Blog•Feb 2, 2026
It Takes Multiple to Mambo
Recent disclosures illustrate how multimeric design is reshaping drug discovery in the beyond‑Rule‑of‑5 (bRo5) space. GSK’s dimeric BET inhibitor GSK785 uses a rigid diazaspiro linker to achieve >30‑fold BRD4 selectivity, while Eli Lilly’s muvalaplin dimer‑to‑trimer architecture delivers a 10,000‑fold potency boost against Lp(a) formation. In targeted protein degradation, MRT‑31619 creates a 1,500 Ų CRBN homodimer that sidesteps the classic hook effect, and the VHL pseudodimer CC124 forms a long‑lived inactive ternary complex. Collectively, these examples prove that multivalency can overcome oral exposure hurdles and unlock new pharmacology.
By Drug Hunter
Blog•Feb 2, 2026
Stripe Antiferromagnetism and Chiral Superconductivity Achieved in tWSe at -Point Van Hove Singularity
Researchers reported that antiferromagnetic interactions in twisted bilayer tungsten diselenide (tWSe₂) can induce a chiral superconducting state when the Fermi level sits near the M‑point van Hove singularity. By constructing a moiré model directly from density‑functional theory and applying a t‑J‑U...
By Quantum Zeitgeist
Blog•Feb 2, 2026
Giant Second-Harmonic Generation Achieves 104 Susceptibility in Bismuth Monolayer
Researchers at Fudan and Sun Yat‑Sen Universities demonstrated that buckling a bismuth monolayer triggers a topological transition, dramatically boosting its second‑harmonic generation (SHG) response. First‑principles calculations show a static susceptibility exceeding that of MoS₂ by two orders of magnitude, with...
By Quantum Zeitgeist
Blog•Feb 2, 2026
Quantum Approach Achieves Competitive Graph Coloring Solutions Using Gaussian Boson Sampling
A recent study demonstrates that Gaussian Boson Sampling (GBS), a photonic quantum technique, can be used to solve graph‑coloring problems by reformulating them as independent‑set integer programs. By encoding graph adjacency into a Gaussian boson distribution, the method samples dense...
By Quantum Zeitgeist
Blog•Feb 2, 2026
XSAR: Crystallographic SAR From Crude Reactions
Researchers at Diamond Light Source and the University of Oxford introduced xSAR, a quantitative crystallographic SAR approach that converts fragments into Morgan fingerprint bits to calculate Positive and Negative Binding Scores (PBS/NBS). Applying PBS to 957 crude‑reaction fragments recovered 23...
By Practical Fragments
Blog•Feb 2, 2026
Article Intro - JHU Eye Robot
A team from Johns Hopkins has demonstrated an autonomous retinal vein cannulation (RVC) system that combines two Steady‑Hand Eye Robots with deep‑learning vision models. The workflow uses three convolutional neural networks to guide a 100‑µm needle and a medical spatula...
By SurgRob
Blog•Feb 2, 2026
Section 4: The All-Important Dose
The blog post emphasizes dose as a pivotal factor distinguishing first‑in‑class from next‑generation therapeutics. It links total dose and dosing regimen to core drug attributes such as potency, pharmacokinetics, and safety. The discussion covers route of administration, dosing schedules, and...
By Drug Hunter
Blog•Feb 2, 2026
IRID + AIMING: The Pure-Play Quantum Computing Stocks vs Tech Giants Defining the Next Computing Era
Quantum computing investment is split between pure‑play hardware builders (IRID) and diversified tech giants (AIMING). The IRID group includes IonQ, Rigetti, Infleqtion and D‑Wave, each dedicated to manufacturing gate‑based or annealing machines, while AIMING comprises Amazon, IBM, Microsoft, Intel, Nvidia...
By Quantum Zeitgeist
Blog•Feb 2, 2026
Web-Based Tool Visualizes Catalyst Gene Profiles for Materials Design
Researchers at Hokkaido University have launched a web‑based graphical interface that visualizes catalyst gene profiles, turning complex catalyst datasets into intuitive, interactive visualizations. The platform clusters catalysts by sequence similarity, displays synchronized heat maps, and lets users explore global trends...
By Nanowerk
Blog•Feb 2, 2026
Reshaping Nanoporous Gold Leads to New Electronic and Optical Properties
Researchers at Umeå University have shown that reshaping gold into a nanoporous, sponge‑like metamaterial dramatically changes its interaction with light. When exposed to ultrashort laser pulses, the porous film reaches electronic temperatures of about 3200 K, far exceeding the 800 K observed...
By Nanowerk
Blog•Feb 2, 2026
18 PPC Statistics To Inform Your Pay-Per-Click Strategy
The episode breaks down 18 key PPC statistics across conversion rates, social media, search, marketplace, and video advertising, highlighting benchmarks like a 7.52% average conversion rate on Google Ads and a $5.26 average CPC. It shows the massive scale of...
By eCommerce Fastlane
Blog•Feb 2, 2026
Small RNAs Altered in Human Calorie Restriction
Researchers analyzed small non‑coding RNAs in participants of the CALERIE Phase 2 calorie‑restriction trial, which achieved a 12‑15% reduction in intake over 12‑24 months. Using smRNA sequencing of plasma, muscle, and adipose tissue, they identified 16 RNAs linked to the degree of...
By Fight Aging!
Blog•Feb 2, 2026
The Γδ T-Cell Population Changes with Age
A recent mouse study shows that aging dramatically reshapes the peripheral γδ T‑cell compartment, expanding innate‑like subsets that produce higher levels of IL‑17. The age‑associated shift coincides with a marked loss of the transcription factor Foxo1 within these cells. Researchers...
By Fight Aging!
Blog•Feb 2, 2026
Quantum State Preparation Achieves 97% CNOT Reduction for 14 Qubit Systems
Researchers from Virginia Tech and IANL introduced Co‑ADAPT‑VQE, a hardware‑aware variant of the ADAPT‑VQE algorithm that embeds device constraints directly into ansatz construction. By penalising circuit components unsuitable for linear nearest‑neighbor (LNN) architectures, the method trims two‑qubit gate counts dramatically....
By Quantum Zeitgeist
Blog•Feb 2, 2026
Molecular Hamiltonian Learning Extracts Parameters From Stm-Iets Data for Single Molecules
Researchers at Aalto University introduced "molecular Hamiltonian learning," a machine‑learning framework that infers the full Hamiltonian of single‑molecule magnets directly from set‑point‑dependent scanning tunneling spectroscopy (STM‑IETS) data. By training on a library of theoretical spectra that include crystal‑field, Coulomb and...
By Quantum Zeitgeist
Blog•Feb 2, 2026
Beyond Headwinds: Building Durable Growth in APAC Insurance
APAC insurers are poised for double‑digit growth through 2026, but must navigate heightened geopolitical tensions, rising claim costs from new‑energy vehicles, and an increasingly complex regulatory environment. Bloomberg’s suite—including MARS, PORT, AIM, and RMS—offers end‑to‑end asset‑liability management, scenario testing, and...
By Tech Disruptors
Blog•Feb 2, 2026
Two-Stage Dc-Squid Amplifier Achieves Low Noise with 100 SQUID Cells
Researchers led by Nan Li have demonstrated a low‑noise two‑stage dc‑SQUID amplifier tailored for TES detector readout. The device combines a four‑cell input SQUID with a 100‑cell series SQUID array, delivering a magnetic flux noise of about 1 µΦ₀/√Hz and a...
By Quantum Zeitgeist
Blog•Feb 2, 2026
Julie Guirado to Lead CHT as Executive Director
The Center for Humane Technology announced Julie Guirado’s promotion from COO to Executive Director, positioning her to lead the organization through a pivotal year for AI. Daniel Barcay, who guided CHT during the rise of generative AI, will transition to...
By Tristan Harris
Blog•Feb 2, 2026
EBay’s New Ad Attribution Rules Look a Lot Like a Seller Tax
The episode breaks down eBay’s new Promoted Listings General attribution model that takes effect on January 13, 2026, explaining that any click on a promoted listing within the past 30 days will attribute all subsequent sales of that SKU to...
By EcomCrew
Blog•Feb 2, 2026
Top 8 Doran Alternatives For Shopify In 2026
In this episode Greg Styczynski outlines why Shopify merchants outgrow basic review apps like Doran and need more powerful solutions. He reviews eight top alternatives—Yotpo, Judge.me, Loox, Stamped, REVIEWS.io, Okendo, Junip, and Vitals—highlighting each platform’s key features such as AI‑driven...
By eCommerce Fastlane
Blog•Feb 2, 2026
Jane Street Enhances ETF Liquidity and Execution Efficiency with Bloomberg RFQe
Jane Street is expanding ETF liquidity and execution efficiency in Asia‑Pacific by leveraging Bloomberg RFQe. The platform uncovers deeper order‑book depth than exchange screens and supports sophisticated NAV and portfolio trades. Automated RFQe workflows deliver sub‑second responses, saving two hours...
By Tech Disruptors
Blog•Feb 2, 2026
U.S. eCommerce Reaches $10 Trillion in Total Sales
In Q3 2025 U.S. e‑commerce surpassed $10 trillion in cumulative sales, highlighting the sector’s massive scale despite a slowdown to 5‑10% quarterly growth. The episode explains how growth spikes during the pandemic and the 2008 crisis were temporary, and notes a...
By EcomCrew
Blog•Feb 2, 2026
Product Photography Pricing Factors: How Much Photos Cost
The episode breaks down product photography pricing in 2026, explaining that daily rates typically range from $500 to $3,000 and per‑image fees from $50 to $350, with costs varying by experience, shot type, equipment, location, scope, editing, and turnaround time....
By eCommerce Fastlane
Blog•Feb 1, 2026
Tiny Titanium Pillars Move Hydrogen-Powered Flight Closer to Reality
Researchers at the University of Birmingham and Loughborough University have used digital design and laser micromachining to create ultrathin titanium flow distributors for polymer electrolyte fuel cells. The optimized micropillar structures achieved a record peak power density of 1.62 W cm⁻², translating...
By Nanowerk
Blog•Feb 1, 2026
Why Your Best Ads Are in Your Comments Section
The episode explores how beauty brand Ouai turns customer comments into its most effective advertising and product decisions, highlighting the $300 million company's use of real user language for the hit St. Barts fragrance and hair‑type‑based campaigns. Former CEO Hannah Beals explains...
By eCommerce Fastlane
Blog•Feb 1, 2026
USPS Delivered Duty Paid Launches for Outbound Packages
The U.S. Postal Service introduced a new international offering called Delivered Duty Paid (DDP), allowing shippers to prepay import duties, taxes, and fees for outbound packages. The service launches today for shipments to Canada, Germany, and the United Kingdom and...
By EcommerceBytes
Blog•Feb 1, 2026
10 Bloop Alternatives & Competitors For 2026
In this episode Aaron Orendorff walks listeners through the top ten alternatives to Bloop for loyalty and rewards, highlighting each platform’s key features, from Yotpo Loyalty’s strategic partnership model to Smile.io’s Shopify‑centric simplicity. He stresses three pillars for choosing a...
By eCommerce Fastlane
Blog•Feb 1, 2026
How To Calculate, Use, and Boost Customer Growth
In this SAP Emarsys episode the hosts define customer growth as the net increase in a brand’s customer base and walk through the simple growth‑rate formula, highlighting the need to account for both new acquisitions and churn. They stress that...
By eCommerce Fastlane
Blog•Feb 1, 2026
Converting Floats to Strings Quickly
Converting binary floating‑point numbers to decimal strings is a core step in JSON, CSV, and logging pipelines. Recent research benchmarks modern algorithms—Dragonbox, Schubfach, and Ryū—showing they are roughly ten times faster than the original Dragon4 from 1990. The study finds...
By Daniel Lemire’s blog
Blog•Feb 1, 2026
I Wrote Off $4M to $0. My Co-Investor Marked Up the Same Deal to $30M. Here’s What Founders Need to...
The author wrote off a $4 million SaaStr Fund investment to zero, while a co‑investor marked the same deal up to $30 million. The divergence stems from the co‑investor’s need to showcase a strong TVPI while fundraising for a new fund, prompting...
By SaaStr
Blog•Feb 1, 2026
Holographic Entanglement Achieves Pure States Via Measurement and Minimal Surfaces
Stanford and Brandeis researchers have demonstrated a practical method to engineer quantum states with holographic entanglement using only Gaussian operations and measurements on a discretized bulk geometry. Their constant‑time quench‑and‑measure protocol produces boundary states whose entanglement entropies closely follow the...
By Quantum Zeitgeist
Blog•Feb 1, 2026
Number of the Day - 13-15% Growth
Intuitive Surgical projects worldwide da Vinci surgical system procedures to grow 13‑15% in 2026, a slowdown from the 18% growth recorded in 2025. The forecast was disclosed in the company’s fourth‑quarter earnings release and outlines the full‑year outlook. Despite the...
By SurgRob
Blog•Feb 1, 2026
High-Fidelity Superpositions Advance Bose-Einstein Condensate Quantum Computation Techniques
Researchers at the University of St Andrews have introduced a dynamic‑optical‑potential technique to engineer high‑fidelity superpositions of persistent currents in toroidal Bose‑Einstein condensates. By independently shaping the condensate’s amplitude and phase, they can program arbitrary motional states, achieving stable superpositions even...
By Quantum Zeitgeist
Blog•Feb 1, 2026
Negative Reviews: How To Handle Negative Product Reviews
The episode explores why negative product reviews happen and how businesses can turn them into strategic assets. Host Jake Miller of Fellow explains that gaps between expectations and reality drive most bad reviews, and that passionate customers often leave detailed...
By eCommerce Fastlane
Blog•Feb 1, 2026
When to Use ChatGPT, Claude, Gemini, Perplexity, and Copilot
The article maps five popular AI assistants—ChatGPT, Claude, Gemini, Perplexity, and Copilot—to the specific tasks they handle best. ChatGPT shines for polished, decisive writing, while Claude is more tolerant of half‑formed ideas and exploratory drafts. Perplexity delivers short, sourced answers...
By Lilach Bullock’s Blog
Blog•Feb 1, 2026
Overview of Content Published in January
Didier Stevens published a concise January roundup highlighting two Python tool updates—zipdump.py 0.0.33 and hash.py 0.0.14—and three SANS Internet Storm Center diary entries covering a basic geography quiz, the release of Wireshark 4.6.3, and YARA‑X 1.11.0’s new hash function warnings....
By Didier Stevens’ Blog
Blog•Feb 1, 2026
Weekly Reads: Human SCBEM Framework, Reporter Self-Injects Peptides, ASD, NAMs
A new two‑tier framework for human stem‑cell‑based embryo models (SCBEM) proposes a developmental ceiling of 56 days, sparking debate over its impact on clinical applications. The blog also highlights ethical concerns after a reporter injected wellness peptides on record, questioning...
By The Niche
Blog•Feb 1, 2026
Shopify Retail Release Roundup (2026)
The January 2026 Shopify retail roundup introduces a wired POS Hub for reliable countertop setups, new Verifone Victa card readers, and enhancements to the Shop app’s pickup experience with QR‑code order retrieval. It also adds multi‑entity offline payments, refined location storefront...
By eCommerce Fastlane
Blog•Feb 1, 2026
Quantum Annealing Achieves Efficient Micro-Mobility Dispatch Via Historical Data Incorporation
Researchers have reformulated micro‑mobility vehicle dispatch as a QUBO problem and solved it on D‑Wave’s quantum annealer, integrating Bayesian‑derived historical demand data. The quantum approach, especially with reverse annealing, outperforms classical solvers like Gurobi in both dynamic (real‑time positions) and...
By Quantum Zeitgeist
Blog•Jan 31, 2026
NASA Needs To Leverage Its Cool Tech Better
NASA’s Perseverance rover completed the first drive on another planet that was planned entirely by artificial intelligence, showcasing a breakthrough in autonomous space navigation. The mission leveraged Anthropic’s Claude AI models in collaboration with JPL, aligning with the White House...
By NASA Watch
Blog•Jan 31, 2026
🧠 Community Wisdom: How You Feel About Your Job Right Now, What to Do While Waiting for AI Responses, Making...
In this Community Wisdom episode, the host curates top Slack discussions covering how members feel about their current jobs, strategies for staying productive while awaiting AI model responses, and the merits of publishing product roadmaps publicly. The conversation also contrasts...
By Lenny Rachitsky
Blog•Jan 31, 2026
Why Ecommerce Revenue Is Being Won (And Lost) At Discovery—Not Checkout
The episode argues that ecommerce revenue is now decided during the discovery phase rather than at checkout, emphasizing that shoppers form confidence and intent early through search, category navigation, and recommendations. While checkout optimization remains important, it only impacts a...
By eCommerce Fastlane
Blog•Jan 31, 2026
How To Use a CRM POS System To Grow Sales (2026)
In this episode Brooke Kiley explains how integrating a CRM with Shopify POS creates a unified customer record that syncs online and in‑store activity, enabling true omnichannel commerce. She outlines the benefits—single‑view insights, personalized clienteling, and automated loyalty/retention marketing—backed by...
By eCommerce Fastlane
Blog•Jan 31, 2026
Cigarette Butts Could Power the Next Generation of Energy Storage
Researchers at Henan University have developed a scalable method to turn discarded cigarette butts into high‑performance carbon electrodes for supercapacitors. By combining hydrothermal carbonization with potassium hydroxide activation, they produced nanoporous carbon with a surface area of 2,133.5 m² g⁻¹ and a...
By Nanowerk
Blog•Jan 31, 2026
Mini Tornadoes Spin Out Dried Cellulose Nanofibers
Researchers at the University of Maine and Oak Ridge National Laboratory have unveiled a patent‑pending vortex drying technique that uses counter‑rotating, Mach‑3 heated air streams to rapidly remove water from cellulose nanofiber slurries. The high‑shear method avoids the fiber aggregation...
By Nanowerk
Blog•Jan 31, 2026
Stimulated Magnonic Frequency Combs Achieve Efficient Control over Spectral Line Number
Researchers led by Xueyu Guo demonstrated a stimulated three‑magnon generation scheme that creates magnonic frequency combs (MFCs) with precise control over spectral line number and spacing. By applying a low‑power modulation signal (~0.5 GHz) alongside a primary microwave drive, they produced...
By Quantum Zeitgeist
Blog•Jan 31, 2026
RF-Over-Fiber Achieves Scalable Control of Spin Qubits Via ODMR Spectroscopy
Researchers have demonstrated remote radio‑frequency control of nitrogen‑vacancy spin qubits using an optical‑fiber link, a technique dubbed RF‑over‑fiber (RFoF). The photonic system converts optical signals to microwave tones that drive NV centers in a 2.8‑3.0 GHz band, delivering about 0.7 dBm of...
By Quantum Zeitgeist
Blog•Jan 31, 2026
Silicon Quantum Computing Achieves 99% Spin Initialisation with 10THz Photons
Scientists have demonstrated a new method to initialise and read the spin of boron‑doped silicon qubits using ~10 THz photons from a free‑electron laser. The optical‑pumping technique achieves 99 % spin polarisation within 250 ps at temperatures above 3 K, a thousand‑fold speedup over...
By Quantum Zeitgeist
Blog•Jan 31, 2026
Machine Learning Achieves Advantages with Minimal Quantum Computer Use in LUQPI
Researchers from Leiden University and collaborators introduced Learning Under Quantum Privileged Information (LUQPI), proving that a quantum computer used solely as a feature extractor during training can deliver exponential advantages over classical machine learning. The quantum features are generated without...
By Quantum Zeitgeist
Blog•Jan 31, 2026
The Trade Desk Was Priced for Perfection. Then Growth Slowed. Now It’s the Worst Performing Stock in the S&P 500.
The Trade Desk, once the ad‑tech darling, saw its stock plunge 73% as revenue growth slowed from 26% in 2024 to roughly 18% in Q3 2025. The market cap collapsed from $70 billion to under $15 billion, reflecting a sharp multiple contraction...
By SaaStr