Neanderthal DNA Legacy Might Be More Complex than Thought
The idea that modern humans inherited DNA from Neanderthal ancestors is one of the 21st century’s most celebrated discoveries in evolution. It may not be that simple.
GLP‑1 Receptors Protect Liver in Mouse MASH Model
Adding to the GLP-1 drug weight-loss independent effect benefit : impact on liver sinusoidal endothelial cell GLP-1 receptors for liver protection in mouse MASH model @Cell_Metabolism @DanielJDrucker @ChusaGzlzRellan https://t.co/0A13QYgm05
NASA's Nuclear‑Powered SR‑1 Targets Mars Launch by 2028
NASA has announced SR-1, the first-ever nuclear-reactor-powered interplanetary spacecraft, with a planned Mars launch before the end of 2028—a timeline experts call aggressive but exciting.
Scientists Map Light Cues for Optic Nerve Regeneration
Scientists are working on regenerating optic nerves for people who have lost their sight. The first step is done: A map of how changes in light, color, and frequency affect the visual axis. https://spectrum.ieee.org/optic-nerve-damage-electrical-stimulation
Rocket Lab Ramps up NZ-Built Gauss Thrusters for Constellations
.@RocketLab says its Gauss electric thruster is built in New Zealand, so no US tech-export control issues; now producing the thrusters at 200-per-year rate.
Data, Not Compute, Will Bottleneck Scientific AI
AI progress in science depends on high quality training data and the ability to rapidly verify results. E.g., as @michael_nielsen pointed out recently, the training data is what made AlphaFold possible. Data and experimentation will be the science AI bottleneck,...
Command-Line Genome Viewers: Terminal Genome Viewer & ASCIIGenome
Terminal Genome Viewer https://t.co/ppe3ckC5kp Another one that is around for a while: ASCIIGenome https://t.co/pnrzu48qZo https://t.co/qRCjn2Rft2
Idaho Dairy Herds Add to Growing US H5N1 Outbreak
It's not gone: #USDA reports 5 more dairy herds in Idaho have tested positive for #H5N1 #birdflu, the first in months. In the 2+ years since the virus was first detected in cows in the US, 1,093 herds in 19 states...
From Bras to Space: Seamstresses Redesign NASA Suit
When a bra maker got the job of making the first NASA spacesuit In 1966, when seamstresses at the International Latex Corporation arrived at its new Apollo Suit shopfloor in Frederica, Delaware, they were essentially “taught to sew again from scratch.”...
Age Spots Linked to Epigenetic Drift, Potentially Reversible
Could age spots be due to a suspected cause of aging? New paper says: "Consistent with the Information Theory of Aging, we found a global disruption of tight epigenetic regulation of methylation states." If so, they are reversible. Can't wait to...
Low P‑tau217 Indicates Minimal Alzheimer’s Risk in Seniors
Another study indicative of predictive power of p-tau217 for Alzheimer's disease in cognitively unimpaired older adults (mean age 71 at baseline) A very low p-tau217 denoted minimal risk https://t.co/6RPJcCloWI https://t.co/XikzsvJjhM
Choosing the Right Color Map Transforms Heatmap Insight
🧵 Heatmaps are everywhere in bioinformatics. But most people get one critical thing wrong: the color map. Understanding this can make or break your visualizations. Let’s dig into how to choose the right color map for your heatmap. https://t.co/TgYRmaVC4b
In‑vivo Base Editing Rescues Zellweger Disorder in Mice
Today in @natBME we report an in vivo base editing strategy that corrects a common disease-causing mutation and rescues pathology in a mouse model of Zellweger spectrum disorder (ZSD) and restore peroxisomal function in patient derived cells. This work highlights...
BCI Implants Grant Freedom, yet Reveal Real Limits
For people with paralysis, brain implants offer new independence—but also real limits. Early BCI users explain what the technology gives and what it takes. https://spectrum.ieee.org/bci-user-experience?share_id=9362216
EU Bans China From Research, but Europe Pays the Price
Commentary: EU Shuts China Out of Science Projects, but Europe Will Pay the Price https://t.co/nVLtwgVav5
Irregular, Short Sleep Boosts Major Heart Event Risk
One bedtime habit may significantly reduce heart risks https://t.co/D8A1qEMmri "A new study examined the association between sleep habits and heart disease. After getting 7 days of sleep data from the participants, the researchers used the following 10 years of health data...
Modern Humans Outlive Pre‑modern Peers by ~15 Years
Among hunter-gatherers who reach the age of 45, the most common age of death is 68-72. However, only 64% of those who live until age 15 reach the age of 45. The most common age of death for Americans who lived until...
AI‑designed Sensors Promise Earlier Cancer Detection
As a medical school professor, I can tell you: we catch most cancers too late. MIT and Microsoft may have just changed that forever. They built an AI system called CleaveNet that designs molecular sensors detecting cancer enzymes called proteases --...
Low HRV Significantly Increases Heart Attack and Death Risk
1/2) Heart rate variability (HRV). You’ve probably heard of it—but do you actually understand it? It’s incredibly important metric. Low HRV is associated with ~50% higher risk of heart attack, even after accounting for common confounders. And... In people who’ve already had...
Tick Bites Can Trigger Red Meat Allergy (Alpha‑gal)
I now have two friends that are dealing with this. It is no joke, and pray I never have to deal with this as much as I love red meat. This is going to become a bigger story soon....
Scientists Urge Continuous Monitoring for Emergent Consciousness in Organoids
"Perhaps most crucially for this field is the concern that emergent properties, such as consciousness, might arise in complex organoids. So far, there has been no evidence that any form of sentience could emerge, but researchers would like this to...
SGLT2 Inhibitors Protect Kidneys, Yet Raise Non‑Renal Risks
Sodium-Glucose Cotransporter-2 Inhibitors and Acute Kidney Injury Risk: A Systematic Review and Meta-Analysis of Randomized Trials "SGLT2is conferred substantial renoprotective benefits but increases the risk of certain nonrenal AEs." https://t.co/n0yhZgcShy
Carb Mouth Rinse Boosts Heavy‑Lift Performance, Shows CNS Fatigue
Carbohydrate mouth rinsing increases work done during a strength training workout involving a small number of reps with a heavy load, showing that exercise need not be long-duration in order for supraspinal CNS fatigue to occur. https://t.co/Q11E9Ep6bb
Wallenberg Family Backs Stegra's Massive Green‑steel Plant
Ailing startup Stegra secures funding from the influential Wallenberg family to help complete what will be the world’s biggest green-steel plant https://t.co/Ic70chW4kW
Join OARSI PTOA Meeting: Updates & Involvement Opportunities
Join us for the annual @OARSInews PTOA Discussion Group Meeting on Friday 24 April @ #OARSI2026 We will be sharing updates from our PTOA research priority setting, definition & prevalence working groups - lots of opportunities to get involved https://t.co/AlrAwcrhRb
Alzheimer's May Be Multifactorial End‑Stage, Not Single Cause
Absolutely astounding that two of the most interesting candidates for lowering Alzheimer’s risk in the last decade came accidentally: GLP-1 drugs and the shingles vaccine. Really suggests Alzheimer’s has no true “cause”, but is the end stage of a long, complex...
Navy SEAL and Doctor Discuss Stem Cell Breakthroughs
Great podcast with my good friend and Navy Seal William Clark and Dr. Harmon on Stem Cells https://t.co/BDKfPiMHnF
SpaceX to Reuse Booster Now, Engines Later
Interesting. So they will re-fly the booster itself on this mission, and the re-fly the engines in the future one. https://t.co/tHgcEEzzag
NASA Unveils ERNEST, Rover for Extreme Planetary Missions
Meet ERNEST: NASA’s Smart Rover Designed for Extreme Planetary Exploration by @spaceandtech_ #SpaceTech #Tech #Technology #EmergingTech #Space https://t.co/BmO3uxBCmv
Science and Innovation Chart Climate’s Future Path
“The Climate Path Forward: Science and Innovation” | My first panel at #CWA tomorrow 3:30pm Mountain Time (remote option available)
Proline‑mediated Dichloromethyl Tagging Enables Ultra‑pure Drug Synthesis
A new method uses the amino acid proline to precisely attach dichloromethyl groups to complex molecules, enabling ultra-pure drug synthesis with built-in quality control and expanding possibilities for advanced medicine design. drugdiscovery
Critique: Normalizing Effects with Arbitrary Exponential Scaling
I’m sure Roger Pielke Jr can find some arbitrary exponentially increasing quantity to divide by and normalize away this effect
NASA Finds Humor Key for Mars Mission Crews
NASA ran a study on a potential trip to Mars and found the most important trait for team dynamics was humor https://t.co/tB3gQlKZPL
Tech-Enhanced Visits Boost Lemur Interaction and Engagement
Zoo study shows shared human-animal technology experiences increase lemur interaction and improve visitor engagement with wildlife. https://t.co/2qmKNlsmra
Serum Proteomics Distinguishes Endurance versus Strength Adaptations
Adaptations to endurance vs strength training in elite athletes revealed by serum proteomics https://t.co/ii3xAiNEcT https://t.co/hBfQ0E0v9W
Industry Coalition Urges EU to Revise Methane Rules
A coalition of energy companies, chemical makers and trade associations are asking the European Union to urgently consider changes to the bloc’s upcoming regulations on methane emissions https://t.co/vpb6gn9eJJ
Personal Loss Exposes Danger of Dismissing Cancer Breakthroughs
Hype is bad. That includes calling an unprecedented advance in cancer treatment hype when it is not. Don’t think about the knee jerk comment this tweet is replying to. Think about this man’s wife getting three vacations.
Genetics Reveal Heritability of Specific Math Ability
Independent evidence, this time directly from the genome rather than twin comparisons, that specific cognitive abilities (in this case, math), not just general intelligence (g), is heritable. By Emily Willoughby, my former student James Lee, Matt McGue, et al. |...
NASA Releases Moon Base Guide for Permanent Off‑world Living
NASA just quietly published something incredible. A map of how we build a permanent human presence off Earth. It’s called the Moon Base User’s Guide. Here's what's in it! 🧵 https://t.co/oMEKKo5O8Q
This Week’s Top Five Unexpected Science Discoveries
5 science stories from the last week that you might have missed… 🚀 Artemis II crew home after furthest human spaceflight 👵🏻 Women’s immune systems change more dramatically with age 🧘♀️ How long do you actually need to meditate for? 🥚 Our ancestors may...
Bourbon Byproduct Powers Next-Gen EV Energy Storage
Researchers have found a way to turn waste grain from making bourbon into high-performance energy-storage materials for EVs. https://spectrum.ieee.org/supercapacitor-electrodes-bourbon-waste
DeepSeqAI Trains on Function to Future‑proof Biologics
Most AI protein tools are trained on structure. DeepSeqAI trains on function. They're running billions of experimental protein-protein interactions through their platform to map biologics against viruses, immune receptors, and the entire human proteome. The goal: candidates that hold up against...
Optimize Fertility: Hormone Health, Testing, and Lifestyle Choices
The new Huberman Lab episode is out: How Women Can Improve Their Fertility & Hormone Health | Dr. Natalie Crawford (@ncrawfordmd) 0:00 Natalie Crawford 2:26 Fertility as a Health Marker, Infertility 5:34 Perimenopause, Menopause, Hormone Replacement Theory 11:01 Sponsors: David & BetterHelp 13:35 Hormone Therapy,...
CRISPR Turns 25: Explore Its Past, Present, Future
Introducing the GEN Keynote Webinar: "CRISPR at 25: The Past, Present, and Future of Genome Editing" Guest speaker: Rodolphe Barrangou @CRISPRchef May 4, 2026: noon ET/9 am PT Sponsored by @elevatebio https://t.co/cYsSsaod4Y via @GENbio
MGU Revives Apophis Mission as Modern Cubesat
Moscow State University, MGU (my alma mater;) suddenly revived the idea of a mission to Apophis, but now in a cubesat form. No mention of the original project from two decades ago, but https://t.co/5Uo4JA9Xcu uniquely preserves the context: https://t.co/oNmeevbzhR https://t.co/nNmr4JJzyS
Gut Microbes' Tryptophan Metabolites Crucial for Fetal Survival
Your gut bacteria plays a bigger role in whether a pregnancy survives than anyone realized. A study published in Cell found that maternal gut microbiota produce tryptophan metabolites that help maintain immune tolerance at the placenta. Without them, the immune...
Calorie Cutting Lowers Epigenetic Age and Inflammaging Protein C3a
Caloric restriction (CR) slows aging in rodents. People who cut calories by 14% over 2 years had lower epigenetic ages of some tissues & inflammatory protein C3a, regardless of BMI. In mice, lowering C3a levels reduced inflammaging, especially in fat....
Robust Bio Tools Demand Exhaustive Edge‑Case Testing
Hardest part of making bio tools is the endless testing of edge cases, to make sure that sequences are holy, circular permutation is accounted for, degenerate bases are considered, etc. To make robust code worthy of wetlab requires attention. I'm...
Off‑the‑Shelf CAR‑T Shows Promise Delaying Lymphoma Relapse
Allogene data suggest ‘off-the-shelf’ CAR-T could delay relapse in lymphoma https://t.co/UrSNYpQFqB by @gwendolynawu $ALLO + 25%
Dad's Genes Make Mom Insulin‑resistant to Feed Baby
Your baby uses genes inherited from its father to manipulate your metabolism during pregnancy. The paternal copy of a gene called Igf2 is active in the placenta while the maternal copy is silenced. This gene is one of the signals...