Science Social Media and Updates

Lilly's Retatrutide Achieves 28.7% Weight Loss, Higher Dropouts
SocialApr 21, 2026

Lilly's Retatrutide Achieves 28.7% Weight Loss, Higher Dropouts

Lilly’s triple G agonist boasts 28.7% weight loss in Phase III trial Lilly is investigating retatrutide in seven other Phase III trials, which are due to read out in 2026. 👨🏻‍⚕️“Discontinuation rates due to adverse events were 12.2% and 18.2% with retatrutide...

By David Barzilai, MD PhD
Four Molecules Boost Mouse Lifespan 33% Without Diet Change
SocialApr 21, 2026

Four Molecules Boost Mouse Lifespan 33% Without Diet Change

They said it was unproven. It's published now. Mice. Western diet. No lifestyle changes. Just four molecules and 33% more life. https://t.co/ctPE6QgjEq

By Dave Asprey
5‑MeO‑DMT Reveals Self‑Other Illusion in Brain
SocialApr 21, 2026

5‑MeO‑DMT Reveals Self‑Other Illusion in Brain

> Self and other is a toggle switch in the brain > 5-MeO-DMT flipped mine > 100% decoupling from self > 150% tightening with others > Others felt like me for four weeks > First-in-human data Makes you wonder if "me" and...

By Bryan Johnson
NMN Eases Liver ER Stress, Resets Circadian Rhythm
SocialApr 21, 2026

NMN Eases Liver ER Stress, Resets Circadian Rhythm

Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity https://t.co/mXbwdQlAzt https://t.co/iQxPG0NKYf

By David Barzilai, MD PhD
Monoclonal Antibodies Boost Fight Against Infectious Diseases
SocialApr 21, 2026

Monoclonal Antibodies Boost Fight Against Infectious Diseases

This is a great conversation w @Invivyd chairman and @politico today on why monoclonal antibodies will enhance our war against infectious diseases.

By Michael Mina
NASA Reveals New Skyfall Helicopter Mars Landing Render
SocialApr 21, 2026

NASA Reveals New Skyfall Helicopter Mars Landing Render

New rendering (at least to me) shared by NASA's Lori Glaze today of multiple Skyfall helicopters during entry, descent, and landing on Mars. https://t.co/WW0NWRzQPf

By Stephen Clark
Centrum Silver’s Anti‑aging Claim Rests on Limited Evidence
SocialApr 21, 2026

Centrum Silver’s Anti‑aging Claim Rests on Limited Evidence

Have ya’all heard the breathless news that daily multivitamin use slows down biological aging and preserves memory? Celebrity wellness influencers like Dr. Rhonda Patrick claim that the COSMOS study found Centrum Silver improved memory and slashed aging by 4 months...

By Gregory Charlop, MD
LLMs Beat JEPA World Models on Sparse Biological Data
SocialApr 21, 2026

LLMs Beat JEPA World Models on Sparse Biological Data

Sci-JEPA's and Biology: I'm testing & training LeCunn style JEPA's @SciRouterAI vs more classical Dual encoder LLMs (small 35k data sets) for novel molecule targets for disease quick scans. What's interesting is that even though world models have, in theory, powerful...

By Ryan Bethencourt
AI Speeds Disease Insight and Treatment Discovery
SocialApr 21, 2026

AI Speeds Disease Insight and Treatment Discovery

AI accelerates disease understanding and treatment discovery. https://t.co/pE6ppH5VR8 #sustainability #infrastructure #IoT #AI #5G #cloud #edge #futureofwork @virginia_tech https://t.co/k0Kpc0ATAF

By Peggy Smedley
Beyond CAR T: Programmable Immune Cells Shaping Future Therapies
SocialApr 21, 2026

Beyond CAR T: Programmable Immune Cells Shaping Future Therapies

CAR T cells cured patients who had no other options. That was just the opening move. #SynBioBeta2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK The next generation of T...

By John Cumbers
Fossil Gas and Oil Power 2025 Emissions Surge
SocialApr 21, 2026

Fossil Gas and Oil Power 2025 Emissions Surge

Fossil gas and oil were the two key drivers of global energy-related emissions growth in 2025, according to the IEA's latest report. Another reminder that we urgently need to get rid of these fuels because their use kills our life...

By Ketan Joshi
Two New Methods Advance RNA 3D Structure Prediction
SocialApr 21, 2026

Two New Methods Advance RNA 3D Structure Prediction

Predicting RNA 3D structure is a grand challenge of biology. 2 new approaches published today to get at it https://t.co/KQ2oCGlUrN @MolecularCell https://t.co/ofupia6du2 @NatMachIntell https://t.co/EwL0iymmt2

By Eric Topol
Use AI to Decode Human Consciousness, Not Debate Its Own
SocialApr 21, 2026

Use AI to Decode Human Consciousness, Not Debate Its Own

Instead of arguing about whether AI is conscious, we should be using AI to find the biological mechanism of human consciousness.

By Noah Smith
Diet Can Reverse Phosphatidylcholine‑driven Mitochondrial Aging
SocialApr 21, 2026

Diet Can Reverse Phosphatidylcholine‑driven Mitochondrial Aging

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging "a previously unrecognized natural driver of mitochondrial decline in aging that is malleable by dietary interventions." https://t.co/jICV37bT1N https://t.co/DxBCO7WXJa

By David Barzilai, MD PhD
Ivonescimab Plus Chemo Rivals Tislelizumab in First‑line sqNSCLC
SocialApr 21, 2026

Ivonescimab Plus Chemo Rivals Tislelizumab in First‑line sqNSCLC

#ASCO26 LBA4 - Zhiwei - Ivonescimab + chemo vs tislelizumab + chemo 1L sq NSCLC - Ph3 HARMONi-6 [May 31, 2026] Zhiwei et al. https://t.co/oWEeVo2oyq #NCT05840016 #lcsm #ImmunoOnc https://t.co/NP2qr2gPuY

By Mike Thompson, MD PhD
Bacterial Flagellar Motor Revealed as Proton-Powered Electric Engine
SocialApr 21, 2026

Bacterial Flagellar Motor Revealed as Proton-Powered Electric Engine

After 50 years, the flagellar motor used by bacteria is finally understood. It's a true electric motor that funnels and unbinds protons to produce torque. beautifully explained by Pulizter winner Natalie Wolchover: https://www.quantamagazine.org/what-physical-life-force-turns-biologys-wheels-20260420/

By Philip Fung
Senolytics Fail to Reset Senescence DNA Methylation Marks
SocialApr 21, 2026

Senolytics Fail to Reset Senescence DNA Methylation Marks

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment https://t.co/uemETuWkqI H/T @NataliaMitin

By Michael Lustgarten, PhD
90‑95% of Cancers Stem From Lifestyle, Not Genes
SocialApr 21, 2026

90‑95% of Cancers Stem From Lifestyle, Not Genes

From all the way back in 2008. "Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle" https://t.co/Fjd6izZyuT https://t.co/j8mh4DEqeU

By Ed Latimore
Phase 3 Trial Shows Abemaciclib Benefits Advanced Liposarcoma
SocialApr 21, 2026

Phase 3 Trial Shows Abemaciclib Benefits Advanced Liposarcoma

#ASCO26 LBA2 - Dickson -SARC041: Ph3 DBRCT abemaciclib vs placebo in Pts w/ adv dedifferentiated liposarcoma [May 31, 2026] https://t.co/oWEeVo2oyq #NCT04967521 #scmsm https://t.co/uD6A9JmBCn

By Mike Thompson, MD PhD
New Model Enables Multi‑Institutional Sarcoma Video Collaboration
SocialApr 21, 2026

New Model Enables Multi‑Institutional Sarcoma Video Collaboration

A model for multi-institutional, multidisciplinary sarcoma videoconferencing [2013] Attia, Maki, @JTrentMDPhD , Okuno, Indelicato, @nickwebbermd , Curtis, Kozak #ASCO13 Abstr 10521 https://t.co/opAHZRDTTr #scmsm

By Mike Thompson, MD PhD
Genomic Profiling Boosts Survival for Advanced Sarcoma Patients
SocialApr 21, 2026

Genomic Profiling Boosts Survival for Advanced Sarcoma Patients

Using Tumor Genomic Profiling to Guide Treatment Selection Extends Survival in Advanced Sarcoma [May 10, 2019] @ASCO Daily News #scmsm #PrecisionMedicine https://t.co/8625ixTvQu

By Mike Thompson, MD PhD
Perioperative
SocialApr 21, 2026

Perioperative

#ASCO26 LBA1 - Taplin - Perioperative APA + ADT - prostate CA [May 31, 2026] https://t.co/oWEeVo2oyq #NCT03767244 #pcsm https://t.co/8o91ntAwL9

By Mike Thompson, MD PhD
Three Key Nutrients for Brain Longevity, Plus Polyphenols
SocialApr 21, 2026

Three Key Nutrients for Brain Longevity, Plus Polyphenols

As a bioscientist studying aging, my top 3 nutrients for brain longevity are: → Omega-3s (fatty fish 2–3x/week) → Vitamin B12 (beef, dairy) → Choline (2 eggs daily) Plus plenty of polyphenol-rich foods: berries, extra virgin olive oil, cocoa, nuts, and coffee.

By Ollie Whitby | Health Scientist
Microplastics Detected in Every Human Brain Sample
SocialApr 21, 2026

Microplastics Detected in Every Human Brain Sample

New research found microplastics in every brain sample tested. Here’s what the study says and what it means for daily exposure. https://t.co/ga3UHHTvGo

By Dave Asprey
WGS Uncovers Clinically Relevant Findings Missed in MDS
SocialApr 21, 2026

WGS Uncovers Clinically Relevant Findings Missed in MDS

Whole genome sequencing [WGS] to identify novel, clinically relevant findings missed by standard of care for Pts w/ myelodysplastic syndrome [MDS] - @AlexBataller etal @garciamanero @UTMDAnderson @TempusAI #ASCO26 abst 6570 Pst 363 https://t.co/t7aNW89eRL #MDSsm #leusm #cagenome

By Mike Thompson, MD PhD
AQUARIUS Registry Uncovers Biomarkers in Blood Cancers
SocialApr 21, 2026

AQUARIUS Registry Uncovers Biomarkers in Blood Cancers

AQUARIUS: A longitudinal multi-center molecular biomarker discovery registry for Pts w/ hematologic malignancies - @mtmdphd et al. @TempusAI & IFLI - Instit Follicular Lymphoma Innovation #ASCO26 abstr TPS7105, Poster 599a https://t.co/70G0v1P968 #NCT07154823 #lymsm #cagenome

By Mike Thompson, MD PhD
High Sodium Accelerates Memory Decline in Older Men
SocialApr 21, 2026

High Sodium Accelerates Memory Decline in Older Men

Higher sodium intake is associated with episodic memory decline in cognitively unimpaired older males: A 6-year longitudinal study https://t.co/8snYRP7sRR https://t.co/kDhs9b2Y8s

By David Barzilai, MD PhD
From Dorm to $275M: Early Ovarian Cancer Detection Breakthrough
SocialApr 21, 2026

From Dorm to $275M: Early Ovarian Cancer Detection Breakthrough

This is my friend Surbhi Sarna. She came to Draper University in 2012. She had painful ovarian cysts as a teenager, but doctors didn’t have tools that could detect cancer without harming the ovaries. She studied molecular biology at UC Berkeley. Then came...

By Tim Draper
Record $2.3 Trillion Climate Tech Funding Amid Stalled Ambition
SocialApr 21, 2026

Record $2.3 Trillion Climate Tech Funding Amid Stalled Ambition

International climate ambition has faltered since the start of President Donald Trump’s second term. Yet funding for the global energy transition climbed to a record $2.3 trillion in 2025. Read more about the companies that are leading the way in...

By Vox – Climate
ASCO26 Unveils Pancreatic
SocialApr 21, 2026

ASCO26 Unveils Pancreatic

#ASCO26 abstract titles were released today: $RVMD RASolute Ph3 study in pancreatic cancer will be presented during the plenary session. Also, Akeso $SMMT ivonescimab HARMONi-6 trial in lung cancer. China-only data.

By Adam Feuerstein
Dark Matter Passes New Cosmic Test, MOND Fails
SocialApr 21, 2026

Dark Matter Passes New Cosmic Test, MOND Fails

Dark matter passes a new cosmic test, while MOND fails A new cosmic test has finally, with CMB and large-scale structure data, become realistic: using the kinetic Sunyaev-Zel'dovich effect to test dark matter vs. MOND. Guess who wins? https://t.co/jja8ObZ5OQ

By Ethan Siegel
Muscle Mass Predicts Older Adults' Survival Better than BMI
SocialApr 21, 2026

Muscle Mass Predicts Older Adults' Survival Better than BMI

Muscle mass is a stronger predictor of survival than BMI in older adults Read here: https://www.sciencedirect.com/science/article/abs/pii/S0002934314001387

By David Sinclair
Curing Disease Adds Years; Slowing Aging Adds Decades
SocialApr 21, 2026

Curing Disease Adds Years; Slowing Aging Adds Decades

In the future, very few will die from cancer and heart disease. But it's estimated that eliminating both completely only increases life expectancy by ~5–10 years. The real dramatic gains in life expectancy will be achieved by figuring out how to slow...

By Siim Land
Lithium Shortage Threatens 100% Renewable Energy Goal
SocialApr 21, 2026

Lithium Shortage Threatens 100% Renewable Energy Goal

Does the world have enough lithium to power all the electric vehicles and stationary batteries needed to transition the world to 100% clean, renewable energy and storage for everything? More info https://pubs.usgs.gov/periodicals/mcs2026/mcs2026-lithium.pdf https://web.stanford.edu/group/efmh/jacobson/WWSStillNMN/StillNMN.html Video: https://www.youtube.com/watch?v=XKBTnj1nTWo

By Mark Z. Jacobson
Cancer-Like Microglial Mutations May Fuel Alzheimer's Inflammation
SocialApr 21, 2026

Cancer-Like Microglial Mutations May Fuel Alzheimer's Inflammation

Somatic mutations in microglia brain cells (the same mutations as seen in cancer) are enriched in and may drive the neuroinflammation of Alzheimer's disease @CellCellPress https://t.co/PS7pIBFW4H

By Eric Topol
Falcon Launches Every Few Days—Watch Live in Florida or California
SocialApr 21, 2026

Falcon Launches Every Few Days—Watch Live in Florida or California

Falcon flies every few days. You can see launches in person from Florida or California.

By Elon Musk
Scientists Drill Beneath Arctic Seafloor to Predict Future
SocialApr 21, 2026

Scientists Drill Beneath Arctic Seafloor to Predict Future

To understand what the future holds for Earth’s northernmost waters, scientists are burrowing deep below the seabed.

By MIT Technology Review Threads
Engineers Build Self‑Wiring Neurobots From Living Cells
SocialApr 21, 2026

Engineers Build Self‑Wiring Neurobots From Living Cells

Engineers have created "neurobots": tiny, free-swimming assemblages of living cells that organize into self-directed systems, complete with neurons that wire themselves into functional circuits. https://spectrum.ieee.org/neurobot-living-robot-nervous-system

By IEEE Spectrum Threads
Promising Mufemilast Results Unveiled at DDW
SocialApr 21, 2026

Promising Mufemilast Results Unveiled at DDW

Strong mufemilast data being presented at DDW this week for anyone still following the $PALI story. https://t.co/Oi4WI6R0iW

By Adam May
Red Wolf Controversy Deepens After Colossal’s Clone Claim
SocialApr 21, 2026

Red Wolf Controversy Deepens After Colossal’s Clone Claim

The red wolf has long been a contentious species. The debate over its preservation got even messier last year, when Colossal said it had cloned the animal.

By MIT Technology Review Threads
Pesticide Exposure Correlates with Early‑Onset Colorectal Cancer
SocialApr 21, 2026

Pesticide Exposure Correlates with Early‑Onset Colorectal Cancer

Why are we seeing so much early-onset colorectal cancer? The correlation with pesticide exposure and its epigenetic signature, adjusted for all known risk factors. (doesn't establish cause and effect) https://t.co/1UiBiHkgo5

By Eric Topol
Robotic Cataract Surgery Opens Path for Millions
SocialApr 21, 2026

Robotic Cataract Surgery Opens Path for Millions

this is so exciting to see a robot just performed the first complete cataract surgery on a human patient, with no surgeon's hands on the tools and no general anesthesia cataract surgery is where the eye's clouded lens gets swapped for an...

By itsolelehmann
Our Bodies Accumulate DNA Replication Errors over a Lifetime
SocialApr 21, 2026

Our Bodies Accumulate DNA Replication Errors over a Lifetime

Your DNA replicates a lot between the time you're a fertilized egg and the 30T or so (human) cells in your adult body; fidelity is high but not perfect. In today's @WSJ I review a new book taking a deep...

By David Shaywitz, MD, PhD
Research Shows Nicotine May Boost Cognition, Guard Against Parkinson's
SocialApr 21, 2026

Research Shows Nicotine May Boost Cognition, Guard Against Parkinson's

The New York Times mentioned me in an article about nicotine. They're skeptical. Here's what they didn't include... Dr. Paul Newhouse at Vanderbilt ran controlled trials showing nicotine improved concentration and cognitive function in people with mild cognitive impairment. Peer-reviewed, published...

By Dave Asprey
Spacetime May Not Exist—Abandon Unifying Quantum and Relativity
SocialApr 21, 2026

Spacetime May Not Exist—Abandon Unifying Quantum and Relativity

“we must abandon the project of reconciling spacetime and quantum mechanics, and accept that spacetime, at least as Einstein described it, does not exist.” https://t.co/Pe73C4GgbT

By Donald D. Hoffman
War in Iran Spurs Surge in Green Investment
SocialApr 21, 2026

War in Iran Spurs Surge in Green Investment

Is the Iran war accelerating the clean energy transition? Where are green investors putting their money? Bloomberg journalists answer your questions in a Live Q&A on April 22 at 10:30 a.m. EDT. Join the conversation: https://t.co/JOM34HDIhU https://t.co/6CyE8T6Knn

By Vox – Climate
2026 on Track for Second‑warmest Year, 1.47°C Above Pre‑industrial
SocialApr 21, 2026

2026 on Track for Second‑warmest Year, 1.47°C Above Pre‑industrial

Global temperatures in 2026 are on track to be the second warmest on record, at around 1.47C above preindustrial levels across the five different records assessed by Carbon Brief. Read more in our latest State of the Climate update for...

By Zeke Hausfather
High‑Intensity Training Linked to Greater Brain Atrophy in Seniors
SocialApr 21, 2026

High‑Intensity Training Linked to Greater Brain Atrophy in Seniors

🤔This study followed older adults for 9 years and found that those assigned to long-term high‑intensity interval training (HIIT) actually had slightly more hippocampal and thalamic atrophy than controls who just followed national physical activity guidelines, while higher baseline fitness...

By David Barzilai, MD PhD
APOE Ε4 Predicts Early Cognitive Decline in Midlife Adults
SocialApr 21, 2026

APOE Ε4 Predicts Early Cognitive Decline in Midlife Adults

APOE ε4 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults 🗣️” In this study, APOE ε4 carrier status was associated with early cognitive decline, highlighting midlife risk awareness and lifestyle interventions, while non-APOE polygenic risk may require longer...

By David Barzilai, MD PhD