CFSv2 Shows Monthly El Niño Projection Evolution
Here is the evolution of the projected El Nino event by month in the latest CFSv2 model runs (last 8 days): https://t.co/Q2jlk0zmTv
Diet Shapes Gut Metabolites, Amino
Correlations For Gut Bacterial Metabolites, Amino Acids, And The Omega-3 Index With Diet (Metabolomic Tests #23 and #24) https://t.co/rXwkEfxOA0 https://t.co/mBZEGGdb8S
Early Massive Galaxy Without Rotation Defies Formation Models
The James Webb Space Telescope has identified a massive early galaxy lacking rotation, a feature typically seen only in much older systems, challenging current models of galaxy formation and evolution. astronomy
Severe Malaria Leaves Cognitive Deficits for Up to 15 Years
Children who survive severe malaria may experience lasting cognitive and academic challenges, with effects persisting up to 15 years after illness, highlighting the need for long-term support in affected regions. malaria
Just 11 Minutes More Sleep Cuts Heart Risk 10%
11 More Minutes of Sleep, 5 More of Activity: 10% Lower Heart Risk As a medical school professor, patients ask whether tiny lifestyle changes really do anything. New data from 53,000 adults says yes. European Journal of Preventive Cardiology, March 2026 (Koemel...
Irreversible Space Settlement: The Overlooked Existential Threat
What's the most underrated existential risk? Irreversible space settlement. 1. AI could make space settlement possible in our lifetimes: 1 minute of solar energy is enough to accelerate 10 billion 1kg self-replicating AI probes to 99% the speed of light.
SIRT5 Crucial for Heart Health in Longevity Era
Unveiling the importance of SIRT5 for cardiac health and disease in an era of increasing longevity https://t.co/a8fXNPRIKp
Choosing Traits: Mercy vs Competitive Advantage in Embryo Selection
Listening to @hsu_steve and @AlexTISYoung discuss the ethics of embryo selection is disorienting. Seems disingenuous to laugh off the difference between screening out Huntington’s and optimizing for height or IQ, as if the distinction is some kind of philosophical naivety. A...
Stop Wasting Hours Matching Sample IDs Across Assays
1/ How many hours do bioinformaticians lose matching sample IDs across assays? Too many. And it’s avoidable. Let’s talk about why this happens—and how to stop it. https://t.co/wxR6DIMzPv
Gut Bacteria Species Are Actually Multiple Distinct Populations
Your Gut Bacteria Are Not What Your Textbooks Said As a medical school professor, I've taught gut bacteria as a list of species. A new Nature paper says many of those "species" are actually multiple distinct populations. Nature, May 2026 (University of...
AI-Driven Method Creates Robust Clinical Trial Surrogate Markers
Super interesting via @oziadias & @DeanKateBaicker on an approach to generating robust surrogate markers, urgently needed but elusive, for clin trials, essentially via channeling the AI-enabled empiric analysis that I associate w PRS (cc @pnatarajanmd) https://t.co/FDP4Ym8ycC
FMS Predictive Value Varies Across Athlete Populations
New podcast: I review research on whether the Functional Movement Screen predicts injuries in baseball players. More importantly, I speak broadly to the goal of assessments, and why what’s predictive in one population might not hold up in other athletes....
Billions Spent on Research We Could Simply Stop
We spend $50 billion now on biomedical research through NIH, and several billion more through other agencies. We could "save" that money by not spending it, yet we do. Same story.
Low‑Cost Vaccines and Open Science Aren’t Evil
Hmmm, presumably making low-cost vaccines to help humanity, $2-4 per dose, no onerous patent restrictions, pioneering a way to bypass big pharma, helping the nation through a terrible pandemic, writing books with academic presses on history of science/medicine, constitute evil?
Gut Metabolites Shape Immunity in Aging and Disease
Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases https://t.co/iVUKH7ONVa https://t.co/8M3LmurbCa
Polypharmacy and Anticholinergic Load Accelerate Aging via Inflammation
Polypharmacy, anticholinergic burden and inflammation in relation to accelerated biological ageing Note the observational design, with corresponding limitation in inference. The authors concluded: "Both polypharmacy and anticholinergic burden are associated with accelerated biological ageing, partly mediated by inflammation, including a potential serial...
SAR Penetrates Clouds, Detects Changes Anytime—ICEYE Showcases
Synthetic Aperture Radar is cool af — a change detection machine that rips through cloud cover, day or night. And ICEYE knows how to show it. https://t.co/z9UHDCcyHB
From Purgatorius to Humans: 66 Million Years Apart
The little guy on the branch is a purgatorius, one of the earliest primates, hoping the terrifying dinosaur doesn't see him. What a difference 66 million years makes. https://t.co/GHfegO6jGv
First Evidence of Traditional Psilocybin Use Beyond Americas
(5) Psilocybin changes people’s brains after their first trip; Anthropologists share first evidence of traditional psilocybin use outside of the Americas https://t.co/t4DakDMVvJ
Zoonotic Spillovers Becoming the New Normal
Many thanks @OutFrontCNN @ErinBurnett for hosting me this evening with colleague Dr. Gustavo Palacios a hantavirus expert. I made the point that zoonotic spillover events are now occurring with increasing frequency: SARS-1 MERS, Ebola, SARS-2, H5N1, now Andes virus, a...
Earliest Northern Sri Lanka Settlement Reveals Advanced Seafaring
New evidence from Velanai Island confirms the earliest prehistoric occupation in northern Sri Lanka, challenging assumptions about human settlement and highlighting advanced seafaring and resource use by early island dwellers. archaeology
Attenborough Honored on 100th with Wasp Namesake
“Completely overwhelmed” Attenborough feted on 100th birthday, new wasp species named after him #energysky -- via Renew Economy: https://t.co/9HeHKK42L5 https://t.co/Uike0UibkU
Patchouli Lotion Matches DEET, Blocks Mosquito Bites for 3 Hours
A patchouli oil-infused lotion provided three hours of complete protection against Aedes aegypti mosquito bites, matching the effectiveness of DEET at a lower concentration and offering a promising natural alternative. mosquitocontrol
Longevity Field Shifts From Consensus to Convergence
‘We are not at consensus but we are at convergence’ @LongevityTech @TinkingGumbel with @prof_horvath https://t.co/rGqQhNHYxw https://t.co/tcfNH3S2bH
OutFrontCNN to Cover Latest H
Scheduled for @OutFrontCNN 7 PM Eastern this Friday evening to discuss the latest on Hantavirus
INBX to Release INBRX‑106 Phase 2 Data Monday
$INBX reporting INBRX-106 ph2 data on Monday. This is the ox40 cancer drug that reportedly drew interest from Merck and others?
MRNA Nanoparticles Reprogram T Cells In Vivo, Show Promise
Impressive. In vivo reprogramming of killer T cells with mRNA-nanoparticle packaging in non-human primates. Multiple use cases in the clinic vs pathogens and cancer, no less an alternative version vs autoimmune diseases https://t.co/ddhebnxvkE @SciImmunology
New Electrolyte Stabilizes High‑Voltage Sodium‑Ion Batteries
New electrolyte tech enables stable operation of high-voltage sodium-ion batteries #energysky -- via pv magazine usa: https://t.co/IvQBAb2YER
Optimal Exercise‑Fasting Dose Boosts Metabolic Health
Optimal dosage of exercise combined with intermittent fasting for body composition and cardiometabolic health in adults: a systematic review and multilevel meta-analysis https://t.co/JFrFVMpGDq
Billion-Dollar Ideas Lurk in Free PubMed Data
Martin Shkreli came on MFM a while back and told Shaan and I something interesting: PubMed has 40M+ biomedical papers. It's the government database of every medical innovation ever logged. And it's 100% free. He told us if you sit there and read long...
Reality Emerges When the Universe Observes Itself
The universe viewed as a self excited circuit, the origin of 'I am a strange loop'. Universe starting small, grows, emerges into observer-participancy, which in turn imparts tangible reality. Wheeler. https://t.co/qTf56IzE34
CDC Alerts New Jersey of Possible Hantavirus Exposure
JUST IN: The CDC has notified New Jersey health officials about 2 residents who may have been exposed to hantavirus
Mabwell IPO Highlights China’s Rising Biologics Powerhouse
Do you remember the company which sold their IL11 nanobody to Google Calico after it realized that after 13 years in the business they need a drug for aging? The company is called Mabwell and they just listed in Hong...
Peptides: Separating Social Media Hype From Real Science
Sat down with the Science Quickly podcast to chat peptides — what's the internet hype and what's the science? A fun conversation about an increasingly cursed topic. https://www.scientificamerican.com/podcast/episode/the-science-behind-social-medias-peptide-obsession/
Nobel Laureate Harold Urey's Letter Reveals Early Fusion Interest
Curious letter from the Nobel Prize winner physicist Harold Urey and his mention of fusion. https://t.co/U1qSfdxfM2
New Model Shows El Niño Matching 1998
With the new NMME model update, even the more conservative relative Oceanic Nino Index metric now has us roughly tied with 1998 and 2026 El Nino events: https://t.co/DqXtEIMsQ8 https://t.co/FZYRTW74iw
Space Is Never Truly Empty, Even in Deep Vacuum
Ask Ethan: How empty are the depths of space? We often talk about "the vacuum of space" as being a place where pressures and particle densities drop to zero. But outer space is never truly empty, even in the emptiest places. https://t.co/7TeWcEiT7Q
Rapamycin's 50-Year Odyssey: From Easter Island to Medicine
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine https://t.co/Jn67QrGVi6 https://t.co/dwGPgUVB83
ZYME ADC
Catching up with $ZYME pan-RAS inhibitor payload ADCs from #AACR26. Seems the setting for each one is tumours that are RAS-mutated as well as expressing the target antigen (PTK7, Ly6E or Claudin18.2). https://t.co/hljX5soZQi
AI-Generated Hospitalization Summaries Cut Clerk Workload, Boost Physician Well‑being
Agentic AI summaries of hospitalizations were safe and reduced data clerk burden, burnout, and improved sense of well-being for physicians in a prospective study https://t.co/0nXZ0wjugg
NEJM Publishes Moderna Flu Data After FDA Refusal
A Friday footnote: The New England Journal of Medicine has published the Moderna influenza vaccine data -- the same that led the FDA's CBER division to refuse to review the vaccine under Vinay Prasad. (That decision, called a refuse-to-file or...
Organ‑Specific Aging Clocks Reveal Multi‑Omics Lifespan Patterns
The big advance in the science of human aging is the ability to quantify it and relate the metrics to health and disease. A new paper today @CellCellPress takes this to the next level with organ clocks and multiple biologic...
Psilocybin Shows Promise After Decades of Failed Cocaine Treatments
For 50 years the National Institute on Drug Abuse has spent hundreds of millions of dollars to find an effective cocaine addiction medication. After 100+ molecules & many hundreds of studies nothing has been FDA approved. It's the Holy Grail...
Most March Russian Starlink Satellites Maneuvering to Operational Orbit
All but one "Russian Starlinks" launched in March showed signs of maneuvers, presumably on their way to operational orbits. Context: https://t.co/aDdeCmCNC9
Metformin's Primary Action Is Gut, Not Liver
Metformin, one of the most commonly prescribed drugs, was thought to work via the liver. Check that. It's primarily through the gut. @NatMetabolism https://t.co/i2CpZip61B https://t.co/bhsI7p7SYx
Check Gene A–B Co‑Expression in Your Single‑Cell Data
1/ You have a clear question: Is gene A and gene B co-expressed in my cell type of interest? You feel ready. You have single-cell data. https://t.co/9ET61foUET
AI Agents Poised to Automate End‑to‑end Scientific Research
AI is moving beyond assisting research to conducting parts of it autonomously. With agentic systems now able to plan, reason and use external tools, academic papers and scientific workflows can increasingly be automated end to end. The implication is profound. Science may...
Heart, Kidney, Metabolic Issues Raise Cancer Risk 30%
Heart, Kidney, Metabolic Disease Linked to 30% Higher Cancer Risk As a medical school professor, I teach cardiovascular and cancer medicine as separate silos. A new study of 1.4 million adults says we have to stop. Circulation: Population Health and Outcomes, April...
Magnetic Fluid Cuts 93% Microplastics, Startup Scales
From school project to startup 🌊🔬 In 2019, Fionn Ferreira invented a magnetic fluid that removes 93% of microplastics from water 💡 Now he's scaling his innovation through Fionn & Co. to tackle global wastewater. Science that sticks. Literally. 🧲 🖼️ InterestingEngineering #Microplastics #ClimateTech...
Third Edition Muscle Hypertrophy Textbook Now Open for Preorder
Super excited to share that the 3rd edition of my textbook, "Science and Development of Muscle Hypertrophy," is now available for preorder on Amazon. This revision has been several years in the making, reflecting the substantial body of new...