele‑Operated Micro‑Robot Delivers Ultra‑Precise Minimally Invasive Surgery
Tele-Operated Micro-#Robot Enables Ultra-Precise Minimally Invasive Surgery by @VicariousSurg #HealthTech #Tech #Technology #EmergingTech #TechForGood https://t.co/bVGDoHbWui
Melatonin Spikes Growth Hormone, Amplified by Resistance Training
Taking 5 mg of melatonin raised growth hormone by 157% within 40 minutes. When resistance training was performed 60 minutes after ingestion, GH rose again - reaching a 132% increase by the 83rd minute. Exercise alone (placebo group) likely increased GH by...
Gaming Consoles Can Now Charge While You Play
Green #Technology in the game industry: Scientists find way to charge your game console while playing by Delft University of Technology @TechXplore_com Learn more: https://t.co/kzW8X092w4 #EmergingTech #Innovation #CleanEnergy https://t.co/JzeJybv80y
Contact Sports Brain Injury: Misunderstood Paradoxes and Unknowns
This is a very interesting area of contact sport and brain injury research, and often misunderstood and inaccurately reported. Here's a thread with some interesting (I think) paradoxes and unknowns... 1/
Bad Sleep Drives Depression and Insulin Resistance, Not Just Symptom
One of the most expensive mistakes in health is treating bad sleep as a side effect. Very often, it is part of the mechanism. A new study on depression and insulin resistance caught my attention. Link at the end. I will walk...
Insilico Tops AI Drug Discovery, Drives Oncology Breakthroughs
I had to skip this year's #AACR2026 but I am watching it from the distance. Our posters and team did a very good job - it looks like our clinical-stage oncology assets are finally being better understood by the pharma...
Blue Light Worsens Obesity via Fat Mitochondrial Damage
Blue light exposure exacerbates obesity in high-fat diet-fed mice by inducing mitochondrial dysfunction in the white adipose tissue "Collectively, our results suggest that BL may target the adipose tissue, trigger oxidative stress, suppress oxidative phosphorylation, impair mitochondrial function, and exacerbate obesity." https://t.co/5flPOv2iDS
Only 30 of 90 Cataloged Transporter 16 Payloads Identified
I believe 95 payloads were meant to be deployed from SpaceX's Transporter 16 rideshare. 90 have been cataloged to date, and with some ID'd by radio amateurs and the first IDs on Space-Track, 30 are now identified.
JWST Zooms In, Roman Maps the Cosmos Together
This is a fantastic question. The difference is their fields of view. The JWST is like a zoom lens that captures intricate details of objects, often only parts of an object because its field of view is small. Roman zooms out...
Firefly Launch Objects Possibly Misidentified by SpaceTrack
The last Firefly launch put one object (A) in a 222 x 366 km orbit, and one (B) in 390 x 408 km. B's still in orbit, A just reentered. SpaceTrack say A was the @LockheedMartin Martin...
Blocking PGAM‑Chk1 Kills Senescent Cells, Eases Lung Fibrosis
Researchers found that senescent cells depend on a PGAM–Chk1 interaction to boost glycolysis and survive, and blocking this interaction selectively kills these cells and reduces disease effects like lung fibrosis. https://t.co/VTsHTkBcad
SIRT6 Controls Brain Protein Homeostasis, Slowing Aging
SIRT6 Regulates Brain Protein Balance and Aging https://t.co/prPtswc8kh @bengurionu Further reading (primary source) @Aging_Cell: SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling https://t.co/w1SfUiUxg4 https://t.co/TA9UjYkxvN
Durvalumab Plus FLOT Improves Resectable Gastric Cancer Outcomes
EFS in MATTERHORN: A Ph3 RCT of durvalumab plus 5-fluorouracil, leucovorin, oxaliplatin & docetaxel chemotherapy (FLOT) in resectable gastric/gastroesophageal junction cancer (GC/GEJC) - @YJanjigianMD et al. #ASCO25 LBA5 https://t.co/lW8KUtXdB3 #NCT04592913 #stcsm #esocsm
Rusfertide Shows Efficacy in Phase 3 PV Trial
Results from VERIFY, a phase 3, double-blind, placebo (PBO)-controlled study of rusfertide for treatment of polycythemia vera (PV) - @KuykendallMd et al. #ASCO25 LBA3 https://t.co/XID3tkj6Sk #NCT05210790 #mpnsm
Adjuvant Nivolumab Boosts Outcomes in High‑Risk HNSCC
NIVOPOSTOP (GORTEC 2018-01): Ph3 RCT of adjuvant nivolumab added to radio-chemotherapy in Pts w/ resected head & neck squamous cell carcinoma at high risk of relapse - Bourhis et al. #ASCO25 LBA2 https://t.co/Uxh4JhZyDE #NCT03576417 #hncsm #ImmunoOnc
Atezolizumab Boosts Adjuvant Therapy for dMMR Colon
RCT of standard chemotherapy +/- atezolizumab as adjuvant therapy for Pts w/ stage III deficient DNA mismatch repair (dMMR) colon cancer (@ALLIANCE_org A021502; ATOMIC) - @FASinicropeMD et al. #ASCO25 LBA1 https://t.co/cGalNPlxMe #NCT02912559 #crcsm
WGS Uncovers KMT2A PTD, Surpassing Old AML Tests
Detection of KMT2A partial tandem duplication (PTD) in AML by whole genome sequencing (WGS): Addressing limitations of traditional techniques in the era of revumenib approval - Huether et al. #ASCO25 Abst 6532 https://t.co/EEsXm7JGdv #AMLsm #leusm #PrecisionMedicine @TempusAI
First Tumor NGS Usage Varies Across Top Five Cancers
Utilization and timing of first tumor next-generation sequencing testing (NGS) in Pts w/ 5 most common cancers in the USA - @chadihcmd et al. @huntsmancancer #ASCO25 Abstract 11014 https://t.co/lWefncnTb2 #PrecisionMedicine #hemonc #bcsm #crcsm #lcsm #pancsm #pcsm https://t.co/oIX8QTRD8x
Biology’s Data Gap: Making Lab Results AI-Ready
Biology generates enormous amounts of data. Almost none of it is ready for AI. #SynBioBeta2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK Most experimental infrastructure was built for individual...
Redefine the Thing, Create a Whole New Category
Redefining what a thing is can create an entirely new category of thing. In 1945, Soviet schoolchildren gifted the US Ambassador a wooden Great Seal. It hung in his Moscow office for 7 years. It contained a listening device with no battery,...
AI Model Beats General AI at Quantum Calibration
I fear the AI engineers are going to cook us, quantum. 13 institutions across industry, national labs, and academia, covering superconducting, neutral atom, and electron-on-helium hardware just released Ising Calibration 1 and QCalEval. It's a 35B parameter vision-language model (mixture of experts)...
Nurix's NRX-0305 Shows
New degrader from Nurix looks interesting: NRX-0305 demonstrated antitumour activity across a wide range of Class 1 BRAF inhibitor-resistant and Class 2/3 mutant PDX models #aacr26 https://t.co/0UGF5Od2Cp
NASA Goddard Unveils Nancy Grace Roman Space Telescope
Was at @nasa Goddard today for the unveiling of the Nancy Grace Roman Space Telescope 👀
First Personalized CAR‑T Shows Mobility Gains in Stiff Person Syndrome
$KYTX Kyverna Therapeutics cell therapy improves mobility in patients with stiff person syndrome. If cleared, the medicine would be first personalized CAR-T therapy for an autoimmune disease https://t.co/B28Zp9IA2O
Avacta Unveils FAP‑cleavable Dual TOPO‑Ii/DDR‑i Payload
Intriguing #AACR26 poster from Avacta w/ CSO Francis Wilson presenting on their dual payload tech. The idea is to release TOPO-Ii + DDRi via FAP cleavage https://t.co/UMeB8y8KaC
Urolithin A From Pomegranate Stabilizes Plaques Independently of Cholesterol
Gut-derived metabolites from pomegranate polyphenols, particularly urolithin A, have been shown to stabilize atherosclerotic plaques by reducing inflammation and altering immune cell activity, independent of cholesterol levels. cardiovascularhealth
Deep‑rooted Grasses Lock More Carbon than Crops
Deep-rooted grasses store substantially more carbon in their root systems than shallow-rooted crops, enhancing soil health without depleting existing organic material. This approach offers a sustainable strategy for carbon sequestration. soilscience
ARVN KRAS G12D Preclinical Shows Weak Tumor Inhibition
In the battle of the inhibitors vs glues vs degraders, this one (KRAS G12D preclinical) from ARVN doesn't look too encouraging with little TGI #aacr26 https://t.co/Ng9UWTQcsv
AI Integrates Omics and Lifestyle to Forecast Health Outcomes
A multimodal AI agentic model that integrates electronic medical records, lifestyle, layers of biologic omics data to predict health outcomes and, with perturbations, "what if" scenarios a person improved lifestyle or took a medication @Cell_Metabolism https://t.co/qgVomjkipS https://t.co/JDaeYv0JGu
NOAA Defines El Niño Using Relative, Not Absolute, Nino Indices
NOAA uses the *relative* Nino (or "RONI") indices, as shown below, to define El Nino state (>0.5C = El Nino; <-0.5C = La Nina, neutral otherwise). Some will try to confuse you by showing absolute Nino values (which depend on...
Sodium Batteries Breakthrough Amid Lithium Price Volatility
Volatile lithium prices and advances in technology mean sodium batteries are finally making a decisive breakthrough https://t.co/IRqZeUwuGz
Aging Mechanisms Are Now Engineerable, Says SynBioBeta
Aging isn't just inevitable decline. It's a set of biological systems that are starting to look engineerable. #SynBioBeta2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK DNA damage accumulates. Protein...
One Week Plastic-Free Diet Slashes Hormone Disruptors 60%
A “plastic-free diet” cut endocrine-disrupting chemicals in the body by up to 60% in just 1 week. Participants in a recent study switched to low-plastic food, plastic-free kitchenware, and screened personal care products for 7 days. Urinary BPA fell by 59%, and...
Four‑Sigma Anomaly in Rare Decay Suggests New Physics
Physicists observe a four-sigma anomaly in a rare decay process, hinting at possible new physics, while uncertainties still limit firm conclusions https://t.co/rISktBtkqJ