Human‑scale Data Aims to Close Drug Trial Gap
90% of drugs that enter clinical trials fail. A big part of why: the models they're based on weren't trained on human biology. Mouse data, non-representative cell lines, sparse perturbation coverage. The gap between in silico predictions and what actually happens in a human body is where drug development dies. This session at SynBioBeta 2026 goes straight at it. @iamjohnnyyu @tahoe_ai built Tahoe-100M: 100 million single-cell data points measuring how thousands of drugs impact cells across 50 diverse cancer lines, the largest atlas of its kind. @vivodyne is testing drugs directly on lab-grown human tissues at scale. Avantika Lal brings the perspective from inside @Genentech's ML teams. Daniel Georgiev of Sampling Human is working on the human data collection side of the problem. Moderated by Krish Ramadurai of @aixventureshq. SynBioBeta 2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK
Park Walks Boost Cognition, Even if You Dislike Them
The foundational study in environmental neuroscience, from 2008: the “Walk in the Park” study found that cognitive performance is boosted by (wait for it) a walk in the park, regardless of whether or not you enjoy it. For more, check out...
Gut Microbiome Predicts Melanoma Recurrence Post-Immunotherapy
Gut microbiome markers predict recurrence of cancer after immunotherapy for metastatic melanoma @CellCellPress https://t.co/k5YuNnqfvt https://t.co/9UbuNAcYJh
Interferon Pathway Drives Inflammaging, Offers Epigenetic Target
We've known inflammaging is a big part of why the human aging process accelerates. Now the interferon pathway is invoked as having a causal role (via epigenetics) and potential for targeting https://t.co/0Di0xiLGyy
Hands‑on PCA & CCA Tutorial for Cell Annotation
want to understand PCA projection and CCA for cell type annotation?my hands-on tutorial for cell type annotation is at https://t.co/lxePZCuypY https://t.co/hhrIQBcxll
Smart Experts Reveal Future of Cancer Treatment at AACR
Join us at AACR as a bunch of smart people explain what's next in cancer treatment
Ultra-Processed Foods Boost Death Risk for Cancer Survivors
As a medical school professor, this study should be front-page news. Researchers tracked cancer survivors and found those eating the most ultra-processed food had: -- 48% higher risk of death from any cause -- 57% higher risk of... https://www.youtube.com/@RobertLufkinMD https://www.aacr.org/about-the-aacr/newsroom/news-releases/high-consumption-of-ultraprocessed-foods-may-be-linked-to-cancer-survivors-risk-of-death/ CancerPrevention #UltraProcessedFood #MetabolicHealth #Nutrition #Longevity
Amazon Leo Targets Commercial LEO Launch by Mid‑2026
Amazon Leo promises commercial LEO service by mid-2026: “They all work with the same physics." https://t.co/CNO04otphl @FierceNetwork_ @lindahardesty https://t.co/CNO04otphl
Stable Weight Maintenance Predicts Longer Lifespan in Mice
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice "We observed that the ability to maintain stable body weight, despite fluctuations in energy intake and expenditure, was positively associated with lifespan in an...
Super‑agers Defy Aging: Brains Stay 25‑year‑old Sharp
‘Harvard Thinking’: How super-agers keep their brains young Experts break down ‘biological contradiction’ of a 65-year-old with the memory of a 25-year-old — and what that means for the rest of us https://t.co/29qpNudp1J https://t.co/X951FiSfiS
Rosalind Franklin Rover Finally Secures Mars Launch
ESA's Rosalind Franklin rover, a perennial outcast among space missions, finally has a ride to Mars. https://t.co/tIdOJVymc7
Week of Wild Breakthroughs Fuels Optimistic Future
Quaise 1st superhot geothermal plant Panthalassa wave-powered lollipop AI DC Vital Lyfe Access drinkable water in a box Sabi hat that can read your mind Prophetic dream lucidity Salk Lab gets $41.3M Sonogenetics +Science Breakthroughs + Friedberg What a week for the optimists. https://t.co/ZOV7BGYruW
Six States Accelerate Renewable Energy Project Approvals
California, Colorado, Minnesota, New York, New Jersey and Oregon are among the states expediting renewable energy projects. https://t.co/KftgZHgZHv
Metformin Misses Target in Type 1 Diabetes Trial
As a medical school professor, I love when medicine humbles us. Metformin has been around for a century. We thought we understood it. We were wrong. A new clinical trial gave metformin to people with type 1 diabetes -- not type 2....
Ketone Ester Adds No Benefit to 120 G/Hr Carbs
Ketone monoester does not offer metabolic advantage when consuming 120 g/hr carbohydrate 🥤 This new study recruited 8 trained male cyclists to a crossover design where they completed 3hr at 95% lactate threshold (LT) followed by 150% LT to exhaustion tests...
Women Experience Faster Tau Buildup and Cognitive Decline
Women show greater tau buildup and faster cognitive decline than men in Alzheimer's https://t.co/5GKfzXZPSo https://t.co/8L9wxDsFAp
Pentagon Denies Climate Change, Still Fortifies Bases
Pete Hegseth said the Pentagon wouldn’t do any “climate change crap.” It’s still fortifying bases against rising seas and stronger storms. https://t.co/5V5PDyfAJr
Copying a Fruit Fly Brain Sparks Unprogrammed Digital Behavior
Most AI companies are trying to simulate intelligence. Meet Dr. Alex Wissner-Gross, co-founder of Eon Systems, a startup trying to copy a real brain and run it inside a machine. That is why this story is so hard to ignore. Instead of building...
Cast Works as Well as Surgery for Kids' Wrist Fractures
Most children with severely displaced wrist fractures can achieve similar long-term recovery with a plaster cast instead of surgery, minimizing risks and reducing healthcare costs. pediatrics
High SHBG Increases Sarcopenia Risk; Free Hormones Protect
Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative "Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia,...
Tight Bounds Reveal Optimal Inference Complexity for Quantum Kernels
Optimal algorithmic complexity of inference in quantum kernel methods for classical data. Quantum kernel methods are among the leading candidates for achieving quantum advantage in supervised machine learning. A key bottleneck is the cost of inference: evaluating a trained model on...
Patagonian Saurop
A newly identified 155-million-year-old sauropod from Patagonia, Bicharracosaurus dionidei, displays a unique blend of features linking both brachiosaurid and diplodocid lineages, offering fresh insight into Jurassic dinosaur evolution in Gondwana. paleontology
Watch Artemis II Crew Post‑Flight Press Conference Today
I strongly suggest a viewing of the Artemis II crew post-flight press conference today. Well worth your time. https://t.co/rQLDz78DB8
Celebrating Science: Discussing #ScienceUnderSiege with Neil Tyson
After so many dark months of countering RFK Jr and the ACIP/HHS/Children’s Health Offense pseudoscience disinformation campaign it was a real joy to spend an evening with @neiltyson discuss our book #ScienceUnderSiege @MichaelEMann @PeterHotez https://t.co/49e3hC7bSz
China Aims to Double Non‑fossil Energy by 2035
China will seek to double its supply of non-fossil fuel energy by 2035, in a plan that analysts see as a boost to Beijing’s green targets https://t.co/Pzxupdpkbq
Student Experiment Tightens Axion Dark Matter Constraints
A student-led experiment has set new constraints on axion dark matter properties, demonstrating that small-scale setups can meaningfully contribute to narrowing the search for one of physics’ most elusive particles. darkmatter
Soyuz-2-1b Launches Kosmos Satellites Into 457×547 Km Orbit
LAUNCH at about 2318 UTC Apr 16 of one or more Kosmos satellites by Soyuz-2-1b from Plesetsk to a 457 x 547 km x 98.3 deg orbit (h/t @Dillonshrop06 )
I Built Dragon’s LiDAR, yet People Doubted Me
People oddly assumed that I didn’t understand LiDAR, even though I oversaw the custom LiDAR development that Dragon uses to dock with the Space Station
7‑8 Hours Nightly Cuts Type 2 Diabetes Risk
This Is How Much Sleep You Need to Lower Your Type 2 Diabetes Risk https://t.co/UI9VyQiv3a https://t.co/ac9eBXPIBu
Certain Fibers Boost Colonic Sugar Fermentation in Obesity
Ha, it may seem like an esoteric subject, but I'm hot on the trail of something Specific dietary fibers steer toward distal colonic saccharolytic fermentation using the microbiota of individuals with overweight/obesity https://t.co/6b8y6du2On
Review Panel Finds Anti‑amyloid Alzheimer Drugs Offer Little Benefit
Medical Review Group Questions Usefulness of Some Alzheimer’s Drugs Group says anti-amyloid treatments don’t offer noticeable benefits https://t.co/Z9tRQquyZX
GLP‑1 Drugs Show Promise for Treating All Addictions
GLP-1 medications get at the heart of addiction: study Diabetes and obesity drugs show promise in treating and preventing all substance use disorders https://t.co/buHywnw9Wk https://t.co/0lunbQbjsb
AI Creates Orexin Activator to Boost Focus, Reduce Sleep
Two researchers just used AI to design a selective orexin activator. If you care about focus, steady energy, or needing less sleep, this is worth paying attention to. https://t.co/3qbzB6J7X3
AI-Driven CRISPR‑GPT Enables Fully Autonomous Lab Experiments
A junior researcher walks up to a CRISPR experiment they've never run before. An AI agent has already decomposed the workflow, selected the guide RNAs, anticipated failure modes, and drafted the protocol. They run it successfully on their first attempt. That's not...
Mitochondrial Transplantation Reverses Cell Degeneration
In terms of my top bets for rejuvenation-based therapies, mitochondrial transplanation has entered the chat Cell-type-targeted mitochondrial transplantation rescues cell degeneration https://t.co/izvDaRk7kz
Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets
Beyond Cell Death: The Hidden Drivers of Stem Cell Aging “The findings shed light on how cellular stress shapes stem cell aging and highlight potential pathways for developing therapies to counter age-related decline...” https://t.co/hBUchsNtQ4 https://t.co/6HyOSZZ6ZS
Reversing Aging Could Halt Chronic Disease Progression
Aging is the primary driver of most chronic diseases. But what if aspects of aging can be reversed? I join @TomBilyeu on Impact Theory to discuss the latest about what we’re learning in the lab and in human clinical trials Full conversation:...
Wet Dress Rehearsal Boosts Confidence for Upcoming Flight
Nice full Wet Dress today is making flight in a few weeks look real good. We are close my friends.
Over 3,000 Brain Genes Show Sex‑Specific Expression
Sex-specific gene expression of the human brain, for >3,000 genes (of our ~20,000 total) @ScienceMagazine https://t.co/jQUFgARmuA https://t.co/0qNr9XPnP4
Stress‑induced Mitochondrial Condensate Fusion Drives Aging
It works by phase separation, where mitochondrial DNA and proteins cluster into droplet-like biomolecular condensates that organize gene activity, but under stress these droplets fuse and grow abnormally, disrupting function and contributing to aging. https://t.co/dRzhFVzxQQ
Choose the Right Design, Not One‑Size Truth
n=1 is can work for cancer and infectious disease, but often you need a clinical trial. We need to always be asking what the best tool is to get to truth. Don't assume that one experimental design is always correct. And don't...
P21⁺TREM2⁺ Macrophages Drive Inflammaging and Liver Disease
Delighted to be part of this study identifying p21⁺TREM2⁺ senescent macrophages as drivers of inflammaging and metabolic liver disease. A fantastic collaboration led by @ACovarrubiasPhD 👏
Artemis 4 Targets Moon’s South Pole for Water
Artemis 4 in early 2028 aims for a crewed landing on the Moon's south pole. Why the south pole? That's where we've found ice in permanently shadowed craters. Water on the Moon changes everything.
Lightweight 8 kW/Kg Motor Powers Hydrogen Hybrid Aircraft
The 12.5kg gas cylinder-sized motor achieves 8 kW per kilogram with a fault-tolerant design, targeting hydrogen hybrid regional aircraft under Project AMBER. https://t.co/vk6CdOCVvD
Even Small Alcohol Increases Heart Rate, Lowers HRV
"Researchers looked at over 5 million days of data and found that even a modest amount of alcohol caused resting heart rates to climb and heart rate variability (a sign of how well your body handles stress) to drop." https://t.co/qg4663hHCS
Optical Links Replace Radio as Space Data Bottleneck
The radio spectrum is reaching the limit of space-to-Earth communication, with more spacecraft in orbit and more data to transmit each year. That’s why startup Transcelestial is working on optical communications for transferring data from Earth to space. https://spectrum.ieee.org/satellite-communication-laser-radio-transcelestial
Flawed Study Groups Failed and Successful Alzheimer Drugs Together
This new analysis of Alzheimer's drugs is such a good example of why we can't make any headway as a society. There is probably a good debate to be had on whether the risks and costs of the two approved beta...
High‑Resolution TORC2 Structure Opens Path to Age‑Related Therapies
Activating TORC2 holds potential in medicine for treating age-related memory & hearing loss. New study out today @MolecularCell reveals the structure of TORC2 in highest-ever resolution - which is good news for drug developers & all of us who age...
Drug Discovery Expands Beyond AI to New Frontiers
The marked expansion of paths and methods for new drug development including and beyond AI @Joseph_C_Wu @james_y_zou @WuXuekun @ScienceMagazine https://t.co/hTJ4Rt181n https://t.co/H3U5BNR1ER
Orbiting Needs Speed, Not Height: Artemis II Curve Explained
Why does the @nasa Artemis II curve so much on launch? Getting into orbit is more about going fast than going up. For low Earth orbit, it's over 80 percent kinetic energy. https://www.instagram.com/p/DXMmMxrAOtJ/?img_index=1