
1 of 4 people have an APOE4 allele, a risk factor for Alzheimer's disease. New evidence this is linked to abnormal meningeal lymphatic function, brain inflammation, and important sex-differences @NeuroCellPress https://t.co/mUUqLedS9V https://t.co/FADCoemvum

One large psilocybin dose beat nicotine patches by 6x odds for smoking cessation. 82 otherwise-healthy cigarette smokers, 42 received a single high-dose 30mg/70kg psilocybin session, and 40 initiated an 8- to 10-week course of nicotine patch treatment. At 6 months; participants were 6x...
Parental age effects on offspring fitness in a wild population of a short-lived reptile G "adds to the growing literature suggesting that negative effects of parental age on offspring fitness may not be as prevalent as once thought, particularly in wild...

The rollout of the first Soyuz-5 rocket to launch pad Site 45 in Baikonur, Kazakhstan, was postponed from today to March 29, in turn, pushing its inaugural flight to April 2, at the earliest, according to Kazakh media. Context: https://t.co/DBcHRiQe36 https://t.co/S8p6AAE3IL
This week's Biotech Scorecard: Allogene $ALLO: A preview of its April interim analysis. Very interesting (to me, at least) There just might be a path forward for off-the-shelf CAR-T therapy in B-cell lymphoma. Frontline consolidation. Read all about it: https://t.co/tcPFelUH3C
Gene therapy isn't just targeting diseases anymore—it's targeting aging itself. The hallmarks of aging are becoming editable code. Longevity Escape Velocity isn't a fantasy. It's an engineering problem. And we're solving it.

Harvard’s twistable light chip could give drug developers a new tool for sorting mirror-image molecules https://t.co/WkjjD38exo https://t.co/5kr4d9f6sa

As a medical school professor, I've spent decades writing papers and reviewing studies. Now AI can do it all -- start to finish. Researchers from Sakana AI, Oxford, and UBC just published in Nature: "The AI Scientist" -- a system that...

I have a story today about the quest to turn eggs into low-cost factories for medicines. Gift link: https://nyti.ms/4bzSabB

I almost sent a figure with wrong cluster labels to my collaborators. The R code ran perfectly. No errors, no warnings. I caught it because cluster 2 showed upregulated genes in RNAseq but reduced chromatin accessibility in ATACseq. Biologically, that's backwards....

Today we're introducing TRIBE v2 (Trimodal Brain Encoder), a foundation model trained to predict how the human brain responds to almost any sight or sound. Building on our Algonauts 2025 award-winning architecture, TRIBE v2 draws on 500+ hours of fMRI recordings...

As a medical school professor, I can tell you: the textbooks got this one wrong. We taught that once you have prostate cancer, exercise is nice but optional. New data says it may be the most powerful tool in your arsenal. 828...
“These findings challenge the assumption that lifespan extension necessarily compresses morbidity, highlighting the need to consider lifespan, healthspan, and CoM as endpoints when evaluating anti-aging interventions. We do not claim that life-extending interventions categorically fail to achieve CoM; rather, we demonstrate...
Meager new emissions reduction plans from New Delhi limit the prospects of major progress through 2035 from the three biggest polluting nations https://t.co/H7X2IWuZRQ

How does the menstrual cycle affect gastrointestinal symptoms during exercise? 🩸 This new study recruited 12 eumenorrheic females to complete 2 x 45-min bouts of a simulated football match on a treadmill ⚽️ Simulations were completed in… 1️⃣ Phase 1 (P1, days...
For the first time, scientists have mapped how genetic factors drive aging in specific brain regions, revealing why some areas are more vulnerable to Alzheimer's and dementia. This detailed genetic atlas advances understanding of brain aging. neuroscience

🔺 These Mini Brains Just Learned to Solve a Classic Engineering Problem 🧠 In a step toward biological computing, brain organoids rewired their networks as they learned to balance a digital pole on a cart. https://t.co/w2wHDTvIVp https://t.co/h51xTVlR4D
World’s First Soft #3D Hydrogel Semiconductor That Mimics Living Tissue by @tweetciiiim #EmergingTech #Innovation #Technology https://t.co/jt0fxgrrdt
NASA Gears Up for Artemis II Launch Around the Moon a Week From Now https://t.co/EkQMgSOIZJ
I'd still rather measure the actual biomarkers, but the best epigenetic clocks (PhenoAge, GrimAge, DunedinPACE) are consistently associated with all-cause mortality risk Another study was just published showing this: https://t.co/RZntDTn02c
Tiny Swimming #Robots That Move Like Fish Could Transform Medicine and Science by @IntEngineering #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/smfTSXZyHx
Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations 🐒"These results parallel recent findings from humans in demonstrating that chronic inflammation is not a natural consequence of aging but may rather be driven by environmental contexts that are mismatched to the evolutionary...
Proud of the work of our Seaport team & collaborators published today in @ScienceTM. This ~13 page peer reviewed paper is the first comprehensive data disclosure of our GlyphAllo™ program from discovery through initial human proof‑of‑concept.
How and why does aging occur? Updating evolutionary theory to meet a new era of data "We argue that by incorporating richer biological detail to create more integrative predictive models, we can gain insight into expected future distributions of aging within...
Interesting paper - looks at what's high and what's low in centenarians vs others. Of course this doesn't reveal what's causal vs simply a biomarker. High apoptosis signals, low IGF-1 pathways.
The surprising science behind red-light therapy — and how it really works. People are buying helmets, face masks, vests and beds that emit long-wavelength light. Beneath the hype, there is some interesting biology. https://t.co/JWV80QOuQU
Microtubules actively regulate chromosome segregation during cell division by controlling enzyme access to substrate proteins, ensuring accurate attachment and separation, and preventing chromosomal instability linked to cancer. cellbiology

So pleased that people like Professor Denis Migliorini @MiglioriniDenis are leading the fight against solid tumors such as GBM / glioblastoma: he is an inspiration. https://t.co/8ohKJG4mQq
Epigenetic modifications—chemical changes to DNA that do not alter its sequence—help explain why individuals with identical genes can develop unique traits and behaviors, shaping their own ecological niches and influencing evolutionary processes. epigenetics
Alpha-amyrin, a molecule found in passion fruit, has demonstrated the ability to protect brain mitochondria and reduce memory loss in Alzheimer's mouse models, suggesting potential for future therapeutic development. neuroscience

When we published our H2H in @NEJM Ian Jordan raised an excellent letter re SSRI discontinuation & how it might impact response. We looked & found he was right. Those who discontinued SSRIs and went back on (escitalopram) did far...

Here it is again. Amazing how researchers could get away with this back then. Regular systematic bias of excluding TAD nonresponders. Also note another thing inconsistent with core psychedelic trial period i.e., that Ps were allowed to continue psychotherapy outside...

.@isaraerospace launch aborts at second of scheduled liftoff, cause unclear. countdown had been delayed by a boat in launch area earlier. https://t.co/TXLNBwmRVz
This is the Crab Nebula. It's a supernova remnant — the leftover debris from a star that exploded. But not all nebulae are the same. Some form stars, some mark the death of Sun-like stars, and some block light completely.
2D carbon selenide offers route to competitive sodium-ion batteries #energysky -- via pv magazine global: https://t.co/deTW0kC8Qd
There's a new object cataloged as 68376 and tagged as a debris object from the 2026-009 ALSAT-3A launch; it's in the catalog number range I was expecting for the 2026-061 Rassvet launch, but no TLEs for that launch yet.
Microscopic #Robot Navigates the Bloodstream to Deliver Targeted Medication by @CeoImed #MedTech #Healthcare #HealthTech #Tech #Technology https://t.co/LBJeDdwTuq
The incredible study using "Rivers of telomeres" to rejuvenate tissues and extend lifespan in mice is now undergoing open peer-review. I did a review, pointing out issues with the methods and the lifespan curves. They're looking for more reviewers. https://t.co/KOiR4F85sT

FLASH therapy at CERN harnesses particle accelerator technology to deliver ultra-fast, high-dose radiation treatment, potentially transforming cancer care with fewer side effects. https://spectrum.ieee.org/flash-radiotherapy

Inspired by the man who built a personalized cancer vaccine for his dog, I’ve written an open-source guide to DIY mRNA vaccine production: philfung.github.io/openvaxx Drawing on my background in running lab startups, the guide covers the entire process - from sequencing...

A bat-inspired approach denoises ultrasound echolocation signals, enabling a palm-sized drone to navigate challenging environments while avoiding transparent or thin obstacles. Learn more in Science #Robotics: https://t.co/utyw7UGfJ9 https://t.co/eesQvK3IJU
Science is epically cool. Making the emptiest place in the solar system to move the tiniest, tiniest amount of antimatter.
Humanoid robots + AI will mean everyone on Earth has access to better medical care than the richest person alive today. THAT is what abundance looks like.
When people ask "How can we make #AAV #GeneTherapy accessible and affordable" --> this is how 👇

Rethinking why the pancreas β-cells become vulnerable to autoimmune attack, leading to Type 1 diabetes. An illuminating review with ideas to counter β-cell stress @ScienceTM https://t.co/zn6a6wEg7u https://t.co/BV0LYnWRNL
One thing that really makes the in-person summits we run at STAT so amazing: the people in the room. Here's what happened when we asked some of them for the last big breakthrough they saw. Featuring: the infectious @DrBlytheAdamson, genomcis pioneer...

It was a great pleasure—and truly exciting—to moderate the “Key Dialogue Quantum Technologies” and to listen to the great and impressive talk “Transforming Computing with Quantum-Centric Supercomputing” by @jmchow. His talk at the #GCConference was a wonderful showcase of cutting-edge technology and the...

How about... No? It's a synthetic, highly radioactive metal, and is the 14th member of the actinide series. Also, it is named after Alfred Nobel. https://t.co/2j8KzgnU9B
This Vine-Inspired #Robot Can Gently Lift Almost Anything by @MIT #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/lfKLB58nJB

Pour one out for NASA's Joel Montalbano. Months ago he is confirmed to appear before the US House to speak about the future of humans in low-Earth orbit. On the day before his appearance NASA basically says there isn't much...