Rising Fossil Fuel Prices Boost Clean Energy Push
Soaring oil and gas prices are helping to bolster the argument that the world needs to accelerate its move to clean energy sources https://t.co/HivJRoJBib
Progress MS-34 Rolls to Baikonur Pad for Saturday Launch
A Soyuz-2-1a rocket with the Progress MS-34 cargo ship reached the launch pad at Site 31 in Baikonur this morning, in preparation for a liftoff on the night from Saturday to Sunday and a two-day trip to the ISS: https://t.co/RJw3e4HJ5Y...
Memory Loss Can Spread via Gut Microbiome
Comment “curious” for the deep dive Memory loss might be… infectious. A new Nature study found that when young mice live with older mice that have poor memory, the young mice begin to lose memory too. The natural question is: why? The answer lies...
War and Climate Change Alter Iran’s Weather Patterns
There’s climate change and the there’s the way the US/ISR war has changed the weather in Iran. A good collection of studies and observations from @justinpodur https://t.co/qWUfsiTJvN
Pacific Storms Prompt Fresh Look at Climate Links
I normally do not attempt to link climate change to local events, but current storms in the central Pacific demand we take a fresh look. Full Newsletter: https://t.co/JMOSkdKCNb #guam #climate https://t.co/pXtbl8WCxQ
Legislation Saved Polar Bears From Extinction
There are only about 20,000 polar bears remaining throughout the world. There has been a modest increase in the past 50 years precisely because of legislation banning polar bear hunting, the Marine Mammal Protection Act of 1972 and the 1973...
Fitness Drives Immune Resilience in Healthy Aging
Physical Fitness Dynamics Shape Immune Remodeling in Healthy Aging: A 3-Year Longitudinal Study 👉 “These results highlight physical fitness as a potentially modifiable determinant of immune trajectories and immune resilience in healthy aging.” https://t.co/NsgzpoH5Tb
ASCO Grants IDYA Late‑breaker Despite Extensive Prior Data
Given how much $IDYA has already released (ORR, PFS, stats, PFS curves) I'm a little surprised #ASCO26 is OK with giving it a late-breaker.
Sex‑disaggregated Data Crucial, yet Underused in Women's Health
Uncharted: understanding women’s health across the body Disaggregating data by sex is a powerful way to help develop better diagnostics and treatments for women — but researchers say it’s not used enough. https://t.co/7TeEYN4yPf https://t.co/95VdJKI05c
CEPI Shows Courage; Institutions Must Follow Suit
Many institutions are failing to meet the moment, but not all. @CEPIvaccines proves it has the courage & conviction to carry out essential vaccine work regardless of political pressure for complicity. I wish more institutions would follow their funder’s example.
Key Traits for Self‑Replicating, Evolving Automata
"In almost any biological organism, you have an automaton that can not only reproduce identical copies of itself but also (through evolution) give rise to organisms that are more complex than itself. So von Neumann asked, What are the essential...
OSK Reprogramming Restores Adult Heart Regeneration
NEW STUDY: OSK rewinds the clock and pushes adult heart cells into a regenerative state that improves heart repair Why is this such a big deal? Because adult heart cells do not meaningfully divide, which is why the heart heals with scar...
Insilico Launches First Longevity Board to Accelerate AI Aging Research
Insilico Medicine Announces Industry's First Longevity Board to Accelerate AI-Driven Aging Research for Drug Discovery https://t.co/Xd8GpDTVjW
Stay Alive Until the Decade’s Immortality Bridge Opens
You don’t need to live 100 years. You need to live long enough to live forever. The bridge is being built THIS decade. Your only job is to still be here when it opens. LEV-2033.
Artemis II Inspires Hope for Exploration and Science
This week's EVSN is our love letter to the Artemis II mission. I have a lot of weird & contradictory emotions about all the resources going into human space exploration & not into science. But what if there were enough...
Genetic Bridge Links Ageing Theory to Lifespan Interventions
Dynamics of genetic and somatic trade-offs in ageing and mortality “These findings provide a genetic bridge between evolutionary theories of ageing and molecular mechanisms that can guide interventions to extend healthy lifespan.” https://t.co/HFGnELAIqH https://t.co/gAlE7D4OCh
Epidemiology Insights: Tackling Pandemic Threats with Prof Rimoin
Great to host my extraordinary colleague/friend Prof Anne Rimoin @arimoin @UCLAFSPH UCLA Fielding School of Public Health here at @TXMedCenter @BCM_TropMed @TexasChildrens discussing her important work tomorrow on epidemiological approaches to pandemic threats and public health https://t.co/mKRffWimMv
Crowdfunded Rapamycin‑Exercise Trial Shows Promising Aging Data
Five years ago, @BradStanfieldMD reached out with an idea: a crowdfunded clinical trial testing rapamycin combined with exercise in older adults. The results are now published — and Brad and I just sat down for a full 42-minute breakdown...
Scrotal Sun Myths Debunked: UV Boosts Testosterone Generally
Sorry to be the bearer of bad news but this is bullshit. The 1939 paper referenced is a study conducted on institutionalized men with documented depression, measuring a urinary testosterone byproduct, not serum levels, and without a control group. There...
Columnless Midiprep: Pool Minipreps, Elute at Quarter Volume
Nice. Good midiprep. Gonna use this for some gene gun optimizations. All columnless, simply combining a few minipreps and eluting in ¼th volume. https://t.co/0unMuxJTIc
Seeing Earth as a Pixel to Hunt Life
🌎 For Earth Day, consider our pale blue dot as a single pixel 🔵 like Cassini saw looking back at Earth from Saturn. What might we glean from a single...
Shingles Vaccine Cuts Dementia Risk by Half.
Have you had your shingles shot? A major 2026 study of over 300,000 people age 65 and older found that the shingles vaccine reduces the risk of dementia by up to 50%. Remarkably, men, women, and folks across age and ethnic...
Age‑and Sex‑Specific Genes Shape Lifespan Trade‑offs
Delighted to have contributed to this new study @Nature on the genetics of ageing and mortality 🧬 Using a large mouse cohort, we uncover age- and sex-specific genetic effects, including trade-offs where variants are beneficial early in life but detrimental later.
Iran War Fuels Surge in Clean‑energy Demand, Boosts Gotion
Gotion a major Chinese battery manufacturer, is seeing a renewed global focus on the green transition as fossil fuel disruptions due to the Iran war drive demand for clean-energy technology https://t.co/e9OQrxcQ4z
Artemis II Validates Laser Links as Orbital Compute Backbone
Artemis II wasn’t just a deep space mission, it proved that laser communications will be the backbone of compute in orbit, with transceivers from @ObservableSpace Observable will move terabits between Earth and space, enabling datacenters, and more, in space. Observable...
Fenebrutinib Shows Promise, Yet Safety Concerns Loom
Relevant to $TGTX was the Roche $RHHBY fenebrutinib trial results recently announced. Excellent efficacy, but two cases of Hy's Law. Both resolved, but a patient might not be so lucky next time. Hard for me to see this gaining widespread...
Innovation Keeps Crop Yields Ahead of Climate Threats
Ryan is correct. Crop yields continue to outpace the downward pressure of climate change and look likely to for the foreseeable future. There is risk of tipping points, to be clear, and those grow as temperatures rise. As of now,...
AI Discovers Chromogranin A Shields Brains From Alzheimer’s
20 to 30% of older adults have full blown Alzheimer's pathology in their brains (plaques, tangles etc.). But they never develop symptoms and nobody knew why. An AI just read thousands of human brains and named the reason: a protein...
Paxlovid Showed No Hospitalization Benefit in Vaccinated Seniors
In 2 randomized, open-label trials of Paxlovid there was lack of evidence of reduced hospitalizations among the participants, who were age 50+ with coexisting conditions, and who were vaccinated. The endpoint was very low (<1.2%) in the treatment and control...
Quantum Chemistry Advantage Still Unproven, yet Quantum Biology Proceeds
Hot take on the Wellcome Leap Q4Bio results: we haven't shown clean quantum advantage in chemistry yet, and we're already running quantum biology. That's either deeply premature or secretly the right move. Caffeine (24 atoms) is past exact classical simulation —...
Prioritize Climate Solutions Over Debate This Earth Day
I’m a climate scientist, and what I have to say this Earth Day might surprise you: I don’t care if you think climate change is real. Most of us already want cleaner air, healthier communities, less waste, and better food. Those...
COVID Vaccine Halved ER Visits, Hospitalizations for Healthy Adults
The report - that CDC leadership blocked after clearing scientific review - showed the COVID vaccine cut ER visits and hospitalizations for healthy adults by 1/2 last winter. It followed widely used methods, incl in a CDC flu report last...
25% Beta‑Cell Loss and Aging Drive Type 2 Diabetes
Researchers analyzed ~250,000 pancreatic islet cells and found that in type 2 diabetes, about 25% of insulin-producing beta cells are lost and many of the remaining ones become aged and dysfunctional. They identified dozens of genes—along with pathways like vitamin...
Guest Shares Climate Insights on Earth Day Podcast
I'm delighted the New American Colleges & Universities podcast ran this interview with me about climate change for Earth Day: https://t.co/GlpCptEyqq https://t.co/2AFIrDGMY3
Top Protein Degrader Session at AACR26 Highlights Await
Excellent protein degrader session today at #AACR26. Third speaker was all Do Not Post (sorry @HartungIngo !) so some highlights from the other three speakers coming up...
Alzheimer's Drugs Show Minimal Benefit, Review Reveals Deeper Issues
Alzheimer’s drugs offer little benefit, major review finds – and the reasons go deeper than the science https://t.co/cnMPAEQumY https://t.co/wtg8llquON
Maternal Emulsifiers May Close Infant Immune Tolerance Windows
Common food emulsifiers like carboxymethyl cellulose and polysorbate 80 are in processed dairy, baked goods, sauces, and even some baby formulas. When mother mice consumed these during pregnancy and breastfeeding, their offspring's immune development was altered in ways that lasted...
NASA Admits Lunar Gateway Modules Are Corroded
NASA Administrator Jared Isaacman just testified before Congress that both the Lunar Gateway habitable modules delivered to NASA (HALO and I-HAB) were corroded. 🚨
Food, Not Pills, May Solve Obesity and Heart Disease
The next breakthrough in managing obesity, heart disease, or cognitive decline might not come from a pill. It might come from your food. #SynBioBeta2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your...
Relativity’s Algebra Hides Century‑Old Positive Cosmological Constant
What's cooler than finding a 27-year-old bug in OpenBSD? Finding a positive cosmological constant hiding for over a century in the algebra of relativity🌌 No new physics or math needed🧮 Possibly the most elegant novel result we'll see, but even more interesting ones...
Lactate: The Missing Link Between Genes and Cancer Metabolism
For over 100 years, cancer research has been split between genes and metabolism. But what if we’ve been missing the loop that connects them? My latest Substack explores this debate further and suggests how lactate may be the missing link organizing the...
Silicon Oxide Memory Advances Toward Industrial Use
Did you see this?👇 Silicon Oxide Memory Breakthrough | Lecture 12: From Lab to Industry #science #graphene #pchardware https://t.co/dIvQsIQm8V https://t.co/hZ0KyzJC7S
PK/PD Crucial for Next-Gen ADC Development
Wonderful tour de force on ADCs by @raffcolo highlighting the importance of PK/PD going forward with new formats https://t.co/nUpBNNoVil
Antimatter: Humanity’s Only Viable Interstellar Fuel
Only antimatter provides the energy we need for interstellar travel This Earth Day, some dream of saving the Earth, while others dream of leaving it. Here's why using antimatter as fuel is humanity's best bet for interstellar travel. https://t.co/ZBs6y8YGTm
Sun Accounts for Virtually 100% of Solar System Energy
The Sun rounds up to 100% of energy in our solar system, even if Jupiter and all non-solar mass is burned
Cast SDS-PAGE Gels Using Riboflavin, No TEMED
Here is an alternative way to cast SDS-PAGE gels without needing TEMED, using riboflavin, EDTA, and LED lights. Seems very DIY friendly too.
Why Launch Assists Often Aren’t Worth the Effort
Common question I've had... this certainly isn't a new idea and there's a good reason it's often considered not worth it. I did a deep dive on launch assists last year - https://t.co/gYQYjqPTvx
Prelude Tx Unveils Early-Stage KAT6A Degrader
Looking through my #aacr26 collection of posters from yesterday. Prelude Tx have a KAT6A degrader (PRT13722) in early development to compete with inhibitors: https://t.co/23zBtCX8Hs
Personalized CRISPR Poised to Become Standard Care
How individualized CRISPR genome editing can go from rare, expensive use to broader accessibility and a standard of care by @UrnovFyodor and Sadik Kassim @Nature https://t.co/ddc5ASPPAK https://t.co/GOFneIyuai
MIT Creates AI‑controlled Artificial Muscles Mimicking Human Movement
MIT researchers just replicated human muscles with AI-controlled fibers. Inside each fiber is a sealed tube of electrically charged liquid and a tiny electric pump. When the pump activates, one side contracts while the other relaxes, just as your biceps and triceps...