Androgen Receptor Density Drives Muscle Gains, Not Testosterone
Muscle androgen receptor density, but not testosterone, predicts muscle growth from resistance training In this 2018 study, testosterone, IGF-1, growth hormone, DHEA, LH, or DHT predicted muscle hypertrophy - muscle androgen receptor content did Muscles have androgen receptors that mediate hypertrophy through gene expression, satellite cell activation, and protein synthesis. They get activated by androgenic hormones like testosterone and DHT Takeaway: You can have very high testosterone and DHT, but if there's low androgen receptor density, you'll build less muscle than someone with lower testosterone but higher androgen receptor density Factors that determine androgen receptor density: - #1 genetics - high volume resistance training - possibly creatine - higher protein intake - higher vitamin D levels Study: PMID: 30356739
Starship Booster Packs Power of 177 GE90 Jet Engines
Booster 19’s 33 Raptor 3 engines produce as much thrust as approximately 177 GE90-115B jet engines. That’s one Starship booster equaling the power of 177 of the world’s biggest turbofans.
Dads Deliver Distinct Microbes to Their Babies
Most people assume the baby's gut microbiome comes from the mother. A lot of it does, especially early on. But a 2024 study tracked 73 infants and both parents for over a year and found that fathers are a consistent source...
Join Study to Deepen Your Metabolic Health Understanding
Here is a worthwhile study to better understand your metabolic health. Please consider joining it: https://hubs.ly/Q02J7v2Q0 @mimiohealth
Pennsylvania Turns Abandoned Wells Into Renewable Geothermal Power
Pennsylvania has up to 750,000 of inactive oil and gas wells. Now the state will use some of those wells to build a clean, renewable electricity source, enhanced geothermal. https://t.co/SGBLc8g4ck More on EGS https://t.co/yt6XQ52tPW
Optimized Type 2 Diabetes Care Boosts Health and Savings in Spain
Estimating the Clinical, Quality-of-Life and Economic Impact of Optimized Management of Type 2 Diabetes Patients in Spain https://t.co/L3QB4MJf57 https://t.co/pot0usHX7f
Joe Rogan's Text Spurs Federal Psychedelic Policy Shift
How a text from Joe Rogan helped remake the federal government's approach to psychedelics https://t.co/8j55tEgdx6
Solar Powers 75% of Renewables, Nearing Half Global Capacity
Renewables just hit 49.4% of global electricity capacity. 5.15 terawatts. Solar drove 75% of the new additions. Some people thought it was impossible.
Illuminating the Dark Proteome: Protein Sequencing’s Next Frontier
The Human Genome Project mapped our DNA. We still can't read most of our proteins. There are billions of proteins in biology we've never sequenced: no function known, no structure solved, no role in disease understood. They're not hypothetical, they're real...
Longevity, Uploads, or Death: Future’s Polarizing Choice
biological longevity vs. computational immortality vs. finite existence there is a fascinating growing debate among technologists/futurists about where we should invest in - living longer through chemistry or immortality through uploading our data and ultimately our “consciousness.” and then there’s a spiritually...
NovaSeq 6000 Two‑color Chemistry Creates T>G Artifact
NovaSeq 6000's two-color chemistry introduces a recurrent T>G substitution artifact that doesn't show up on HiSeq X10's four-color chemistry. Germline and high-VAF somatic calls are fine. Low-VAF mosaicism calls are not. https://t.co/9PknN8Vyrb
Never Confuse DNA Plus/Minus Strands Again
1/17 Confused by plus/minus strands, coding/template, or forward/reverse in DNA data? You're not alone. Here's how to never mix them up 🧵 https://t.co/4kVXfhJssL
Implausible Apple Cider Vinegar Weight‑Loss Study Retracted
Implausible Apple Cider Vinegar Weight Loss Study Retracted When a trial has results that defy basic biology, it’s reasonable to be skeptical. @PharmacistScott https://t.co/ahEkiEmP7l https://t.co/yVyazUwXou
Our Loss of Real Megafauna Makes Charisma Tragically Ironic
*Charismatic megafauna* is tragically funny given how many authentic members of that class we’ve extirpated.
Microfluidic Lens Rivals Electronics for Glaucoma Monitoring
Can a microfluidic contact lens match electronic systems for glaucoma care while staying comfortable enough for daily wear? https://spectrum.ieee.org/smart-contact-lens-glaucoma-microfluidics?share_id=9388906
Roll‑to‑Roll System Prints 300 Visible Metalenses per Second
A fully automated roll-to-roll platform now enables the production of 300 visible metalenses per second, overcoming key manufacturing barriers and advancing the scalable commercialization of flat optics for next-generation photonic devices. metasurfaces
Protein Aggregates Damage Brain Vascular Barrier in Parkinson’s
Organ-on-a-chip technology demonstrates that Parkinson's-associated protein aggregates disrupt the brain's vascular barrier, leading to endothelial dysfunction and impaired blood flow. This insight highlights the vascular component of neurodegenerative disease. neuroscience
Antibodies: Essential Protectors Often Misunderstood, Says Vonn
Our Immune Systems keep us healthy Antibodies are some of the key protectors to our health and wellness and also some of the most interesting and informative - but they can be misunderstood @lindseyvonn is talking about antibodies, and why they...
Military Quietly Prepares for Climate Impacts Despite Silence
The military might not be talking about climate anymore, but it’s still working to be ready for it. https://t.co/fJS7G0bPXm
PFAS Detected in Dolphin Milk, Threatening Calf Development
PFAS, persistent environmental contaminants, have been detected in dolphin milk, indicating these chemicals can transfer from mothers to calves and potentially impact early development in marine mammals. environmentalhealth
Study Shows Modern Palestinians Share Iron Age Levant DNA
I sent a link to a peer-reviewed research paper from 2025 that shows modern Palestinians have strong DNA links to Iron Age inhabitants of the Levant. Apparently this is "misinformation".
Sweetener and Plastic Microplastics Trigger Worm Obesity
Sucralose and PMMA Microplastics Synergistically Induce Obesity with Altered Locomotion and Metabolism in Caenorhabditis elegans https://t.co/TExtjah4cV
Space‑based Datacenters Will Dwarf Earth GPUs, Boost Security
Tonight I hung out with an entrepreneur who is building https://t.co/1tXBvxF3GP Datacenters in Space. He is putting 42,000 up over next few years. All put in space by @SpaceX And all packets will go through @Starlink. GPU inside made by @nvidia. He said the Vera...
Protein‑rich Breakfast
Big breakfast diet composition impacts on appetite control and gut health: a randomized weight loss trial in adults with overweight or obesity "The HPWL diet was superior to the HFWL diet for suppressing subjective appetite (P=0.003). The faecal microbiota analysis showed beneficial...
Implantable Islet Cells May Eliminate Insulin Injections
Implantable islet cells could control diabetes without insulin injections by Anne Trafton @MIT Learn more: https://t.co/aPCxukXMW1 #MedTech #HealthTech #Tech #TechForGood https://t.co/IwjlYaJitu
PFAS Exposure Linked to Faster Biological Aging in Men
Aging process could accelerate due to 'forever chemicals' exposure, study finds Higher concentrations of PFAS chemicals were associated with faster biological aging in men of certain age groups https://t.co/ZClEw0Gj1p https://t.co/tYBTJTmlt9
Exercise Activates Hypothalamic SF1 Neurons, Boosting Endurance
Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance 👉 “ These results demonstrate that exercise-induced hypothalamic SF1 neuron activity is essential for the coordination of physiological improvements following exercise training.” https://t.co/qLowm6sETh
Light‑activated Gel Advances Ionotronic Wearables and Soft Robotics
Light-activated gel could impact wearables, soft robotics, and more “New MIT work advances the growing field of ionotronics, in which data are transferred through ions, potentially providing a bridge between electronics and biological tissue.” https://t.co/BayczCUVKC https://t.co/ngp4uTvHqe
Warmer Waters Accelerate Fish Life Histories, Shorten Lifespans
Mixed Support for the Temperature-Size Rule in Wild Freshwater Fishes "...We also found evidence that faster life histories in warmer environments are associated with reduced lifespans..." https://t.co/oJtqRUD2o6
Trump Pushes Lunar Nuclear Reactor Despite Past Mishaps
Trump wants a nuclear fisson reactor orbiting the moon by 2028. This is not a joke either. The U.S. launched a nuclear reactor into orbit in 1965, but space-based nuclear programs were abandoned after radioactive releases. 🤦♂️ Given the supreme dedication...
Genetic IL6R Blockade Shows No Impact on Disease or Longevity
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative "Genetic IL6R blockade was not associated with incident chronic-disease risk, including invasive cancer and longevity, in a large, ethnically diverse cohort of postmenopausal women. No significant...
Two Weeks Offline Boosts Mental Health, Reverses Decline
Two weeks without mobile internet improved mental health more than antidepressants and reversed roughly 10 years of attentional decline. Screen time dropped 49% (314 to 161 min/day). https://t.co/9sU6ZFXDCr
Blood‑based ECM Protein Clock Predicts Biological Age and Disease
An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease https://t.co/3VOwhGCz5S
Design‑First Protein Engineering Delivers Round‑One Success
Protein engineering has a dirty secret: most of the work is in the lab, not the algorithm. You design, you test, most variants fail, you iterate for months. Scala Biodesign's bet is that the design layer can do most of that...
US Researchers Achieve 24.3% Efficiency with Copper‑Contacted TOPCon Cell
U.S. scientists build copper-contacted TOPCon solar cell with 24.3% efficiency #energysky -- via pv magazine global: https://t.co/GKPxxSeXDV https://t.co/iuc8RgVcJj
Chinese Astronauts Conduct 5‑hour Spacewalk on April 16
Astronauts Zhang L. and Wu F. made a spacewalk from the Chinese Space Station on Apr 16 from about 1206 UTC to 1736 UTC
Dual-Agent AI Cracks 2014 Algebra Conjecture in 80 Hours
Peking University's dual agent AI solved Anderson's 2014 algebra conjecture in 80 hours with no human intervention and full verification. https://t.co/e5W8R9iD2O
Orion’s Eight‑Processor Redundancy Ensures Deep‑Space Reliability
NASA’s Orion spacecraft uses eight synchronized processors and layered redundancy to maintain operations in deep space, where hardware failures cannot be repaired. https://t.co/QIO7Hkg8qA
STAT's Live AACR Coverage: Newsletter, Event, Recap
A heads up: starting Sunday, and through the beginning of next week, STAT is going to be taking the annual meeting of the American Association of Cancer Research by storm. This is one of the best venues for spotting new ideas...
Moderate Calorie Restriction Lowers Fat C3, Slowing Aging
Moderate calorie restriction in humans reduces levels of the immune protein C3 in fat tissue, potentially slowing aging and inflammation without the negative effects of severe dieting or weight loss. aging
NASA Denies Non‑Polar Artemis IV Landing Rumors
FYI I've been hearing murmurings that NASA is seriously considering a non-polar landing for Artemis IV. @SpcPlcyOnline also had an intriguing story about a month ago (linked below). Anyway, I asked NASA about it this week and got a firm...
France Leads Approval of IV Ketamine for Suicidal Crises
Scientists test if ketamine has antidepressant effects under anesthesia; France is the first to approve IV ketamine for severe suicidal crisis https://t.co/s7W7YlAOMr
Nanobody Fixes CFTR Misfolding, Boosts Cystic Fibrosis Therapy
A cell-penetrating nanobody repairs misfolded CFTR proteins in cystic fibrosis cells, restoring chloride channel function and showing strong synergy with existing therapies, potentially advancing treatment for protein misfolding disorders. biotechnology
CZ-4C Launches Daqi-2 Atmospheric Satellite From Jiuquan
LAUNCH at 0410 UTC Apr 17 of a CZ-4C from Jiuquan with the Daqi-2 atmospheric research satellite
Childhood NAD+ Deficiency Triggers Lifelong Muscle Aging
Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood https://t.co/K0MAkv7hIB https://t.co/eRCOesGwL5
One Week Later: Artemis II’s Purpose and Legacy
A week since splashdown and I’m thinking a lot about the motivations and legacy of Artemis II…
Exercise Aligned with Your Chronotype Reduces Heart Disease Risk
Timing exercise to match body clock chronotype may lower cardiovascular disease risk https://t.co/RhtM0ZlW1k via @medical_xpress #exercise #CardioTwitter #MedTwitter #health #lifestylemedicine
Start High‑Dose Folic Acid Pre‑Pregnancy Cuts Birth Defects 45%
Initiating high-dose folic acid before pregnancy is linked to a 45% lower risk of major birth defects in children of women using antiseizure medication, with no protective effect observed if supplementation begins after pregnancy starts. epilepsycare
AI and Cheap Sequencing Will Unlock Health Risk Genomics
Our use of genomic data is woefully minimal for establishing health risks but the low cost of sequencing along with improved AI analytics can get this moving forward. Nice example here
Deep Rover Enables 1km Underwater Exploration in Acrylic Bubble
With Deep Rover, you could dive a kilometer underwater, gaze into the abyss from an acrylic bubble, and unravel the ocean's mysteries. https://spectrum.ieee.org/deep-sea-submersible