Anti‑inflammatory Diets Curb Neuroinflammation via Gut‑brain Axis
The relationship between dietary patterns and neuroinflammation "These nutritional changes contribute to a pro-inflammatory brain environment both directly, through the immunomodulatory effects of dietary components and metabolites, and indirectly, through increased intestinal permeability, dysbiosis, and activation of peripheral inflammatory cascades. Conversely, nutritional strategies such as plant-based, low-fat, low-carbohydrate, Dietary Approaches to Stop Hypertension (DASH), Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND), and time-restricted diets appear to counteract these detrimental effects. Preclinical and early clinical evidence suggests that these approaches reduce microgliosis, inhibit inflammasome signaling, lower systemic inflammation, and reshape the gut microbiota to promote anti-inflammatory metabolites and better gut–brain communication." https://t.co/osYew1SPoQ
Hubble Telescope Launched Into Space on April 24, 1990
#ThisDayInTechHistory. April 24, 1990. The Hubble Telescope gets launched into space. (WJZ) #Space #History https://t.co/hOfa5LGz4b
Rice Engineers Turn Dead Spiders Into Necrobotic Grippers
Dead Spiders Reanimated as Necrobotic Grippers by Rice University Engineers by @IntEngineering #Innovation #TechForGood #EmergingTech #Technology https://t.co/mMBuXXIbmj
Zinc‑Doped Tin Oxide Matches ITO in Tandem Cells
Perovskite–silicon tandem solar cells using zinc-doped tin oxide achieve comparable performance to indium tin oxide counterparts #energysky -- via pv magazine global: https://t.co/Mpz8WZZ3s4 https://t.co/6Q7tr34wZP
Hubble’s Legacy Spotlighted on NBC’s Stay Tuned Now
I'll be on Stay Tuned Now on NBC tonight with host Morgan Chesky tonight. I'm talking about the Hubble Space Telescope and all it's amazing contributions. Fun Fact: Across it's 5 servicing missions, HST was visited by all 4 shuttles....
Grinspoon & Bakalar 1979: Foundational Pillar of Psychedelic Revival
Grinspoon and Bakalar (1979) was published in the darkest days for psychedelics within academia and medicine. It's a treasure trove of wisdom that should be cited more in academic papers. The modern resurgence in psychedelic medicine owes a lot to...
Undetected Antibodies Can Undermine Phage Therapy Effectiveness
Hidden antibodies in patients can neutralize bacteriophages, limiting the effectiveness of phage therapy for drug-resistant infections and highlighting the need for pre-treatment antibody screening. infectiousdisease
Restoring Cell Communication May Halt Alzheimer’s Progression
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuroimmune interactions to intercellular communication "...Ultimately, early interventions aimed at restoring healthy intercellular communication offer new hope for halting AD progression..." https://t.co/Qj6SfUapHz
Co‑evolving Robot Bodies and Brains via Leader‑Follower Game
ICLR 2026: This paper uses a "Leader-Follower" game to design robots. The Leader evolves the robot's body (e.g. adding limbs & joints) while predicting how the Follower (the brain) will learn to move it. This teamwork creates specialized robots—like creatures...
Plenoptic Detector Enables Ultrafast 3D Neutrino Imaging
A new prototype detector uses plenoptic camera technology and advanced photon sensors to achieve ultrafast, high-resolution 3D imaging of neutrinos in large, unsegmented scintillator volumes, potentially transforming particle detection and medical imaging. physicsinnovation
Targeting iNOS‑IRG1 Binding Offers Precise Anti‑Inflammatory Therapy
A newly discovered interaction between iNOS and IRG1 proteins directly regulates inflammation, suggesting that targeting their physical binding could offer more precise therapies for Crohn's disease, arthritis, and cardiovascular conditions. immunology
Vaccines May Modulate Dementia Risk via Trained Immunity
Infection, vaccination and risk of dementia: a proposed immunological model "Integrating data on BCG and mechanistic hypotheses, recent findings on the AS01 adjuvant, and the role of trained innate immunity, we describe here an immunological model that connects vaccine and adjuvant...
Switzerland Funds Recycling Research for PV, Batteries, Heat Pumps
Switzerland to fund research on PV module, battery, heat pump recycling #energysky -- via pv magazine global: https://t.co/fGLOZvehP2
Nanodrum Beats Identify Bacterial Infections by Sound
Researchers report that bacterial infections could be diagnosed with sound, using a nanoscale drum kit. Different bacteria play different rhythms on the drum. https://spectrum.ieee.org/soundcell-nanodrums-identify-bacteria-sound
Proven Imaging AI Ignored, Unproven LLMs Adopted
Superhuman interpretation AI for medical images, such as mammography and endoscopy, has been proven to improve diagnostic accuracy in multiple randomized trials but mostly not implemented. But LLMs for clinical decision support have little real world medicine proof, but are...
Male Cannabis Use Lowers Fertility, Raises Miscarriage Risk
A week ago, I featured a guest who described studies and clinical data, revealing that cannabis use by men can reduce fertility and increase miscarriage. Strong reactions on both sides about that. Note: spermatogenesis follows about a 90 day cycle...
Scaling Cheap In‑Vivo Causal Testing for Age‑Related Diseases
AI has made hypothesis generation in bio cheap. Anyone can get an answer to ‘could this play a role in my disease’, but how do we go from ‘could’ to ‘does’? The scarce resource now is causal evidence to test hypotheses...
Continuous Glucose Monitors Aid Weight Loss in Non‑Diabetics
The effects of wearing a continuous glucose monitor are generally studied in participants with diabetes, but this new study on non-diabetics shows great promise for CGM’s when it comes to successful weight loss: https://t.co/cvlYi7bdo5 https://t.co/1LLnf2FAWp
Corrosion Concerns Rise for HALO, I‑Hab Modules
Interesting info about the HALO and I-Hab modules following Isaacman’s comments at Wednesday’s hrg about corrosion in two Gateway modules that were delivered.
TRT Gel/Injection Shows More Adverse Events Than Clomiphene
Interesting retrospective chart-based study in VA population - TRT gel/injection vs. clomiphene for hypogonadism. Matched populations at baseline. Far higher rates of AEs with gel/injection vs. clomiphene. "TRT was associated with an increased incidence of mortality, CVA, CAD, hypertension,...
Most People Misunderstand How Stars Actually Work
Ask Ethan: What’s the biggest misconception in astronomy? Sure, misconceptions abound in astronomy: about dark matter, type Ia supernovae, the Big Bang, and much more. But the biggest misconception of all is far more basic: it's how stars work at all. https://t.co/ipVkmvbRF0
Mann Research Predicts 10±3 Storms, Quiet Season via El Niño
The @MannResearch group seasonal hurricane forecast is out. We call for 10 +/- 3 named storms this season. The forecast for a relatively quiet season is driven largely by the prediction of a substantial El Niño event: https://t.co/FIkZFydFca
Quantum Computing Relies on Classical Co‑Processing, Not Just Shor
All quantum computers need classical co-processing. For Shor's, quantum is used for 1 step out of 5. Use quantum just for exactly what it's good for, use HPC for the rest. VQE, QAOA, similar, and NVIDIA and Cisco are building...
Lunar Gateway Corrosion Confirmed as Serious Issue
Both Northrop and European space officials have confirmed the Lunar Gateway corrosion issue is real and significant. https://t.co/Z8Alf6N3mn
New Psychedelic Trials Target Depression and PTSD
Compass Pathways’ psilocybin (COMP360) for treatment-resistant depression (TRD) Usona Institute’s psilocybin for major depressive disorder (MDD) Otsuka’s methylone (TSND-201) for PTSD
GPX4 Inhibitors Eradicate Senescent Tumor Cells, Boost Chemo Efficacy
GPX4 inhibitors discovered that kill "zombie" senescent cells from tumors (increased w/ chemoRx) and effective in multiple preclinical models vs cancer, a new potential strategy to pursue in clinical trials https://t.co/lYX7xkI9xF @NatureCellBio https://t.co/mxbjzRQPck
Midlife Vitamin D Deficiency Forecasts Tau Build‑Up 16 Years Later
Many papers associate low vitamin D levels w/ worse health outcomes. What's notable about this new study is how long subjects were followed: Low vitamin D in midlife predicted tau burden on PET 16 years later. https://t.co/rUWJGbZBgl https://t.co/Qf5z8ueKyp
Harmony Scales scRNA‑seq Integration Beyond 100 Million Cells
Harmony is my go-to tool for scRNAseq integtation. Now it sales to >100M cells. https://t.co/4rdXHT8ask https://t.co/SzbC5MnaoU
AI-Designed PRMT5 Inhibitor Nominated in UAE
Today marks a historic moment for Insilico and another world's first in AI-powered drug discovery. We nominated the first preclinical/developmental candidate in the UAE. It is also our 30th PCC/DC nominated in the past 5 years. 12 molecules reached clinical...
First Global Fossil‑Fuel Phase‑Out Summit Launches in Colombia
The first global summit to phase out fossil fuels begins in Colombia as countries grapple with an acute energy crisis https://t.co/lLDuv15xsE
Is Believing in Evolution a Measure of Intelligence?
Belief in Evolution the Litmus Test for Intelligence? 💥 See full video here: https://t.co/uVjo9dzAT9 #evolution #science https://t.co/HDNTtKOEUl
Flavonoids Emerging as Powerful Tools Against Chronic Disease
Recent Advances in Flavonoids and Chronic Disease: Mechanisms, Therapeutic Applications, and Future Directions https://t.co/nh4sVRvjZo https://t.co/3nIIZm37Jl
Fossil Fuels Threaten Atlantic Circulation, Global Climate
Excellent overview over the risk of major ocean circulation changes in the Atlantic as a result of fossil fuel emissions, strongly impacting climate around the globe. #AMOC
A Fifth Diabetes Type Redefines Medical Textbooks
A Fifth Type of Diabetes Was Just Officially Recognized -- and It Breaks the Textbook Most of the world learns two types of diabetes. The International Diabetes Federation just recognized a fifth. As a medical school professor, I teach that our disease...
Quadruped Robot Masters Low-Gravity Off-World Mobility
Low-Gravity Trials: Quadruped #Robot Pushes the Limits of Off-World Mobility via @ZappyZappy7 #Robotics #MachineLearning #ArtificialIntelligence #ML https://t.co/4lOOnmg7Cb
Optimistic Week: Cancer Vaccine, SpaceX, Biotech Advances
Pancreatic cancer mRNA vaccine shows lasting results SpaceX buys Cursor option Fervo files S-1 Humble unstealths cabless truck Madra launches robot arm bio lab + Science Breakthroughs + Extra Doses What a week for the optimists. https://t.co/7I37VTu3Hr
Lifelong Cognitive Enrichment Slows Brain Aging
A new Neurology study just gave us one of the cleanest lifestyle signals for brain aging we have ever seen. As a medical school professor, I teach that the brain follows the same rule as every other organ: use it or...
Epigenetic Reset: Once Mocked,
From 2008-2024 I was accused of hyping (a common slur) for suggesting that changes to the epigenome might cause aging and that therapeutics could "allow us to reset the epigenome to a more youthful state." - Oberdoerffer & Sinclair...
Speculating on the Glow Pathway: Caffeic Acid?
Gee, I wonder which pathway they chose for the glow. Could it be the caffeic acid one? Lol 🙃
Newborn Massive Star Carves Light‑Escaping Cavities in Nebula
Saw a cool space image I hadn't noticed before and just had to share it with you. This is AFGL 5180, a stellar nursery where a massive star is being born right at the centre. That newborn star is blasting powerful jets...
Balanced View on Low‑level Radiation Calls for Real Research
Good to see a balanced approach to low level radiation risk - although it highlights the need for more research that is genuinely seeking answers
One‑Person Crossover Shows Statin May Impair Workouts
Statin vs Placebo: N = 1 Randomized Crossover Study After posting prior content reviewing data on statins and the potential risk of muscle loss, I was flooded with comments from people saying statins "annihilated" their workouts. Now, I know the party...
Scalable Holonomic Adiabatic Gates Offer Robust Quantum Computing
Holonomic quantum computing is not a new idea, but it has been too little studied in the context of reasonable architectures for quantum computing. Here, we present a scalable adiabatic architecture. I am happy to see this work out in...
Batteries Increasingly Paired with Fossil Fuel Power
Batteries aren't just being used to power the clean energy revolution. They're also increasingly being paired with fossil fuels https://t.co/ljCr00WgLa
AI Accelerates Search for Extraterrestrial Life
AI is expanding the search for life beyond Earth. By combining advanced telescopes, modeling and machine learning, scientists can analyze vast amounts of data and detect patterns that would be impossible to spot manually. It marks a new frontier. AI is not...
One Avocado Daily Cuts Glycemic Load by 14
The Effect of Including One Avocado Daily in a Habitual Diet on the Glycemic Index and Glycemic Load in Free-living Adults with Overweight/Obesity "Daily consumption of one avocado within the habitual diet significantly reduced GL by almost 14 points, without requiring...
China Holds Officials Accountable for Missing Xi’s Green Goals
China warns regional officials that they will be held accountable for failing to make progress toward President Xi Jinping’s green targets https://t.co/4RFldLy7n8
Chinese AI Breakthroughs Shared Openly, Benefit All Labs
While US politicians/lobbyists are scaremongering about “Chinese distillation,” Chinese scientists are actually sharing real AI breakthroughs in the open. These kind of advances have nothing to do with data and benefit everyone, including small (and possibly big) US labs.
Our Collective Memory Spans Just 63 Years
Did you know: The first measles vaccine was licensed in 1963 That is exactly 63 years ago Which means the oldest people vaccinated as a baby are 63 years old I guess 63 years must be about how long our collective memory remains in...
El Niño Resurgence Threatens Climate Policy Progress
El Niño’s Comeback Is Bad News for Climate Politics #energysky -- via Heatmap News https://t.co/uWhLSm7lAb https://t.co/J09nJHq7Uy