Revolution Medicines' Pancreatic Cancer Drug Shows Late‑Stage Success
This is big. All cancers suck. Pancreatic somehow manages to suck even more. Revolution Medicines says its potential breakthrough pancreatic cancer drug succeeds in late-stage trial https://t.co/rFVsvi0mQD
Quantum Breakthrough, Not AI, Will Shatter All Privacy
While most of the charlatans are hyping a societal “singularity” event brought on by AI. The actual societal nuclear bomb is going to be when quantum computing gets figured out and there is no longer any encryption. Not just going...
Comprehensive Genomic Landscape of Small Bowel Adenocarcinoma Revealed
Genomic profiling of small bowel adenocarcinoma: a pooled analysis from 3 databases [May 14, 2024] Aparicio et al. @BrJCancer https://t.co/xfznlhD4fh #sbcsm #cagenome HT @OncoThor
Bad Measurement Cannot Explain Hubble Tension, Study Shows
“One bad measurement” ruled out as Hubble tension explanation When thinking about the Hubble tension, many fault "one bad measurement," somewhere, as the ultimate culprit. Astronomers just showed this cannot be the case. https://t.co/e3cdhUyAZT
Alpha‑gal Allergy: Tick Bites Turn Meat Into Danger
Fascinating episode of the always fun @TheSporkful pcast, usually focused on an interesting aspect of food, today - it's medical epi, a really engaging, scary, interesting story about alpha gal https://t.co/zZFGjJ1gdl featuring red meat & Lone Star ticks. @ValStoneMD @mvhospital_
Neuroscientist Tests Brain's Role in Free Will
Does free will exist? Neuroscientist Uri Maoz devises experiments to illuminate how—or if—the brain makes decisions.
ALLO May
Has $ALLO found a niche for allo Car-T at last? It's early days, so the answer is maybe. Via @APEXONCO -> https://t.co/bO3A1hpAY8
Cannabis Damages Sperm DNA, Causing Miscarriages and IVF Failures
Cannabis is detrimental to sperm: even if they can fertilize, there can be DNA damage. Many miscarriages and (in the case of IVF) “day 3 crashes” which is when paternal DNA normally kicks in, are cannabis related. Dr Natalie Crawford...
Rigorous Trials, Not Hype, Prove Cancer Drug Value
Today's $RVMD study outcome in pancreatic cancer is a good lesson for all the $IBRX @DrPatrick fans. Stop with all the hand-waving "cancer cure" podcasting social media nonsense. Shut up and run well-designed clinical trials with definitive endpoints. If you have...
30‑Minute Sauna Spike Boosts Immune Cells
Sauna bathing mobilizes circulating immune cells. A single 30-minute session at ~165°F (enough to elevate body temperature to 101°F) increased levels of several immune cells including lymphocytes and neutrophils for up to 30 minutes. This occurred in non-users and people who used...
Systems Thinking Unlocks Leverage to Slow Aging
The breakthrough in longevity science is systems thinking. When we map how aging actually works, we gain leverage to slow it down. https://t.co/hheOmHsWX7
Nanodiscs Reveal Antibody Interactions for HIV, Ebola Vaccines
Nanodisc technology enables viral surface proteins from HIV and Ebola to be studied within lifelike membrane environments, offering new insights into antibody interactions and accelerating the development of next-generation vaccines. vaccinedesign
Time‑restricted Eating Cuts Glucose, Insulin Resistance, HbA1c
Efficacy of different types of intermittent fasting in improving glycemic control in adults with overweight or obesity: a systematic review and network meta-analysis "Compared with a CON, TRE resulted in a larger reduction in fasting glucose... insulin resistance... HbA1c..." https://t.co/Jq9EpoAy3u
Peptides Are Potent Therapeutics, yet only a Few Qualify.
“The big picture is that peptides are a legitimate, powerful class of therapeutics, but the legitimacy is confined to a relatively narrow subset of them.” —Peter Attia 👨🏻⚕️
Integrate scRNA‑seq PBMCs only After Evaluating Batch Effects
🧵 Should you integrate single-cell RNA-seq datasets or not? You've got PBMCs from multiple donors. Merge them—or keep them separate? Let's break it down.
Artemis–Chinese Space Station Distance Might Exceed Estimates
Oh, but wait.... A preliminary check suggests the Artemis- Chinese Space Station max distance may be even larger. I'll have to do a more careful analysis
Pancreatic Cancer Trials Yield Only 1‑2 Month Gains
I remember years ago in pancreatic cancer trials you were realistically looking for 1 to 2 months improvement in survival (at best) in pancreatic cancer trials. Bravo $RVMD.👏
Second‑line RVMD Improves Pancreatic Cancer Survival over First
As noted by others, the $RVMD dara mOS in 2nd line PDAC is better than mOS for current first-line regimens.
Artemis 2 Set Record: 413,145 Km From Earth
Artemis 2 was the furthest human voyage from Earth. Per the final JPL Horizons trajectory I estimate the max distance from the geocenter was 413145 km at 2304 UTC Apr 6 (about 4 km less and 1...
Low‑Cost Vaccine Creator Outshines Rogan’s Diet Critique
I make low cost vaccines for global health, including a Covid vaccine technology for $2-3 per dose reached 100 million people, bypassed big pharma, didn’t make money, and all these Rogan types can talk about is a joke I made...
Angara-5M to Launch PTK Prototype by 2028
Upgraded Angara-5M rocket is now promised to fly with a development prototype of the PTK crew vehicle during a 2027-2028 period (a delay from 2025). Context and full story: https://t.co/ithnEIbQfV https://t.co/g9fUBxzoNz
Daraxonrasib Halves Pancreatic Cancer Mortality, Doubles Survival
Finally, best news of the morning (and something you didn't expect so soon)... Revolution Medicines $RVMD daraxonrasib Ph3 results in second-line pancreatic cancer. Median overall survival in ITT patients (KRAS mutants + wild type combined) Dara 13.2 months vs chemo 6.7...
Social Connections Shape Immune Health Under Stress
Stress and the social self – the fascinating science of how relationships affect our immune system https://t.co/WD4JqfGF3U
Parents Underestimate Deadly Risk of Vaccine‑preventable Diseases
https://youtu.be/sLyGdEtRPyQ?si=HhO95z45Mz20D6kp We never imagine that our children could suffer or die from a vaccine-preventable disease.
Allogeneic CAR‑T Achieves 42% MRD Boost, Safe Profile
Allogene $ALLO cema-cel interim ALPHA3 results just reported: B-cell lymphoma MRD negativity: cema-cel 58% vs observation 16% A 42% absolute difference in MRD clearance is better than expected. Clean safety profile, too. Allogeneic CAR-T may have found its role. Nice...
Morning Hormone Peaks, Evening Temperature Rise: Body Clock Overview
The human body has a circadian rhythm with fluctuations in hormones, body temperature, and blood pressure Here's a graph for the most important diurnal rhythms in the human body: - cortisol rises in the morning and peaks around 9 AM - testosterone also...
Spyre's SPY001 Achieves 40% Remission in UC Trial
Spyre $SYRE just reported SPY001 (long-acting alpha4beta7 antibody) ulcerative colitis induction data. Here's the efficacy chart, notable for a 40% clinical remission rate at week 12, albeit with small number of patients. https://t.co/aEoLWPRjEL
Regular Sleep Reduces Risk of Major Cardiac Events
Consistent sleep patterns may be essential for cardiovascular health 🫀💤 This new study investigated sleep habits and cardiovascular events in over 3,000 individuals 🔍 Participants were followed for ~10 years or until experienced a MACE (acute myocardial infarction, unstable angina, stroke, heart...
ALLO's Alpha-3 DLBCL Data Set to Spark Pre‑Market Move
Key $ALLO catalyst coming pre market today, with first data from cema-cel's Alpha-3 study in DLBCL consolidation. What to look for: https://t.co/a19BVEppqP
Darovasertib Shows Promise in Optimum-02 Uveal Melanoma Trial
$IDYA darovasertib data from registrational Optimum-02 trial in uveal melanoma are out. What to look for: https://t.co/1LQa0X6xJa
Europa Clipper Probes Hidden Ocean for Extraterrestrial Life
NASA’s Europa Clipper Explores Hidden Oceans for Signs of Life by @BrianRoemmele #SpaceTech #Tech #Technology #EmergingTech #Space https://t.co/2O5Lx5ewb1
Flip‑Flop Steps Power Wearable Medical Devices via Graphene
📰 🧪 James Tour Group in the News: Wearable generator powers medical devices with every step of a flip-flopAn article features Rice research that has adapted laser-induced graphene […] https://t.co/R9H7Ozu1pL
Cold Exposure Boosts Pain Tolerance and Flexibility
Cold application is used in research to create a temporary increase in pain tolerance. Interestingly, applying cold water to an upper body limb causes an immediate increase in lower body flexibility. This shows how stretch tolerance is close in nature...
EU to Cut Energy Taxes, Grid Fees for Clean Tech
The European Commission is set to recommend lowering energy taxes and power grid charges to boost the uptake of clean technologies https://t.co/ObeTZGDVZt
Congrats Artemis II—NASA’s Backup Crew Ready for Artemis III
Congrats on Artemis II. Just in case you need a backup crew for Artemis III... @nasa
Japan Proposes Remote Pacific Island for Nuclear Waste Disposal
Japan is proposing a remote Pacific island as a possible host for a nuclear waste-disposal site, reports say https://t.co/ENL5U1qOWd
From Gagarin to Artemis: Stepwise Journey to Lunar Settlement
Today is International Day of Human Spaceflight. On April 12, 1961, Russian cosmonaut Yuri Gagarin became the first human to leave Earth. He made one orbit. That was just the beginning. Now, 65 years later, Artemis II has taken humans beyond...
Repairing Aging Blood‑Brain Barrier to Halt CNS Disease
Aging of the Blood-Brain Barrier and Altered Permeability to Peripheral Immune Cells: Implications for Central Nervous System Disorders "We discuss interventions focused on barrier repair and immune recalibration, including the reinforcement of tight junctions, restoration of pericyte homeostasis, and modulation of...
Mouse‑Inspired Robot Mimics Brain’s Place Recognition
How a Mouse-Inspired Robot Learns to Recognize Places Like a Brain by @lukas_m_ziegler #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/EPjRBzZMwn
Moon Mission Reveals Earth’s Forgotten Shared Perspective
We sent a woman to the moon and joked that she might find something new that the men hadn’t seen yet. Yet what she found was a new perspective of Earth that we possessed all along but had lost sight...
Pets May Shield Against Cognitive Decline, Review Finds
The protective role of companion animal ownership in cognitive aging: current status of the literature https://t.co/TKXjlA0FTR https://t.co/kmWE6BHeQm
Discrepancy in Mouse Counts Raises Partial Reprogramming Concerns
okay, tell me why you think browder et al had 21 mice in -dox and only 15 mice in the +dox group when they did partial reprogramming? https://t.co/gedJiKSRKo 6 more mice in the dox group got tummy aches and asked out of...
Rapid Lab Automation Needed to Scale Bio Testing
Interesting take on lab automation and serial scale vs parallel scale for data generation. Innovation in how we can rapidly Test more and more in the lab is badly needed as Design, Build and Learn capabilities in bio have exploded...
OSK Reprogramming Triggers Tumors, Undermining Mouse Study Confidence
OSK reprogramming also produces tumors see https://t.co/dNhcHVSBf3 cancer is a selective process clones grow out because they have a proliferative advantage or apoptotic disadvantage when mouse papers say no cancer despite the fact that half of lab mice die from cancer, i don't feel...
Appendix Presence Linked to Longer Lifespans Across Mammals
The cecal appendix is correlated with greater maximal longevity in mammals “We found, through analyses of data on 258 mammalian species, that cecal appendix presence is correlated with increased maximal observed longevity… . In addition, we show that the cecal appendix...
Anticipating History's Most Powerful V3 Raptor Static Fire
Let's go! 🔥 Can't wait to see this magic for the first time. Presumably will be the most powerful static fire in history using V3 Raptors. No big deal.... right?
India’s Solar Capacity Hits 150 GW, Installations Surge 87%
India has now passed 150GWs of solar, with annual installations increasing a whopping 87% this year.
AI Powers Cancer Cures While Robots Learn Chores
AI is designing molecules that boost chemotherapy effectiveness by 70%, and humanoid robots are learning tasks by watching gig workers record themselves doing chores... we're literally teaching machines to cure cancer AND do our laundry.
Targeted mRNA Nanoparticles Halt Lung Tumors and Cachexia
Follistatin mRNA delivered via targeted lipid nanoparticles enables a dual therapeutic effect by simultaneously suppressing lung tumor growth and preventing cancer-associated muscle wasting (cachexia). https://t.co/56fCFZU0vk
Aging Opens Chromatin, Altering Cell Behavior
The researchers then looked into the changes in the old cells that might explain such pronounced differences in behavior compared with the young cells. Liao Says "It seems as though chromatin opens up with age, so to speak." https://t.co/1kdRDunTea