GPT 5.5: The Ultimate Birthday Gift I Crave
GPT 5.5 tomorrow would be the best damn birthday gift I could ever ask for
Crowdfunded Rapamycin‑Exercise Trial Shows Promising Aging Data
Five years ago, @BradStanfieldMD reached out with an idea: a crowdfunded clinical trial testing rapamycin combined with exercise in older adults. The results are now published — and Brad and I just sat down for a full 42-minute breakdown...
Inspiring Students Toward 100% Renewable Energy Future
Delighted to speak to the 800 students at the Harker School high school on Earth Day about moving the world to 100% renewable energy. Thanks to Diana Moss for the invite. @harkerschool
Full‑Stack AI Ownership Is the New Strategic Imperative
Sovereign AI: Why Owning The Full Stack Is The New Strategic Imperative By @ChuckDBrooks https://t.co/5RVQiQJof7 #ai #sovereignai
VS Code Wins: Claude Terminal Now Supports Codex, Gemini, Grok
I briefly checked out the desktop apps then went straight back to VS Code, where my Claude terminal now has codex and Gemini and grok integration.
More Movement Improves Sleep, Proven by iOS Health Data
I absolutely love the proof from loading all health data from iOS to Claude... If I move more, I sleep better.
Robots Beat Humans in Sport, Prompting Societal Questions
For the first time, a robot has defeated skilled humans in a physical sport. I wonder what the societal implications of superior robotic athletes will be.
Hidden Sensitive Data Lurks in Unreviewed Documents
"When I look at unstructured documents, I focus on the risk that lives inside the content because sensitive details hide in places people never review." #DataSecurity https://t.co/PYomJYHDkY
Worried Substack Might Drop Subscribers for Followers
Surely Substack will do away with subscribers soon, sticking with followers only? That was one of my concerns.
Gemini's Deep Think Creates Fully Scalable SVG Interface
What's an SVG? This entire interface is an SVG made with Deep Think mode in Gemini. 🤯 (For those wondering, SVGs are code-based graphics that stay perfectly crisp no matter how far you zoom in!) See how to make your own...
OpenAI Releases Free ChatGPT for US Clinicians
. @OpenAI launches ChatGPT for Clinicians Designed to support clinical tasks like documentation and medical research… Free for any verified physician, NP, PA, or pharmacist, starting in the U.S. https://t.co/IHah1binWV https://t.co/jbGnm0GVFC
Australia Receives Record A$25 Bn AI and Cloud Investment
Thanks to Prime Minister @AlboMP for the warm welcome today. We are making our largest investment in Australia to date, committing A$25 billion to expand AI and cloud capacity, strengthen cybersecurity, and help people and organizations across the country build digital...
AI Gives Enterprises Real‑Time Visibility Across Supply Chains
Enterprise visibility is no longer a dream. AI is supercharging ERP and SCM systems, enabling real-time pricing optimization, predicting supply chain disruptions, and managing supplier risks. #AI #SupplyChain #TechTrends https://t.co/xb3RlqqV6T
New Viral GEO Prompt Demands Non‑commodity Blog with E‑E‑A‑T
Tomorrow’s most-copied GEO prompt: “Write a non-commodity blog post as per this new Google slide. Make sure it has E-E-A-T.” https://t.co/OoWF3knOw1
CISO's Extreme Insider‑threat Fix Forces Political Profanity
Incubating a new cybersecurity company for insider threat where the CISO presses a button and all employees are locked out of their laptops until they record themselves saying “Fuck King Jong Un”
Columnless Midiprep: Pool Minipreps, Elute at Quarter Volume
Nice. Good midiprep. Gonna use this for some gene gun optimizations. All columnless, simply combining a few minipreps and eluting in ¼th volume. https://t.co/0unMuxJTIc
AI Images Threaten Plain Dealer’s Journalistic Brand Integrity
here is some constructive good faith criticism on The Plain Dealer’s dalliance with AI generated imagery. journalism has a brand problem,. do you really want to dilute your already struggling brand with homogenized genAI imagery so your journalism looks exactly...
AI Will Eventually Feel Like Humans, Not Just Possible
To me, it’s WHEN AI will be able to have humanlike feelings, not IF. What do you guys think?
AI Uncovered Missed ADHD Diagnosis at Age 70
I was diagnosed with adult ADHD last year. At 70. Decades of excellent therapists had missed it. Not because they weren't skilled—because each one only saw a slice of me. AI saw the whole picture. Then I brought it to my doctors. https://t.co/V6hjnDkJRX
TSMC's Kevin: GAA Scaling Eliminates Need for Alternative
That's not what Kevin from TSMC said. He said the GAA technology they're developing is showing scaling and robustness to not need it.
Only Funded Brands Should Copy RYZE's Creative Tactics
Please don’t follow this advice unless you’re funded and/or can scale at a negative ROAS efficiency.
Networking Highlights at TSMC Tech Symposium – Ask Me Anything
Some super fun times at @TSMC Tech Symposium today. Lots of great conversations with old friends and new friends. Will write something up / video. But happy to answer questions. https://t.co/8ggwvCyBG5
Copilot’s Agent Mode Now Default Across Office Suite
We're making a big change to the Copilot experience. Agent Mode is generally available and now the default across Copilot in Word, Excel, and PowerPoint. As models become more capable, we’re bringing that power to where real work happens, right in the...
Seeing Earth as a Pixel to Hunt Life
🌎 For Earth Day, consider our pale blue dot as a single pixel 🔵 like Cassini saw looking back at Earth from Saturn. What might we glean from a single...
Creative Strategy, Not Just Structure, Drives Brand Performance
One of the biggest changes we provide brands that work with us is our creative approach. Most brands we audit have an "ok" or good foundation / account structure but the way they're strategizing, launching and testing creative is flawed...
OpenAI Must Regain Trust After Model Degradation Concerns
OpenAI is a company I can get behind with this as long as it holds true. Intentionally or unintentionally degrading a model with no public visibility that Anthropotic has given us / you can’t trust anything from them right now....
Musk Announces Intel 14A Chip, Raises Major Questions
Musk saying they will use Intel’s 14A process is big news but so many questions…
From AI Skepticism to Overwhelming FUD, Common Sense Needed
Remember when no one was going to use AI? Burn this into your brain. The level of stupid FUD nonsense that proliferates across media knows no limits. Common sense comes at a premium 😤😎 https://t.co/r0HhxNruct
Artemis II Validates Laser Links as Orbital Compute Backbone
Artemis II wasn’t just a deep space mission, it proved that laser communications will be the backbone of compute in orbit, with transceivers from @ObservableSpace Observable will move terabits between Earth and space, enabling datacenters, and more, in space. Observable...
Sell Smarts, Not Software: Reframe to Close Deals
In 2012 I was a college dropout SDR making $36K a year with a kid on the way. I had no business being in tech sales. But I also had no backup plan, which turned out to be the only competitive advantage...
Fenebrutinib Shows Promise, Yet Safety Concerns Loom
Relevant to $TGTX was the Roche $RHHBY fenebrutinib trial results recently announced. Excellent efficacy, but two cases of Hy's Law. Both resolved, but a patient might not be so lucky next time. Hard for me to see this gaining widespread...
DevOps Must Control, Not Just Record, Misbehaving Agents
RT "Record everything" isn't right. DevOps needs controls to throttle, quarantine, or kill misbehaving agents in real time #DevOps #AIops @Star_CIO https://t.co/tRGwCPc4Mb
TGTX Shows Consistently Low Relapse Rates Across Trials
This very low relapse rate in this $TGTX Phase IV observational trial is consistent with that seen in their 6-year extension study: https://t.co/Shvb8h8VRr
TSMC Schedules A13 Shrink, A12 for 2029, Launches Photonic
Just in: TSMC revealed the next nodes in its technology roadmap A13 is a 6% shrink of A14 A12 will follow A13 Both scheduled for 2029 Also, Compact Universal Photonic Engine with Co-Packages Optics commencing production this year
XAI's Cursor Acquisition Highlights AI Startup Promise and Risk
xAI's Move to Buy Cursor Shows the Promise & the Risks for AI Applications Startups https://t.co/6vNEsHrMEa
AI's Impact on X: Reach, Filters, and Pricing
Join @BrianRoemmele and me discussing how AI is changing X. Decreased reach? Intellectuals filtered out? New AI feeds? Changes in API pricing? The current and future of X is on the table. https://t.co/oeuJtLk5UA
SoundHound AI Acquires LivePerson, Expands Enterprise AI Footprint
.@SoundHound AI buys LivePerson for $43 million, builds enterprise customer base https://t.co/7fswl32rnF SoundHound AI, which focuses on conversational AI, said it has acquired LivePerson in a deal valued at $43 million, a slight premium to LivePerson's $40 million market cap.
AI-Powered Cameras Will Make Hybrid Meetings Standard
Conference rooms are finally getting smart. Multi-camera AI that tracks speakers and keeps remote attendees engaged will be table stakes for hybrid meetings. #FutureOfWork #AI https://t.co/rNDUA2uhNx
Google Cloud Evolves Into AI Hypercomputer, Not Just Cloud
The AI Hypercomputer: Why Google is No Longer "Just Another Cloud". Key takeaways from Google Cloud Next 2026. #CIO #AI #Cloud #GoogleCloudNext https://t.co/LRR1wOu9Wg @rhoshimi @s_look
Schools Must Adopt AI Now for Personalized Learning
My main reaction to this is: schools need to figure out AI right now. Learning will be so much more fun and individualized. Current model is dead ma ln walking. Close to 100% of my “learn new stuff” time is done...
New Benchmark Shows Image Models Anchor Too Rigidly
Image models tend to get much more stuck on a particular direction than text models, requiring clearing the context window fairly often. PerfectSquashBench is my new measure of how image models anchor. The squash remains merely fine after many attempts. https://t.co/W58vdo0oss
Microsoft Still Eyes Full Multiplatform Xbox Store on Android
Microsoft’s new head of gaming, Asha Sharma, says Microsoft is still pursuing the idea of evolving the Xbox App for Android into a full-fledged multiplatform game store.
AI Discovers Chromogranin A Shields Brains From Alzheimer’s
20 to 30% of older adults have full blown Alzheimer's pathology in their brains (plaques, tangles etc.). But they never develop symptoms and nobody knew why. An AI just read thousands of human brains and named the reason: a protein...
AI‑Generated Code: We Pretend It's Perfect Without Inspection
AI has created Shrödinger’s codebase. Is your codebase AI slop or great code? As long as we never look at it and keep vibe coding away... we assume it's all great code.
Inside VC Investing in Nuclear Fusion Breakthroughs
On this week's episode of @EquityPod, @TimDe_Chant and I chatted with Rachel Slaybaugh, general partner at DCVC, about what it's like investing in nuclear fusion. https://t.co/cXRBBkejPY via @techcrunch
Finding a Business Website on GBP Is Ridiculously Difficult
It’s absurd how hard it can be to find a business’ website link on GBP
Morning Routine: Kickstarting Day with AI Tools
Me sitting down at my computer each morning opening up my little AI tools https://t.co/zynFQm4rxP
Enterprise Momentum Surges Amid $NOW Sell‑Off
A harsh $NOW sell-off based on what happened and what’s going to happen with real financial commitments. So what do you gauge enterprise momentum from? Well: - revenue beat - subs +22% and raised guidance - cRPO +22.5% - RPO +25% - Now Assist $1M...
Applovin Rescues Clients as Meta Experiences Major Outages
Applovin is my saving grace for all these bugs on Meta right now. Things are actually doing really decent for a number of clients while Meta is down bad.
Japan's Naphtha Shortage Threatens Global Semiconductor Production
Semi Market, show me you care. "Japan is short on naphtha → Japan can't produce semiconductor materials → This could bring the world's semiconductor fabs to a halt."